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Enhancement of osteoconductivity and prevention of peri-implant inflammation with bioceramic coating

Research Project

Project/Area Number 20K09992
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionKyoto Institute of Technology

Principal Investigator

Pezzotti Giuseppe  京都工芸繊維大学, その他部局等, 理事・副学長 (70262962)

Co-Investigator(Kenkyū-buntansha) 足立 哲也  京都府立医科大学, 医学(系)研究科(研究院), 講師 (10613573)
Marin Elia  京都工芸繊維大学, 材料化学系, 准教授 (10814014)
小原 幸  京都薬科大学, 薬学部, 准教授 (80275198)
扇谷 えり子  京都府立医科大学, 医学(系)研究科(研究院), 特任准教授 (80300820)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords窒化ケイ素 / インプラント周囲炎 / 骨伝導 / 抗菌性 / バイオセラミックス / ラマン分光法 / 歯科インプラント / ラマン分光分析 / 再生医療
Outline of Research at the Start

YAGレーザー処理により、チタン合金表面に窒化ケイ素の粉末をコーティングすることで、窒化ケイ素複合化インプラント材料を創成する。窒化ケイ素複合化インプラントの抗菌性や骨伝導が強化するかをin vitroまたはin vivoの系で検証する。

Outline of Final Research Achievements

To provide high-quality dental implant treatment to elderly people with reduced regenerative and immune systems, it is desirable to use implant materials with high bioactivity and antibacterial properties. However, it is difficult to say that titanium alloys, which are the most commonly used implant material, fully meet these requirements. This study examined in vitro and in vivo systems with concurrent osteoconductivity and antibacterial properties (prevention of peri-implantitis). Both properties could be enhanced by applying on the implant a thin silicon nitride coating. In order to further clarify at the molecular scale the positive effects of silicon nitride bioceramics on synthesis of bone tissue and bacterial lysis, various spectroscopic analytical methods were applied.

Academic Significance and Societal Importance of the Research Achievements

歯科インプラント手術件数は年々増加しているものの、骨質が低下した患者や術後感染症であるインプラント周囲炎に対する対策は十分されておらず、高機能化インプラント材料の開発が喫緊の課題となっている。現在、生物活性と抗菌性を同時に強化する処理方法は国内外でも例は少ない。窒化ケイ素コーティングによりチタンの生物活性、抗菌性と骨伝導性を強化する試みは、再生力・免疫力が低下した高齢者においても早期の骨結合の獲得と術後感染予防が可能となり、QOLの向上に大いに貢献できると考えられる。本研究は、生体材料学・歯科医学領域だけでなく、整形外科や形成外科領域においても大きなインパクトを与えると考えられる。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (16 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (12 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 11 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Int'l Joint Research] UCLA School of Dentistry(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] Venice Ca'Foscari University(イタリア)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Silicon nitride as a biomaterial2023

    • Author(s)
      Pezzotti Giuseppe
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 131 Issue: 8 Pages: 398-428

    • DOI

      10.2109/jcersj2.23057

    • ISSN
      1348-6535, 1882-0743
    • Year and Date
      2023-08-01
    • Related Report
      2023 Annual Research Report
  • [Journal Article] Three-Dimensional Culture of Cartilage Tissue on Nanogel-Cross-Linked Porous Freeze-Dried Gel Scaffold for Regenerative Cartilage Therapy: A Vibrational Spectroscopy Evaluation2022

    • Author(s)
      Adachi Tetsuya、Miyamoto Nao、Imamura Hayata、Yamamoto Toshiro、Marin Elia、Zhu Wenliang、Kobara Miyuki、Sowa Yoshihiro、Tahara Yoshiro、Kanamura Narisato、Akiyoshi Kazunari、Mazda Osam、Nishimura Ichiro、Pezzotti Giuseppe
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 15 Pages: 8099-8099

    • DOI

      10.3390/ijms23158099

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytotoxicity and osteogenic effects of aluminum ions2022

    • Author(s)
      Mizuno Kai、Boschetto Francesco、Yamamoto Kenta、Honma Taigi、Miyamoto Nao、Adachi Tetsuya、Kanamura Narisato、Yamamoto Toshiro、Wenliang Zhu、Marin Elia、Pezzotti Giuseppe
    • Journal Title

      Journal of Inorganic Biochemistry

      Volume: 234 Pages: 111884-111884

    • DOI

      10.1016/j.jinorgbio.2022.111884

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Innovative electrospun PCL/fibroin/l-dopa scaffolds scaffolds supporting bone tissue regeneration2022

    • Author(s)
      Marin Elia、Yoshikawa Orion、Boschetto Francesco、Honma Taigi、Adachi Tetsuya、Zhu Wenliang、Xu Huaizhong、Kanamura Narisato、Yamamoto Toshiro、Pezzotti Giuseppe
    • Journal Title

      Biomedical Materials

      Volume: 17 Issue: 4 Pages: 045010-045010

    • DOI

      10.1088/1748-605x/ac6c68

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Explorative study on the antibacterial effects of 3D-printed PMMA/nitrides composites2021

    • Author(s)
      E. Marin, F. Boschetto, M. Zanocco, T. Honma, W. Zhu, G. Pezzotti
    • Journal Title

      Mater. & Design

      Volume: 206 Pages: 109788-109788

    • DOI

      10.1016/j.matdes.2021.109788

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Raman spectroscopy in cell biology and microbiology2021

    • Author(s)
      Pezzotti Giuseppe
    • Journal Title

      Journal of Raman Spectroscopy

      Volume: 52 Issue: 12 Pages: 2348-2443

    • DOI

      10.1002/jrs.6204

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antibacterial Property of Cellulose Acetate Composite Materials Reinforced with Aluminum Nitride2021

    • Author(s)
      Sunthar Thefye P. M.、Boschetto Francesco、Doan Hoan Ngoc、Honma Taigi、Kinashi Kenji、Adachi Tetsuya、Marin Elia、Zhu Wenliang、Pezzotti Giuseppe
    • Journal Title

      Antibiotics

      Volume: 10 Issue: 11 Pages: 1292-1292

    • DOI

      10.3390/antibiotics10111292

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biological responses to silicon and nitrogen-rich PVD silicon nitride coatings2021

    • Author(s)
      E. MARIN, F. BOSCHETTO, M. ZANOCCO, W. ZHU, T. ADACHI, N. KANAMURA, T. YAMAMOTO, B.J. MACENTIRE, E. N. JONES, C. POWELL, J. HENDRY, R.M. BOCK, B.S. BAL, G. PEZZOTTI
    • Journal Title

      Materials Today Chemistry

      Volume: 19 Pages: 100404-100404

    • DOI

      10.1016/j.mtchem.2020.100404

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Surface Functionalization of Polyethylene by Silicon Nitride Laser Cladding2020

    • Author(s)
      M. ZANOCCO, E. MARIN, F. BOSCHETTO, T. ADACHI, T. YAMAMOTO, N. KANAMURA, W. ZHU, B. J. MCENTIRE, B. S. BAL, R. ASHIDA, O. MAZDA, G. PEZZOTTI
    • Journal Title

      Applied Science

      Volume: 10 Issue: 7 Pages: 2612-2612

    • DOI

      10.3390/app10072612

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Silicon nitride laser cladding: A feasible technique to improve the biological response of zirconia2020

    • Author(s)
      Marin Elia、Zanocco Matteo、Boschetto Francesco、Santini Michele、Zhu Wenliang、Adachi Tetsuya、Ohgitani Eriko、McEntire Bryan J.、Bal B. Sonny、Pezzotti Giuseppe
    • Journal Title

      Materials & Design

      Volume: 191 Pages: 108649-108649

    • DOI

      10.1016/j.matdes.2020.108649

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] KUSA-A1 mesenchymal stem cells response to PEEK-Si3N4 composites2020

    • Author(s)
      Marin E.、Boschetto F.、Zanocco M.、Adachi T.、Toyama N.、Zhu W.、McEntire B.J.、Bock R.M.、Bal B.S.、Pezzotti G.
    • Journal Title

      Materials Today Chemistry

      Volume: 17 Pages: 100316-100316

    • DOI

      10.1016/j.mtchem.2020.100316

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In Vitro Comparison of Bioactive Silicon Nitride Laser Claddings on Different Substrates2020

    • Author(s)
      E. MARIN, M. ZANOCCO, F. BOSCHETTO, T. YAMAMOTO, N. KANAMIURA, W. ZHU, B. J. MCENTIRE, B. S. BAL, R. ASHIDA, O. MAZDA, G. PEZZOTTI
    • Journal Title

      Applied Science

      Volume: 10 Issue: 24 Pages: 9039-9039

    • DOI

      10.3390/app10249039

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 抗ウィルス性セラミックス2023

    • Author(s)
      Pezzotti Giuseppe
    • Organizer
      日本セラミックス協会-第36回秋季シンポジウム
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ラマン分光法による光診断技術について2022

    • Author(s)
      Giuseppe Pezzotti
    • Organizer
      第34 回NPO 法人日本口腔科学会近畿地方部会
    • Related Report
      2022 Research-status Report
    • Invited

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Published: 2020-04-28   Modified: 2025-01-30  

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