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Study on elucidating the mechanism of oral disease development in a polar closed environment

Research Project

Project/Area Number 20K10245
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Zaitsu Takashi  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (80611508)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords長期隔離環境 / 口腔疾患リスク / 遠隔歯科相談システム / 南極観測基地 / 口腔保健管理 / 南極 / 遠隔歯科 / 労働 / 口腔保健 / 極地環境 / 閉鎖環境
Outline of Research at the Start

南極観測隊基地や国際宇宙ステーションなど長期隔離環境では歯科医師不在、歯科医療器具の制限のため、口腔疾患の急性化は深刻な問題である。極地閉鎖環境ではストレスの増悪により、口腔セルフケアが不十分になることや口腔の免疫機能が低下することが報告されている。このような環境で口腔疾患を予防するには極地環境の歯科疾患の発症リスクを正確に把握する必要がある。本研究では長期隔離環境における口腔疾患リスクを生化学的、行動学的に分析し評価を行う。本研究の有効性が確認されれば、長期遠隔地滞在における口腔疾患の発症のリスクを下げ、災害医療、在宅医療などでの効率的な口腔ケアプログラムの確立に役立たせることができる。

Outline of Final Research Achievements

The academic significance of this research lies in its detailed biochemical and behavioral analysis of oral disease risks in long-term isolated environments such as Antarctic bases and the International Space Station. Previous studies had not sufficiently elucidated the mechanisms of oral disease onset in these environments. This study identified risk factors and demonstrated the effectiveness of a remote dental consultation system, ensuring prompt and appropriate dental care even in remote locations. Consequently, this research improves oral disease prevention and management in long-term isolated environments and contributes to the establishment of efficient oral care programs in disaster and home healthcare settings.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、南極観測基地などの長期隔離環境における口腔疾患リスクを生化学的および行動学的に詳細に分析した点にあります。従来の研究では十分に解明されていなかったこれらの環境における口腔疾患の発症メカニズムを明らかにし、リスク因子を特定しました。また、遠隔歯科相談システムの有効性を検証し、遠隔地でも迅速かつ適切な歯科医療が提供できることを示しました。これにより、長期隔離環境での口腔疾患予防と管理が向上し、災害医療や在宅医療においても効率的な口腔ケアプログラムの確立に寄与します。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (41 results)

All 2024 2023 2022 2021 2020

All Journal Article (15 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 12 results,  Open Access: 12 results) Presentation (26 results) (of which Invited: 2 results)

  • [Journal Article] Association of Stressful Life Events With Oral Health Among Japanese Workers2024

    • Author(s)
      Aoki Jin、Zaitsu Takashi、Ohshiro Akiko、Aida Jun
    • Journal Title

      Journal of Epidemiology

      Volume: 34 Issue: 1 Pages: 16-22

    • DOI

      10.2188/jea.JE20220225

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2024-01-05
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simplifying Oral Health Evaluation: A Novel Approach Through Single-Item Surveys2024

    • Author(s)
      Zaitsu T, Saito T, Oshiro A, Kawaguchi Y, Kawachi I
    • Journal Title

      BMC oral health

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of oral health with various work problems: a cross-sectional study of Japanese workers2023

    • Author(s)
      Shimada Satomi、Zaitsu Takashi、Oshiro Akiko、Kino Shiho、Aida Jun
    • Journal Title

      BMC Oral Health

      Volume: 23 Issue: 1

    • DOI

      10.1186/s12903-023-03196-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between place of dental check-ups and work absenteeism among Japanese workers2023

    • Author(s)
      Masuko Sayo、Zaitsu Takashi、Oshiro Akiko、Ishimaru Miho、Aida Jun
    • Journal Title

      Journal of Occupational Health

      Volume: 65 Issue: 1 Pages: n/a

    • DOI

      10.1002/1348-9585.12415

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of overtime work duration with oral health-related quality of life in Japanese workers2023

    • Author(s)
      Tanemura Takashi、Zaitsu Takashi、Oshiro Akiko、Inoue Yuko、Kawaguchi Yoko、Aida Jun
    • Journal Title

      Journal of Oral Science

      Volume: 65 Issue: 1 Pages: 44-47

    • DOI

      10.2334/josnusd.22-0267

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2022 Research-status Report
  • [Journal Article] Association of marital status and access to dental care among the Japanese population: a cross-sectional study2022

    • Author(s)
      Inoue Yuko、Zaitsu Takashi、Oshiro Akiko、Ishimaru Miho、Taira Kento、Takahashi Hideto、Aida Jun、Tamiya Nanako
    • Journal Title

      BMC Oral Health

      Volume: 22 Issue: 1

    • DOI

      10.1186/s12903-022-02311-1

    • Related Report
      2022 Research-status Report
  • [Journal Article] Characteristics of Hospitals Employing Dentists, and Utilization of Dental Care Services for Hospitalized Patients in Japan: A Nationwide Cross-Sectional Study2022

    • Author(s)
      Ishimaru Miho、Taira Kento、Zaitsu Takashi、Inoue Yuko、Kino Shiho、Takahashi Hideto、Tamiya Nanako
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 11 Pages: 6448-6448

    • DOI

      10.3390/ijerph19116448

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of visual display terminal time with prevalence of temporomandibular disorder among Japanese workers2022

    • Author(s)
      Zaitsu Takashi、Inoue Yuko、Oshiro Akiko、Nishiyama Akira、Kawaguchi Yoko、Aida Jun
    • Journal Title

      Journal of Occupational Health

      Volume: 64 Issue: 1 Pages: n/a

    • DOI

      10.1002/1348-9585.12370

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2022 Research-status Report
  • [Journal Article] Associations of the number of remaining natural teeth and oral health behaviors with subjective chewing problems based on the Thailand National Oral Health Survey 20172022

    • Author(s)
      Srinarupat Jarassri、Zaitsu Takashi、Oshiro Akiko、Prasertsom Piyada、Niyomsilp Kornkamol、Kawaguchi Yoko、Aida Jun
    • Journal Title

      Journal of Oral Science

      Volume: 64 Issue: 3 Pages: 190-193

    • DOI

      10.2334/josnusd.21-0486

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of occlusal status of Japanese adults based on functional tooth units2022

    • Author(s)
      Zaitsu Takashi、Ohnuki Mari、Ando Yuichi、Kawaguchi Yoko
    • Journal Title

      International Dental Journal

      Volume: 72 Issue: 1 Pages: 100-105

    • DOI

      10.1016/j.identj.2021.02.005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Periodontal health predicts self‐rated general health: A time‐lagged cohort study2021

    • Author(s)
      Nguyen Vy Thi Nhat、Furuta Michiko、Zaitsu Takashi、Oshiro Akiko、Shimazaki Yoshihiro、Ando Yuichi、Miyazaki Hideo、Kambara Masaki、Fukai Kakuhiro、Aida Jun
    • Journal Title

      Community Dentistry and Oral Epidemiology

      Volume: open access Issue: 5 Pages: 421-429

    • DOI

      10.1111/cdoe.12691

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inequalities in Periodontal Disease According to Insurance Schemes in Thailand2021

    • Author(s)
      Srinarupat Jarassri、Oshiro Akiko、Zaitsu Takashi、Prasertsom Piyada、Niyomsilp Kornkamol、Kawaguchi Yoko、Aida Jun
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 11 Pages: 5945-5945

    • DOI

      10.3390/ijerph18115945

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of School-Based Oral Health Education on Vietnamese Adolescents: A 6-Month Study2021

    • Author(s)
      Nguyen Vy Thi Nhat、Zaitsu Takashi、Oshiro Akiko、Tran Tai Tan、Nguyen Yen Hoang Thi、Kawaguchi Yoko、Aida Jun
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 5 Pages: 2715-2715

    • DOI

      10.3390/ijerph18052715

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multilevel Analysis of the Association of Dental-Hygienist-Related Factors on Regular Dental Check-Up Behavior2021

    • Author(s)
      Inoue Yuko、Shimazaki Yoshihiro、Oshiro Akiko、Zaitsu Takashi、Furuta Michiko、Ando Yuichi、Miyazaki Hideo、Kambara Masaki、Fukai Kakuhiro、Aida Jun
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 6 Pages: 2816-2816

    • DOI

      10.3390/ijerph18062816

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of oral bacteria in the tongue coating of patients with halitosis using 16S rRNA analysis2020

    • Author(s)
      Oshiro Akiko、Zaitsu Takashi、Ueno Masayuki、Kawaguchi Yoko
    • Journal Title

      Acta Odontologica Scandinavica

      Volume: 78 Issue: 7 Pages: 541-546

    • DOI

      10.1080/00016357.2020.1754459

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Oral Health Promotion in Space and Antarctic Environment2023

    • Author(s)
      Takashi Zaitsu
    • Organizer
      Stovit Summer Course 2023
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 南極・宇宙等の特殊環境における口腔保健2023

    • Author(s)
      財津崇
    • Organizer
      日本産業衛生学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 機械学習による舌写真を用いた口臭判定モデルの開発2023

    • Author(s)
      財津 崇, 永井 雅人, 有冨 理左, 大城 暁子, 相田 潤
    • Organizer
      日本口苦区衛生学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Association of dental check-up with work absenteeism among Japanese workers2022

    • Author(s)
      Masuko Sayo, Zaitsu Takashi, Oshiro Akiko, Shimada Satomi, Ishimaru Miho, Kino Shiho, Aida Jun
    • Organizer
      日本公衆衛生学会
    • Related Report
      2022 Research-status Report
  • [Presentation] Association of oral health problems with work2022

    • Author(s)
      Shimada Satomi, Zaitsu Takashi, Oshiro Akiko, Ishimaru Miho, Kino Shiho, Aida Jun
    • Organizer
      日本公衆衛生学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 時間外労働時間と口腔関連QOLとの関連について2022

    • Author(s)
      種村 崇, 財津 崇, 大城 暁子, 相田 潤
    • Organizer
      日本公衆衛生学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 自立高齢者の口腔ケアと肺炎経験の関連 機械学習(TMLE)を用いた分析2022

    • Author(s)
      井上 裕子, 財津 崇, 大城 暁子, 木野 志保, 石丸 美穂, 相田 潤.
    • Organizer
      日本公衆衛生学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 口腔清掃習慣と口臭値の関連について2022

    • Author(s)
      赤塚 彩乃,財津 崇,大城 暁子,深谷 あゆ香,羽田 葉月,釼持 郁,足達 淑子,相田 潤
    • Organizer
      日本歯科衛生学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 口臭症患者の口臭に対する不安と社会心理特性および口臭測定値との関連について2022

    • Author(s)
      深谷 あゆ香,財津 崇,大城 暁子,足達 淑子,相田 潤
    • Organizer
      日本口腔衛生学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 新型コロナウイルス感染症の3歳児歯科健康診査受診率への影響について2022

    • Author(s)
      種村 崇, 井上 裕子, 古谷 みゆき, 小畑 充彦, 坂本 友紀, 大城 暁子, 財津 崇, 相田 潤
    • Organizer
      日本口腔衛生学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 口臭症患者の口臭に対する不安と社会心理特性および口臭測定値との関連について2022

    • Author(s)
      深谷 あゆ香,財津 崇,大城 暁子,足達 淑子,相田 潤.
    • Organizer
      第71回日本口腔衛生学会・総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 日本成人の歯科検診受診状況と社会活動参加状況・運動実施状況との関連. J2022

    • Author(s)
      財津 崇, 井上 裕子, 平 健人, 石丸 美穂, 木野 志保, 高橋 秀人, 田宮 菜奈子.
    • Organizer
      日本疫学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 成人における社会的不平等および歯数(Social inequalities and number of teeth in adult)2021

    • Author(s)
      Jarassri Srinarupat, 財津 崇, 大城 暁子, 相田 潤.
    • Organizer
      日本歯科医師会
    • Related Report
      2021 Research-status Report
  • [Presentation] 口臭症の患者に対する舌清掃指導の有効性について検討した1例.2021

    • Author(s)
      羽田 葉月,大城 曉子,坂口 由季,深谷 あゆ香,財津 崇,足達 淑子,相田 潤.
    • Organizer
      日本歯科衛生学会第16回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 家庭における受動喫煙が現在歯数に与える影響について.2021

    • Author(s)
      井上 裕子, 財津 崇, 平 健人, 石丸 美穂, 高橋 秀人, 相田 潤, 田宮 菜奈子.
    • Organizer
      日本歯科医学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 口臭が気になったきっかけと口臭値の関連について.2021

    • Author(s)
      大城 暁子, 井上 裕子, 深谷 あゆ香, Srinarupat Jarassi, Vy Nguyen, 財津 崇, 相田 潤.
    • Organizer
      日本歯科医学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 定期健診と歯科衛生士の職務環境との関連 8020推進財団「歯科医療による健康増進効果に関する調査研究」より.2021

    • Author(s)
      井上 裕子, 嶋崎 義浩, 大城 暁子, 財津 崇, 古田 美智子, 安藤 雄一, 宮崎 秀夫, 神原 正樹, 深井 穫博, 相田 潤
    • Organizer
      日本歯科医学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 日本成人の歯科検診受診状況と年齢、性別、市郡、口腔保健状態との関連2021

    • Author(s)
      財津 崇, 井上 裕子, 平 健人, 石丸 美穂, 木野 志保, 高橋 秀人, 田宮 菜奈子.
    • Organizer
      口腔衛生学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高齢者の歯科受療実態と年齢、要介護度の関連 市町村医療介護連結レセプトデータを用いた横断研究.2021

    • Author(s)
      石丸 美穂, 平 健人, 財津 崇, 井上 裕子, 木野 志保, 高橋 秀人, 田宮 菜奈子.
    • Organizer
      日本口腔衛生学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 標準化歯科疾患有訴者比(国民生活基礎調査)と標準化歯科診療行為算定比(NDBオープンデータ)との関連.2021

    • Author(s)
      平 健人, 石丸 美穂, 財津 崇, 井上 裕子, 木野 志保, 高橋 秀人, 田宮 菜奈子
    • Organizer
      日本口腔衛生学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 労働者における仕事中及び仕事外VDT作業と顎関節症リスクとの関連について.2021

    • Author(s)
      財津 崇, 大城 暁子, 相田 潤.
    • Organizer
      産業衛生学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 労働パフォーマンスと口腔保健状態の関連について2020

    • Author(s)
      財津 崇、斉藤 智也、井上 裕子、大城 暁子、川口 陽子
    • Organizer
      第69回日本口腔衛生学会・総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 口臭専門外来受診患者の特徴について2020

    • Author(s)
      大城 暁子, 井上 裕子, 斉藤 智也, Zar Chi Kyaw Myint , Nguyen Thi Nhat Vy, Srinarupat Jarassri, Aung Ei Ei, 財津 崇, 川口 陽子
    • Organizer
      第69回日本口腔衛生学会・総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Chewing ability and its related factors among elderly population in Thailand2020

    • Author(s)
      Srinarupat Jarassri, Zaitsu Takashi, Oshiro Akiko, Aung Ei Ei, Kawaguchi Yoko
    • Organizer
      第69回日本口腔衛生学会・総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effectiveness of oral health education program on 12-year-old students in Vietnam2020

    • Author(s)
      Nguyen Thi Nhat Vy, Zaitsu Takashi, Oshiro Akiko, Kawaguchi Yoko
    • Organizer
      第69回日本口腔衛生学会・総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Impact of school-based oral health education program in Myanmar2020

    • Author(s)
      Myint Zar Chi Kyaw, Zaitsu Takashi, Oshiro Akiko, Kawaguchi Yoko
    • Organizer
      第69回日本口腔衛生学会・総会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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