Integrated Regulation of Articular Cartilage by Runx2 and Runx3

• Project/Area Number: 20K09451
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: The University of Tokyo
• Principal Investigator: Taniguchi Yuki 東京大学, 医学部附属病院, 講師 (80722165)
• Co-Investigator(Kenkyū-buntansha): 齋藤 琢 東京大学, 医学部附属病院, 准教授 (30456107) ; 大島 寧 東京大学, 医学部附属病院, 准教授 (50570016)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: Runx3 / Runx2 / 変形性関節症 / ２型コラーゲン / ルブリシン / 関節軟骨 / RNAシークエンス / ChIPシークエンス / 転写制御機構

Outline of Research at the Start

本研究では、まず成体関節軟骨の表層と深層でRunx2, 3をそれぞれノックアウトし、関節軟骨の維持と変性に与える影響を詳細に解析する。同時に表層、深層の関節軟骨由来の初代培養細胞を用いてRunx2, 3のChIPシーケンス、ATACシーケンス、RNAシーケンスを行い、2つのRunxの転写標的を比較検討する。またRunx結合部位の周辺のゲノム配列から共役分子をスクリーニングするとともに、LC-MSによってその分子の同定に挑む。これらの一連の研究によって、成体関節軟骨の維持とOA発症にRunx2, 3がどのように作用しているかを明らかにする。

Outline of Final Research Achievements

We examined the role of Runx2 and Runx3 for osteoarthritis development in vivo and in vitro. Runx3-knockout mice exhibited accelerated osteoarthritis following surgical induction, accompanied by decreased expression of lubricin and aggrecan. Meanwhile, Runx2 conditional knockout mice showed biphasic phenotypes: heterozygous knockout inhibited osteoarthritis and decreased matrix metallopeptidase 13 (Mmp13) expression, while homozygous knockout of Runx2 accelerated osteoarthritis and reduced type II collagen (Col2a1) expression. Comprehensive transcriptional analyses revealed lubricin and aggrecan as transcriptional target genes of Runx3, and indicated that Runx2 sustained Col2a1 expression through an intron 6 enhancer when Sox9 was decreased. Runx3 protects adult articular cartilage through extracellular matrix protein production under normal conditions, while Runx2 exerts both catabolic and anabolic effects under the inflammatory condition.

Academic Significance and Societal Importance of the Research Achievements

関節軟骨は 2 型コラーゲンなどのタンパクによって構成され、表面はルブリシンなどの滑らかなタンパクによって覆われている。これらのタンパクが減少すると軟骨が変性し、変形性関節症に至る。この研究では、 Runx2、Runx3 という2つの転写因子がこれらのタンパクを作り出し、関節軟骨を保護していることを明らかにした。Runx3の関節軟骨での作用はこれまで知られておらず、Runx2はむしろ変形性関節症を悪くすると考えられてきた。Runx3の関節保護作用のほか、Runx2にも隠れた関節保護作用があることを示した本成果は、変形性関節症の病態解明のみならず、治療法開発にも貢献すると期待される。

Research Products

• [Journal Article] A common variant rs2054564 in ADAMST17 is associated with susceptibility to lumbar spondylosis (2023)
  • Author(s): Taniguchi Yuki、Akune Toru、Nishida Nao、Omori Go、HA Kim、Ueno Kazuko、Saito Taku、Oichi Takeshi、Koike Asako、Mabuchi Akihiko、Oka Hiroyuki、Muraki Shigeyuki、Oshima Yasushi、Kawaguchi Hiroshi、Nakamura Kozo、Tokunaga Katsushi、Tanaka Sakae、Yoshimura Noriko
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 4900-4900
  • DOI: 10.1038/s41598-023-32155-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Congenital atlanto-occipital dislocation in a patient with Down syndrome: a case report (2023)
  • Author(s): Onodera Ryoko、Sakamoto Ryuji、Taniguchi Yuki、Hirai Shima、Matsubayashi Yoshitaka、Kato So、Oshima Yasushi、Tanaka Sakae
  • Journal Title: Skeletal Radiology Volume: 0 Issue: 9 Pages: 0-0
  • DOI: 10.1007/s00256-023-04297-5
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Early Postoperative Resolution of MRI Signal Intensity Changes on the Outcomes of Degenerative Cervical Myelopathy (2023)
  • Author(s): Tozawa Keiichiro、Nagata Kosei、Ohtomo Nozomu、Ito Yusuke、Nakamoto Hideki、Kato So、Doi Toru、Taniguchi Yuki、Matsubayashi Yoshitaka、Tanaka Sakae、Oshima Yasushi
  • Journal Title: Spine Volume: 48 Issue: 9 Pages: 591-599
  • DOI: 10.1097/brs.0000000000004612
  • Peer Reviewed
• [Journal Article] Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development (2022)
  • Author(s): Nagata K, Hojo H, Chang SH, Okada H, Chijimatsu R, Omata Y, Mori D, Makii Y, Kawata M, Kaneko T, Iwanaga Y, Nakamoto H, Maenohara Y, Tachibana N, Ishikura H, Higuchi J, Taniguchi Y, Ohba S, Chung Ul, Tanaka S, Saito T
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 6187-6204
  • DOI: 10.1038/s41467-022-33744-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification (2022)
  • Author(s): Tachibana N、Chijimatsu R、Okada H、Oichi T、Taniguchi Y、Maenohara Y、Miyahara J、Ishikura H、Iwanaga Y、Arino Y、Nagata K、Nakamoto H、Kato S、Doi T、Matsubayashi Y、Oshima Y、Terashima A、Omata Y、Yano F、Maeda S、Ikegawa S、Seki M、Suzuki Y、Tanaka S、Saito T
  • Journal Title: Science Advances Volume: 8 Issue: 33 Pages: 2138-2154
  • DOI: 10.1126/sciadv.abn2138
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a Functional Susceptibility Variant for Adolescent Idiopathic Scoliosis that Upregulates Early Growth Response 1 (EGR1)‐Mediated <scp> <i>UNCX</i> </scp> Expression (2022)
  • Author(s): Yonezawa Yoshiro、Guo Long、Kakinuma Hisaya、Otomo Nao、Yoshino Soichiro、Takeda Kazuki、Nakajima Masahiro、他42名
  • Journal Title: Journal of Bone and Mineral Research Volume: 38 Issue: 1 Pages: 144-153
  • DOI: 10.1002/jbmr.4738
  • Peer Reviewed
• [Journal Article] Noninvasive Skin Autofluorescence of Advanced Glycation End Products for Detecting Ossification of the Posterior Longitudinal Ligament in the Thoracic Spine (2022)
  • Author(s): Doi Toru、Horii Chiaki、Tozawa Keiichiro、Nakarai Hiroyuki、Sasaki Katsuyuki、Yoshida Yuichi、Ito Yusuke、Ohtomo Nozomu、Sakamoto Ryuji、Nakajima Koji、Nagata Kosei、Okamoto Naoki、Nakamoto Hideki、Kato So、Taniguchi Yuki、Matsubayashi Yoshitaka、Tanaka Sakae、Oshima Yasushi
  • Journal Title: Spine Volume: 48 Issue: 4 Pages: E40-E45
  • DOI: 10.1097/brs.0000000000004516
  • Peer Reviewed
• [Journal Article] Effect of conventional treatment on dental complications and ectopic ossifications among 30 adults with XLH. (2022)
  • Author(s): Kato H, Okawa R, Ogasawara T, Hoshino Y, Hidaka N, Koga M, Kinoshita Y, Kobayashi H, Taniguchi Y, Fukumoto S, Nangaku M, Makita N, Hoshi K, Nakano K, Ito N.
  • Journal Title: J Clin Endocrinol Metab Volume: dgac732. Issue: 6 Pages: 1-10
  • DOI: 10.1210/clinem/dgac732
  • Peer Reviewed / Open Access
• [Journal Article] Incidence of ossification of the spinal ligaments in acromegaly patients. (2022)
  • Author(s): Hoshino Y, Hidaka N, Kato H, Koga M, Taniguchi Y, Kobayashi H, Nangaku M, Makita N, Ito N.
  • Journal Title: Bone Rep Volume: 17 Pages: 101628-101628
  • DOI: 10.1016/j.bonr.2022.101628
  • Peer Reviewed / Open Access
• [Journal Article] Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early‐Onset Osteoporosis (2022)
  • Author(s): Kato Hajime、Ansh Anenya J、Lester Ethan R、Kinoshita Yuka、Hidaka Naoko、Hoshino Yoshitomo、Koga Minae、Taniguchi Yuki、Uchida Taisuke、Yamaguchi Hideki、Niida Yo、Nakazato Masamitsu、Nangaku Masaomi、Makita Noriko、Takamura Toshinari、Saito Taku、Braddock Demetrios T、Ito Nobuaki
  • Journal Title: Journal of Bone and Mineral Research Volume: - Issue: 6 Pages: 1125-1135
  • DOI: 10.1002/jbmr.4550
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of Perioperative Antithrombic Agent Discontinuation in Elective Posterior Spinal Surgery: A Propensity-Score-Matched Analysis (2022)
  • Author(s): Okamoto Naoki、Kato So、Doi Toru、Nakamoto Hideki、Matsubayashi Yoshitaka、Taniguchi Yuki、Inanami Hirohiko、Higashikawa Akiro、Kawamura Naohiro、Hara Nobuhiro、Azuma Seiichi、Takeshita Yujiro、Ono Takashi、Fukushima Masayoshi、Tanaka Sakae、Oshima Yasushi
  • Journal Title: World Neurosurgery Volume: 158 Pages: e362-e368
  • DOI: 10.1016/j.wneu.2021.10.182
  • Peer Reviewed
• [Journal Article] TRPV2 is involved in induction of lubricin and suppression of ectopic endochondral ossification in articular joints (2021)
  • Author(s): Nakamoto Hideki、Katanosaka Yuki、Chijimatsu Ryota、Mori Daisuke、Xuan Fengjun、Yano Fumiko、Omata Yasunori、Maenohara Yuji、Murahashi Yasutaka、Kawaguchi Kohei、Yamagami Ryota、Inui Hiroshi、Taketomi Shuji、Taniguchi Yuki、Kanagawa Motoi、Naruse Keiji、Tanaka Sakae、Saito Taku
  • Journal Title: Arthritis & Rheumatology Volume: - Issue: 8 Pages: 1441-1450
  • DOI: 10.1002/art.41684
  • Peer Reviewed / Open Access
• [Journal Article] Predictive Physical Manifestations for Progression of Scoliosis in Marfan Syndrome (2021)
  • Author(s): Taniguchi Yuki、Matsubayashi Yoshitaka、Kato So、Doi Toru、Takeda Norifumi、Yagi Hiroki、Inuzuka Ryo、Oshima Yasushi、Tanaka Sakae
  • Journal Title: Spine Volume: 46 Issue: 15 Pages: 1020-1025
  • DOI: 10.1097/brs.0000000000003939
  • Peer Reviewed
• [Journal Article] Impact of pathogenic FBN1 variant types on the development of severe scoliosis in patients with Marfan syndrome (2021)
  • Author(s): Taniguchi Yuki、Takeda Norifumi、Inuzuka Ryo、Matsubayashi Yoshitaka、Kato So、Doi Toru、Yagi Hiroki、Yamauchi Haruo、Ando Masahiko、Oshima Yasushi、Tanaka Sakae
  • Journal Title: Journal of Medical Genetics Volume: in press Issue: 1 Pages: 108186-108186
  • DOI: 10.1136/jmedgenet-2021-108186
  • Peer Reviewed / Open Access
• [Journal Article] Diabetes is associated with greater leg pain and worse patient-reported outcomes at 1 year after lumbar spine surgery (2021)
  • Author(s): Nagata Kosei、Nakamoto Hideki、Taniguchi Yuki、Tanaka Sakae、Oshima Yasushi et al.,
  • Journal Title: Scientific Reports Volume: 11 Issue: 1
  • DOI: 10.1038/s41598-021-87615-y
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Spinal Alignment Changes on Lower Back Pain in Patients Treated with Total Hip Arthroplasty for Hip Osteoarthritis (2021)
  • Author(s): Saiki Fumiko、Tanaka Takeyuki、Tachibana Naohiro、Oshima Hirofumi、Kaneko Taizo、Horii Chiaki、Nakamoto Hideki、Kato So、Doi Toru、Matsubayashi Yoshitaka、Taniguchi Yuki、Tanaka Sakae、Oshima Yasushi
  • Journal Title: Medicina Volume: 57 Issue: 11 Pages: 1219-1219
  • DOI: 10.3390/medicina57111219
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for worsening sexual function after lumbar spine surgery and characteristics of non-responders to the questionnaire of sex life (2021)
  • Author(s): Nakajima Koji、Nakamoto Hideki、Nakarai Hiroyuki、Nagata Kosei、Kato So、Doi Toru、Matsubayashi Yoshitaka、Taniguchi Yuki、Kawamura Naohiro、Higashikawa Akiro、Takeshita Yujiro、Fukushima Masayoshi、Ono Takashi、Hara Nobuhiro、Azuma Seiichi、Tanaka Sakae、Oshima Yasushi
  • Journal Title: European Spine Journal Volume: 30 Issue: 9 Pages: 2661-2669
  • DOI: 10.1007/s00586-021-06867-4
  • Peer Reviewed
• [Journal Article] Association Between Deep Posterior Cervical Paraspinal Muscle Morphology and Clinical Features in Patients With Cervical Ossification of the Posterior Longitudinal Ligament (2021)
  • Author(s): Doi Toru、Ohtomo Nozomu、Oguchi Fumihiko、Tozawa Keiichiro、Nakarai Hiroyuki、Nakajima Koji、Sakamoto Ryuji、Okamoto Naoki、Nakamoto Hideki、Kato So、Taniguchi Yuki、Matsubayashi Yoshitaka、Oka Hiroyuki、Matsudaira Ko、Tanaka Sakae、Oshima Yasushi
  • Journal Title: Global Spine Journal Volume: ー Issue: 1 Pages: 219256822198965-219256822198965
  • DOI: 10.1177/2192568221989655
  • Peer Reviewed / Open Access
• [Journal Article] Associations between curve severity and revised Scoliosis Research Society-22 and scoliosis Japanese Questionnaire-27 scores in female patients with adolescent idiopathic scoliosis: a multicenter, cross-sectional study (2021)
  • Author(s): Doi Toru、Watanabe Kei、Doi Tokuhide、Inoue Hirokazu、Sugawara Ryo、Arai Yasuhisa、Shirado Osamu、Yamazaki Ken、Uno Koki、Yanagida Haruhisa、Kato So、Taniguchi Yuki、Matsubayashi Yoshitaka、Oshima Yasushi、Tanaka Sakae、Takeshita Katsushi
  • Journal Title: BMC Musculoskeletal Disorders Volume: 22 Issue: 1 Pages: 312-312
  • DOI: 10.1186/s12891-021-04189-6
  • Peer Reviewed / Open Access
• [Journal Article] Tracheal stenosis due to cervicothoracic hyperlordosis in patients with cerebral palsy treated with posterior spinal fusion: a report of the first two cases (2021)
  • Author(s): Taniguchi Yuki、Matsubayashi Yoshitaka、Kato So、Oguchi Fumihiko、Nohara Ayato、Doi Toru、Oshima Yasushi、Tanaka Sakae
  • Journal Title: BMC Musculoskeletal Disorders Volume: 22 Issue: 1
  • DOI: 10.1186/s12891-021-04094-y
  • Peer Reviewed / Open Access
• [Journal Article] Comparison Between the Japanese Orthopaedic Association (JOA) Score and Patient-Reported JOA (PRO-JOA) Score to Evaluate Surgical Outcomes of Degenerative Cervical Myelopathy (2020)
  • Author(s): Oshima Yasushi、Takeshita Katsushi、Kato So、Doi Toru、Matsubayashi Yoshitaka、Taniguchi Yuki、Nakajima Koji、Oguchi Fumihiko、Okamoto Naoki、Sakamoto Ryuji、Tanaka Sakae
  • Journal Title: Global Spine Journal Volume: - Issue: 5 Pages: 795-800
  • DOI: 10.1177/2192568220964167
  • Peer Reviewed / Open Access
• [Journal Article] A Multicenter Observational Study on the Postoperative Outcomes of C3 Laminectomy in Cervical Double-door Laminoplasty (2020)
  • Author(s): Nakajima Koji、Nakamoto Hideki、Kato So、Doi Toru、Matsubayashi Yoshitaka、Taniguchi Yuki、Yoshida Yuichi、Kawamura Naohiro、Nakarai Hiroyuki、Higashikawa Akiro、Tozawa Keiichiro、Takeshita Yujiro、Fukushima Masayoshi、Iizuka Masaaki、Ono Takashi、Shirokoshi Tomohiko、Azuma Seiichi、Tanaka Sakae、Oshima Yasushi
  • Journal Title: Clinical Spine Surgery: A Spine Publication Volume: Publish Ahead of Print Issue: 4 Pages: 146-152
  • DOI: 10.1097/bsd.0000000000001100
  • Peer Reviewed / Open Access
• [Journal Article] Influence of unintended dural tears on postoperative outcomes in lumbar surgery patients: a multicenter observational study with propensity scoring (2020)
  • Author(s): Nakajima Koji、Nakamoto Hideki、Kato So、Doi Toru、Matsubayashi Yoshitaka、Taniguchi Yuki、Kawamura Naohiro、Higashikawa Akiro、Takeshita Yujiro、Fukushima Masayoshi、Ono Takashi、Hara Nobuhiro、Azuma Seiichi、Tanaka Sakae、Oshima Yasushi
  • Journal Title: The Spine Journal Volume: 20 Issue: 12 Pages: 1968-1975
  • DOI: 10.1016/j.spinee.2020.06.009
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for progression of ossification of the posterior longitudinal ligament in asymptomatic subjects (2020)
  • Author(s): Doi Toru、Sakamoto Ryuji、Horii Chiaki、Okamoto Naoki、Nakajima Koji、Hirai Shima、Oguchi Fumihiko、Kato So、Taniguchi Yuki、Matsubayashi Yoshitaka、Hayashi Naoto、Tanaka Sakae、Oshima Yasushi
  • Journal Title: Journal of Neurosurgery: Spine Volume: 33 Issue: 3 Pages: 316-322
  • DOI: 10.3171/2020.3.spine2082
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pathomechanism of intervertebral disc degeneration (2020)
  • Author(s): Oichi Takeshi、Taniguchi Yuki、Oshima Yasushi、Tanaka Sakae、Saito Taku
  • Journal Title: JOR SPINE Volume: 3 Issue: 1
  • DOI: 10.1002/jsp2.1076
  • Peer Reviewed / Open Access
• [Journal Article] Lubricin Contributes to Homeostasis of Articular Cartilage by Modulating Differentiation of Superficial Zone Cells (2020)
  • Author(s): Maenohara Yuji、Chijimatsu Ryota、Tachibana Naohiro、Uehara Kosuke、Xuan Fengjun、Mori Daisuke、Murahashi Yasutaka、Nakamoto Hideki、Oichi Takeshi、Chang Song Ho、Matsumoto Takumi、Omata Yasunori、Yano Fumiko、Tanaka Sakae、Saito Taku
  • Journal Title: Journal of Bone and Mineral Research Volume: 36 Issue: 4 Pages: 792-802
  • DOI: 10.1002/jbmr.4226
  • Peer Reviewed / Open Access
• [Journal Article] Evidence that TD‐198946 enhances the chondrogenic potential of human synovium‐derived stem cells through the NOTCH3 signaling pathway (2020)
  • Author(s): Kobayashi Masato、Chijimatsu Ryota、Hart David A.、Hamamoto Shuichi、Jacob George、Yano Fumiko、Saito Taku、Shimomura Kazunori、Ando Wataru、Chung Ung‐il、Tanaka Sakae、Yoshikawa Hideki、Nakamura Norimasa
  • Journal Title: Journal of Tissue Engineering and Regenerative Medicine Volume: 15 Issue: 2 Pages: 103-115
  • DOI: 10.1002/term.3149
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ear Cartilage Reconstruction Combining Induced Pluripotent Stem Cell-Derived Cartilage and Three-Dimensional Shape-Memory Scaffold (2020)
  • Author(s): Uto Sakura、Hikita Atsuhiko、Sakamoto Tomoaki、Mori Daisuke、Yano Fumiko、Ohba Shinsuke、Saito Taku、Takato Tsuyoshi、Hoshi Kazuto
  • Journal Title: Tissue Engineering Part A Volume: - Issue: 9-10 Pages: 604-617
  • DOI: 10.1089/ten.tea.2020.0106
  • Peer Reviewed
• [Journal Article] The small compound, TD-198946, protects against intervertebral degeneration by enhancing glycosaminoglycan synthesis in nucleus pulposus cells (2020)
  • Author(s): Kushioka Junichi、Kaito Takashi、Chijimatsu Ryota、Okada Rintaro、Ishiguro Hiroyuki、Bal Zeynep、Kodama Joe、Yano Fumiko、Saito Taku、Chung Ung-il、Tanaka Sakae、Yoshikawa Hideki
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 14190-14190
  • DOI: 10.1038/s41598-020-71193-6
  • Peer Reviewed / Open Access
• [Journal Article] Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis (2020)
  • Author(s): Higuchi Junya、Yamagami Ryota、Matsumoto Takumi、Terao Tomohiro、Inoue Keita、Tsuji Shinsaku、Maenohara Yuji、Matsuzaki Tokio、Chijimatsu Ryota、Omata Yasunori、Yano Fumiko、Tanaka Sakae、Saito Taku
  • Journal Title: Regenerative Therapy Volume: 14 Pages: 332-340
  • DOI: 10.1016/j.reth.2020.04.003
  • Peer Reviewed / Open Access
• [Presentation] ADAM17/TACE accerates osteoarthritis develpoment through EGFR signaling and TNF pathways (2021)
  • Author(s): Kaneko T, Yano F, Chijimatsu R, Tanaka S, Saito T
  • Organizer: 2021 Auunal Meeting of the Orthopaedic Resarch Societ
  • Int'l Joint Research
• [Presentation] Runx3 protects articular cartilage by direct induction of Prg4 (2020)
  • Author(s): 永田向生
  • Organizer: 米国骨代謝学会ASBMR
  • Int'l Joint Research
• [Presentation] Notch signaling contributes to articular cartilage homeostasis by suppressing differentiation of superficial zone cells (2020)
  • Author(s): Iwanaga Y, Nagata K, Yano F, Tanaka S, Saito T
  • Organizer: 米国骨代謝学会ASBMR
  • Int'l Joint Research
• [Presentation] Taceは変形性関節症を促進的に制御する (2020)
  • Author(s): 金子泰三、千々松良太、矢野文子、堀内圭輔、田中栄、齋藤琢
  • Organizer: 第38回日本骨代謝学会学術集会
• [Presentation] Notchは最表層細胞の維持を介して関節軟骨の恒常性に貢献する (2020)
  • Author(s): 岩永康秀、永田向生、千々松良太、矢野文子、田中栄、齋藤琢
  • Organizer: 第35回日本整形外科学会基礎学術集会
• [Presentation] 脂肪幹細胞を用いた変形性膝関節症治療の臨床成績と、治療効果に関係するMRI所見の検討 (2020)
  • Author(s): 樋口淳也, 山神良太, 松本卓巳, 前之原悠司, 寺尾友宏, 井上啓太, 辻晋作, 千々松良太, 小俣康徳, 矢野文子, 田中栄, 齋藤琢
  • Organizer: 第19回再生医療学会総会
• [Presentation] OAの病態における軟骨と周囲組織との関連 (2020)
  • Author(s): 齋藤琢
  • Organizer: 第48回日本関節病学会
  • Invited
• [Presentation] 関節軟骨層ごとの主要シグナルの役割 (2020)
  • Author(s): 齋藤琢
  • Organizer: 第35回日本整形外科学会基礎学術集会
  • Invited
• [Presentation] 関節軟骨の維持機構 (2020)
  • Author(s): 齋藤琢
  • Organizer: 第64回日本リウマチ学会
  • Invited
• [Book] 変形性関節症の分子病態と治療法開発 (2020)
  • Author(s): 齋藤琢
  • Total Pages: 5
  • Publisher: 日本整形外科学会雑誌
• [Book] Elsevier. Chapter “NF-kappaB and HIF Signaling in Osteoarthritis” (2020)
  • Author(s): Saito T
  • Publisher: Reference Module in Biomedical Research. Encyclopedia of Bone Biology
• [Book] 実験医学 (2020)
  • Author(s): 齋藤琢
  • Total Pages: 6
  • Publisher: 関節軟骨のメカノバイオロジー
• [Remarks] 東京大学医学部附属病院 整形外科・脊椎外科
  • URL: http://www.u-tokyo-ortho.jp/