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Muse cell transplantation for spinal cord injury in chronic phase

Research Project

Project/Area Number 20K09494
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

Koda Masao  筑波大学, 医学医療系, 准教授 (50361449)

Co-Investigator(Kenkyū-buntansha) 古矢 丈雄  千葉大学, 医学部附属病院, 講師 (00507337)
出沢 真理  東北大学, 医学系研究科, 教授 (50272323)
山崎 正志  筑波大学, 医学医療系, 教授 (50281712)
高橋 宏  東邦大学, 医学部, 講師 (80597047)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脊髄損傷 / 再生医療 / 細胞移植 / 多能性幹細胞 / 慢性期 / Muse細胞 / 細胞移植療法 / 細胞治療 / 幹細胞
Outline of Research at the Start

研究目的:脊髄損傷慢性期に対するMuse細胞移植の有効性を明らかにすること。
脊髄損傷慢性期は空洞形成・グリア瘢痕により再生が困難な環境であり有効な治療法はない。Multi-lineage differentiating Stress Enduring cell (Muse) 細胞は出澤が発見した内在性多能性幹細胞である。すでに脊髄損傷亜急性期を対象とした治験が開始されている。本研究計画ではラット脊髄損傷モデル慢性期にMuse細胞を移植し、行動学的・組織学的解析を行い有効性確認・作用機序を解明し、前臨床POCの取得を目指す。

Outline of Final Research Achievements

Effective treatments for chronic spinal cord injury have not been established. The aim of this study was to investigate the effectiveness of Muse (Multilineage differentiating Stress Enduring) cell transplantation for chronic spinal cord injury. An eight-week-old female C57BL6 mouse was subjected to spinal cord contusion injury under general anesthesia, and cell transplantation was performed six weeks after the surgery. Muse cells were transplanted via intravenous injection through the tail vein. The locomotor function of the mice after transplantation was evaluated longitudinally using the Basso mouse score, and tissue sections were examined to confirm tissue repair. Both behavioral and histological evaluations did not demonstrate therapeutic effects of Muse cell transplantation in chronic spinal cord injury.

Academic Significance and Societal Importance of the Research Achievements

脊髄損傷に対するMuse細胞移植の臨床応用に際して、適切な投与時期を検討するための重要な基礎データとなりうる。すなわちヒト脊髄損傷患者においては受傷後早期~数週後程度の時期が適切であると思われる(マウスの脊髄損傷後6週は人間で言えばおそらく数か月後に該当すると言われているため)。あるいは慢性期脊髄損傷に対しては細胞移植単独ではその効果に限界があることを示唆するともいえよう。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (12 results)

All 2022 2021 2020

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (1 results)

  • [Journal Article] Postoperative Changes in Resting State Functional Connectivity and Clinical Scores in Patients With Cervical Myelopathy2022

    • Author(s)
      Eto F、Inomata K、Sakashita K、Gamada H、Asada T、Sato K、Miura K、Noguchi H、Takahashi H、Funayama T、Koda M、Yamazaki M
    • Journal Title

      World Neurosurgery

      Volume: 167 Pages: e1354-e1359

    • DOI

      10.1016/j.wneu.2022.09.030

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical Apgar Score and Controlling Nutritional Status Score are significant predictors of major complications after cervical spine surgery2022

    • Author(s)
      Miura Kousei、Koda Masao、Funayama Toru、Takahashi Hiroshi、Noguchi Hiroshi、Mataki Kentaro、Shibao Yosuke、Sato Kosuke、Eto Fumihiko、Kono Mamoru、Asada Tomoyuki、Yamazaki Masashi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 6605-6605

    • DOI

      10.1038/s41598-022-10674-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immediate effects of hybrid assistive limb gait training on lower limb function in a chronic myelopathy patient with postoperative late neurological deterioration2022

    • Author(s)
      Kubota S、Kadone H、Shimizu Y、Koda M、Takahashi H、Miura K、Eto F、Furuya T、Sankai Y、Yamazaki M
    • Journal Title

      BMC Research Notes

      Volume: 15 Issue: 1 Pages: 89-89

    • DOI

      10.1186/s13104-022-05979-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomized trial of granulocyte colony-stimulating factor for spinal cord injury2021

    • Author(s)
      Koda Masao、Hanaoka Hideki、Fujii Yasuhisa、Hanawa Michiko、et al.
    • Journal Title

      Brain

      Volume: 144 Issue: 3 Pages: 789-799

    • DOI

      10.1093/brain/awaa466

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between osteoarthritis of the atlantoaxial facet joint and a high‐riding vertebral artery2021

    • Author(s)
      Shimizu Tomoaki、Koda Masao、Abe Tetsuya、Shibao Yosuke、Kono Mamoru、Eto Fumihiko、Miura Kousei、Mataki Kentaro、Noguchi Hiroshi、Takahashi Hiroshi、Funayama Toru、Yamazaki Masashi
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 22 Issue: 1 Pages: 406-406

    • DOI

      10.1186/s12891-021-04275-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sudden, Transient Intraoperative Hypotension During the Use of the Cantilever Technique for Correction of Adult Spine Deformity2021

    • Author(s)
      Mataki Kentaro、Koda Masao、Funayama Toru、Takahashi Hiroshi、Yamazaki Masashi
    • Journal Title

      Cureus

      Volume: 13

    • DOI

      10.7759/cureus.13835

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of relief and residual low back pain after discectomy in patients with lumbar disc herniation: analysis using a detailed visual analog scale2021

    • Author(s)
      Takahashi Hiroshi、Aoki Yasuchika、Inoue Masahiro、Saito Junya、et al.
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 22 Issue: 1 Pages: 167-167

    • DOI

      10.1186/s12891-021-04015-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adjustment effect during shoulder abduction training with the Hybrid Assistive Limb in a patient with postoperative C5 palsy2021

    • Author(s)
      Kubota Shigeki、Kadone Hideki、Shimizu Yukiyo、Koda Masao、Miura Kousei、Takahashi Hiroshi、Watanabe Hiroki、Marushima Aiki、Hada Yasushi、Sankai Yoshiyuki、Yamazaki Masashi
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 88 Pages: 197-204

    • DOI

      10.1016/j.jocn.2021.03.042

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Factors associated with failure of bony union after conservative treatment of acute cases of unilateral lumbar spondylolysis2021

    • Author(s)
      Tatsumura Masaki、Gamada Hisanori、Okuwaki Shun、Eto Fumihiko、Nagashima Katsuya、Ogawa Takeshi、Mammoto Takeo、Hirano Atsushi、Koda Masao、Yamazaki Masashi
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 22 Issue: 1 Pages: 75-75

    • DOI

      10.1186/s12891-020-03940-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Segmental motion at the peak of the ossification foci is independent risk factor except for mal-alignment and thick ossification foci for poor outcome after laminoplasty for cervical ossification of the posterior longitudinal ligament: analyses in patients with positive K-line, lordotic alignment, and lower canal occupying ratio2020

    • Author(s)
      Saito Junya、Koda Masao、Furuya Takeo、Maki Satoshi、Ijima Yasushi、Kitamura Mitsuhiro、Miyamoto Takuya、Orita Sumihisa、Inage Kazuhide、Hasue Fumio、Fujiyoshi Takayuki、Kamiya Koshiro、Ikeda Yoshikazu、Nakajima Fumitake、Hashimoto Mitsuhiro、Noguchi Hiroshi、Takahashi Hiroshi、Yamazaki Masashi、Ohtori Seiji
    • Journal Title

      Journal of Orthopaedic Surgery and Research

      Volume: 15 Issue: 1 Pages: 407-407

    • DOI

      10.1186/s13018-020-01903-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thoracic kyphosis and pelvic anteversion in patients with adult spinal deformity increase while walking: analyses of dynamic alignment change using a three-dimensional gait motion analysis system2020

    • Author(s)
      Miura Kousei、Kadone Hideki、Koda Masao、Abe Tetsuya、Funayama Toru、Noguchi Hiroshi、Mataki Kentaro、Nagashima Katsuya、Kumagai Hiroshi、Shibao Yosuke、Suzuki Kenji、Yamazaki Masashi
    • Journal Title

      European Spine Journal

      Volume: 29 Issue: 4 Pages: 840-848

    • DOI

      10.1007/s00586-020-06312-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Muse細胞を用いた脊髄損傷に対する脊髄再生医療2022

    • Author(s)
      國府田正雄
    • Organizer
      第51回日本脊椎脊髄病学会
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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