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The development of periodontal and endodontal tissue regenetation targeted amelogenin/GRP78 complex

Research Project

Project/Area Number 20K09958
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionKyushu University

Principal Investigator

Sanui Terukazu  九州大学, 大学病院, 講師 (70507780)

Co-Investigator(Kenkyū-buntansha) 福田 隆男  九州大学, 大学病院, 講師 (80507781)
武富 孝治  久留米大学, 医学部, 准教授 (10553290)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアメロジェニン / テプレノン / GRP78 / 血管新生 / 創傷治癒 / amelogenin / tissue regeneration
Outline of Research at the Start

本研究はアメロジェニン・GRP78複合体が免疫応答や創傷治癒等に与える影響、およびそこに至るまでの分子メカニズムを解明するため、複合体の構造解析により複合体の核内移行の機序や生理的機能を解明することと、またGRP78を誘導するテプレノンにより、人為的にこの複合体の活性増強が可能かを検証することを目的としている。これらの結果をもって、テプレノンとアメロジェニンの複合投与による新しい歯周組織再生療法を開発すると共に、歯髄の再生に応用可能か否かについて研究の展開を図る。

Outline of Final Research Achievements

We observed that teprenone (GGA) treatment increased Grp78 protein expression in hPDLCs and enhanced cell migration. Microarray analysis demonstrated that increased Grp78 expression triggered the production of Angptl4 and amphiregulin, which are involved in the enhancement of angiogenesis and subsequent wound healing. Moreover, the addition of recombinant murine amelogenin (rM180) further accelerated hPDLC migration and tube formation of human umbilical vein endothelial cells due to the upregulation of IL-8, MCP-1, and IL-6, which are also known as angiogenesis-inducing factors. These findings suggest that the application of GGA to gingival tissue and alveolar bone damaged by periodontal disease would facilitate the wound healing process by inducing periodontal ligament cells to migrate to the root surface and release cytokines involved in tissue repair.

Academic Significance and Societal Importance of the Research Achievements

本研究によりテプレノン(GGA)・アメロジェニンによる組織再生のメカニズムが証明されたため、将来的に安価かつ安全な歯周・歯髄組織再生薬によって医療福祉政策に大きく貢献する可能性が示唆される。さらに、免疫抑制剤や治癒促進剤等として医科領域まで適応範囲を拡げることができれば、医療費の抑制にも繋がるかもしれない。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (44 results)

All 2023 2022 2021 2020 Other

All Journal Article (11 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 11 results,  Open Access: 11 results) Presentation (28 results) (of which Int'l Joint Research: 14 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Endothelial Insulin Resistance Exacerbates Experimental Periodontitis2023

    • Author(s)
      Zeze T.、Shinjo T.、Sato K.、Nishimura Y.、Imagawa M.、Chen S.、Ahmed A.-k.、Iwashita M.、Yamashita A.、Fukuda T.、Sanui T.、Park K.、King G.L.、Nishimura F.
    • Journal Title

      Journal of Dental Research

      Volume: 102 Issue: 10 Pages: 1152-1161

    • DOI

      10.1177/00220345231181539

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development2023

    • Author(s)
      Imagawa Mio、Shinjo Takanori、Sato Kohei、Kawakami Kentaro、Zeze Tatsuro、Nishimura Yuki、Toyoda Masaaki、Chen Shuang、Ryo Naoaki、Ahmed Al-kafee、Iwashita Misaki、Yamashita Akiko、Fukuda Takao、Sanui Terukazu、Nishimura Fusanori
    • Journal Title

      Frontiers in Physiology

      Volume: 14 Pages: 01-16

    • DOI

      10.3389/fphys.2023.1298813

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis.2022

    • Author(s)
      Nishimura Y, Iwashita M, Hayashi M, Shinjo T, Watanabe Y, Zeze T, Yamashita A, Fukuda T, Sanui T, Sano T, Asano T, Nishimura F.
    • Journal Title

      Acta Diabetol

      Volume: 59 Issue: 10 Pages: 1275-1286

    • DOI

      10.1007/s00592-022-01930-y

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression.2022

    • Author(s)
      Watanabe Y, Fukuda T, Hayashi C, Nakao Y, Toyoda M, Kawakami K, Shinjo T, Iwashita M, Yamato H, Yotsumoto K, Taketomi T, Uchiumi T, Sanui T, Nishimura F.
    • Journal Title

      Sci Rep

      Volume: 12(1) Issue: 1 Pages: 13344-13344

    • DOI

      10.1038/s41598-022-17692-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.2022

    • Author(s)
      Hayashi C, Fukuda T, Kawakami K, Toyoda M, Nakao Y, Watanabe Y, Shinjo T, Sano T, Iwashita M, Yotsumoto K, Shida M, Taketomi T, Sanui T, Uchiumi T, Kanematsu T, Nishimura F.
    • Journal Title

      Front Cell Dev Biol

      Volume: 10 Pages: 1061216-1061216

    • DOI

      10.3389/fcell.2022.1061216

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells.2021

    • Author(s)
      Yamato H, Sanui T, Yotsumoto K, Nakao Y, Watanabe Y, Hayashi C, Aihara R, Iwashita M, Tanaka U, Taketomi T, Fukuda T, Nishimura F
    • Journal Title

      J Cell Biochem

      Volume: 122(7) Issue: 7 Pages: 716-730

    • DOI

      10.1002/jcb.29903

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss2021

    • Author(s)
      Nakao Yuki、Fukuda Takao、Zhang Qunzhou、Sanui Terukazu、Shinjo Takanori、Kou Xiaoxing、Chen Chider、Liu Dawei、Watanabe Yukari、Hayashi Chikako、Yamato Hiroaki、Yotsumoto Karen、Tanaka Urara、Taketomi Takaharu、Uchiumi Takeshi、Le Anh D.、Shi Songtao、Nishimura Fusanori
    • Journal Title

      Acta Biomaterialia

      Volume: 122 Pages: 306-324

    • DOI

      10.1016/j.actbio.2020.12.046

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adipose-specific C-C motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain2021

    • Author(s)
      Hayashi Masato、Iwashita Misaki、Nishimura Yuki、Shinjo Takanori、Sano Tomomi、Yamashita Akiko、Fukuda Takao、Sanui Terukazu、Asano Tomoichiro、Nishimura Fusanori
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 9 Issue: 1 Pages: e001871-e001871

    • DOI

      10.1136/bmjdrc-2020-001871

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages2020

    • Author(s)
      Yotsumoto K, Sanui T, Tanaka U, Yamato H, Alshargabi R, Shinjo T, Nakao Y, Watanabe Y, Hayashi C, Taketomi T, Fukuda T, Nishimura F.
    • Journal Title

      Frontiers in Immunology

      Volume: 11 Pages: 709-709

    • DOI

      10.3389/fimmu.2020.00709

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth2020

    • Author(s)
      Alshargabi Rehab、Sano Tomomi、Yamashita Akiko、Takano Aiko、Sanada Taiki、Iwashita Misaki、Shinjo Takanori、Fukuda Takao、Sanui Terukazu、Kishida Shosei、Nishimura Fusanori
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 9785-9785

    • DOI

      10.1038/s41598-020-66660-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SPOCK1 induces adipose tissue maturation: New insights into the function of SPOCK1 in metabolism2020

    • Author(s)
      Alshargabi Rehab、Shinjo Takanori、Iwashita Misaki、Yamashita Akiko、Sano Tomomi、Nishimura Yuki、Hayashi Masato、Zeze Tatsuro、Fukuda Takao、Sanui Terukazu、Nishimura Fusanori
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 533 Issue: 4 Pages: 1076-1082

    • DOI

      10.1016/j.bbrc.2020.09.129

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] miR-582-5p, that targets Skp1 and suppresses NF-kB signaling-mediated inflammation, is down-regulated in periodontitis and obesity.2023

    • Author(s)
      Li Rongzhi, Tomomi Sano, Takao Fukuda, Takanori Shinjyo, Misaki Iwashita, Akiko Yamashita, Terukazu Sanui, Fusanori Nishimura.
    • Organizer
      日本歯科保存学会2023年度春季学術大会(158回)
    • Related Report
      2023 Annual Research Report
  • [Presentation] バイオ3Dプリンターを用いた歯肉幹細胞由来骨様立体構造物の作製方法の確立と骨分化能、石灰化度に関する解析2023

    • Author(s)
      豊田真顕、梶岡俊一、福田隆男、川上賢太郎、信太実有、李金鳳、林千華子、中尾雄紀、讃井彰一、西村英紀
    • Organizer
      第66回秋季日本歯周病学会学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ト歯肉由来幹細胞を用いて作製した骨様立方構造体の解析2023

    • Author(s)
      豊田真顕、梶岡俊一、福田隆男、藤本亮太、川上賢太郎、信太実有、李金鳳、林千華子、中尾雄紀、讃井彰一、中山功一、西村英紀
    • Organizer
      第9回細胞凝集研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] バイオ3Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦2022

    • Author(s)
      豊田真顕、梶岡俊一、福田隆男、渡辺ゆかり、林千華子、川上賢太郎、中尾雄紀、四本かれん、大和寛明、讃井彰一、西村英紀
    • Organizer
      第65回日本歯周病学会春季学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯周炎骨吸収抑制効果2022

    • Author(s)
      林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀
    • Organizer
      第65回日本歯周病学会春季学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] TNF-a/IFN-a共刺激した歯肉幹細胞由来エクソソームはCD73とCD5Lを介して抗炎症性M2マクロファージを誘導する2022

    • Author(s)
      渡邊ゆかり、林千華子、川上賢太郎、豊田真顕、中尾雄紀、大和寛明、四本かれん、新城尊徳、岩下未咲、讃井彰一、福田隆男、西村英紀
    • Organizer
      第156回日本歯科保存学会2022年度春季学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Fabrication of stem cell-based scaffold-free bone-like 3D structures.2022

    • Author(s)
      Toyoda M, Kajioka S, Fujimoto R, Hayashi C, Kawakami K, Watanabe Y, Nakao Y, Yotsumoto K, Sanui T, Fukuda T, Nakayama K, Nishimura. F.
    • Organizer
      The 108th Annual Meeting of the American Academy of Periodontology
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて2022

    • Author(s)
      川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀
    • Organizer
      第156回日本歯科保存学会2022年度春季学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Endothelial insulin resistance contributes to the pathogenesis of diabetes-related periodontitis.2022

    • Author(s)
      Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Mio Imagawa, Yuki Nishimura, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura.
    • Organizer
      2022 IADR/APR General Session & Exhibition
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Endothelial insulin resistance contributes to the exacerbation of diabetes-related periodontitis.2022

    • Author(s)
      Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Mio Imagawa, Yuki Nishimura, Misaki Iwashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura.
    • Organizer
      108th AAP Annual Meeting
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fabrication of stem cell-based scaffold-free bone-like 3D structures.2022

    • Author(s)
      Toyoda M, Kajioka S, Fujimoto R, Hayashi C, Kawakami K, Watanabe Y, Nakao Y, Yotsumoto K, Sanui T, Fukuda T, Nakayama K, Nishimura F..
    • Organizer
      108th AAP Annual Meeting
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] miR-1260b inhibits periodontal bone loss by targeting ATF6β.2022

    • Author(s)
      Hayashi C, Kawakami K, Toyoda M, Watanabe Y, Nakao Y, Yotsumoto K, Yamato H, Shinjo T, Sanui T, Fukuda T, Nishimura F.
    • Organizer
      108th AAP Annual Meeting
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] バイオ3Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦2022

    • Author(s)
      豊田真顕、梶岡俊一、川上賢太郎、林千華子、渡邊ゆかり、中尾雄紀、四本かれん、讃井彰一、福田隆男、西村英紀
    • Organizer
      令和4年度日本歯周病学会九州五大学 日本臨床歯周病学会九州支部合同研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて2022

    • Author(s)
      川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀
    • Organizer
      第157回日本歯科保存学会2022年度秋季学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した抗炎症作用.2021

    • Author(s)
      林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀.
    • Organizer
      第64回春季日本歯周病学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] ゲラニルゲラニルアセトンとアメロジェニンの歯周組織再生への複合的効果2021

    • Author(s)
      大和寛明、讃井彰一、四本かれん、中尾雄紀、渡邊ゆかり、林千華子、相原良亮、岩下未咲、田中麗、福田隆男、西村英紀
    • Organizer
      2021年度日本歯科保存学会春季学術大会(第154回)
    • Related Report
      2021 Research-status Report
  • [Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯槽骨吸収抑制作用.2021

    • Author(s)
      林千華子, 福田隆男, 渡邊ゆかり, 川上賢太郎, 豊田真顕, 中尾雄紀, 四本かれん,大和寛明,新城尊徳,讃井彰一,西村英紀.
    • Organizer
      2021年度日本歯科保存学会秋季学術大会(第155回)
    • Related Report
      2021 Research-status Report
  • [Presentation] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss.2021

    • Author(s)
      Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Hiroaki Yamato, Karen Yotsumoto, Terukazu Sanui, Takanori Shinjo, Takao Fukuda, Fusanori Nishimura.
    • Organizer
      Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress.2021

    • Author(s)
      Chikako Hayashi, Takao Fukuda, Yukari Watanabe, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Fusanori Nishimura
    • Organizer
      Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Therapeutic potential of exosomes derived from GMSCs in periodontal disease.2020

    • Author(s)
      Yuki Nakao, Takao Fukuda, Yukari Watanabe, Chikako Hayashi, Kentaro Kawakami, Masaaki Toyoda, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Urara Tanaka, Terukazu Sanui, Fusanori Nishimura.
    • Organizer
      IADR General Session & Exhibition
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Amelogenin inhibits IFNγ-induced MHC class II expression in macrophages.2020

    • Author(s)
      Karen Yotsumoto, Urara Tanaka, Terukazu Sanui, Takao Fukuda, Chikako Hayashi, Yuki Nakao, Hiroaki Yamato, Yukari Watanabe, Fusanori Nishimura
    • Organizer
      IADR General Session & Exhibition
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 歯肉幹細胞由来エクソソームは、miR-1260bによるRANKL阻害により歯槽骨吸収を抑制する2020

    • Author(s)
      中尾雄紀、福田隆男、渡邊ゆかり、林千華子、川上賢太郎、豊田真顕、四本かれん、大和寛明、新城尊徳、田中麗、讃井彰一、西村英紀
    • Organizer
      第153回日本歯科保存学会2020年度秋季学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 歯肉幹細胞GMSC由来エクソソームによるCD73を介した免疫制御機構2020

    • Author(s)
      渡邊ゆかり、福田隆男、中尾雄紀、林千華子、川上賢太郎、豊田真顕、四本かれん、大和寛明、讃井彰一、西村英紀
    • Organizer
      第153回日本歯科保存学会2020年度秋季学術会
    • Related Report
      2020 Research-status Report
  • [Presentation] Therapeutic potential of exosomes derived from GMSCs in periodontal disease.2020

    • Author(s)
      Yuki Nakao, Takao Fukuda, Yukari Watanabe, Chikako Hayashi, Kentaro Kawakami, Masaaki Toyoda, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjyo, Urara Tanaka, Terukazu Sanui, Fusanori Nishimura.
    • Organizer
      American Academy of Periodontology (AAP), 106th Annual meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells.2020

    • Author(s)
      Hiroaki Yamato, Terukazu Sanui, Karen Yotsumoto, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takao Fukuda, Urara Tanaka, Fusanori Nishimura.
    • Organizer
      American Academy of Periodontology (AAP), 106th Annual meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Amelogenin suppresses IFNγ-induced MHC class II expression in macrophages.2020

    • Author(s)
      Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takao Fukuda, Fusanori Nishimura
    • Organizer
      American Academy of Periodontology (AAP), 106th Annual meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Exosomes from TNF-α-treated human gingiva-derived MSCs inhibit periodontal bone loss via miR-1260b-mediated RANKL inhibition.2020

    • Author(s)
      Yuki Nakao, Takao Fukuda, Yukari Watanabe, Chikako Hayashi, Kentaro Kawakami, Masaaki Toyoda, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjyo, Urara Tanaka, Terukazu Sanui, Fusanori Nishimura.
    • Organizer
      JADR, The 68th annual meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Amelogenin down-regulates MHC class II antigen presentation on macrophages.2020

    • Author(s)
      Karen Yotsumoto, Terukazu Sanui, Hiroaki Yamato, Urara Tanaka, Yuki Nakao, Chikako Hayashi, Hiroaki Yamato, Yukari Watanabe, Takao Fukuda, Fusanori Nishimura
    • Organizer
      JADR, The 68th annual meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Book] 日本歯周病学会編 糖尿病患者に対する歯周治療ガイドライン改定第3版2023

    • Author(s)
      西村英紀, 青山典生, 稲垣幸司, 梅﨑陽二朗, 讃井彰一, 白方良典, 鈴木茂樹, 高橋慶壮, 富田幸代, 内藤徹, 中川種昭, 長澤敏行, 中島貴子, 二宮雅美, 沼部幸博, 林丈一朗, 水谷幸嗣, 水野智仁, 三辺正人, 山下明子, 山本直史
    • Total Pages
      106
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2023 Annual Research Report
  • [Book] ザ・ペリオドントロジー第4版2023

    • Author(s)
      讃井彰一 他
    • Total Pages
      291
    • Publisher
      永末書店
    • Related Report
      2023 Annual Research Report
  • [Book] EMD Science Flash「Emdogain Gelの炎症抑制効果」2020

    • Author(s)
      讃井彰一, 四本かれん, 西村英紀.
    • Total Pages
      4
    • Publisher
      ストローマンジャパン
    • Related Report
      2020 Research-status Report
  • [Remarks] 九州大学 研究者情報

    • URL

      https://hyoka.ofc.kyushu-u.ac.jp/search/index.html

    • Related Report
      2023 Annual Research Report
  • [Remarks] 九州大学 研究者情報

    • URL

      https://hyoka.ofc.kyushu-u.ac.jp/searchSP/details/K003417/index.html

    • Related Report
      2022 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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