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Toward Reducing the Risk of Fatty Liver Syndrome in Post-Growth Infants Caused by Undernutrition in Utero

Research Project

Project/Area Number 20K09666
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Kohmura Yukiko  浜松医科大学, 医学部, 助教 (80537415)

Co-Investigator(Kenkyū-buntansha) 伊東 宏晃  浜松医科大学, 医学部, 教授 (70263085)
内田 季之  浜松医科大学, 医学部附属病院, 准教授 (90570234)
成味 恵  浜松医科大学, 医学部附属病院, 診療助教 (50594321)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsDOHaD / 慢性炎症 / metaflamation / 胎生期低栄養 / Metaflammation / 胎児期低栄養環境 / 小胞体ストレス / 肝脂肪変性 / エピゲノム
Outline of Research at the Start

胎生期低栄養マウスモデルにおける、肝細胞内の脂肪滴のサイズが著しく増大し脂肪蓄積の原因としてマイクロアレイの解析よりCell Death-Inducing DNA Fragmentation Factor-Like Effector A (Cidea) およびC (Cidec)が中心的な役割を果たしている可能性に注目し、エピゲノムに着目し解析を行う。

Outline of Final Research Achievements

We focused on endoplasmic reticulum stress as a mechanism involved in the exacerbation of chronic inflammation in tissues due to catch-up growth following prenatal malnutrition, and administered Tauroursodeoxycholic acid (TU), an endoplasmic reticulum stress reliever, in adult animals, and fat weight was significantly reduced. Microarray analysis of adipose tissue identified four Gene Ontologies (GOs) related to inflammation, which were common to both hypofertilization and TU administration. Mφ counts were increased by prenatal malnutrition and decreased by TU administration.

Academic Significance and Societal Importance of the Research Achievements

マウス動物モデルの解析から、胎生期低栄養と出生後のcatch upにより、脂肪組織に炎症に関わる一群の遺伝子発現の変化ならびにマクロファージの集簇が明らかとなった。
二次胆汁酸であるTauroursodeoxycholic acid が、プログラムされたMetaflamtionを改善する可能性が指摘された。Developmental Origins of Metaflamationという新規視点から研究の展開が期待される。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (18 results)

All 2024 2023 2022 2021 2020

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (10 results) (of which Invited: 6 results) Book (1 results)

  • [Journal Article] Comparative analysis of hyperfibrinolysis with activated coagulation between amniotic fluid embolism and severe placental abruption2024

    • Author(s)
      Ide Rui、Oda Tomoaki、Todo Yusuke、Kawai Kenta、Matsumoto Masako、Narumi Megumi、Kohmura-Kobayashi Yukiko、Furuta-Isomura Naomi、Yaguchi Chizuko、Uchida Toshiyuki、Suzuki Kazunao、Kanayama Naohiro、Itoh Hiroaki、Tamura Naoaki
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 272-272

    • DOI

      10.1038/s41598-023-50911-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial: A Half-Century History of Nutritional Guidance for Pregnant Women in Japan: A Promising Research Target of the DOHaD Study2022

    • Author(s)
      Itoh Hiroaki、Aoyama Tomoko、Kohmura-Kobayashi Yukiko、Nemoto Takahiro
    • Journal Title

      Frontiers in Endocrinology

      Volume: 13 Pages: 942256-942256

    • DOI

      10.3389/fendo.2022.942256

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental Origins of Metaflammation; A Bridge to the Future Between the DOHaD Theory and Evolutionary Biology2022

    • Author(s)
      Itoh Hiroaki、Ueda Megumi、Suzuki Misako、Kohmura-Kobayashi Yukiko
    • Journal Title

      Frontiers in Endocrinology

      Volume: 13 Pages: 839436-839436

    • DOI

      10.3389/fendo.2022.839436

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative Analysis of Gene Expression Profiles in the Adipose Tissue of Obese Adult Mice With Rapid Infantile Growth After Undernourishment In Utero2022

    • Author(s)
      Suzuki Misako、Kohmura-Kobayashi Yukiko、Ueda Megumi、Furuta-Isomura Naomi、Matsumoto Masako、Oda Tomoaki、Kawai Kenta、Itoh Toshiya、Matsuya Madoka、Narumi Megumi、Tamura Naoaki、Uchida Toshiyuki、Mochizuki Kazuki、Itoh Hiroaki
    • Journal Title

      Frontiers in Endocrinology

      Volume: 13 Pages: 818064-818064

    • DOI

      10.3389/fendo.2022.818064

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of three classification systems of Prepregnancy Body Mass Index with Perinatal Outcomes in Japanese Obese Pregnant Women: A retrospective study at a single center2020

    • Author(s)
      Sugimura Ryo、Kohmura-Kobayashi Yukiko、Narumi Megumi、Furuta-Isomura Naomi、Oda Tomoaki、Tamura Naoaki、Uchida Toshiyuki、Suzuki Kazunao、Sugimura Motoi、Kanayama Naohiro、Itoh Hiroaki
    • Journal Title

      International Journal of Medical Sciences

      Volume: 17 Issue: 13 Pages: 2002-2012

    • DOI

      10.7150/ijms.47076

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute inflammation in the uterine isthmus coincides with postpartum acute myometritis in the uterine body involving refractory postpartum hemorrhage of unknown etiology after cesarean delivery.2020

    • Author(s)
      Jain D, Oda T, Kohmura-Kobayashi Y, Furuta-Isomura N, Yaguchi C, Uchida T, Suzuki K, Itoh H, Kanayama N, Tamura N.
    • Journal Title

      J Reprod Immunol.

      Volume: 139 Pages: 103116-103116

    • DOI

      10.1016/j.jri.2020.103116

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Consumptive Coagulopathy Involving Amniotic Fluid Embolism: The Importance of Earlier Assessments for Interventions in Critical Care2020

    • Author(s)
      Oda Tomoaki、Tamura Naoaki、Ide Rui、Itoh Toshiya、Horikoshi Yoshimasa、Matsumoto Masako、Narumi Megumi、Kohmura-Kobayashi Yukiko、Furuta-Isomura Naomi、Yaguchi Chizuko、Uchida Toshiyuki、Suzuki Kazunao、Itoh Hiroaki、Kanayama Naohiro
    • Journal Title

      Critical Care Medicine

      Volume: 48 Issue: 12 Pages: e1251-e1259

    • DOI

      10.1097/ccm.0000000000004665

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 母児の健康を目指した 妊娠中の栄養管理について2023

    • Author(s)
      幸村友季子
    • Organizer
      第146回関東連合産科婦人科学会学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 無痛分娩のチームビルディング2023

    • Author(s)
      幸村友季子
    • Organizer
      第146回日本産科麻酔学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 当院における潰瘍性大腸炎合併妊娠とクローン病合併妊娠の周産期事象の比較2023

    • Author(s)
      幸村友季子
    • Organizer
      第75回日本産科婦人科学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 当院における潰瘍性大腸炎合併妊娠とクローン病合併妊娠の周産期事象の比較2023

    • Author(s)
      幸村友季子
    • Organizer
      第60回日本周産期新生児学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 妊婦の栄養摂取と次世代の 組織慢性炎症(Metaflammation)との関わり2022

    • Author(s)
      幸村友季子
    • Organizer
      日本周産期新生児医学会学術集会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 胎生期低栄養による肝脂肪変性増悪マウスモデルにおける網羅的DNAメチル化解析2021

    • Author(s)
      幸村友季子
    • Organizer
      日本産科婦人科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 母児の健康を目指した妊娠中の栄養管理について2021

    • Author(s)
      幸村友季子
    • Organizer
      日本女性栄養代謝学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 胎生期低栄養による臓器慢性炎症のプログラミング-マウス動物実験から-2020

    • Author(s)
      幸村友季子
    • Organizer
      第44回日本女性栄養代謝学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 若年女性、妊婦の栄養 -母体および児の将来の健康を目指して-2020

    • Author(s)
      幸村友季子
    • Organizer
      第61回日本母性衛生学会総会・学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 妊婦のエネルギー摂取不足に起因する成長後の児の脂肪肝発症リスク軽減を目指して エピゲノム記憶再編集の視点から2020

    • Author(s)
      幸村友季子
    • Organizer
      第72回 日本産科婦人科学会 学術集会
    • Related Report
      2020 Research-status Report
  • [Book] 分娩の生理・病態に基づいた 頸管熟化と分娩誘発法2022

    • Author(s)
      幸村友季子
    • Total Pages
      140
    • Publisher
      メジカルビュー社
    • ISBN
      9784758321389
    • Related Report
      2022 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

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