| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We investigated the analgesic effect and site of action of Mirogabalin (MG), a novelα2δ ligand, using the rat formalin test, an acute inflammatory pain model. Open field tests were performed to evaluate the effect of MG on moving distance. Oral MG produced an analgesic effect when formalin test was performed 4 h, but not 1 h and 2 h, after oral administration. IT, but not ICV, MG produced analgesic effects. MG attenuated moving distance 1h, 2h, and 4 h after oral administration or after ICV, but not IT, administration. In the oral group, time course of analgesic effect was different from that of moving distance. In the ICV group, MG attenuated moving distance, but did not produce an analgesic effect. In the IT group, MG produced an analgesic effect, but did not affect moving distance. These findings suggest that the analgesic effect of MG is mediated by spinal action, and that inhibitory effect of MG on moving distance is mediated by the supa-spinal brain.
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