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Development of next generation BNCT targeted to the tumor endothelial cell

Research Project

Project/Area Number 20K09517
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionHirosaki University

Principal Investigator

Hatakeyama Shingo  弘前大学, 医学研究科, 准教授 (10400136)

Co-Investigator(Kenkyū-buntansha) 米山 徹  弘前大学, 医学研究科, 助教 (50587649)
大山 力  弘前大学, 医学研究科, 教授 (80282135)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords中性子補足療法 / 癌特異的療法 / 泌尿器癌 / 癌特異的中性子補足療法
Outline of Research at the Start

現在の抗がん剤治療が抱える弱点は、細胞毒性の強い薬剤を全身投与する点にある。これら副作用を減らし高い抗腫瘍効果を得るためには高濃度の抗がん剤をがんのみに到達させる必要がある。私たちは、がんの腫瘍血管に選択的に結合するペプチド(IF7ペプチド)を世界に先駆けて開発し、抗がん剤との組み合わせによる腫瘍血管内皮細胞を標的とした治療効果を報告した。一方、ホウ素やガドリニウムを用いた中性子補足療法は高い効果が期待されているが、がん組織への低い特異性が解決すべき課題である。本研究では、IF7ペプチドを中性子補足療法に応用し、より低侵襲かつ高効果ながん治療法の開発を目指すことを目的とする。

Outline of Final Research Achievements

To improve the current anticancer drug treatment issues, we investigated the efficacy of next-generation neutron supplementation therapy using the IF7 peptide and boron or gadolinium.
The compound IF7-BSH, which combines IF7 and boron, was found to exhibit antitumor effects at doses as low as 1/25 of those of conventional BPA agents. A gadolinium cross-linked 157Gd-IF7 compound was subsequently prepared, and its accumulation was confirmed by animal MRI, but urinary excretion was enhanced and it was excreted in the urine before collecting in the tumor. Tumor accumulation by administration of the 157Gd-IF7 compound was also not confirmed.
For clinical application, the development of IF7-BSH-based therapies may be useful.

Academic Significance and Societal Importance of the Research Achievements

中性子捕捉療法は腫瘍特異的な細胞傷害作用を示す放射線治療法である。有望な次世代放射線治療として注目されているが、10BやGd薬剤の腫瘍細胞への集積効率が悪く、将来的な治療適応拡大のためには、腫瘍特異性を改選する必要があった。我々は、腫瘍血管内皮表面に発現するアネキシンA1に結合するIF7ペプチドとホウ素製剤の複合薬剤(IF7-BSH/BPA)を開発し、既存ホウ素製剤に比べ、600倍の腫瘍特異的ホウ素集積を示し、抗腫瘍効果を明らかにした。臨床応用までにはまだ時間が必要であるが、現在の抗がん剤治療の課題を改善する試みとして研究成果の学術的意義や社会的意義は大きいと考えられる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (63 results)

All 2022 2021 2020 Other

All Journal Article (59 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 59 results,  Open Access: 18 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Effect of upfront intensive therapy on oncological outcomes in older patients with high tumor burden metastatic castration‐sensitive prostate cancer: A multicenter retrospective study2022

    • Author(s)
      Miura Yuki、Hatakeyama Shingo、Narita Shintaro、Kimura Takahiro、Hata Kenichi、Yanagisawa Takafumi、Tanaka Toshikazu、Ishi Noritaka、Kawamura Sadafumi、Hoshi Senji、Ishidoya Shigeto、Mitsuzuka Koji、Ito Akihiro、Tsuchiya Norihiko、Egawa Shin、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      The Prostate

      Volume: 82 Issue: 13 Pages: 1304-1312

    • DOI

      10.1002/pros.24404

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proportion of patients eligible for adjuvant immunotherapy in nonmetastatic clear‐cell renal cell carcinoma treated with radical or partial nephrectomy2022

    • Author(s)
      Tanaka Ryuma、Hatakeyama Shingo、Miura Hikari、Hamaya Tomoko、Yoneyama Takahiro、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 29 Issue: 10 Pages: 1235-1237

    • DOI

      10.1111/iju.14952

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of pelvic lymph node dissection during radical prostatectomy in high-risk prostate cancer patients receiving neoadjuvant chemohormonal therapy2022

    • Author(s)
      Hiromichi Iwamura, Shingo Hatakeyama, Takuma Narita, Yusuke Ozaki, Sakae Konishi, Hirotaka Horiguchi, Hirotake Kodama, Yuta Kojima, Naoki Fujita, Teppei Okamoto, Yuki Tobisawa, Tohru Yoneyama, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama
    • Journal Title

      Scientific reports

      Volume: 12 Issue: 1 Pages: 9675-9675

    • DOI

      10.1038/s41598-022-13651-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of active anticancer therapy on serologic response to SARS‐CoV‐2 BNT162b2 vaccine in patients with urothelial and renal cell carcinoma2022

    • Author(s)
      Togashi Kyo、Hatakeyama Shingo、Yoneyama Tohru、Hamaya Tomoko、Narita Takuma、Fujita Naoki、Iwamura Hiromichi、Okamoto Teppei、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: - Issue: 7 Pages: 733-739

    • DOI

      10.1111/iju.14882

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of body size on skin‐related adverse events in advanced prostate cancer treated with apalutamide: A multicenter retrospective study2022

    • Author(s)
      Sasaki Daichi、Hatakeyama Shingo、Tanaka Toshikazu、Okamoto Teppei、Yoneyama Takahiro、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: - Issue: 7 Pages: 772-773

    • DOI

      10.1111/iju.14860

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Editorial Comment to Comparative oncological outcomes after radical prostatectomy or external beam radiation therapy plus androgen deprivation therapy in men with clinical T3b prostate cancer2022

    • Author(s)
      Narita Takuma、Hatakeyama Shingo、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: - Issue: 5 Pages: 420-421

    • DOI

      10.1111/iju.14849

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Real-world survival outcomes of adding docetaxel or abiraterone in patients with high-volume metastatic castration-sensitive prostate cancer: historically controlled, propensity score matched comparison with androgen deprivation therapy2022

    • Author(s)
      Narita Shintaro、Kimura Takahiro、Hatakeyama Shingo、et al
    • Journal Title

      World Journal of Urology

      Volume: - Issue: 5 Pages: 1135-1141

    • DOI

      10.1007/s00345-022-03963-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of upfront combination therapy on the overall survival of patients with metastatic castration‐sensitive prostate cancer: A multicenter retrospective study2022

    • Author(s)
      Tanaka Toshikazu、Hatakeyama Shingo、Noro Daisuke、Togashi Kyo、Yoneyama Takahiro、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: - Issue: 5 Pages: 476-478

    • DOI

      10.1111/iju.14817

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Gleason pattern>=5 on prognosis for newly diagnosed metastatic hormone‐sensitive prostate cancer with Gleason score >=82022

    • Author(s)
      Morozumi Kento、Mitsuzuka Koji、Narita Shintaro、Takahashi Masahiro、Kawamura Sadafumi、Tochigi Tatsuo、Arai Yoichi、Hoshi Senji、Shimoda Jiro、Ishidoya Shigeto、Okamoto Teppei、Hatakeyama Shingo、Sakurai Toshihiko、Tsuchiya Norihiko、Ohyama Chikara、Habuchi Tomonori、Ito Akihiro
    • Journal Title

      International Journal of Urology

      Volume: 29 Issue: 4 Pages: 324-331

    • DOI

      10.1111/iju.14781

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of six-cycle completion and earlier use of radium-223 therapy on prognosis for metastatic castration-resistant prostate cancer: A real-world multicenter retrospective study2022

    • Author(s)
      Sasaki Daichi、Hatakeyama Shingo、Kawaguchi Hideo、Hatayama Yoshiomi、Ishibashi Yusuke、Kusaka Ayumu、Noro Daisuke、Tanaka Toshikazu、Ito Hiroyuki、Okuyama Yoshiharu、Okamoto Teppei、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Aoki Masahiko、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: 40 Issue: 2 Pages: 64.e1-64.e8

    • DOI

      10.1016/j.urolonc.2021.11.005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of upfront cytoreductive nephrectomy stratified by IMDC risk for metastatic renal cell carcinoma in targeted therapy era ? a multi-institutional retrospective study2022

    • Author(s)
      Kato Renpei、Naito Sei、Numakura Kazuyuki、Hatakeyama Shingo、Koguchi Tomoyuki、Kojima Takahiro、Kawasaki Yoshihide、Kandori Shuya、Kawamura Sadafumi、Arai Yoichi、Ito Akihiro、Nishiyama Hiroyuki、Kojima Yoshiyuki、Ohyama Chikara、Habuchi Tomonori、Tsuchiya Norihiko、Obara Wataru
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 27 Issue: 3 Pages: 563-573

    • DOI

      10.1007/s10147-021-02091-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Editorial Comment to A case of miliary tuberculosis following transurethral surgery and prostate biopsy after intravesical bacillus Calmette‐Guerin immunotherapy2021

    • Author(s)
      Hatakeyama Shingo、Ohyama Chikara
    • Journal Title

      IJU Case Reports

      Volume: 5 Issue: 1 Pages: 47-48

    • DOI

      10.1002/iju5.12387

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of oncological response between the first‐line chemotherapy and subsequent immune checkpoint inhibitors therapy in patients with unresectable or metastatic urothelial carcinoma2021

    • Author(s)
      Ozaki Kai、Hatakeyama Shingo、Hamaya Tomoko、Okita Kazutaka、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 29 Issue: 4 Pages: 362-364

    • DOI

      10.1111/iju.14778

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations of impaired grip strength and gait function with the severity of erectile dysfunction in men undergoing dialysis: a cross-sectional study2021

    • Author(s)
      Fujita Naoki、Hatakeyama Shingo、Momota Masaki、Tobisawa Yuki、Yoneyama Tohru、Okamoto Teppei、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Yoshikawa Kazuaki、Ohyama Chikara
    • Journal Title

      The Aging Male

      Volume: 25 Issue: 1 Pages: 1-7

    • DOI

      10.1080/13685538.2021.2016690

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management of bladder cancer in older patients2021

    • Author(s)
      Hatakeyama Shingo、Narita Shintaro、Okita Kazutaka、Narita Takuma、Iwamura Hiromichi、Fujita Naoki、Inokuchi Junichi、Matsui Yoshiyuki、Kitamura Hiroshi、Ohyama Chikara
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 52 Issue: 3 Pages: 203-213

    • DOI

      10.1093/jjco/hyab187

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of one-surgeon basketing technique for stone extraction during flexible ureteroscopy for urolithiasis2021

    • Author(s)
      Anan Go、Hattori Kazunori、Hatakeyama Shingo、Ohyama Chikara、Sato Makoto
    • Journal Title

      Arab Journal of Urology

      Volume: 19 Issue: 4 Pages: 447-453

    • DOI

      10.1080/2090598x.2021.1889943

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous analysis of serum α2,3-linked sialylation and core-type fucosylation of prostate-specific antigen for the detection of high-grade prostate cancer2021

    • Author(s)
      Hatano Koji、Yoneyama Tohru、Hatakeyama Shingo、Tomiyama Eisuke、Tsuchiya Mutsumi、Nishimoto Mitsuhisa、Yoshimura Kazuhiro、Miyoshi Eiji、Uemura Hirotsugu、Ohyama Chikara、Nonomura Norio、Fujita Kazutoshi
    • Journal Title

      British Journal of Cancer

      Volume: 126 Issue: 5 Pages: 764-770

    • DOI

      10.1038/s41416-021-01637-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of total cell-free DNA levels for surgical damage evaluation in patients with urological surgeries2021

    • Author(s)
      Konishi Sakae、Narita Takuma、Hatakeyama Shingo、Yoneyama Tohru、Yoneyama Mihoko Sutoh、Tobisawa Yuki、Noro Daisuke、Sato Tendo、Togashi Kyo、Okamoto Teppei、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-01430-z

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The influence of gut microbiome on progression of overactive bladder symptoms: a community-based 3-year longitudinal study in Aomori, Japan2021

    • Author(s)
      Okuyama Yoshiharu、Okamoto Teppei、Sasaki Daichi、Ozaki Kai、Songee Jung、Hatakeyama Shingo、Mikami Tatsuya、Ohyama Chikara
    • Journal Title

      International Urology and Nephrology

      Volume: 54 Issue: 1 Pages: 9-16

    • DOI

      10.1007/s11255-021-03044-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of α2,3‐sialyl N‐glycosylated PSA as a biomarker for clinically significant prostate cancer in men with elevated PSA level2021

    • Author(s)
      Yoneyama Tohru、Yamamoto Hayato、Sutoh Yoneyama Mihoko、Tobisawa Yuki, Hatakeyama Shingo, Narita Takuma, Ohyama Chikara, et al.
    • Journal Title

      The Prostate

      Volume: 81 Issue: 16 Pages: 1411-1427

    • DOI

      10.1002/pros.24239

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Butyrylcholinesterase level as an independent prognostic factor for overall survival in patients on maintenance hemodialysis: a single-center retrospective study2021

    • Author(s)
      Fukushi Ken、Okamoto Teppei、Ozaki Yusuke、Ozaki Kai、Sasaki Daichi、Miura Yuuki、Okuyama Yoshiharu、Tanaka Yoshimi、Imanishi Kengo、Hatakeyama Shingo、Saitoh Fumitada、Ohyama Chikara
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 26 Issue: 2 Pages: 190-197

    • DOI

      10.1007/s10157-021-02140-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] External validation of the REMARCC model for the selection of cytoreductive nephrectomy in patients with primary metastatic renal cell carcinoma: A multicenter retrospective study2021

    • Author(s)
      Okita Kazutaka、Hatakeyama Shingo、Naito Sei、Numakura Kazuyuki、Kato Renpei、Koguchi Tomoyuki、Kojima Takahiro、Kawasaki Yoshihide、Kandori Shuya、Kawamura Sadafumi、Nishiyama Hiroyuki、Ito Akihiro、Kojima Yoshiyuki、Habuchi Tomonori、Obara Wataru、Tsuchiya Norihiko、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: 39 Issue: 12 Pages: 836.e11-836.e17

    • DOI

      10.1016/j.urolonc.2021.08.015

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Impact of Detecting Low-Frequency Variants in Cell-Free DNA on Treatment of Castration-Resistant Prostate Cancer2021

    • Author(s)
      Kei Mizuno
    • Journal Title

      Clinical Cancer Research

      Volume: 28 Issue: 22 Pages: 6164-6173

    • DOI

      10.1158/1078-0432.ccr-21-2328

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcomes of axitinib versus sunitinib as first‐line therapy to patients with metastatic renal cell carcinoma in the immune‐oncology era2021

    • Author(s)
      Numakura Kazuyuki、Muto Yumin、Naito Sei、Hatakeyama Shingo、Kato Renpei、Koguchi Tomoyuki、Kojima Takahiro、Kawasaki Yoshihide、Kandori Syuya、Kawamura Sadafumi、Arai Yoichi、Ito Akihiro、Nishiyama Hiroyuki、Kojima Yoshiyuki、Obara Wataru、Ohyama Chikara、Tsuchiya Norihiko、Habuchi Tomonori
    • Journal Title

      Cancer Medicine

      Volume: 10 Issue: 17 Pages: 5839-5846

    • DOI

      10.1002/cam4.4130

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognosis of Japanese metastatic renal cell carcinoma patients in the targeted therapy era2021

    • Author(s)
      Naito Sei、Kato Tomoyuki、Numakura Kazuyuki、Hatakeyama Shingo、Koguchi Tomoyuki、Kandori Shuya、Kawasaki Yoshihide、Adachi Hisanobu、Kato Renpei、Narita Shintaro、Yamamoto Hayato、Ogawa Soichiro、Kawamura Sadafumi、Obara Wataru、Ito Akihiro、Nishiyama Hiroyuki、Kojima Yoshiyuki、Ohyama Chikara、Habuchi Tomonori et al
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 10 Pages: 1947-1954

    • DOI

      10.1007/s10147-021-01979-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between female urinary urgency and aponeurotic ptosis: Results from a community‐based cross‐sectional study in Japan2021

    • Author(s)
      Ozaki Yusuke、Okamoto Teppei、Miura Yuuki、Iida Keiichiro、Uemura Nozomi、Sugimura Yoshikuni、Hatakeyama Shingo、Urushidate Satoshi、Ohyama Chikara
    • Journal Title

      Neurourology and Urodynamics

      Volume: 40 Issue: 6 Pages: 1678-1685

    • DOI

      10.1002/nau.24736

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perioperative Outcomes of Robot-Assisted Radical Cystectomy with Intracorporeal Versus Extracorporeal Urinary Diversion2021

    • Author(s)
      Teoh Jeremy Yuen-Chun、Chan Erica On-Ting、Kang Seok-Ho、Patel Manish I.、Muto Satoru、Yang Cheng-Kuang、Hatakeyama Shingo、Chow Timothy Shing-Fung、Mok Alex、Zhang Ruiyun、Kijvikai Kittinut、Lee Lui-Shiong、Chen Haige、Ohyama Chikara、Horie Shigeo、Chan Eddie Shu-Yin
    • Journal Title

      Annals of Surgical Oncology

      Volume: 28 Issue: 13 Pages: 9209-9215

    • DOI

      10.1245/s10434-021-10295-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of pretreatment anemia on upfront abiraterone acetate therapy for metastatic hormone-sensitive prostate cancer: a multicenter retrospective study2021

    • Author(s)
      Okamoto Teppei、Noro Daisuke、Hatakeyama Shingo、Narita Shintaro、Mitsuzuka Koji、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Shimoda Jiro、Tanaka Toshikazu、Kawaguchi Toshiaki、Ishidoya Shigeto、Ito Akihiro、Tsuchiya Norihiko、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      BMC Cancer

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12885-021-08206-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of pembrolizumab with conventional chemotherapy after first‐line platinum‐based chemotherapy for advanced urothelial carcinoma in real‐world practice: A multicenter retrospective study2021

    • Author(s)
      Narita Takuma、Hatakeyama Shingo、Numakura Kazuyuki、Kobayashi Mizuki、Muto Yumina、Saito Mitsuru、Narita Shintaro、Tanaka Toshikazu、Noro Daisuke、Tokui Noriko、Yoneyama Takahiro、Hashimoto Yasuhiro、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 28 Issue: 9 Pages: 899-905

    • DOI

      10.1111/iju.14601

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Editorial Comment from Dr Hatakeyama and Dr Ohyama to Discrepancy between clinical and pathological T stages in upper urinary tract urothelial carcinoma: Analysis of the Hospital‐Based Cancer Registry data in Japan2021

    • Author(s)
      Hatakeyama Shingo、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 28 Issue: 8 Pages: 820-820

    • DOI

      10.1111/iju.14593

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Narrative review of urinary glycan biomarkers in prostate cancer2021

    • Author(s)
      Hatakeyama Shingo、Yoneyama Tohru、Tobisawa Yuki、Yamamoto Hayato、Ohyama Chikara
    • Journal Title

      Translational Andrology and Urology

      Volume: 10 Issue: 4 Pages: 1850-1864

    • DOI

      10.21037/tau-20-964

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship of frailty with treatment modality selection in patients with muscle-invasive bladder cancer (FRART-BC study)2021

    • Author(s)
      Iwamura Hiromichi、Hatakeyama Shingo、Momota Masaki、Kojima Yuta、Narita Takuma、Okamoto Teppei、Fujita Naoki、Hamano Itsuto、Togashi Kyou、Hamaya Tomoko、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      Translational Andrology and Urology

      Volume: 10 Issue: 3 Pages: 1143-1151

    • DOI

      10.21037/tau-20-1351

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short-term outcomes of risk-adapted upfront docetaxel administration in patients with metastatic hormone-sensitive prostate cancer: a multicenter prospective study in Japan2021

    • Author(s)
      Muto Yumina、Narita Shintaro、Hatakeyama Shingo、Maita Shinya、Chiba Shuji、Kubo Kyohei、Aoyama Yuu、Ito Ryuichi、Takahashi Yoshiko、Takahashi Shuhei、Nakamura Kumiko、Honma Naoko、Sato Hiromi、Ohyama Chikara、Habuchi Tomonori
    • Journal Title

      Medical Oncology

      Volume: 38 Issue: 4 Pages: 37-37

    • DOI

      10.1007/s12032-021-01480-3

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of total plasma cell-free DNA level and androgen receptor amplification in castration-resistant prostate cancer2021

    • Author(s)
      Kubota Yuka、Hatakeyama Shingo、Yoneyama Tohru、Yoneyama Mihoko Sutoh、Hamano Itsuto、Konishi Sakae、Okamoto Teppei、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      World Journal of Urology

      Volume: 39 Issue: 9 Pages: 3265-3271

    • DOI

      10.1007/s00345-021-03649-x

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of the combined androgen blockade therapy versus luteinizing hormone-releasing hormone analog monotherapy in patients with hormone naive metastatic prostate cancer: a multi-institutional comparative analysis2021

    • Author(s)
      Narita Takuma、Hatakeyama Shingo、Narita Shintaro、Takahashi Masahiro、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Shimoda Jiro、Kawaguchi Toshiaki、Ishidoya Shigeto、Mitsuzuka Koji、Arai Yoichi、Ito Akihiro、Tsuchiya Norihiko、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      Translational Andrology and Urology

      Volume: 10 Issue: 1 Pages: 417-425

    • DOI

      10.21037/tau-20-966

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trends in the use of neoadjuvant chemotherapy and oncological outcomes for high‐risk upper tract urothelial carcinoma: a multicentre retrospective study2021

    • Author(s)
      Hamaya Tomoko、Hatakeyama Shingo、Tanaka Toshikazu、Kubota Yuka、Togashi Kyo、Hosogoe Shogo、Fujita Naoki、Kusaka Ayumu、Tokui Noriko、Okamoto Teppei、Yamamoto Hayato、Yoneyama Tohru、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      BJU International

      Volume: - Issue: 4 Pages: 468-476

    • DOI

      10.1111/bju.15346

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy2021

    • Author(s)
      Yoneyama Tohru、Hatakeyama Shingo、Sutoh Yoneyama Mihoko、Yoshiya Taku、Uemura Tsuyoshi、Ishizu Takehiro、Suzuki Minoru、Hachinohe Shingo、Ishiyama Shintaro、Nonaka Motohiro、Fukuda Michiko N.、Ohyama Chikara
    • Journal Title

      BMC Cancer

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12885-020-07760-x

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Editorial Comment to Regional and facility disparities in androgen deprivation therapy for prostate cancer from a multi‐institutional Japan‐wide database2021

    • Author(s)
      Hatakeyama Shingo、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: - Issue: 5 Pages: 591-592

    • DOI

      10.1111/iju.14539

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correction to: Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy2021

    • Author(s)
      Yoneyama Tohru、Hatakeyama Shingo、Sutoh Yoneyama Mihoko、Yoshiya Taku、Uemura Tsuyoshi、Ishizu Takehiro、Suzuki Minoru、Hachinohe Shingo、Ishiyama Shintaro、Nonaka Motohiro、Fukuda Michiko N.、Ohyama Chikara
    • Journal Title

      BMC Cancer

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12885-021-07815-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] N‐glycan signature of serum immunoglobulins as a diagnostic biomarker of urothelial carcinomas2021

    • Author(s)
      Kodama Hirotake、Yoneyama Tohru、Tanaka Toshikazu、Noro Daisuke、Tobisawa Yuki、Yamamoto Hayato、Suto Shinichiro、Hatakeyama Shingo、Mori Kazuyuki、Yoneyama Takahiro、Hashimoto Yasuhiro、Kakizaki Ikuko、Nakaji Shigeyuki、Ohyama Chikara
    • Journal Title

      Cancer Medicine

      Volume: 10 Issue: 4 Pages: 1297-1313

    • DOI

      10.1002/cam4.3727

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oncologic and patient-reported outcomes after robot-assisted radical prostatectomy in men aged >75 years2021

    • Author(s)
      Togashi Kyo、Hatakeyama Shingo、Okamoto Teppei、Kojima Yuta、Iwamura Hiromichi、Fujita Naoki、Narita Takuma、Hamano Itsuto、Hamaya Tomoko、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: - Issue: 10 Pages: 729.e17-729.e25

    • DOI

      10.1016/j.urolonc.2020.12.001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of the Ki67 index and programmed death-ligand 1 expression after radical cystectomy in patients with muscle-invasive bladder cancer2021

    • Author(s)
      Horiguchi Hirotaka、Hatakeyama Shingo、Yoneyama Tohru、Yoneyama Mihoko Sutoh、Tanaka Toshikazu、Fujita Naoki、Okamoto Teppei、Yamamoto Hayato、Yoneyama Takahiro、Yoshizawa Tadashi、Hashimoto Yasuhiro、Kawaguchi Toshiaki、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: 39 Issue: 4 Pages: 238.e9-238.e17

    • DOI

      10.1016/j.urolonc.2020.11.029

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial Comment2021

    • Author(s)
      Hatakeyama Shingo、Hamano Itsuto、Ohyama Chikara
    • Journal Title

      Journal of Urology

      Volume: 205 Issue: 1 Pages: 107-107

    • DOI

      10.1097/ju.0000000000001325.01

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of frailty on the quality of life and lower urinary symptoms following robot-assisted radical prostatectomy: A longitudinal analysis (FRARP-QL Study)2021

    • Author(s)
      Togashi Kyo、Hatakeyama Shingo、Kojima Yuta、Momota Masaki、Narita Takuma、Iwamura Hiromichi、Hamano Itsuto、Hamaya Tomoko、Fujita Naoki、Okamoto Teppei、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: 39 Issue: 3 Pages: 192.e7-192.e14

    • DOI

      10.1016/j.urolonc.2020.08.010

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of chronic kidney disease on oncological outcomes in patients with high-risk non-muscle-invasive bladder cancer who underwent adjuvant bacillus Calmette-Gu?rin therapy2021

    • Author(s)
      Fujita Naoki、Hatakeyama Shingo、Okita Kazutaka、Momota Masaki、Narita Takuma、Tobisawa Yuki、Yoneyama Tohru、Yamamoto Hayato、Imai Atsushi、Ito Hiroyuki、Yoneyama Takahiro、Hashimoto Yasuhiro、Yoshikawa Kazuaki、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: 39 Issue: 3 Pages: 191.e9-191.e16

    • DOI

      10.1016/j.urolonc.2020.06.032

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of frailty and comorbidity on surgical contraindication in patients with localized prostate cancer (FRART-PC Study)2021

    • Author(s)
      Kodama Hirotake、Hatakeyama Shingo、Momota Masaki、Togashi Kyo、Hamaya Tomoko、Hamano Itsuto、Fujita Naoki、Kojima Yuta、Okamoto Teppei、Yoneyama Tohru、Yamamoto Hayato、Yoshikawa Kazuaki、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: 39 Issue: 3 Pages: 191.e1-191.e8

    • DOI

      10.1016/j.urolonc.2020.06.019

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of number of treatment cycles of platinum-based first-line chemotherapy on maximum radiological response in patients with advanced urothelial carcinoma2021

    • Author(s)
      Okita Kazutaka、Hatakeyama Shingo、Hagiwara Kazuhisa、Suzuki Yuichiro、Tanaka Toshikazu、Noro Daisuke、Tokui Noriko、Fujita Naoki、Konishi Sakae、Okamoto Teppei、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: - Issue: 12 Pages: 832.e17-832.e23

    • DOI

      10.1016/j.urolonc.2021.03.011

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancer2020

    • Author(s)
      Hamano Itsuto、Hatakeyama Shingo、Hamaya Tomoko、Togashi Kyo、Okamoto Teppei、Yamamoto Hayato、Yoneyama Tohru、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      IJU Case Reports

      Volume: 3 Issue: 4 Pages: 141-144

    • DOI

      10.1002/iju5.12172

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of cytoreductive nephrectomy in patients with primary metastatic renal cell carcinoma receiving systemic tyrosine kinase inhibitor therapy: A multicenter retrospective study2020

    • Author(s)
      Hatakeyama Shingo、Naito Sei、Numakura Kazuyuki、Kato Renpei、Koguchi Tomoyuki、Kojima Takahiro、Kawasaki Yoshihide、Kandori Shuya、Kawamura Sadafumi、Tsushima Eiki、Nishiyama Hiroyuki、Ito Akihiro、Kojima Yoshiyuki、Habuchi Tomonori、Obara Wataru、Tsuchiya Norihiko、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 28 Issue: 4 Pages: 369-375

    • DOI

      10.1111/iju.14466

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Longitudinal Study of Bidirectional Relationships between Sleep Disorder and Frequency of Nocturia: Results from the Iwaki Health Promotion Project2020

    • Author(s)
      Konishi Sakae、Hatakeyama Shingo、Imai Atsushi、Kumagai Mika、Okamoto Teppei、Okita Kazutaka、Hamano Itsuto、Narita Takuma、Kojima Yuta、Iwamura Hiromichi、Yamamoto Hayato、Yoneyama Tohru、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      Urologia Internationalis

      Volume: - Issue: 3-4 Pages: 1-8

    • DOI

      10.1159/000509976

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between the baseline frailty and quality of life in patients with prostate cancer (FRAQ-PC study)2020

    • Author(s)
      Hamaya Tomoko、Hatakeyama Shingo、Momota Masaki、Narita Takuma、Iwamura Hiromichi、Kojima Yuta、Hamano Itsuto、Fujita Naoki、Okamoto Teppei、Togashi Kyo、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 1 Pages: 199-206

    • DOI

      10.1007/s10147-020-01798-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of nivolumab plus ipilimumab with tyrosine kinase inhibitors as first-line therapies for metastatic renal-cell carcinoma: a multicenter retrospective study2020

    • Author(s)
      Kido Koichi、Hatakeyama Shingo、Numakura Kazuyuki、Tanaka Toshikazu、Oikawa Masaaki、Noro Daisuke、Hosogoe Shogo、Narita Shintaro、Inoue Takamitsu、Yoneyama Takahiro、Ito Hiroyuki、Nishimura Shoji、Hashimoto Yasuhiro、Kawaguchi Toshiaki、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 1 Pages: 154-162

    • DOI

      10.1007/s10147-020-01797-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Response to Re: Geriatric?8 screening of frailty in patients with prostate cancer2020

    • Author(s)
      Hatakeyama Shingo、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 27 Issue: 12 Pages: 1162-1163

    • DOI

      10.1111/iju.14399

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognosis of metastatic castration‐resistant prostate cancer in the era of the second‐generation androgen receptor‐targeted agents: A retrospective multicenter study2020

    • Author(s)
      Iwamura Hiromichi、Hatakeyama Shingo、Narita Shintaro、Arai Yoichi、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 28 Issue: 1 Pages: 125-127

    • DOI

      10.1111/iju.14392

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Editorial Comment to Successful pembrolizumab treatment in a patient with metastatic urothelial carcinoma and underlying overlap syndrome involving systemic sclerosis and systemic lupus erythematosus2020

    • Author(s)
      Hatakeyama Shingo、Ohyama Chikara
    • Journal Title

      IJU Case Reports

      Volume: 3 Issue: 5 Pages: 183-184

    • DOI

      10.1002/iju5.12193

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of first‐line nivolumab plus ipilimumab in patients with metastatic renal cell carcinoma: A multicenter retrospective study2020

    • Author(s)
      Tanaka Toshikazu、Hatakeyama Shingo、Numakura Kazuyuki、Kido Koichi、Noro Daisuke、Oikawa Masaaki、Hosogoe Shogo、Tokui Noriko、Yamamoto Hayato、Narita Shintaro、Ito Hiroyuki、Yoneyama Takahiro、Hashimoto Yasuhiro、Kawaguchi Toshiaki、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 27 Issue: 12 Pages: 1095-1100

    • DOI

      10.1111/iju.14363

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] One‐surgeon basketing technique for stone extraction during flexible ureteroscopy for urolithiasis: A comparison between novice and expert surgeons2020

    • Author(s)
      Anan Go、Komatsu Kenji、Hatakeyama Shingo、Iwamura Hiromichi、Kohada Yuki、Mikami Jotaro、Ito Jun、Kaiho Yasuhiro、Shimbo Masaki、Endo Fumiyasu、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara、Hattori Kazunori、Sato Makoto
    • Journal Title

      International Journal of Urology

      Volume: 27 Issue: 12 Pages: 1072-1077

    • DOI

      10.1111/iju.14355

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Geriatric 8 screening of frailty in patients with prostate cancer2020

    • Author(s)
      Momota Masaki、Hatakeyama Shingo、Soma Osamu、Tanaka Toshikazu、Hamano Itsuto、Fujita Naoki、Okamoto Teppei、Yoneyama Tohru、Yamamoto Hayato、Imai Atsushi、Yoshikawa Kazuaki、Yoneyama Takahiro、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 27 Issue: 8 Pages: 642-648

    • DOI

      10.1111/iju.14256

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-dialysis serum creatinine as an independent predictor of responsiveness to zinc supplementation among patients on hemodialysis2020

    • Author(s)
      Okamoto Teppei、Hatakeyama Shingo、Togashi Kyo、Hamaya Tomoko、Tanaka Yoshimi、Imanishi Kengo、Takashima Tooru、Saitoh Fumitada、Suzuki Tadashi、Ohyama Chikara
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 24 Issue: 10 Pages: 955-962

    • DOI

      10.1007/s10157-020-01911-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 腫瘍血管内皮を標的にした新規ホウ素中性子捕捉療法による膀胱癌治療法の開発2020

    • Author(s)
      畠山真吾
    • Organizer
      日本泌尿器科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] BORON NEUTRON CAPTURE THERAPY OF BLADDER CANCER BY TUMOR VASCULAR ENDOTHELIAL TARGETING IF7 PEPTIDE-BORON DRUG2020

    • Author(s)
      Shingo Hatakeyama*, Tohru Yoneyama, Mihoko Yoneyama, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Shintaro Ishiyama, Minoru Suzuki, and Chikara Ohyama
    • Organizer
      米国泌尿器科学会総会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Remarks] International Session Award 受賞者

    • URL

      https://www.congre.co.jp/jua2021/award/index.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 総会賞ポスター 受賞者

    • URL

      http://www.congre.co.jp/jua2020/award/index.html#section03

    • Related Report
      2022 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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