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Examination of hearing prognostic factors in Ménière's disease from the perspective of immune and stress responses

Research Project

Project/Area Number 20K09688
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionGifu University

Principal Investigator

Aoki Mitsuhiro  岐阜大学, 大学院医学系研究科, 招へい教員 (30283302)

Co-Investigator(Kenkyū-buntansha) 奥田 弘  岐阜大学, 医学部附属病院, 助教 (20769509)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsメニエール病 / 両側化 / 進行性難聴 / 慢性炎症 / 難聴 / MCP-1 / PBMC / 自己炎症
Outline of Research at the Start

ストレス応答や免疫応答に中心的役割を果たす転写因子のひとつであるNF-κBを介した慢性炎症が難治性メニエール病の進行する難聴や両側化に、関与するかどうかを2年間の前向き研究で検討する。患者の末梢血単核細胞(PBMC)を分離し、コントロール(非刺激)、酸性刺激下、リポポリサッカライド(LPS)刺激下で培養した上で、炎症性サイトカインやアヂィポカインなどの放出の違いが聴力レベルへ与える影響から進行性難聴ならびに両側化の病態解明ならびにその対処法を解明する。

Outline of Final Research Achievements

MCP-1 exerts its efficacy by binding to its receptor, C-C chemokine receptor type 2 (CCR2). MCP-1 and CCR2 are not expressed in normal vascular walls, but their expression increases in vascular wall cells from the early stage of vascular injury. We reported that plasma MCP-1 in refractory Meniere's disease patients was significantly elevated compared to healthy adults, and that this was significant in bilateral Meniere’s disease patients. In Meniere's disease cases, either NF-κB signaling is enhanced or the downstream monocyte chemoattractant MCP-1 is increased, resulting in increased levels of TNF-α and IL-6, leading to a slow progressive disease. It was thought to cause hearing impairment and vestibular damage.

Academic Significance and Societal Importance of the Research Achievements

メニエール病は自然治癒あるいは薬物に反応して速やかに軽快する症例もいる一方、すべての薬物治療に抵抗を示し、強度が高い治療法を選択せざるをない場合もあり、中耳加圧治療や内リンパ嚢開放術が行われている。めまいは制御できたとしても、大半の症例で難聴や平衡障害の進行がみられ、47%のケースで両側化すると言われている。特に、40歳~50歳で発症することが多く、社会活動に多大な影響を及ぼすため、経済的損出は極めて大きい。しかし、進行する難聴や前庭障害ならびに両側化に至るメカニズムは不明である。メニエール病の進行性難聴や両側化を予防あるいは抑制できる治療法の開発につなげることができる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (12 results)

All 2022 2021 2020

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Increased Monocyte Chemotactic Protein-1 Accompanying Pro-Inflammatory Processes are Associated with Progressive Hearing Impairment and Bilateral Disability of Meniere’s Disease2022

    • Author(s)
      Iinuma Ryota、Okuda Hiroshi、Obara Natsuko、Matsubara Yoshitaka、Aoki Mitsuhiro、Ogawa Takenori
    • Journal Title

      Audiology and Neurotology

      Volume: 27 Issue: 3 Pages: 1-9

    • DOI

      10.1159/000518839

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum Fibrinogen Level and Cytokine Production as Prognostic Biomarkers for Idiopathic Sudden Sensorineural Hearing Loss2022

    • Author(s)
      Okuda Hiroshi、Aoki Mitsuhiro、Ohashi Toshimitsu、Ogawa Bakushi、Shibata Hirofumi、Ueda Natsuko、Hayashi Hisamitsu、Nishihori Takezumi、Kuze Bunya、Ohnishi Hidenori、Ogawa Takenori
    • Journal Title

      Otology & Neurotology

      Volume: 43 Issue: 7 Pages: 712-719

    • DOI

      10.1097/mao.0000000000003552

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of transtympanic intermittent pressure therapy using a new tympanic membrane massage device for intractable Meniere’s disease and delayed endolymphatic hydrops: a prospective study.2022

    • Author(s)
      Shojaku H, Aoki M, Takakura H, Fujisaka M, Asai M, Tsubota M, Ito Y, Watanabe Y.
    • Journal Title

      Acta Otolaryngol.

      Volume: 141 Issue: 10 Pages: 907-914

    • DOI

      10.1080/00016489.2021.1942979

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メニエール病2022

    • Author(s)
      奥田 弘、青木光広
    • Journal Title

      耳鼻咽喉科

      Volume: 1 Pages: 285-291

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 両側前庭障害2022

    • Author(s)
      青木光広、丸田恭子、アンスール亜千夢
    • Journal Title

      Brain and Nerve

      Volume: 74 Pages: 1261-1266

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in responsiveness of intratympanic steroid injection for intractable vertigo in Meniere's disease2021

    • Author(s)
      Okuda Hiroshi、Aoki Mitsuhiro、Ogawa Bakushi、Shibata Hirofumi、Ueda Natsuko、Ohashi Toshimitsu、Hayashi Hisamitsu、Nishihori Takezumi、Kuze Bunya、Ogawa Takenori
    • Journal Title

      American Journal of Otolaryngology

      Volume: 42 Issue: 6 Pages: 103141-103141

    • DOI

      10.1016/j.amjoto.2021.103141

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic and therapeutic strategies of the Japan Society of Equilibrium Research.2021

    • Author(s)
      Iwasaki S, Shojaku, H, Murofushi T, Seo T, Kitahara T, Origasa H, Watanabe Y, Suzuki M, Takeda N on behalf of Committee for Clinical Practice Guidelines of Japan Society of Equilibrium Research.
    • Journal Title

      Auris Nasus Larynx

      Volume: 48 Issue: 3 Pages: 15-22

    • DOI

      10.1016/j.anl.2021.08.008

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Presentation] RFC 1 遺伝子のイントロン領域における AAGGG の リピート延長を認めた CANVAS 例2022

    • Author(s)
      青木光広 丸田恭子、奥田 弘 林 寿光
    • Organizer
      日本めまい平衡医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] メニエール病の聴力予後に与える因子の検討2021

    • Author(s)
      青木光広 奥田 弘 林 寿光 西堀丈純 久世文也
    • Organizer
      日本めまい平衡医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] メニエール病の難聴進行および両側化におけるMCP-1の関与2021

    • Author(s)
      飯沼亮太 奥田 弘 青木光広
    • Organizer
      日本めまい平衡医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] メニエール病の聴力予後に与える因子の検討2020

    • Author(s)
      青木光広 奥田 弘 林 寿光 西堀丈純 久世文也
    • Organizer
      日本めまい平衡医学会
    • Related Report
      2020 Research-status Report
  • [Book] めまい診療ハンドブック プラクティス耳鼻咽喉科の臨床 42022

    • Author(s)
      青木光広
    • Total Pages
      374
    • Publisher
      中山書店
    • Related Report
      2022 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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