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Role of TET family molecules in the efficacy of sublingual immunotherapy and development of novel adjuvant

Research Project

Project/Area Number 20K09736
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionInternational University of Health and Welfare

Principal Investigator

OKANO MITSUHIRO  国際医療福祉大学, 医学部, 教授 (60304359)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords舌下免疫療法 / アレルギー性鼻炎 / TET / 制御性T細胞 / 免疫寛容
Outline of Research at the Start

舌下免疫療法はアレルギー性鼻炎の根治的治療法である。今回の研究では免疫寛容に中心的に働く制御性T細胞の安定性にTET (ten-eleven translocation) ファミリー分子によるエピゲノム修飾が強く関与することに注目し、舌下免疫療法によるTETファミリー分子の発現誘導とその臨床的意義を検討する。さらにTETファミリー分子の発現を促進する物質を探索・同定し、アジュバントを開発する。

Outline of Final Research Achievements

Sublingual immunotherapy is a curative treatment for allergic rhinitis. We sought to determine the expression of TET family molelcutes and their clinical characteriation in sublingual immunotherapy. Peripheral blood mononuclear cells were collected from patients with Japanese cedar/cypress pollinosis underwent sublingual immunotherapy, and regulatory T cells were separated using magnetic beads. Expressions of TET1, TET2 and TET3 mRNA on regulatory T cells were determined by real-time PCR. Expressions of TET1, TET2 orTET3 mRNA on regulatory T cells were not differenct between before and one year alter sublingual immunotherapy.

Academic Significance and Societal Importance of the Research Achievements

本研究からは、舌下免疫療法における制御性T細胞に発現するTET遺伝子について明確な臨床的な意義は見いだせなかった。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (28 results)

All 2023 2022 2021 2020

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (13 results) (of which Int'l Joint Research: 4 results,  Invited: 7 results) Book (1 results)

  • [Journal Article] Executive summary: Japanese guidelines for allergic rhinitis 20202023

    • Author(s)
      Okano M, Fujieda S, Gotoh M, Kurono Y, Matsubara A, Ohta N, Kamijo A, Yamada T, Nakamaru Y, Asako M, Sakurai D, Terada T, Yonekura S, Sakashita M, Okubo K.
    • Journal Title

      Allergology International

      Volume: 72 Issue: 1 Pages: 41-53

    • DOI

      10.1016/j.alit.2022.11.003

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A MULTICENTER CLINICAL SURVEY ABOUT THE PREVALENCE OF JAPANESE CYPRESS POLLINOSIS AND THE EFFICACY OF SUBLINGUAL IMMUNOTHERAPY WITH JAPANESE CEDAR POLLEN EXTRACT DURING JAPANESE CYPRESS POLLEN DISPERSAL PERIOD2023

    • Author(s)
      岡 愛子、三村 英也、岡野光博ほか
    • Journal Title

      Japanese Journal of Allergology

      Volume: 72 Issue: 9 Pages: 1138-1146

    • DOI

      10.15036/arerugi.72.1138

    • ISSN
      0021-4884, 1347-7935
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese cedar pollen sublingual immunotherapy is effective in treating seasonal allergic rhinitis during the pollen dispersal period for Japanese cedar and Japanese cypress2022

    • Author(s)
      Yonekura Syuji、Gotoh Minoru、Okano Mitsuhiro、Kurokawa Tomoya、Maekawa Yuriko、Okubo Kimihiro、Okamoto Yoshitaka
    • Journal Title

      Allergology International

      Volume: 71 Issue: 1 Pages: 140-143

    • DOI

      10.1016/j.alit.2021.08.012

    • NAID

      130008145206

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mapping naso-ocular symptom scores to EQ-5D-5L utility values in Japanese cedar pollinosis2022

    • Author(s)
      Kumanomidou Hiroshi、Kanai Kengo、Oka Aiko、Haruna Takenori、Hirata Yuji、Makihara Sei-ichiro、Higaki Takaya、Akamatsu Maki、Okamoto Yoshitaka、Ikeda Shunya、Okano Mitsuhiro
    • Journal Title

      Allergology International

      Volume: 71 Issue: 2 Pages: 207-213

    • DOI

      10.1016/j.alit.2021.11.002

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of omalizumab on paid and unpaid work productivity among severe Japanese cedar pollinosis (JCP) patients2022

    • Author(s)
      M?ller M.、Igarashi A.、Hashiguchi K.、Kappel M.、Paolini F.、Yoshisue H.、Funakubo M.、Sharma H.、Okano M.
    • Journal Title

      Journal of Medical Economics

      Volume: 25 Issue: 1 Pages: 220-229

    • DOI

      10.1080/13696998.2022.2033051

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Correlation between sensitization to house dust mite major allergens, age, and symptoms in Japanese house dust mite allergic subjects2022

    • Author(s)
      Hasegawa Akira、Utsumi Daichi、Lund Kaare、Okano Mitsuhiro、Ohashi-Doi Katsuyo、Okubo Kimihiro
    • Journal Title

      International Immunopharmacology

      Volume: 107 Pages: 108640-108640

    • DOI

      10.1016/j.intimp.2022.108640

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an Allergic Rhinitis Diagnosis Application Using the Total Tear IgE Detection Kit for Examining Nasal Fluid: Comparison and Combination with the Conventional Nasal Smear Examination for Eosinophils2022

    • Author(s)
      Kumanomidou Hiroshi、Okano Mitsuhiro
    • Journal Title

      Allergies

      Volume: 2 Issue: 4 Pages: 146-153

    • DOI

      10.3390/allergies2040014

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Symptom‐based stratification for hay fever: A crowdsourced study using the smartphone application AllerSearch2021

    • Author(s)
      Inomata Takenori、Nakamura Masahiro、Iwagami Masao、Sung Jaemyoung、Nakamura Masahiro、Ebihara Nobuyuki、Fujisawa Kumiko、Muto Kaori、Nojiri Shuko、Ide Takuma、Okano Mitsuhiro、Okumura Yuichi、Fujio Kenta、Fujimoto Keiichi、Nagao Masashi、Hirosawa Kunihiko、Akasaki Yasutsugu、Murakami Akira
    • Journal Title

      Allergy

      Volume: 76 Issue: 12 Pages: 3820-3824

    • DOI

      10.1111/all.15078

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between Saliva and Sublingual Immunotherapy2021

    • Author(s)
      Oka Aiko、Okano Mitsuhiro
    • Journal Title

      Pathogens

      Volume: 10 Issue: 11 Pages: 1358-1358

    • DOI

      10.3390/pathogens10111358

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Underwater posterior nasal neurectomy compared to resection of peripheral branches of posterior nerve in severe allergic rhinitis2021

    • Author(s)
      Makihara Seiichiro、Okano Mitsuhiro、Miyamoto Syotaro、Uraguchi Kensuke、Tsumura Munechika、Kariya Shin、Ando Mizuo
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 141 Issue: 8 Pages: 780-785

    • DOI

      10.1080/00016489.2021.1925151

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of salivary microbiome in IL‐10 production and efficacy of sublingual immunotherapy2021

    • Author(s)
      Oka Aiko、Kidoguchi Masanori、Kariya Shin、Fujiwara Tazuko、Yuta Atsushi、Miyashita Hiromi、Higaki Takaya、Ogawa Yukiko、Kanai Kengo、Makihara Sei‐ichiro、Haruna Takenori、Kunisawa Jun、Adachi Naoto、Koyama Keisuke、Ii Rieko、Noguchi Emiko、Fujieda Shigeharu、Nishizaki Kazunori、Okano Mitsuhiro
    • Journal Title

      Allergy

      Volume: - Issue: 8 Pages: 2617-2620

    • DOI

      10.1111/all.14858

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Japanese cedar and cypress pollinosis updated: New allergens, cross-reactivity, and treatment2021

    • Author(s)
      Osada Toshihiro、Okano Mitsuhiro
    • Journal Title

      Allergology International

      Volume: 70 Issue: 3 Pages: 281-290

    • DOI

      10.1016/j.alit.2021.04.002

    • NAID

      130008064031

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in patients with combined Japanese cedar and Japanese cypress.2020

    • Author(s)
      Kikuoka H, Kouzaki H, Matsumoto K, Arai H, Yamamoto S, Tojima I, Shimizu S, Miyashita H, Ogawa Y, Osada T, Okano M, Yuta A, Shmizu T.
    • Journal Title

      Clinical Immunology

      Volume: 210 Pages: 108310-108310

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Add-on omalizumab for inadequately controlled severe pollinosis despite standard-of-care: a randomized study.2020

    • Author(s)
      Okubo K, Okano M, Sato N, Tamaki Y, Suzuki H, Uddin A, Fogel R.
    • Journal Title

      Journal of Allergy and Clinical Immunology in Practice

      Volume: 8 Pages: 3130-3140

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Rhinitis in elderly: A new endotype of rhinitis2023

    • Author(s)
      岡野光博
    • Organizer
      IFOS Dubai 2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] アレルギー性鼻炎に対する局所薬アップデート~抗ヒスタミン薬からセルロースまで~2022

    • Author(s)
      岡野光博
    • Organizer
      第60回日本鼻科学会総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] スギ花粉症における症状スコアの効用値へのマッピングの試み2022

    • Author(s)
      赤松摩紀, 金井健吾, 岡 愛子, 春名威範, 平田裕二, 牧原靖一郎, 檜垣貴哉, 西崎和則, 安藤瑞生, 岡野光博,
    • Organizer
      第2日本耳鼻咽喉科免疫アレルギー感染症学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 関東地区におけるヒノキ花粉症と舌下免疫療法に関するアンケート調査(第一報)2022

    • Author(s)
      岡野光博, 増野聡, 高原恵理子, 金井憲一, 永倉仁史, 中里真帆子, 中里秀史, 荒木進, 熊埜御堂浩, 金井健吾, 岡愛子, 假屋ゆう子, 北村寛志, 杉浦瑠夏,
    • Organizer
      第8回日本アレルギー学会関東地方会
    • Related Report
      2022 Research-status Report
  • [Presentation] 鼻アレルギー診療ガイドライン:第9版改訂の向こうにみえたもの2021

    • Author(s)
      岡野光博
    • Organizer
      第1回日本耳鼻咽喉科免疫アレルギー感染症学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] アレルギー性鼻炎と口腔マイクロバイオーム2021

    • Author(s)
      岡野光博
    • Organizer
      第34回日本口腔咽頭科学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Mechanisms of allergic rhinitis and allergen immunotherapy: Update2021

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      20th Asian Research Symposium in Rhinology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] What is IgG4 disease2021

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      European Rhinologic Society
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] SCIT and SLIT for respiratory allergic diseases2021

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      Asian Pacific Association of Allergy Asthma and Clinical Immunolgy
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] アレルギー性鼻炎診療アップデート:鼻アレルギー診療ガイドラインの改訂点について2020

    • Author(s)
      岡野光博
    • Organizer
      第51回日本職業・環境アレルギー学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 鼻アレルギー診療ガイドラインの改訂点2020

    • Author(s)
      岡野光博
    • Organizer
      第34回日本耳鼻咽喉科学会秋季大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Clinicial characteristics of Japanese patients wit physician-diagnosed allergic rhinitis in the JMDC claims database2020

    • Author(s)
      Yoshisue H, Ito C, Okano M.
    • Organizer
      JSA/WAO Joint Congress
    • Related Report
      2020 Research-status Report
  • [Presentation] What benefit can HDM SLIT-tablet provide to patients living with HDM allergic rhinitis?2020

    • Author(s)
      Okano M
    • Organizer
      JSA/WAO Joint Congress
    • Related Report
      2020 Research-status Report
  • [Book] 今日の治療指針 2022年版[デスク判]2022

    • Author(s)
      福井 次矢、高木 誠、小室 一成
    • Total Pages
      2224
    • Publisher
      医学書院
    • ISBN
      9784260047760
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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