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A cohort study for identifying risk factors of periodontal disease in Japanese

Research Project

Project/Area Number 20K10249
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionEhime University

Principal Investigator

Tanaka Keiko  愛媛大学, 医学系研究科, 准教授 (40341432)

Co-Investigator(Kenkyū-buntansha) 三宅 吉博  愛媛大学, 医学系研究科, 教授 (50330246)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords前向きコーホート研究 / 歯周疾患 / リスク要因 / 中高年 / 生活習慣病 / 口腔機能 / 舌圧 / 歯牙喪失 / 歯周病
Outline of Research at the Start

歯周病は、最もありふれた生活習慣病の一つであり、心筋梗塞や脳梗塞等、より重篤な全身疾患のリスク要因でもある。
中高年を対象とした「愛大コーホート研究」のデータを活用し、食事・栄養摂取要因、及び遺伝要因との関連について解析する。
栄養・食事要因と歯周病との関連、さらに遺伝要因との交互作用が明らかになれば、体質を考慮した上で、食事変容という比較的簡便な方法で歯周病を予防できる可能性が高まり、ひいては全身疾患の発症抑制に寄与できる。

Outline of Final Research Achievements

The Aidai Cohort Study (AICOS) is an ongoing prospective cohort study in Japan. We enrolled 10376 participants aged 20-95 years until March in 2024. At the baseline survey, using a self-administered questionnaire, information on various lifestyle factors such as smoking, drinking, and physical activity was collected. In addition, we performed health examinations.
We found that higher number of teeth was associated with decreased prevalence of hearing impairment. Among women, but not men, tongue strength was associated with lower prevalence of mild cognitive impairment. Further studies are needed to clarify the causality of the observed associations.

Academic Significance and Societal Importance of the Research Achievements

口腔内の健康状態が全身の健康へ与える影響について、日本人を対象としたエビデンスは、あまり多くはない。愛大コーホート研究では、口腔の健康に関する情報を詳細に収集しており、全身疾患との関連について、多くのエビデンスの産出が期待できる。今回、コーホート研究の一部の対象者のデータを活用した解析結果から、喪失歯の減少によって、難聴を予防できる可能性や、口腔機能の一つである咬合力を保つことにより、軽度認知機能障害を予防できる可能性が示唆された。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (25 results)

All 2023 2022 2021 2020 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results,  Open Access: 6 results) Presentation (1 results) Remarks (3 results)

  • [Journal Article] Fish and Polyunsaturated Fatty Acid Intake and Carotid Intima–Media Thickness in Japan: the Aidai Cohort Study in Yawatahama, Uchiko, Seiyo, and Ainan2023

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Nagata Chisato、Senba Hidenori、Hasebe Yasuko、Miyata Toyohisa、Higaki Takashi、Kimura Eizen、Matsuura Bunzo、Kawamoto Ryuichi
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 30 Issue: 8 Pages: 934-942

    • DOI

      10.5551/jat.63781

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2023-08-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL12B rs6887695 polymorphism and interaction with alcohol intake in the risk of ulcerative colitis in Japan.2022

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Nagata Chisato、et al.
    • Journal Title

      Cytokine

      Volume: 155 Pages: 155901-155901

    • DOI

      10.1016/j.cyto.2022.155901

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between hearing loss and prevalence of depressive symptoms in Japan: baseline data from the Aidai Cohort Study in Yawatahama and Uchiko2022

    • Author(s)
      Nobori Junichiro、Miyake Yoshihiro、Tanaka Keiko、Senba Hidenori、Okada Masahiro、Takagi Daiki、Teraoka Masato、Yamada Hiroyuki、Matsuura Bunzo、Hato Naohito
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 102 Pages: 104735-104735

    • DOI

      10.1016/j.archger.2022.104735

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional AGXT2 SNP rs37369 Variant Is a Risk Factor for Diabetes Mellitus: Baseline Data From the Aidai Cohort Study in Japan2022

    • Author(s)
      Kumon Hiroshi、Miyake Yoshihiro、Yoshino Yuta、Iga Jun-ichi、Tanaka Keiko、Senba Hidenori、Kimura Eizen、Higaki Takashi、Matsuura Bunzo、Kawamoto Ryuichi、Ueno Shu-ichi
    • Journal Title

      Canadian Journal of Diabetes

      Volume: 46 Issue: 8 Pages: 829-834

    • DOI

      10.1016/j.jcjd.2022.06.004

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal calcium intake during pregnancy and childhood blood pressure: The Kyushu Okinawa Maternal and Child Health Study2022

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Okubo Hitomi、Sasaki Satoshi、Arakawa Masashi
    • Journal Title

      Annals of Epidemiology

      Volume: 73 Pages: 17-21

    • DOI

      10.1016/j.annepidem.2022.06.035

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study2022

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Okubo Hitomi、Sasaki Satoshi、Arakawa Masashi
    • Journal Title

      European Journal of Nutrition

      Volume: 61 Issue: 8 Pages: 4215-4222

    • DOI

      10.1007/s00394-022-02969-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre- and postnatal maternal hair dye use and risk of wheeze and asthma in 5-year-old Japanese children: the Kyushu Okinawa Maternal and Child Health Study2022

    • Author(s)
      Tokinobu Akiko、Tanaka Keiko、Arakawa Masashi、Miyake Yoshihiro
    • Journal Title

      International Journal of Environmental Health Research

      Volume: 印刷中 Issue: 12 Pages: 1697-1705

    • DOI

      10.1080/09603123.2022.2120189

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between parental occupations, educational levels, and household income and children’s psychological adjustment in Japan2022

    • Author(s)
      Abdul Karim Alifa、Tanaka Keiko、Nagata Chisato、Arakawa Masashi、Miyake Yoshihiro
    • Journal Title

      Public Health

      Volume: 213 Pages: 71-77

    • DOI

      10.1016/j.puhe.2022.10.011

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal consumption of dairy products during pregnancy is associated with decreased risk of emotional problems in 5-year-olds: the Kyushu Okinawa Maternal and Child Health Study2022

    • Author(s)
      Nguyen Mai Quynh、Miyake Yoshihiro、Tanaka Keiko、Hasuo Shizuka、Takahashi Keiji、Nakamura Yoshitaka、Okubo Hitomi、Sasaki Satoshi、Arakawa Masashi
    • Journal Title

      Nutrients

      Volume: 14 Issue: 22 Pages: 4713-4713

    • DOI

      10.3390/nu14224713

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex differences in the association between smoking exposure and prevalence of wheeze and asthma in 3-yars-old children2022

    • Author(s)
      Yamada Maoka、Tanaka Keiko、Nagata Chisato、Arakawa Masashi、Miyake Yoshihiro
    • Journal Title

      The Journal of Asthma: official journal of the Association for the Care of Asthma

      Volume: 印刷中 Issue: 7 Pages: 1369-1376

    • DOI

      10.1080/02770903.2022.2147081

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher number of teeth is associated with decreased prevalence of hearing impairment in Japan2021

    • Author(s)
      Tanaka Keiko、Okada Masahiro、Kato Hiromasa、Utsunomiya Hisanori、Senba Hidenori、Takagi Daiki、Teraoka Masato、Yamada Hiroyuki、Matsuura Bunzo、Hato Naohito、Miyake Yoshihiro
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 97 Pages: 104502-104502

    • DOI

      10.1016/j.archger.2021.104502

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Education and household income and carotid intima-media thickness in Japan: baseline data from the Aidai Cohort Study in Yawatahama, Uchiko, Seiyo, and Ainan2021

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Senba Hidenori、Hasebe Yasuko、Miyata Toyohisa、Higaki Takashi、Kimura Eizen、Matsuura Bunzo、Kawamoto Ryuichi
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 26 Issue: 1 Pages: 88-88

    • DOI

      10.1186/s12199-021-01011-6

    • NAID

      210000159304

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal caffeine intake during pregnancy and risk of food allergy in young Japanese children2021

    • Author(s)
      Tanaka Keiko、Okubo Hitomi、Sasaki Satoshi、Arakawa Masashi、Miyake Yoshihiro
    • Journal Title

      Journal of Paediatrics and Child Health

      Volume: - Issue: 6 Pages: 903-907

    • DOI

      10.1111/jpc.15351

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maternal Use of Induction Heating Cookers During Pregnancy and Birth Outcomes: The Kyushu Okinawa Maternal and Child Health Study2021

    • Author(s)
      Tokinobu Akiko、Tanaka Keiko、Arakawa Masashi、Miyake Yoshihiro
    • Journal Title

      Bioelectromagnetics

      Volume: - Issue: 4 Pages: 329-335

    • DOI

      10.1002/bem.22339

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maternal metal intake during pregnancy and childhood behavioral problems in Japan: the Kyushu Okinawa Maternal and Child Health Study2021

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Okubo Hitomi、Sasaki Satoshi、Tokinobu Akiko、Arakawa Masashi
    • Journal Title

      Nutritional Neuroscience

      Volume: - Issue: 8 Pages: 1-9

    • DOI

      10.1080/1028415x.2021.1885241

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cesarean section is associated with increased risk of postpartum depressive symptoms in Japan: the Kyushu Okinawa Maternal and Child Health Study2021

    • Author(s)
      Yokoyama M, Tanaka K, Sugiyama T, Arakawa M, Miyake Y
    • Journal Title

      J Affect Disord

      Volume: 278 Pages: 497-501

    • DOI

      10.1016/j.jad.2020.09.106

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations of job type, income, and education with postpartum depressive symptoms: The Kyushu Okinawa Maternal and Child Health Study2020

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Arakawa Masashi
    • Journal Title

      Psychiatry Research

      Volume: 291 Pages: 113224-113224

    • DOI

      10.1016/j.psychres.2020.113224

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maternal prenatal stress and infantile wheeze and asthma: The Osaka Maternal and Child Health Study2020

    • Author(s)
      Kawamoto Tetsuya、Miyake Yoshihiro、Tanaka Keiko、Nagano Jun、Sasaki Satoshi、Hirota Yoshio
    • Journal Title

      Journal of Psychosomatic Research

      Volume: 135 Pages: 110143-110143

    • DOI

      10.1016/j.jpsychores.2020.110143

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study2020

    • Author(s)
      Tanaka K.、Arakawa M.、Miyake Y.
    • Journal Title

      Allergologia et Immunopathologia

      Volume: 48 Issue: 6 Pages: 530-536

    • DOI

      10.1016/j.aller.2020.03.008

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between hypertension, dyslipidemia, and diabetes and prevalence of hearing impairment in Japan2020

    • Author(s)
      Hara Kazuya、Okada Masahiro、Takagi Daiki、Tanaka Keiko、Senba Hidenori、Teraoka Masato、Yamada Hiroyuki、Matsuura Bunzo、Hato Naohito、Miyake Yoshihiro
    • Journal Title

      Hypertension Research

      Volume: 43 Issue: 9 Pages: 963-968

    • DOI

      10.1038/s41440-020-0444-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] BAIAP2 rs8079781, postnatal smoking exposure, and emotional problems in Japanese children aged 5?years: the Kyushu Okinawa Maternal and Child Health Study2020

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Arakawa Masashi
    • Journal Title

      Journal of Neural Transmission

      Volume: 127 Issue: 7 Pages: 1081-1087

    • DOI

      10.1007/s00702-020-02203-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 残存歯数と難聴との関連:愛大コーホート研究2021

    • Author(s)
      田中景子、加藤弘正、宇都宮久記、仙波英徳、岡田昌浩、高木大樹、寺岡正人、山田啓之、松浦文三、羽藤直人、三宅吉博
    • Organizer
      第31回日本駅学会学術総会
    • Related Report
      2020 Research-status Report
  • [Remarks] 愛媛大学疫学・公衆衛生学講座

    • URL

      https://www.m.ehime-u.ac.jp/school/publichealth/index.php

    • Related Report
      2022 Annual Research Report
  • [Remarks] 愛媛大学大学院医学系研究科疫学・公衆衛生学講座

    • URL

      https://www.m.ehime-u.ac.jp/school/publichealth/index.php

    • Related Report
      2021 Research-status Report
  • [Remarks] 愛媛大学大学院医学系研究科疫学・予防医学講座

    • URL

      https://www.m.ehime-u.ac.jp/school/publichealth/index.php

    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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