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macular sensitivity changes depending on capillary dropout and macular edema

Research Project

Project/Area Number 20K09770
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionShinshu University

Principal Investigator

MURATA Toshinori  信州大学, 学術研究院医学系, 教授 (50253406)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords光干渉断層計 / アンギオグラフィー / 網膜感度 / 血管密度 / 漏出 / 人工知能 / 深層学習 / 網膜静脈分枝閉塞症 / OCT-Angopgraphy / 黄斑浮腫
Outline of Research at the Start

黄斑浮腫の発症および遷延においては、黄斑部、特に傍中心窩に、発症直後に形成される毛細血管の閉塞による循環動態の変化が、その後の黄斑浮腫の遷延化を規定するのではないかという仮説を検証する。
OCT-Angiographyにより明らかになるvessel densityやflow densityが網膜感度に相関することを証明する。さらにこれと最終視力との関係を検討することである。網膜感度が保たれている範囲が、中心窩周囲で広ければ、最終的に良好な視力が得られる可能性が高い

Outline of Final Research Achievements

We report that optical coherence tomography angiography (OCTA) measures blood flow density in retinal vessels and correlates positively with retinal sensitivity in areas of retinal vascular occlusion. We reported that the sensitivity of retina with preserved blood flow in branch retinal vein occlusions correlated with final visual acuity. We confirmed that OCTA is comparable to fluorescent fundus angiography in detecting new vessels. Furthermore, in OCTA, which cannot detect leakage from blood vessels because no contrast agent is used, we attempted to detect leakage based on the thickness change resulting from leakage by superimposing a retinal thickness map

Academic Significance and Societal Importance of the Research Achievements

糖尿病網膜症は失明原因の一つであり、その病態は網膜血管の閉塞と漏出と、続発する新生血管による正常網膜の破壊である。従来、網膜血管の評価には蛍光眼底造影が不可欠であったが、アナフィラクシーショックのリスクがあった。
Optical Coherence Tomography Angiography (OCTA)は造影剤を使わずに網膜血管の閉塞と新生血管を描出可能で、アナフィラクシーショックのリスクがない。我々はArtificial Intelligenceを用いることで漏出を検出できる可能性を報告した。有効でかつ安全な、糖尿病網膜症および黄斑浮腫の治療に、大きく貢献することが期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 2021 2020

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Wide-field swept-source OCT angiography (23 × 20 mm) for detecting retinal neovascularization in eyes with proliferative diabetic retinopathy2023

    • Author(s)
      Hirano T, Hoshiyama K, Takahashi Y, Murata T.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 261 Issue: 2 Pages: 339-344

    • DOI

      10.1007/s00417-022-05878-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OCULAR ANGIOGRAPHIC FEATURES IN JAPANESE PATIENTS WITH VAL30MET HEREDITARY TRANSTHYRETIN AMYLOIDOSIS2022

    • Author(s)
      Shinji Kakihara, Takao Hirano, Junya Kitahara, Yorishige Matsuda, Akira Imai, Teruyoshi Miyahara, Toshinori Murata
    • Journal Title

      Retina

      Volume: 42 Issue: 1 Pages: 210-215

    • DOI

      10.1097/iae.0000000000003291

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between central retinal sensitivity, thickness, perfusion density and visual acuity in patients with branch retinal vein occlusion2021

    • Author(s)
      Kazutaka Hirabayashi, Ken Hoshiyama, Akira Imai, Yasuhiro Iesato, Takao Hirano, Toshinori Murata
    • Journal Title

      Acta Ophthalmologica

      Volume: 14 Issue: 2 Pages: 10-11

    • DOI

      10.1111/aos.14841

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prediction of post-treatment retinal sensitivity by baseline retinal perfusion density measurements in eyes with branch retinal vein occlusion2020

    • Author(s)
      Soraya Rachima, Kazutaka Hirabayashi, Akira Imai, Yasuhiro Iesato, Toshinori Murata
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 9614-9621

    • DOI

      10.1038/s41598-020-66708-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A novel OCT-Angiography that delineates retinal vessels and the leakage utilizing deep learning with fluorescein angiography videos as training data2023

    • Author(s)
      Toshinori Murata
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病黄斑浮腫を何としても治す2023

    • Author(s)
      村田敏規
    • Organizer
      日本眼科学会総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 急性憎悪時の糖尿病網膜症における軟性白斑部位のOCTAによる経時的評価2022

    • Author(s)
      星山 健、平野 隆雄、伊藤 駿、高橋 良彰、佐藤 亜位、村田 敏規
    • Organizer
      第28回日本糖尿病眼学会総会・第37回日本糖尿病合併症学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] OCTA findings before and after onset of foveal retinal neovascularization in diabetic retinopathy2022

    • Author(s)
      Shun Nakayama Toshinori Murata
    • Organizer
      FUJIRETINA
    • Related Report
      2022 Annual Research Report
  • [Presentation] Posterior vitreous detachment observed by wide-angle 23mm swept-source OCT in healthy subjects including preschool children2021

    • Author(s)
      Toshinori Murata
    • Organizer
      Asia Pacific Retinal Imaging SOciety 8th international symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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