| Project/Area Number |
20K09898
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57010:Oral biological science-related
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
安藤 宏 松本歯科大学, 歯学部, 准教授 (30312094)
北川 純一 松本歯科大学, 歯学部, 教授 (50373006)
海野 俊平 松本歯科大学, 歯学部, 講師 (80418920)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | Swallowing Reflex / TRPA1 / TRPV4 / Swallowing reflex / Oropharyngeal dysphagia / Therapeutic targets |
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| Outline of Research at the Start |
Difficulty in swallowing is a major health problem. We will investigate whether stimulation to the swallowing-related regions by natural products (e.g.; chemical extract from wasabi/mustard oil) can use as a treatment strategy to faciliate the triggering of swallowing and their undelying mechanism.
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| Outline of Final Research Achievements |
We investigate the involvement of TRPA1 and TRPV4 in initiating the swallowing reflex. Our observations reveal that TRPA1 predominantly localizes on small to medium-diameter neurons, whereas TRPV4 primarily localizes on large to medium-diameter neurons. The topical administration of chemical agonists targeting TRPA1, such as allyl isothiocyanate (AITC), or TRPV4, such as GSK1016790A, in swallowing-related regions, leads to a dose-dependent facilitation of the swallowing reflex. Furthermore, the pre-application of antagonists for TRPA1 or TRPV4 significantly mitigates the AITC or GSK1016790A-induced swallowing reflex, respectively. These findings demonstrate the potential of targeting TRPA1 and TRPV4 to develop therapeutics to enhance swallowing function.
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| Academic Significance and Societal Importance of the Research Achievements |
Dysphagia poses a significant health challenge, with no established pharmacological treatment currently available. By targeting TRPA1 and TRPV4, our study suggests the importance of further exploration and development of therapeutics to address this pressing health issue.
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