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Promotion of Glaucoma Precision Medicine Using Virtual Healthcare Facilities within Yamanashi Prefecture

Research Project

Project/Area Number 20K09786
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionUniversity of Yamanashi

Principal Investigator

Kashiwagi Kenji  山梨大学, 大学院総合研究部, 教授 (30194723)

Co-Investigator(Kenkyū-buntansha) 坂本 雅子  山梨大学, 医学部附属病院, 医員 (70758846)
北村 一義  山梨大学, 大学院総合研究部, 講師 (80535617)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords緑内障 / 人工知能 / precision medicine / 眼科地域連携 / ビッグデータ / プレシジョンメディシン / 診療データ共有化 / 地域医療
Outline of Research at the Start

失明原因第1位である緑内障は慢性疾患に共通する課題を有しているる。緑内障の治療は眼圧下降であるがその治療反応性はには個人差が大きい。この対策として、本研究では全国的に収集した眼科ビッグデータ・AI研究を活用した緑内障診療アルゴリズムの成果を、山梨県域をモデルとして構築しているバーチャル診療ネットワークに導出、地域における実際的な緑内障のプレシジョンメディシンにつなげることを目標に有効性と課題を明確にする。

Outline of Final Research Achievements

We have developed an algorithm for glaucoma screening using artificial intelligence (AI). Furthermore, we have initiated the construction and implementation of a comprehensive screening system for clinically frequent retinal diseases other than glaucoma, with a focus on health examination centers. Since glaucoma is characterized by significant individual differences due to genetic abnormalities being the main factor, we have conducted research on the analysis of glaucoma-related genetic information. Currently, we are making progress in the field of advanced glaucoma treatment (precision medicine) through the utilization of big data, AI, and genetic analysis. Additionally, in order to promote precision medicine for glaucoma, we have established a foundational organization, which consists of ophthalmologists, educational institutions, government authorities, and patient associations, and have begun efforts to enhance ophthalmic medical care.

Academic Significance and Societal Importance of the Research Achievements

高齢社会において緑内障患者数は増加するが専門医は不十分のため、未受診や診療から脱落する患者が少なくない。このような症例を発見し、適切な治療を行うためには人工知能の活用は非常に意義が高い。また緑内障は個人差が大きいため、個別化医療が重要であるが、このためには遺伝情報と臨床情報の活用が必須である。さらに眼科医療向上のためには眼科医のみではなく、地域行政、教育、患者の協力などが必須である。以上から今回の成果は非常に社会的意義が高い。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (46 results)

All 2023 2022 2021 2020 2019 Other

All Journal Article (33 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 33 results,  Open Access: 21 results) Presentation (8 results) (of which Invited: 6 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Repeated Measurements Are Necessary for Evaluating Accurate Diurnal Rhythm Using a Self-Intraocular Pressure Measurement Device2023

    • Author(s)
      Shigemoto Yumi、Hasebe Yuka、Kitamura Kazuyoshi、Fukuda Yoshiko、Sakamoto Masako、Matsubara Mio、Minaguchi Shinya、Kashiwagi Kenji
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 7 Pages: 2460-2460

    • DOI

      10.3390/jcm12072460

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mid-Term Results of Ab Interno Trabeculectomy among Japanese Glaucoma Patients2023

    • Author(s)
      Kitamura Kazuyoshi、Fukuda Yoshiko、Hasebe Yuka、Matsubara Mio、Kashiwagi Kenji
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 6 Pages: 2332-2332

    • DOI

      10.3390/jcm12062332

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Astrocyte Immune Functions and Glaucoma2023

    • Author(s)
      Shinozaki Youichi、Kashiwagi Kenji、Koizumi Schuichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 3 Pages: 2747-2747

    • DOI

      10.3390/ijms24032747

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ocular P2 receptors and glaucoma2023

    • Author(s)
      Shinozaki Youichi、Saito Kozo、Kashiwagi Kenji、Koizumi Schuichi
    • Journal Title

      Neuropharmacology

      Volume: 222 Pages: 109302-109302

    • DOI

      10.1016/j.neuropharm.2022.109302

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulatory-approved deep learning/machine learning-based medical devices in Japan as of 2020: A systematic review2022

    • Author(s)
      Aisu Nao、Miyake Masahiro、Takeshita Kohei、Akiyama Masato、Kawasaki Ryo、Kashiwagi Kenji、Sakamoto Taiji、Oshika Tetsuro、Tsujikawa Akitaka
    • Journal Title

      PLOS Digital Health

      Volume: 1 Issue: 1 Pages: e0000001-e0000001

    • DOI

      10.1371/journal.pdig.0000001

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic variants associated with glaucomatous visual field loss in primary open-angle glaucoma2022

    • Author(s)
      Mabuchi Fumihiko、Mabuchi Nakako、Sakurada Yoichi、Yoneyama Seigo、Kashiwagi Kenji、Yamagata Zentaro、Takamoto Mitsuko、Aihara Makoto、Iwata Takeshi、Hashimoto Kazuki、Sato Kota、Shiga Yukihiro、Nakazawa Toru、Akiyama Masato、Kawase Kazuhide、Ozaki Mineo、Araie Makoto
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 20744-20744

    • DOI

      10.1038/s41598-022-24915-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy2022

    • Author(s)
      Shinozaki Youichi、Leung Alex、Namekata Kazuhiko、Saitoh Sei、Nguyen Huy Bang、Takeda Akiko、Danjo Yosuke、Morizawa Yosuke M.、Shigetomi Eiji、Sano Fumikazu、Yoshioka Nozomu、Takebayashi Hirohide、Ohno Nobuhiko、Segawa Takahiro、Miyake Kunio、Kashiwagi Kenji、Harada Takayuki、Ohnuma Shin-ichi、Koizumi Schuichi
    • Journal Title

      Science Advances

      Volume: 8 Issue: 44 Pages: 1081-1081

    • DOI

      10.1126/sciadv.abq1081

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Japan Ocular Imaging Registry: a national ophthalmology real-world database2022

    • Author(s)
      Miyake Masahiro、Akiyama Masato、Kashiwagi Kenji、Sakamoto Taiji、Oshika Tetsuro
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 66 Issue: 6 Pages: 499-503

    • DOI

      10.1007/s10384-022-00941-0

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma2022

    • Author(s)
      Pan Yang、Suga Akiko、Kimura Itaru、Kimura Chojiro、Minegishi Yuriko、Nakayama Mao、Yoshitake Kazutoshi、Iejima Daisuke、Minematsu Naoko、Yamamoto Megumi、Mabuchi Fumihiko、Takamoto Mitsuko、Shiga Yukihiro、Araie Makoto、Kashiwagi Kenji、Aihara Makoto、Nakazawa Toru、Iwata Takeshi
    • Journal Title

      Journal of Clinical Investigation

      Volume: 132 Issue: 21

    • DOI

      10.1172/jci153589

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Mlc1 Promoter Directs M?ller Cell-specific Gene Expression in the Retina2022

    • Author(s)
      Danjo Yosuke、Shinozaki Youichi、Natsubori Akiyo、Kubota Yuto、Kashiwagi Kenji、Tanaka Kenji F.、Koizumi Schuichi
    • Journal Title

      Translational Vision Science & Technology

      Volume: 11 Issue: 1 Pages: 25-25

    • DOI

      10.1167/tvst.11.1.25

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 【眼科の人工知能】緑内障における人工知能の活用2022

    • Author(s)
      柏木賢治
    • Journal Title

      眼科手術

      Volume: 35 Pages: 24-27

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Medical Costs of and Changes in Glaucoma Treatment among Patients Newly Starting Glaucoma Care2021

    • Author(s)
      Fukuda Y, Kume A, Kashiwagi K.
    • Journal Title

      Curr Eye Res

      Volume: 46 Pages: 1695-1702

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques.2021

    • Author(s)
      Fujinami-Yokokawa Y, Ninomiya H, Liu X, Yang L, Pontikos N, Yoshitake K, Iwata T, Sato Y, Hashimoto T, Tsunoda K, Miyata H, Fujinami K; Japan Eye Genetics Study (JEGC) Group.
    • Journal Title

      Br J Ophthalmol

      Volume: - Issue: 9 Pages: 1272-1279

    • DOI

      10.1136/bjophthalmol-2020-318544

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of visual and physical factors associated with inadequate instillation of eyedrops among patients with glaucoma2021

    • Author(s)
      Kashiwagi K, Matsuda Y, Ito Y, Kawate H, Sakamoto M, Obi S, Haro H
    • Journal Title

      PLoS One

      Volume: 14 Issue: 5 Pages: e0251699-e0251699

    • DOI

      10.1371/journal.pone.0251699

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Loss of P2Y <sub>1</sub> receptors triggers glaucoma‐like pathology in mice2021

    • Author(s)
      Hamada Kentaro、Shinozaki Youichi、Namekata Kazuhiko、Matsumoto Mami、Ohno Nobuhiko、Segawa Takahiro、Kashiwagi Kenji、Harada Takayuki、Koizumi Schuichi
    • Journal Title

      British Journal of Pharmacology

      Volume: 178 Issue: 22 Pages: 4552-4571

    • DOI

      10.1111/bph.15637

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 次世代を見据えた新たな眼科学への挑戦 緑内障を対象に2021

    • Author(s)
      柏木賢治
    • Journal Title

      山梨医科学雑誌

      Volume: 36 Pages: 11-23

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【AIと網膜関連疾患】JOIレジストリと今後の展開2021

    • Author(s)
      柏木賢治
    • Journal Title

      RetinaMedicine

      Volume: 10 Pages: 102-106

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【眼科疾患レジストリーの現状と未来】IRIS registry2021

    • Author(s)
      三宅正裕、柏木賢治
    • Journal Title

      あたらしい眼科

      Volume: 38 Pages: 119-126

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Five-Year Outcome of Aflibercept Monotherapy for Exudative Age-Related Macular Degeneration with Good Baseline Visual Acuity2021

    • Author(s)
      Kikushima W, Sakurada Y, Sugiyama A, Yoneyama S, Matsubara M, Fukuda Y, Kashiwagi K.
    • Journal Title

      J Clin Med

      Volume: 10 Issue: 5 Pages: 1098-1098

    • DOI

      10.3390/jcm10051098

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect and underlying mechanisms of airborne particulate matter 2.5 (PM2.5) on cultured human corneal epithelial cells2020

    • Author(s)
      Kashiwagi K, Iizuka Y.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 19516-19516

    • DOI

      10.1038/s41598-020-76651-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between Polygenic Risk Score and One-Year Outcomes Following As-Needed Aflibercept Therapy for Exudative Age-Related Macular Degeneration2020

    • Author(s)
      Shijo T, Sakurada Y, Yoneyama S, Kikushima W, Sugiyama A, Matsubara M, Fukuda Y, Mabuchi F, Kashiwagi K.
    • Journal Title

      Pharmaceuticals (Basel)

      Volume: 20 Issue: 9 Pages: 257-257

    • DOI

      10.3390/ph13090257

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetics of primary open-angle glaucoma and its endophenotypes2020

    • Author(s)
      Sakurada Y, Mabuchi F, Kashiwagi K.
    • Journal Title

      Prog Brain Res

      Volume: 256 Pages: 31-47

    • DOI

      10.1016/bs.pbr.2020.06.001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Response to photodynamic therapy combined with intravitreal aflibercept for polypoidal choroidal vasculopathy depending on fellow-eye condition:2-year results2020

    • Author(s)
      Matsubara M, Sakurada Y, Sugiyama A, Fukuda Y, Parikh R, Kashiwagi K.
    • Journal Title

      PLoS One

      Volume: 15 Issue: 8 Pages: e0237330-e0237330

    • DOI

      10.1371/journal.pone.0237330

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Title: Pachydrusen in Fellow Eyes Predict Response to Aflibercept Monotherapy in Patients with Polypoidal Choroidal Vasculopathy2020

    • Author(s)
      Fukuda Y, Sakurada Y, Sugiyama A, Yoneyama S, Matsubara M, Kikushima W, Tanabe N, Parikh R, Kashiwagi K.
    • Journal Title

      J Clin Med

      Volume: 31 Issue: 8 Pages: 2459-2459

    • DOI

      10.3390/jcm9082459

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systemic and ocular diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus2020

    • Author(s)
      Kume A, Kashiwagi K.
    • Journal Title

      BMC Ophthalmol

      Volume: 20 Issue: 1 Pages: 309-309

    • DOI

      10.1186/s12886-020-01578-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Persistence and treatment patterns of fixed combination drugs for glaucoma: a retrospective claims database study in Japan2020

    • Author(s)
      Kashiwagi K, Chono E, Koesters S, Yap PS.
    • Journal Title

      BMC Ophthalmol

      Volume: 10 Issue: 1 Pages: 223-223

    • DOI

      10.1186/s12886-020-01508-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of CRP levels with ARMS2 and CFH variants in age-related macular degeneration2020

    • Author(s)
      Shijo T, Sakurada Y, Fukuda Y, Yoneyama S, Sugiyama A, Matsubara M, Kikushima W, Tanabe N, Parikh R, Kashiwagi K.
    • Journal Title

      Int Ophthalmol

      Volume: 7 Issue: 10 Pages: 2735-2742

    • DOI

      10.1007/s10792-020-01460-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The usefulness of the Deep Learning method of variational autoencoder to reduce measurement noise in glaucomatous visual fields2020

    • Author(s)
      Asaoka R, Murata H, Asano S, Matsuura M, Fujino Y, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N.
    • Journal Title

      Sci Rep

      Volume: 12 Issue: 1 Pages: 7893-7893

    • DOI

      10.1038/s41598-020-64869-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic factors associated with response to as-needed aflibercept therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy2020

    • Author(s)
      Yoneyama S, Sakurada Y, Kikushima W, Sugiyama A, Matsubara M, Fukuda Y, Tanabe N, Parikh R, Mabuchi F, Kashiwagi K, Iijima H.
    • Journal Title

      Sci Rep

      Volume: 28 Issue: 1 Pages: 7188-7188

    • DOI

      10.1038/s41598-020-64301-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic variants associated with the onset and progression of primary open-angle glaucoma2020

    • Author(s)
      Mabuchi F, Mabuchi N, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Takamoto M, Aihara M, Iwata T, Hashimoto K, Sato K, Shiga Y, Nishiguchi KM, Nakazawa T, Akiyama M, Kawase K, Ozaki M, Araie M, Japan Glaucoma Society Omics Group (JGS-OG)
    • Journal Title

      American Journal of Ophthalmology

      Volume: 212 Pages: 135-140

    • DOI

      10.1016/j.ajo.2020.03.014

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of data augmentation for visual field trend analyses in patients with glaucoma.2020

    • Author(s)
      Asaoka R, Murata H, Matsuura M, Fujino Y, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N.
    • Journal Title

      Br J Ophthalmol.

      Volume: ** Issue: 12 Pages: 315027-315027

    • DOI

      10.1136/bjophthalmol-2019-315027

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent epidemiological status of ocular and other major complications related to diabetes mellitus in Japan2020

    • Author(s)
      Kume A, Kashiwagi K.
    • Journal Title

      Ophthalmologica

      Volume: 25 Issue: 6 Pages: 404-412

    • DOI

      10.1159/000506747

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validating the efficacy of the binomial pointwise linear regression method to detect glaucoma progression with multicentral database2019

    • Author(s)
      Asano Shotaro、Murata Hiroshi、Matsuura Masato、Fujino Yuri、Miki Atsuya、Tanito Masaki、Mizoue Shiro、Mori Kazuhiko、Suzuki Katsuyoshi、Yamashita Takehiro、Kashiwagi Kenji、Shoji Nobuyuki、Zangwill Linda M、Asaoka Ryo
    • Journal Title

      British Journal of Ophthalmology

      Volume: 104 Issue: 4 Pages: 569-574

    • DOI

      10.1136/bjophthalmol-2019-314136

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 緑内障実臨床へのAIの活用に向けて2023

    • Author(s)
      柏木賢治
    • Organizer
      第299回広島眼科症例検討会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 緑内障による個人や社会の損失を軽減するシムレスな支援体制に向けて2022

    • Author(s)
      柏木賢治
    • Organizer
      第86回横浜市大・神奈川眼科医会研修会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] よりよい緑内障診療のための緑内障診療ガイドラインの活用と注意症例への対応2022

    • Author(s)
      柏木賢治
    • Organizer
      第44回さざなみ眼科研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 医師の緑内障診断へのAIの影響2022

    • Author(s)
      福田佳子、柏木賢治
    • Organizer
      第33回日本緑内障学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 多施設からの眼底画像における緑内障の重症度推定2022

    • Author(s)
      柏木賢治
    • Organizer
      JAMIT
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 変わりゆく眼科医療への対応 -眼科臨床医の今後2022

    • Author(s)
      柏木賢治
    • Organizer
      千葉県眼科医会総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 医師による緑内障判定に対する人工知能の影響2022

    • Author(s)
      柏木賢治
    • Organizer
      第126回日本眼科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 緑内障診療におけるビッグデータ・人工知能(AI)の可能性2022

    • Author(s)
      柏木賢治
    • Organizer
      岩手県眼科集談会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Book] 眼科領域におけるオンライン診療と人工知能(AI)による診療補助2022

    • Author(s)
      柏木賢治
    • Total Pages
      4
    • Publisher
      文光堂
    • Related Report
      2022 Annual Research Report
  • [Book] 眼科におけるビッグデータ・AIを活用した先制医療2022

    • Author(s)
      柏木賢治
    • Total Pages
      3
    • Publisher
      医薬品出版
    • Related Report
      2022 Annual Research Report
  • [Book] 緑内障診療におけるAIとビッグデータ2022

    • Author(s)
      柏木賢治
    • Total Pages
      4
    • Publisher
      医学書院
    • Related Report
      2022 Annual Research Report
  • [Remarks] 甲斐ひとみネット

    • URL

      https://yamanashi-ophthalmology.com/%e7%94%b2%e6%96%90%e7%9c%bc%e3%83%8d%e3%83%83%e3%83%88/

    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 温度制御により薬効解消可能な眼圧上昇剤2022

    • Inventor(s)
      田中佑治、柏木賢治
    • Industrial Property Rights Holder
      国立大学法人 山梨大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
    • Overseas

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Published: 2020-04-28   Modified: 2024-01-30  

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