Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
In the oncolytic virotherapy of a mouse model of brain tumor, the concomitant use of a CSF-1 receptor inhibitor was found to alter microglial dynamics, alter gene expression profiles in the tumor microenvironment, affect OV-tumor dynamics, and enhance therapeutic efficacy. We were able to accumulate basic data for further improvement of therapeutic efficacy in oncolytic virotherapy.
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