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The development of novel strategies for the prevention and treatment of recalcitrant bone fractures and osteoporosis through the utilization of ultrafine bubbles

Research Project

Project/Area Number 20K09460
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionOsaka University

Principal Investigator

Ebina Kosuke  大阪大学, 大学院医学系研究科, 特任准教授(常勤) (70612076)

Co-Investigator(Kenkyū-buntansha) 平尾 眞  大阪大学, 大学院医学系研究科, 招へい教員 (10527708)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords廃用性骨粗鬆症 / 難治性骨折 / 酸素 / ウルトラファインバブル / 骨癒合 / 治療
Outline of Research at the Start

UFBは安価に大量生成可能で、かつ気体を長期間高濃度で液体中に存在させることが可能などの利点があり、drug deliveryなどの点で注目される新規技術である。酸素UFB(OUB)水の組成は通常水と同様であり、また既にヒトでも投与されていることより安全性も担保されていると考えられる。自宅での経口摂取等を考慮すると服薬コンプライアンスの面でも有利と考えられ、作用機序の異なる既存薬との併用効果も期待される。UFBは既存治療薬と異なり、水と酸素の形状を変化させ投与することで骨粗鬆症と神経損傷の両方の病態を改善する、安全性・利便性・コスト・補完性に優れた革新的な新規治療法となり得ると考えられる。

Outline of Final Research Achievements

Upon the addition of oxygen ultrafine bubbles (OUB) during the cultivation of mouse-derived osteoclasts, RNA sequencing analysis revealed a downregulation of related genes, including those involved in osteoclast differentiation, cell adhesion, and cytoskeletal organization, compared to the control group. A rat model of intractable femoral fracture was established, and intraperitoneal administration of OUB water (3.0ml × 5 times/week) was conducted. After 8 weeks, there was no significant difference in bone union compared to the control group (physiological saline administration). A mouse model of disuse-induced osteoporosis (induced by tail suspension for 3 weeks) was created, and intraperitoneal administration of OUB water (300μl × 5 times/week) was performed for 3 weeks. There were no significant differences observed in femoral bone density at the distal end and tibialis anterior muscle weight compared to the control group.

Academic Significance and Societal Importance of the Research Achievements

酸素ウルトラファインバブル(OUB)は骨代謝において中心的な役割を司る破骨細胞や骨細胞の分化・増殖・機能にダイナミックに関与することが示された。今回の研究では骨代謝に関与することが報告されている酸素をウルトラファインバブル化することで検討を行った。理論上あらゆる気体をウルトラファインバブル化することが可能であり、本研究成果がこの技術を用いた新たなドラッグデリバリーや臨床応用に活用されることが期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (51 results)

All 2023 2022 2021 2020

All Journal Article (33 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 33 results,  Open Access: 21 results) Presentation (18 results) (of which Int'l Joint Research: 1 results,  Invited: 13 results)

  • [Journal Article] Reply to letter to the editor by Yoshii2023

    • Author(s)
      Nagayama Yoshio、Ebina Kosuke、Tsuboi Hideki、Hirao Makoto、Hashimoto Jun、Yoshikawa Hideki、Okada Seiji、Nakata Ken
    • Journal Title

      Journal of Orthopaedic Science

      Volume: - Issue: 3 Pages: 717-718

    • DOI

      10.1016/j.jos.2023.02.023

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of the duration of previous osteoporosis treatment on the effect of romosozumab in patients with postmenopausal osteoporosis2022

    • Author(s)
      Ebina Kosuke、Etani Yuki、Tsuboi Hideki、Nagayama Yoshio、Kashii Masafumi、Miyama Akira、Kunugiza Yasuo、Hirao Makoto、Okamura Gensuke、Noguchi Takaaki、Takami Kenji、Goshima Atsushi、Miura Taihei、Fukuda Yuji、Kurihara Takuya、Okada Seiji、Nakata Ken
    • Journal Title

      Osteoporosis International

      Volume: 33 Issue: 11 Pages: 2441-2443

    • DOI

      10.1007/s00198-022-06545-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of prior osteoporosis treatment on the treatment response of romosozumab followed by denosumab in patients with postmenopausal osteoporosis2022

    • Author(s)
      Ebina K.、Etani Y.、Tsuboi H.、Nagayama Y.、Kashii M.、Miyama A.、Kunugiza Y.、Hirao M.、Okamura G.、Noguchi T.、Takami K.、Goshima A.、Miura T.、Fukuda Y.、Kurihara T.、Okada S.、Nakata K.
    • Journal Title

      Osteoporosis International

      Volume: 33 Issue: 8 Pages: 1807-1813

    • DOI

      10.1007/s00198-022-06386-y

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Add-on effectiveness of methotrexate or iguratimod in patients with rheumatoid arthritis exhibiting an inadequate response to Janus kinase inhibitors: The ANSWER cohort study2022

    • Author(s)
      Ebina Kosuke、Hirano Toru、Maeda Yuichi、Okita Yasutaka、Etani Yuki、Hirao Makoto、Yamamoto Wataru、Hashimoto Motomu、Murata Koichi、Onishi Akira、Jinno Sadao、Hara Ryota、Son Yonsu、Amuro Hideki、Kotani Takuya、Shiba Hideyuki、Katayama Masaki、Yamamoto Keiichi、Kumanogoh Atsushi、Okada Seiji、Nakata Ken
    • Journal Title

      Modern Rheumatology

      Volume: - Issue: 4 Pages: 690-699

    • DOI

      10.1093/mr/roac092

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Baseline serum PINP level is associated with the increase in hip bone mineral density seen with Romosozumab treatment in previously untreated women with osteoporosis2022

    • Author(s)
      Kashii Masafumi、Kamatani Takashi、Nagayama Yoshio、Miyama Akira、Tsuboi Hideki、Ebina Kosuke
    • Journal Title

      Osteoporosis International

      Volume: 34 Issue: 3 Pages: 563-572

    • DOI

      10.1007/s00198-022-06642-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel anti-TNF-α drug ozoralizumab rapidly distributes to inflamed joint tissues in a mouse model of collagen induced arthritis2022

    • Author(s)
      Oyama Shohei、Ebina Kosuke、Etani Yuki、Hirao Makoto、Kyuuma Masanao、Fujii Yasuyuki、Iwata Katsuya、Ogawa Bunichiro、Hasegawa Tomoya、Kawano Sasagu、Nakanishi Yutaka、Okada Seiji、Nakata Ken
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41598-022-23152-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modified Scarf Osteotomy with Medial Capsular Interposition Combined with Metatarsal Shortening Offset Osteotomy2022

    • Author(s)
      Etani Yuki、Hirao Makoto、Ebina Kosuke、Tsuboi Hideki、Noguchi Takaaki、Okamura Gensuke、Miyama Akira、Takami Kenji、Nampei Akihide、Tsuji Shigeyoshi、Owaki Hajime、Okada Seiji、Hashimoto Jun
    • Journal Title

      Journal of Bone and Joint Surgery

      Volume: 104 Issue: 14 Pages: 1269-1280

    • DOI

      10.2106/jbjs.21.01486

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes2022

    • Author(s)
      Murakami Tomohiko、Takahata Yoshifumi、Hata Kenji、Ebina Kosuke、Hirose Katsutoshi、Ruengsinpinya Lerdluck、Nakaminami Yuri、Etani Yuki、Kobayashi Sachi、Maruyama Takashi、Nakano Hiroyasu、Kaneko Takehito、Toyosawa Satoru、Asahara Hiroshi、Nishimura Riko
    • Journal Title

      Science Signaling

      Volume: 15 Issue: 758

    • DOI

      10.1126/scisignal.abl5304

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement of Knee Alignment and Function After Corrective Surgery for Hindfoot Deformity2022

    • Author(s)
      Etani Yuki、Hirao Makoto、Ebina Kosuke、Noguchi Takaaki、Okamura Gensuke、Tsuboi Hideki、Miyama Akira、Tsuji Shigeyoshi、Kunugiza Yasuo、Okada Seiji、Hashimoto Jun
    • Journal Title

      JBJS Case Connector

      Volume: 12 Issue: 2

    • DOI

      10.2106/jbjs.cc.21.00805

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meniscus surface texture is associated with degenerative changes in biological and biomechanical properties2022

    • Author(s)
      Otani S, Kanamoto T, Oyama S, Yamakawa S, Shi W, Miyazaki R, Aihara M, Oka S, Kuroda S, Nakai T, Takenaka K, Sato Y, Tsukamoto M, Tsujii A, Ebina K, Okada S, Nakata K.
    • Journal Title

      Sci Rep.

      Volume: 12(1) Issue: 1 Pages: 11977-11977

    • DOI

      10.1038/s41598-022-16206-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Articular surface integrity assessed by ultrasound is associated with biological characteristics of articular cartilage in early-stage degeneration2022

    • Author(s)
      Shi Wen、Kanamoto Takashi、Aihara Masaharu、Oka Shiro、Kuroda Sanae、Nakai Tsuyoshi、Mazuka Takeo、Takenaka Keisuke、Sato Yuji、Tsukamoto Masahiro、Ebina Kosuke、Nakata Ken
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41598-022-16248-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modified scarf osteotomy with capsular interposition as salvage for resection or silicone implant arthroplasty in patients with rheumatoid arthritis. A report of three cases2022

    • Author(s)
      Noguchi Takaaki、Hirao Makoto、Tsuji Shigeyoshi、Ebina Kosuke、Etani Yuki、Tsuboi Hideki、Okamura Gensuke、Akita Shosuke、Okada Seiji、Hashimoto Jun
    • Journal Title

      Modern Rheumatology Case Reports

      Volume: 7 Issue: 1 Pages: 34-38

    • DOI

      10.1093/mrcr/rxac079

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of Intermetatarsal Angle Between the Second and Fifth Metatarsals (M2-M5A) in the Rheumatoid Foot2022

    • Author(s)
      Noguchi Takaaki、Hirao Makoto、Tsuji Shigeyoshi、Etani Yuki、Ebina Kosuke、Tsuboi Hideki、Okamura Gensuke、Akita Shosuke、Okada Seiji、Hashimoto Jun
    • Journal Title

      Cureus

      Volume: -

    • DOI

      10.7759/cureus.24831

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors affecting drug retention of Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study2022

    • Author(s)
      Ebina Kosuke、Hirano Toru、Maeda Yuichi、Yamamoto Wataru、Hashimoto Motomu、Murata Koichi、Onishi Akira、Jinno Sadao、Hara Ryota、Son Yonsu、Amuro Hideki、Takeuchi Tohru、Yoshikawa Ayaka、Katayama Masaki、Yamamoto Keiichi、Okita Yasutaka、Hirao Makoto、Etani Yuki、Kumanogoh Atsushi、Okada Seiji、Nakata Ken
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41598-021-04075-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Midfoot Derotational Osteotomy for Ankylosing Inversion Deformity in Patients with Rheumatoid Arthritis2022

    • Author(s)
      Etani Yuki、Hirao Makoto、Ebina Kosuke、Kunugiza Yasuo、Noguchi Takaaki、Tsuboi Hideki、Tsuji Shigeyoshi、Okada Seiji、Hashimoto Jun
    • Journal Title

      JBJS Case Connector

      Volume: 12 Issue: 1

    • DOI

      10.2106/jbjs.cc.21.00613

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential efficacy of TNF inhibitors with or without the immunoglobulin fragment crystallizable (Fc) portion in rheumatoid arthritis: the ANSWER cohort study2022

    • Author(s)
      Nakayama Yoichi、Watanabe Ryu、Murakami Kosaku、Murata Koichi、Tanaka Masao、Ito Hiromu、Yamamoto Wataru、Ebina Kosuke、Hata Kenichiro、Hiramatsu Yuri、Katayama Masaki、Son Yonsu、Amuro Hideki、Akashi Kengo、Onishi Akira、Hara Ryota、Yamamoto Keiichi、Ohmura Koichiro、Matsuda Shuichi、Morinobu Akio、Hashimoto Motomu
    • Journal Title

      Rheumatology International

      Volume: - Issue: 7 Pages: 1227-1234

    • DOI

      10.1007/s00296-021-05086-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of prior osteoporosis treatment on 12-month treatment response of romosozumab in patients with postmenopausal osteoporosis2021

    • Author(s)
      Ebina Kosuke、Tsuboi Hideki、Nagayama Yoshio、Kashii Masafumi、Kaneshiro Shoichi、Miyama Akira、Nakaya Hiroyuki、Kunugiza Yasuo、Hirao Makoto、Okamura Gensuke、Etani Yuki、Takami Kenji、Goshima Atsushi、Miura Taihei、Nakata Ken、Okada Seiji
    • Journal Title

      Joint Bone Spine

      Volume: 88 Issue: 5 Pages: 105219-105219

    • DOI

      10.1016/j.jbspin.2021.105219

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug efficacy and safety of biologics and Janus kinase inhibitors in elderly patients with rheumatoid arthritis2021

    • Author(s)
      Ebina Kosuke
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 2 Pages: 256-262

    • DOI

      10.1093/mr/roab003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low serum albumin concentration is associated with increased risk of osteoporosis in postmenopausal patients with rheumatoid arthritis2021

    • Author(s)
      Nagayama Yoshio、Ebina Kosuke、Tsuboi Hideki、Hirao Makoto、Hashimoto Jun、Yoshikawa Hideki、Okada Seiji、Nakata Ken
    • Journal Title

      Journal of Orthopaedic Science

      Volume: - Issue: 6 Pages: 1283-1290

    • DOI

      10.1016/j.jos.2021.08.018

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modified Anterolateral Approach for Total Ankle Arthroplasty2021

    • Author(s)
      Hirao Makoto、Ebina Kosuke、Etani Yuki、Kaneshiro Shoichi、Tsuboi Hideki、Noguchi Takaaki、Okamura Gensuke、Kunugiza Yasuo、Nakaya Hiroyuki、Nishikawa Masataka、Tsuji Shigeyoshi、Takahi Koichiro、Owaki Hajime、Hashimoto Jun
    • Journal Title

      Foot & Ankle Orthopaedics

      Volume: 6 Issue: 2

    • DOI

      10.1177/24730114211013342

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of the drug retention and reasons for discontinuation of tumor necrosis factor inhibitors and interleukin-6 inhibitors in Japanese patients with elderly-onset rheumatoid arthritis?the ANSWER cohort study2021

    • Author(s)
      Jinno Sadao、Onishi Akira、Dubreuil Maureen、Hashimoto Motomu、Yamamoto Wataru、Murata Koichi、Takeuchi Tohru、Kotani Takuya、Maeda Yuichi、Ebina Kosuke、Son Yonsu、Amuro Hideki、Hara Ryota、Katayama Masaki、Saegusa Jun
    • Journal Title

      Arthritis Research & Therapy

      Volume: 23 Issue: 1

    • DOI

      10.1186/s13075-021-02496-w

    • NAID

      120007033556

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of efficacy between anti-IL-6 receptor antibody and other biological disease-modifying antirheumatic drugs in the patients with rheumatoid arthritis who have knee joint involvement: the ANSWER cohort, retrospective study2021

    • Author(s)
      Maeda Yuichi、Hirano Toru、Ebina Kosuke、Hara Ryota、Hashimoto Motomu、Yamamoto Wataru、Murakami Kosaku、Kotani Takuya、Hata Kenichiro、Son Yonsu、Amuro Hideki、Onishi Akira、Jinno Sadao、Katayama Masaki、Kumanogoh Atsushi
    • Journal Title

      Rheumatology International

      Volume: - Issue: 7 Pages: 1233-1241

    • DOI

      10.1007/s00296-021-04862-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Favorable clinical response and drug retention of anti-IL-6 receptor inhibitor in rheumatoid arthritis with high CRP levels: the ANSWER cohort study2021

    • Author(s)
      Nakayama Y、Hashimoto M、Watanabe R、Murakami K、Murata K、Tanaka M、Ito H、Yamamoto W、Ebina K、Hata K、Hiramatsu Y、Katayama M、Son Y、Amuro H、Akashi K、Onishi A、Hara R、Yamamoto K、Ohmura K、Matsuda S、Morinobu A
    • Journal Title

      Scandinavian Journal of Rheumatology

      Volume: - Issue: 6 Pages: 1-10

    • DOI

      10.1080/03009742.2021.1947005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The real-world effectiveness of anti-RANKL antibody denosumab on the clinical fracture prevention in patients with rheumatoid arthritis: The ANSWER cohort study2021

    • Author(s)
      Murata Koichi、Uozumi Ryuji、Hashimoto Motomu、Ebina Kosuke、Akashi Kengo、Onishi Akira、Nagai Koji、Yoshikawa Ayaka、Katayama Masaki、Son Yonsu、Amuro Hideki、Hara Ryota、Yamamoto Wataru、Watanabe Ryu、Murakami Kosaku、Tanaka Masao、Ito Hiromu、Morinobu Akio、Matsuda Shuichi
    • Journal Title

      Modern Rheumatology

      Volume: - Issue: 4 Pages: 834-838

    • DOI

      10.1093/mr/roab043

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of Decreased Physical Activity with Rheumatoid Mid-Hindfoot Deformity/Destruction2021

    • Author(s)
      Noguchi Takaaki、Hirao Makoto、Tsuji Shigeyoshi、Ebina Kosuke、Tsuboi Hideki、Etani Yuki、Akita Shosuke、Hashimoto Jun
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 19 Pages: 10037-10037

    • DOI

      10.3390/ijerph181910037

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combination of Modified Scarf Osteotomy and Metatarsal Shortening Offset Osteotomy for Rheumatoid Forefoot Deformity2021

    • Author(s)
      Etani Yuki、Hirao Makoto、Ebina Kosuke、Noguchi Takaaki、Okamura Gensuke、Miyama Akira、Tsuboi Hideki、Nampei Akihide、Tsuji Shigeyoshi、Owaki Hajime、Okada Seiji、Hashimoto Jun
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 19 Pages: 10473-10473

    • DOI

      10.3390/ijerph181910473

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of iguratimod on glucocorticoid-induced disorder of bone metabolism in vitro2021

    • Author(s)
      Miyama Akira、Ebina Kosuke、Hirao Makoto、Okamura Gensuke、Etani Yuki、Takami Kenji、Goshima Atsushi、Miura Taihei、Oyama Shohei、Kanamoto Takashi、Yoshikawa Hideki、Nakata Ken
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: Epub ahead of print Issue: 4 Pages: 1-1

    • DOI

      10.1007/s00774-021-01206-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug retention of sarilumab, baricitinib, and tofacitinib in patients with rheumatoid arthritis: the ANSWER cohort study2021

    • Author(s)
      Ebina Kosuke、Hirano Toru、Maeda Yuichi、Yamamoto Wataru、Hashimoto Motomu、Murata Koichi、Onishi Akira、Jinno Sadao、Hara Ryota、Son Yonsu、Amuro Hideki、Takeuchi Tohru、Yoshikawa Ayaka、Katayama Masaki、Yamamoto Keiichi、Hirao Makoto、Okita Yasutaka、Kumanogoh Atsushi、Nakata Ken
    • Journal Title

      Clinical Rheumatology

      Volume: Epub ahead of print Issue: 7 Pages: 1-1

    • DOI

      10.1007/s10067-021-05609-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Promoting Effect of Basic Fibroblast Growth Factor in Synovial Mesenchymal Stem Cell-Based Cartilage Regeneration2020

    • Author(s)
      Okamura G, Ebina K, Hirao M, Chijimatsu R, Yonetani Y, Etani Y, Miyama A, Takami K, Goshima A, Yoshikawa H, Ishimoto T, Nakano T, Hamada M, Kanamoto T, Nakata K.
    • Journal Title

      Int J Mol Sci.

      Volume: 22 Issue: 1 Pages: 300-300

    • DOI

      10.3390/ijms22010300

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined effect of teriparatide and an anti-RANKL monoclonal antibody on bone defect regeneration in mice with glucocorticoid-induced osteoporosis2020

    • Author(s)
      Etani Yuki、Ebina Kosuke、Hirao Makoto、Kitaguchi Kazuma、Kashii Masafumi、Ishimoto Takuya、Nakano Takayoshi、Okamura Gensuke、Miyama Akira、Takami Kenji、Goshima Atsushi、Kanamoto Takashi、Nakata Ken、Yoshikawa Hideki
    • Journal Title

      Bone

      Volume: 139 Pages: 115525-115525

    • DOI

      10.1016/j.bone.2020.115525

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of prior osteoporosis treatment on early treatment response of romosozumab in patients with postmenopausal osteoporosis2020

    • Author(s)
      Ebina Kosuke、Hirao Makoto、Tsuboi Hideki、Nagayama Yoshio、Kashii Masafumi、Kaneshiro Shoichi、Miyama Akira、Nakaya Hiroyuki、Kunugiza Yasuo、Okamura Gensuke、Etani Yuki、Takami Kenji、Goshima Atsushi、Nakata Ken
    • Journal Title

      Bone

      Volume: 140 Pages: 115574-115574

    • DOI

      10.1016/j.bone.2020.115574

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of follow-on therapy after denosumab discontinuation in patients with postmenopausal osteoporosis2020

    • Author(s)
      Ebina Kosuke、Hashimoto Jun、Kashii Masafumi、Hirao Makoto、Miyama Akira、Nakaya Hiroyuki、Tsuji Shigeyoshi、Takahi Koichiro、Tsuboi Hideki、Okamura Gensuke、Etani Yuki、Takami Kenji、Yoshikawa Hideki
    • Journal Title

      Modern Rheumatology

      Volume: 31 Issue: 2 Pages: 485-492

    • DOI

      10.1080/14397595.2020.1769895

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Drug retention of 7 biologics and tofacitinib in biologics-na?ve and biologics-switched patients with rheumatoid arthritis: the ANSWER cohort study2020

    • Author(s)
      Ebina Kosuke、Hirano Toru、Maeda Yuichi、Yamamoto Wataru、Hashimoto Motomu、Murata Koichi、Takeuchi Tohru、Shiba Hideyuki、Son Yonsu、Amuro Hideki、Onishi Akira、Akashi Kengo、Hara Ryota、Katayama Masaki、Yamamoto Keiichi、Kumanogoh Atsushi、Hirao Makoto
    • Journal Title

      Arthritis Research & Therapy

      Volume: 22 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s13075-020-02232-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] リウマチ性疾患に伴う骨粗鬆症のマネージメント2022

    • Author(s)
      蛯名耕介、平尾眞、惠谷悠紀、岡田誠司
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 新規抗TNFα抗体オゾラリズマブはアダリムマブより速やかに炎症関節へ移行する2022

    • Author(s)
      蛯名耕介、尾山翔平、平尾眞、惠谷悠紀、久間昌尚、藤井康行、岡田誠司
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 関節リウマチ伴う骨関節破壊機序とその対策-RANKL制御の意義-2022

    • Author(s)
      蛯名耕介、平尾眞、惠谷悠紀、前田悠一、沖田康孝、熊ノ郷淳、岡田誠司
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 関西多施設ANSWERコホートから見えるRA診療の現状2022

    • Author(s)
      蛯名耕介、平尾眞、惠谷悠紀、岡田誠司
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 次世代の抗体医薬とリウマチ治療2022

    • Author(s)
      蛯名耕介
    • Organizer
      第95回日本整形外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 閉経後骨粗鬆症患者に対するロモソズマブの投与効果に前骨粗鬆症治療が及ぼす影響についての検討2022

    • Author(s)
      蛯名耕介、坪井秀規、永山芳大、柏井将文、金城聖一、三山彬、平尾眞、岡村元佑、惠谷悠紀、中田研、岡田誠司
    • Organizer
      第95回日本整形外科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 顎骨壊死と非定型大腿骨骨折に対する骨形成促進薬の位置付け2022

    • Author(s)
      蛯名耕介、平尾眞、惠谷悠紀、岡田誠司、中田研
    • Organizer
      第95回日本整形外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 適切な逐次療法の使い分けについて2022

    • Author(s)
      蛯名耕介、惠谷悠紀、岡田誠司、中田研
    • Organizer
      第24回日本骨粗鬆症学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 骨代謝マーカーや骨関連パラメーターの推移から見た骨モデリングとリモデリング2022

    • Author(s)
      蛯名耕介
    • Organizer
      第24回日本骨粗鬆症学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 前骨粗鬆症治療がロモソズマブとその後のデノスマブによる逐次治療に及ぼす影響2022

    • Author(s)
      蛯名耕介、惠谷悠紀、坪井秀規、永山芳大、柏井将文、三山彬、岡村元祐、椚座康夫、平尾眞、岡田誠司、中田研
    • Organizer
      第24回日本骨粗鬆症学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 関節リウマチにおける骨関節破壊機序とその対策-コホート研究より考える関節リウマチ治療の最適化-2022

    • Author(s)
      蛯名耕介、惠谷悠紀、岡田誠司、中田研
    • Organizer
      第139回中部日本整形外科災害外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 骨粗鬆症治療の最適化-2022update-2022

    • Author(s)
      蛯名耕介、惠谷悠紀、岡田誠司、中田研
    • Organizer
      第139回中部日本整形外科災害外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 最新の関節リウマチ・骨粗鬆症治療の動向2022

    • Author(s)
      蛯名耕介
    • Organizer
      第49回日本股関節学会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 新規抗TNFα抗体オゾラリズマブはアダリムマブより速やかに炎症関節へ移行する2022

    • Author(s)
      蛯名耕介、尾山翔平、惠谷悠紀、平尾眞、久間昌尚、藤井康行、岩田勝也、小川文一朗、長谷川友哉、岡田誠司、中田研
    • Organizer
      第37回日本整形外科学会基礎学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 関節リウマチに伴う骨粗鬆症とサルコペニア2022

    • Author(s)
      蛯名耕介、惠谷悠紀、岡田誠司、中田研
    • Organizer
      第51回日本関節病学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 整形外科医から見たD2TRAに対する治療戦略2022

    • Author(s)
      蛯名耕介
    • Organizer
      第37回日本臨床リウマチ学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 次世代抗体と関節リウマチ治療2022

    • Author(s)
      蛯名耕介
    • Organizer
      第37回日本臨床リウマチ学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Drug retention of 7 biologics and tofacitinib in biologics-naive and biologics-switched patients with rheumatoid arthritis -The ANSWER cohort study-2020

    • Author(s)
      Kosuke Ebina
    • Organizer
      European League Against Rheumatology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2024-01-30  

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