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Development of a system to prevent systemic complications in cancer chemotherapy by targeting oral bacteria

Research Project

Project/Area Number 20K10162
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionHiroshima University

Principal Investigator

Nishi Hiromi  広島大学, 病院(歯), 助教 (70403558)

Co-Investigator(Kenkyū-buntansha) 太田 耕司  広島大学, 医系科学研究科(歯), 教授 (20335681)
一戸 辰夫  広島大学, 原爆放射線医科学研究所, 教授 (80314219)
小松澤 均  広島大学, 医系科学研究科(歯), 教授 (90253088)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords口腔内細菌叢 / 周術期口腔管理 / 口腔内細菌 / 細菌叢解析 / 感染性合併症 / 口腔細菌 / 医歯連携
Outline of Research at the Start

これまでにがん化学療法における合併症が,特定の口腔細菌や細菌叢が原因であることを証明した報告は国内外でもない.本研究ではまず,合併症に関連する口腔のリスク因子や特定の細菌・細菌叢を明らかにする.次にこれらの因子を標的として,口腔管理前と後で因子がどう変化するか,また合併症軽減や予防にどれほど関連するかを検証し,口腔管理の有効性を証明する.最終的に,特異的細菌や細菌叢を標的とした化学療法中の合併症予防へ繋げることを目的とする.

Outline of Final Research Achievements

The applicants were analyzing the incidence of febrile neutropenia and the oral environment in patients undergoing chemotherapy at our hospital. Saliva, plaque, tongue discharge, and stool samples were collected mainly from chemotherapy patients at high risk of developing bacterial complications such as febrile neutropenia. In addition, a conventional oral examination and an oral infection source assessment developed by the applicants were conducted at the first dental visit. Statistical analysis of these oral clinical assessments and items related to complication risk, general condition before chemotherapy (blood tests, etc.), and treatment method was conducted to determine the risk of developing or worsening complications such as febrile neutropenia.
The results showed that PISA, an index to evaluate periodontitis, was significantly higher in the febrile neutropenia group than in the non-neutropenia group.

Academic Significance and Societal Importance of the Research Achievements

口腔の感染源の多さと歯周病重症度が,化学療法中合併症の1つである発熱性好中球減少症と関係するという結果を得た.発熱性好中球減少症の原因に,口腔環境が関連することを示す論文は国内外においてない.
さらにこのエビデンスを元に,関連する特定の口腔細菌や,細菌叢を同定することで,化学療法中の合併症予防に口腔管理が有効であるかを証明し,特異的な口腔環境を標的とした化学療法中合併症の予防システムを構築する事は,今後のがん治療研究において重要な位置づけになる.

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (7 results)

All 2022 2021 2020

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 2 results)

  • [Journal Article] Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy.2022

    • Author(s)
      Nishi H, Ohta K, Kuramoto Y, Shigeishi H, Obayashi T, Yoshioka Y, Konishi M, Munenaga S, Nagoshi H, Yoshida T, Fukushima N, Kakimoto N, Ohge H, Kurihara H, Ichinohe T, Kawaguchi H.
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 2483-2483

    • DOI

      10.1038/s41598-022-06485-0

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of perioperative oral care on postoperative inflammation following heart valve surgery.2021

    • Author(s)
      Nishi H, Takahashi S, Ohta K, Takamoto M, Shigeishi H, Go S, Obayashi T, Yoshioka Y, Konishi M, Shimizu Y, Yano K, Miyagawa T, Kakimoto N, Ohge H, Kawaguchi H, Kurihara H.
    • Journal Title

      Oral Dis.

      Volume: 27 Issue: 6 Pages: 1542-1550

    • DOI

      10.1111/odi.13682

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] PISAは血液がん患者における化学療法誘発性発熱性好中球減少症の発症に関連する2022

    • Author(s)
      西 裕美,大林泰二,宗永修一,河口浩之
    • Organizer
      第65回春季日本歯周病学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] がん治療における口腔ケア2022

    • Author(s)
      西 裕美
    • Organizer
      日本放射線腫瘍学会第35回学術大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 重症患者の栄養を支える口腔ケア2022

    • Author(s)
      西 裕美
    • Organizer
      第5回重症患者栄養管理フォーラム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 食道癌患者における口腔内細菌叢の解析による新たな診断・治療予測因子の同定2021

    • Author(s)
      西 裕美,吉川 徹,恵美 学,太田耕司,井手規暁,河口浩之
    • Organizer
      第66回公益社団法人日本口腔外科学会総会・学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 集中治療を要する呼吸器疾患に特定の口腔細菌が関与する2020

    • Author(s)
      西 裕美, 大林 泰二, 大下慎一郎, 栗原 英見, 志馬 伸朗, 河口 浩之
    • Organizer
      第42回 日本呼吸療法医学会学術集会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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