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Development of Antibacterial Dental Restorations Using Nanostructured Titania Nanosheets

Research Project

Project/Area Number 20K10049
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Nozaki Kosuke  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (00507767)

Co-Investigator(Kenkyū-buntansha) 陳 鵬  東京医科歯科大学, 生体材料工学研究所, 助教 (70708388)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsチタニア / 表面電荷 / ナノ粒子 / 色素分解 / 光触媒活性 / 光触媒 / 光触媒作用 / 結晶成長制御 / 酸化チタン / 生体親和性 / 高次構造制御 / 高次構造 / 電気分極
Outline of Research at the Start

チタニアは,その光触媒活性により抗菌性生体材料への応用が期待されているものの,十分な抗菌活性を有しておらず,臨床応用には至っていない.本研究課題では,チタニアの結晶方位と酸素空孔の3次元空間的位置を制御することにより,チタニアの光触媒活性を向上させ,十分な抗菌活性を有する抗菌性生体材料を開発するとともに,歯科補綴装置への臨床応用に向けた抗菌性歯科補綴装置の開発を目的とする.

Outline of Final Research Achievements

In this study, we demonstrate a safe and facile method for fabricating single-nanometer-sized titania nanosheets (NSs) and reveal that NS0.3 exhibits the highest photocatalytic activity for dye degradation. Our findings suggest that the enhanced activity is primarily attributed to the increased surface area and improved adsorption capacity due to size reduction, rather than the amount of generated active oxygen species. Furthermore, we successfully enhance the photocatalytic activity of TiO2 nanosheets by inducing surface charge without introducing dopants through electrochemical polarization treatment. This enhancement is ascribed to the improved adsorption and decomposition of dyes on the TiO2 nanosheets.

Academic Significance and Societal Importance of the Research Achievements

シングルナノメートルサイズに改良したチタニアナノシートっは,歯科診療領域内のような紫外線量に制限のある場所での汚染物の洗浄作用に有効な可能性が示唆された.また,表面電荷を誘起したTiO2ナノシートを応用することで高い清潔観念が求められる歯科診療領域内の歯科環境材料において脱色,殺菌,および防汚の向上が期待された.本研究で得られた知見は材料学的に非常に重要な知見であり,今後の歯科診療内での環境浄化の発展に寄与するものと考えられる.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (7 results)

All 2024 2023 2021 2020

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Enhanced Photocatalysis of Electrically Polarized Titania Nanosheets2024

    • Author(s)
      Mihara Tomoyuki、Nozaki Kosuke、Kowaka Yasuyuki、Jiang Mengtian、Yamashita Kimihiro、Miura Hiroyuki、Ohara Satoshi
    • Journal Title

      Nanomaterials

      Volume: 14 Issue: 2 Pages: 171-171

    • DOI

      10.3390/nano14020171

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of TiO2 Nanosheets with High Dye Degradation Performance by Regulating Crystal Growth2023

    • Author(s)
      Kowaka Yasuyuki、Nozaki Kosuke、Mihara Tomoyuki、Yamashita Kimihiro、Miura Hiroyuki、Tan Zhenquan、Ohara Satoshi
    • Journal Title

      Materials

      Volume: 16 Issue: 3 Pages: 1229-1229

    • DOI

      10.3390/ma16031229

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of antibacterial effect of copper introduced titanium surface by electrochemical treatment against facultative anaerobic bacteria2020

    • Author(s)
      SHIMABUKURO Masaya、TSUTSUMI Yusuke、NOZAKI Kosuke、CHEN Peng、YAMADA Risa、ASHIDA Maki、DOI Hisashi、NAGAI Akiko、HANAWA Takao
    • Journal Title

      Dental Materials Journal

      Volume: 39 Issue: 4 Pages: 639-647

    • DOI

      10.4012/dmj.2019-178

    • NAID

      130007884187

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2020-07-30
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] チタニアの高機能化と歯科材料への応用2021

    • Author(s)
      野﨑浩佑,小若泰之,三原朋之,三浦宏之,山下仁大,笛木賢二,大原智
    • Organizer
      第43回日本バイオマテリアル学会大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 双極子モーメント制御による高次構造制御チタニアナノシートの高機能化2021

    • Author(s)
      三原朋之,野崎浩佑,小若泰之,山下仁大,三浦宏之
    • Organizer
      第78回日本歯科理工学会学術講演会
    • Related Report
      2021 Research-status Report
  • [Presentation] 結晶成長制御によるチタニアナノシートの開発と光触媒活性の向上2021

    • Author(s)
      小若泰之,野崎浩佑, 三原朋之,山下仁大,三浦宏之
    • Organizer
      第78回日本歯科理工学会学術講演会
    • Related Report
      2021 Research-status Report
  • [Presentation] 電気分極処理による高次構造制御チタニアの光触媒活性の促進2020

    • Author(s)
      野崎浩佑,小若泰之,三原朋之,林建一郎,三浦宏之,大原智.
    • Organizer
      日本補綴歯科学会第129回学術大会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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