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Elucidation of the pathogenicity and formation process of bacterial network triggered periodontal diseases

Research Project

Project/Area Number 20K09934
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Takeuchi Yasuo  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60396968)

Co-Investigator(Kenkyū-buntansha) 渡辺 孝康  日本大学, 歯学部, 講師 (70725514)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords歯周炎 / Dysbiosis / 歯肉炎 / メタトランスクリプトーム解析 / 細菌叢 / メタトランスクリプトーム
Outline of Research at the Start

歯周病はプラーク細菌叢の均衡が乱れることにより炎症が生じ,歯を支える歯周組織が破壊される病気である.歯周病の重症化を防ぐことは,口腔機能の維持だけでなく,全身の健康という観点からも重要なことと言える.歯肉炎から歯周炎に移行する過程については未だ不明な点が多いが,本研究では歯周病の主因であるプラークの細菌叢データから,歯周病が重症化する契機をとなる細菌学的特徴を明らかにし,これを歯周病のリスク検査や歯周治療の際に役立てようとするものである.

Outline of Final Research Achievements

A comprehensive analysis of the periodontal microbiome based on bacterial RNA revealed the differences in bacterial composition and functional activities of the microbiome according to the progression of periodontal disease. Especially in gingivitis, the co-occurrence bacterial network structure was more complex than in periodontitis. Furthermore, the dysbiotic microbiome did not necessarily recover to a healthy state even when clinical symptoms improved with periodontal treatment. This may support the fact that periodontitis is a disease with a high risk of recurrence.

Academic Significance and Societal Importance of the Research Achievements

バランスを乱した病的な細菌叢が治療後も容易に元の細菌組成に戻らないことは、バイオフィルムを形成する細菌の相互作用の強固さや複雑さを我々に再認識させた。本結果は歯周病予防の重要性のほか、現行の治療法の限界を示している。一方で、ある数種の細菌は病状の進行に伴い明らかに細菌の割合が増えるといった傾向が認められたことから、新たな歯周病予防・早期治療のための細菌学的マーカーとして臨床応用が期待できる。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (4 results)

All 2024 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Int'l Joint Research] Harvard School of Dental Medicine(米国)

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Characterization of bacterial communities among healthy, peri-implant mucositis, and peri-implantitis statuses by 16S rRNA gene amplicon sequencing.2024

    • Author(s)
      2.Nagai T, Shiba T, Komatsu K, Matsumura S, Koyanagi T, Nemoto T, Kobayashi R, Takeuchi Y, Iwata T.
    • Journal Title

      The Journal of the Stomatological Society, Japan

      Volume: 91(1) Pages: 8-18

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discrimination of Bacterial Community Structures among Healthy, Gingivitis, and Periodontitis Statuses through Integrated Metatranscriptomic and Network Analyses2021

    • Author(s)
      Nemoto Takashi、Shiba Takahiko、Komatsu Keiji、Watanabe Takayasu、Shimogishi Masahiro、Shibasaki Masaki、Koyanagi Tatsuro、Nagai Takahiko、Katagiri Sayaka、Takeuchi Yasuo、Iwata Takanori
    • Journal Title

      mSystems

      Volume: 6 Issue: 6

    • DOI

      10.1128/msystems.00886-21

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] メタトランスクリプトーム解析を用いた 歯周疾患ステージにおける細菌種間のネットワーク構造と機能組成の比較2020

    • Author(s)
      根本 昂、芝 多佳彦、渡辺 孝康、小柳 達郎、駒津 匡二、片桐 さやか、竹内 康雄、岩田 隆紀
    • Organizer
      第152回日本歯科保存学会春期学術大会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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