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Regeneration of early enamel errosion by crystal transition using low-temperature annealing

Research Project

Project/Area Number 20K09998
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionShowa University

Principal Investigator

Miyazaki Takashi  昭和大学, その他部局等, 特任教授 (40175617)

Co-Investigator(Kenkyū-buntansha) 柴田 陽  昭和大学, 歯学部, 教授 (30327936)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsエナメル質 / ハイドロキシアパタイト / 漂白 / 再生 / 低温アニーリング / 単斜晶アパタイト / 齲蝕
Outline of Research at the Start

エナメル質の最小構造では,重量比で90%を超えるアパタイト微結晶が高密度に配向している.成熟エナメル質のアパタイト結晶は誘電率の低い六方晶であり,再生能力に乏しい.胎生期のエナメル質は非晶質ながら誘電率の高い単斜晶の対称性を示しているため,石灰化を促進しエナメル質全体の発生に関与する.したがって,エナメル質結晶構造を胎生期の単斜晶に遷移(初期化)により,新たなエナメル質齲蝕治療の可能性が開ける.

Outline of Final Research Achievements

The smallest structural motif of tooth enamel is composed of a hexagonal crystal structure of hydroxyapatite combined with a complex of enamel proteins. These nanocrystals are inherently susceptible to acid attacks and prone to demineralization at competitive grain boundary triple points, where they grow. When the triple points are eliminated through bleaching, a driving force prompts apatite crystals to recover their most stable state, inducing a transition in the crystal structure to a monoclinic form. Concurrently, the introduction of fluoride and strontium ions enables the maintenance of the monoclinic state, allowing the enamel to display its prenatal calcification capacity and leading to significant remineralization of early enamel caries. These findings suggest the potential for a novel caries restoration treatment, which diverges considerably from conventional dental procedures that rely on the removal of affected dentin.

Academic Significance and Societal Importance of the Research Achievements

齲蝕は予防できることが最も望ましいが,発生してしまった場合にはエナメル質表層下が侵食された状態のうちに進行を阻止することが有効な手段である.一般臨床で齲蝕の治療法は,国内外を問わず患部を機械的に除去後,レジンや金属などの修復材料を,接着システムを介して患部に接着する方法である.本研究の成功により,チェアーサイドにおいて,少なくとも初期齲蝕では機械的切削を行わず,エナメル質を再生することが可能になる.再石灰化治療が健全歯を増やし,歯科治療はこれまでの切削・充填中心の治療から,予防中心のケアに移行する可能性がある.本研究成果は,我が国の健康長寿に貢献する将来の歯科医療の中心になることが期待できる.

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (8 results)

All 2022 2021 2020 Other

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (1 results) Book (1 results) Remarks (3 results)

  • [Journal Article] <i>In vitro</i> characterization of primary osteoblasts on titanium surfaces processed with wire-type electric discharge machining2022

    • Author(s)
      Kurosaka M, Kataoka Y, Miyazaki T.
    • Journal Title

      Dental Materials Journal

      Volume: 41 Issue: 5 Pages: 655-659

    • DOI

      10.4012/dmj.2021-231

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2022-09-25
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone2022

    • Author(s)
      Zhou Jun、He Zhiyi、Cui Jiarui、Liao Xiaoling、Cao Hui、Shibata Yo、Miyazaki Takashi、Zhang Jiaming
    • Journal Title

      Bone & Joint Research

      Volume: 11 Issue: 6 Pages: 362-370

    • DOI

      10.1302/2046-3758.116.bjr-2021-0436.r1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High-resolution mechanical mapping of the adhesive?dentin interface: The effect of co-monomers in 10-methacryloyloxydecyl dihydrogen phosphate2021

    • Author(s)
      Takahashi Shinpei、Zhou Jun、Wurihan、Shimomura Naofumi、Kataoka Yu、Watanabe Chie、Shibata Yo、Funatsu Takahiro、Gao Ping、Miyazaki Takashi
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: 117 Pages: 104389-104389

    • DOI

      10.1016/j.jmbbm.2021.104389

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 人歯エナメル質および象牙質のクリープ特性2021

    • Author(s)
      井上 利志子, 齊藤 誠, 西村 文夫, 宮崎 隆, 柴田 陽
    • Organizer
      日本歯科理工学会
    • Related Report
      2021 Research-status Report
  • [Book] スタンダード歯科理工学2020

    • Author(s)
      中嶌 裕、宮﨑 隆、米山隆之
    • Total Pages
      400
    • Publisher
      学建書院
    • ISBN
      9784762456145
    • Related Report
      2020 Research-status Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/37848267

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Remarks] Google Scholar

    • URL

      https://scholar.google.co.jp/citations?user=dsBboOQAAAAJ&hl=ja

    • Related Report
      2021 Research-status Report
  • [Remarks] Google Scholar

    • URL

      https://scholar.google.com/citations?user=dsBboOQAAAAJ&hl=ja&oi=ao

    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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