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腸炎関連性発癌予防に寄与する専門的口腔ケア方法の可能性

Research Project

Project/Area Number 20K10258
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionTsurumi University

Principal Investigator

岡田 彩子  鶴見大学, 歯学部, 助教 (60515584)

Co-Investigator(Kenkyū-buntansha) MATIN KHAIRUL  鶴見大学, 歯学部, 非常勤講師 (00372433)
有吉 芽生  東京医科歯科大学, 歯学部, 非常勤講師 (20516299)
花田 信弘  鶴見大学, 歯学部, 教授 (70180916)
藤井 俊光  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (30547451)
齋藤 渉  鶴見大学短期大学部, 歯科衛生科, 准教授 (30624887)
Project Period (FY) 2020-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords腸炎関連性発癌 / 専門的口腔ケア / 次世代シークエンサー
Outline of Research at the Start

炎症性腸疾患長期経過患者の発癌スクリーニングとサーベイランス時に採取した口腔、糞便および大腸粘膜組織サンプルを用いて細菌解析を行い、以下の各項目を明らかにする。
1)寛解期維持者の炎症転機(再燃)に関与する口腔病原細菌を同定する。
2)腸炎関連性発癌非発癌者と発癌者の口腔・腸内細菌叢を比較し、腸炎関連性発癌に関与する細菌を探索する。
3)再燃者を対象に専門的口腔ケアを行い、口腔・腸内細菌叢に及ぼす影響を検証すると共に、臨床所見と突合し各値の改善を目指す。

Outline of Annual Research Achievements

本研究は、国立大学法人東京医科歯科大学医学部附属病院潰瘍性大腸炎・クローン病先端治療センター外来に通院中の炎症性腸疾患長期経過患者を対象とした臨床試験である。
主な目的は、炎症性腸疾患の重篤な合併症である腸炎関連性発癌を発症する可能性のある炎症性腸疾患長期経過患者の口腔細菌叢と腸内細菌叢を検証することである。
1)先行研究で健常者に対して専門的口腔ケア(機械的歯面清掃とDental Drug Delivery System)を行った際にストックしていたプラ-クサンプルについてDNA抽出後に、う蝕原性細菌Streptococcus mutansと歯周病原性細菌Porphyromonas gingivalisについて定量PCRを行い、細菌解析を行った。
2)昨年度、鶴見大学歯学部倫理審査委員会と国立大学法人東京医科歯科大学医学部倫理審査委員会で承認を得ることができた。そのため、本年度は、これまでに準備してきたリクル-ト用のチラシや動画を駆使し、被験者を募り、臨床試験を実施した。介入項目は、歯科専門職による専門的口腔ケア(機械的歯面清掃とDental Drug Delivery System)である。Dental Drug Delivery Systemについては、自宅にて1日2回8週間、継続実施した。各被験者への介入前後に口腔診査を行い、歯周組織状態について検証した。またプラーク、唾液、血液、腸液および糞便サンプル採取を行い、DNAを抽出した。唾液サンプルについては、う蝕原性細菌2種と歯周病原性細菌3菌種について定量PCR解析を行った。現在は、各サンプルの次世代シ-クエンス解析を行うための準備を行っている。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

昨年度、鶴見大学歯学部倫理審査委員会と国立大学法人東京医科歯科大学医学部倫理審査委員会で承認を得ることができ、臨床試験を開始することができた。今年度は、新型コロナ感染症のため、受診を控えていた患者の治療が優先されていることもあり、被験者の確保が難しい面もあったが、次年度に延長することで被験者数を追加する予定であるため。

Strategy for Future Research Activity

被験者のリクル-トを順次進めていき、速やかに臨床試験を実施する。得られた検体の解析を実施する予定である。

Report

(4 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (26 results)

All 2023 2022 2021 2020

All Journal Article (22 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 22 results,  Open Access: 21 results) Presentation (4 results)

  • [Journal Article] Discoloration of Conventional Resin Composite Cements and Self-adhesive Resin Cements Immersed in Water for 180 Days2023

    • Author(s)
      Ayaka HORI-ISHIKAWA, Yuka OGAWA-UZAWA, Ayako OKADA, Daichi AIZAWA, Nana SAKAEDA-NAITO, Hiro MATSUMOTO, Kaoru OHMORI, Masao HANABUSA, Takatsugu YAMAMOTO
    • Journal Title

      Operative Dentistry, Endodontology and Periodontology

      Volume: 3 Issue: 1 Pages: 43-51

    • DOI

      10.11471/odep.2023-005

    • ISSN
      2436-4975
    • Year and Date
      2023-12-31
    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the cariogenic potential of a probiotic candidate strain Lactobacillus gasseri YIT 123212022

    • Author(s)
      Okada Ayako、Imai Susumu、Kikuchi Tomohiro、Matin Khairul、Otsuka Ryoko、Terai Tomohiko、Okumura Takekazu、Yamamoto Takatsugu、Hanada Nobuhiro
    • Journal Title

      Archives of Oral Biology

      Volume: 136 Pages: 105364-105364

    • DOI

      10.1016/j.archoralbio.2022.105364

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment-An Open Label Randomized Controlled Trial.2022

    • Author(s)
      Shimpo Y, Nomura Y, Sekiya T, Arai C, Okada A, Sogabe K, Hanada N, Tomonari H.
    • Journal Title

      J Clin Med.

      Volume: 11(3) Issue: 3 Pages: 854-854

    • DOI

      10.3390/jcm11030854

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tooth loss patterns in older adults residing in nursing homes2022

    • Author(s)
      Kakuta E, Nomura Y, Okada A, Otsuka R, Sogabe K, Hanada N
    • Journal Title

      J Dent Hlth

      Volume: 71 Pages: 153-159

    • NAID

      130008074599

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial2021

    • Author(s)
      Okada Ayako、Murata Takatoshi、Matin Khairul、Ariyoshi Meu、Otsuka Ryoko、Yamashita Mamiko、Suzuki Masayuki、Wakiyama Rumi、Tateno Ken、Suzuki Megumi、Aoyagi Hitomi、Uematsu Hiromi、Imamura Akiko、Kosaka Miki、Mizukaki Tomoko、Sato Tsutomu、Kawahara Hiroshi、Hanada Nobuhiro
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 9 Pages: 0257247-0257247

    • DOI

      10.1371/journal.pone.0257247

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of working environment on job satisfaction: Findings from a survey of Japanese dental hygienists.2021

    • Author(s)
      Okada A, Ohara Y, Yamamoto Y, Nomura Y, Hosoya N, Hanada N, Takei N.
    • Journal Title

      Int J Environ Res Public Health

      Volume: 18(6) Issue: 6 Pages: 3200-3200

    • DOI

      10.3390/ijerph18063200

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors affecting the reinstatement of the Japanese dental hygienist: A Japanese dental hygienist survey conducted in 2019.2021

    • Author(s)
      Okada A, Nomura Y, Ohara Y, Yamamoto Y, Hosoya N, Hanada N, Takei N.
    • Journal Title

      Int J Environ Res Public Health.

      Volume: 18(4) Issue: 4 Pages: 2049-2049

    • DOI

      10.3390/ijerph18042049

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure and Validity of Questionnaire for Oral Frail Screening2021

    • Author(s)
      Nomura Yoshiaki、Ishii Yoshimasa、Chiba Yota、Suzuki Shunsuke、Suzuki Akira、Suzuki Senichi、Morita Kenji、Tanabe Joji、Yamakawa Koji、Ishiwata Yasuo、Ishikawa Meu、Sogabe Kaoru、Kakuta Erika、Okada Ayako、Otsuka Ryoko、Hanada Nobuhiro
    • Journal Title

      Healthcare

      Volume: 9 Issue: 1 Pages: 45-45

    • DOI

      10.3390/healthcare9010045

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Job attractiveness and job satisfaction of dental hygienists: from Japanese dental hygienists' survey 2019.2021

    • Author(s)
      Ohara Y, Nomura Y, Yamamoto Y, Okada A, Hosoya N, Hanada N, Hirano H, Takei N.
    • Journal Title

      Int J Environ Res Public Health.

      Volume: 18(2) Issue: 2 Pages: 755-755

    • DOI

      10.3390/ijerph18020755

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does Last Year’s Cost Predict the Present Cost? An Application of Machine Leaning for the Japanese Area-Basis Public Health Insurance Database2021

    • Author(s)
      Nomura Yoshiaki、Ishii Yoshimasa、Chiba Yota、Suzuki Shunsuke、Suzuki Akira、Suzuki Senichi、Morita Kenji、Tanabe Joji、Yamakawa Koji、Ishiwata Yasuo、Ishikawa Meu、Sogabe Kaoru、Kakuta Erika、Okada Ayako、Otsuka Ryoko、Hanada Nobuhiro
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 2 Pages: 565-565

    • DOI

      10.3390/ijerph18020565

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement of workplace environment that affects motivation of Japanese dental hygienists.2021

    • Author(s)
      Yamamoto Y, Nomura Y, Okada A, Kakuta E, Yoshida N, Hosoya N, Hanada N, Takei N.
    • Journal Title

      Int J Environ Res Public Health.

      Volume: 18(3) Issue: 3 Pages: 1309-1309

    • DOI

      10.3390/ijerph18031309

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement of the working environment and daily work-related tasks of dental hygienists working in private dental offices from the Japan dental hygienists' association Survey 2019.2021

    • Author(s)
      Nomura Y, Ohara Y, Yamamoto Y, Okada A, Hosoya N, Hanada N, Takei N.
    • Journal Title

      Dent J. (Basel)

      Volume: 9(2) Issue: 2 Pages: 22-22

    • DOI

      10.3390/dj9020022

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Daily tasks and willingness to work of dental hygienists in nursing facilities using Japanese dental hygienists' survey 2019.2021

    • Author(s)
      Ohara Y, Nomura Y, Yamamoto Y, Okada A, Hosoya N, Hanada N, Hirano H, Takei N.
    • Journal Title

      Int J Environ Res Public Health.

      Volume: 18(6) Issue: 6 Pages: 3152-3152

    • DOI

      10.3390/ijerph18063152

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Workforce and Contents of Home Dental Care in Japanese Insurance System2020

    • Author(s)
      Nomura Yoshiaki、Okada Ayako、Kakuta Erika、Otsuka Ryoko、Saito Hideaki、Maekawa Hiroshi、Daikoku Hideki、Hanada Nobuhiro、Sato Tamotsu
    • Journal Title

      International Journal of Dentistry

      Volume: 2020 Pages: 1-6

    • DOI

      10.1155/2020/7316796

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of the Serum Level of Albumin and Self-Assessed Chewing Ability on Mortality, QOL, and ADLs for Community-Dwelling Older Adults at the Age of 85: A 15 Year Follow up Study2020

    • Author(s)
      Nomura Yoshiaki、Kakuta Erika、Okada Ayako、Otsuka Ryoko、Shimada Mieko、Tomizawa Yasuko、Taguchi Chieko、Arikawa Kazumune、Daikoku Hideki、Sato Tamotsu、Hanada Nobuhiro
    • Journal Title

      Nutrients

      Volume: 12 Issue: 11 Pages: 3315-3315

    • DOI

      10.3390/nu12113315

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of self-assessed chewing ability, tooth loss and serum albumin on mortality in 80-year-old individuals: a 20-year follow-up study2020

    • Author(s)
      Nomura Yoshiaki、Kakuta Erika、Okada Ayako、Otsuka Ryoko、Shimada Mieko、Tomizawa Yasuko、Taguchi Chieko、Arikawa Kazumune、Daikoku Hideki、Sato Tamotsu、Hanada Nobuhiro
    • Journal Title

      BMC Oral Health

      Volume: 20 Issue: 1 Pages: 122-122

    • DOI

      10.1186/s12903-020-01113-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Properties of manual toothbrush that influence on plaque removal of interproximal surface in?vitro2020

    • Author(s)
      Otsuka R, Nomura Y, Okada A, Uematsu H, Nakano M, Hikiji K, Hanada N, Momoi Y
    • Journal Title

      J Dent Sci

      Volume: 15 Issue: 1 Pages: 14-21

    • DOI

      10.1016/j.jds.2019.07.005

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prioritization of the Skills to Be Mastered for the Daily Jobs of Japanese Dental Hygienists2020

    • Author(s)
      Nomura Yoshiaki、Kakuta Erika、Okada Ayako、Yamamoto Yuko、Tomonari Hiroshi、Hosoya Noriyasu、Hanada Nobuhiro、Yoshida Naomi、Takei Noriko
    • Journal Title

      International Journal of Dentistry

      Volume: 2020 Pages: 1-8

    • DOI

      10.1155/2020/4297646

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nutritional Status and Oral Frailty: A Community Based Study2020

    • Author(s)
      Nomura Yoshiaki、Ishii Yoshimasa、Suzuki Shunsuke、Morita Kenji、Suzuki Akira、Suzuki Senichi、Tanabe Joji、Ishiwata Yasuo、Yamakawa Koji、Chiba Yota、Ishikawa Meu、Sogabe Kaoru、Kakuta Erika、Okada Ayako、Otsuka Ryoko、Hanada Nobuhiro
    • Journal Title

      Nutrients

      Volume: 12 Issue: 9 Pages: 2886-2886

    • DOI

      10.3390/nu12092886

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tooth-Level Analysis of Dental Caries in Primary Dentition in Myanmar Children2020

    • Author(s)
      Nomura Yoshiaki、Otsuka Ryoko、Wint Wit Yee、Okada Ayako、Hasegawa Ryo、Hanada Nobuhiro
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 20 Pages: 7613-7613

    • DOI

      10.3390/ijerph17207613

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Mucosal Brushing on the Serum Levels of C-Reactive Protein for Patients Hospitalized with Acute Symptoms2020

    • Author(s)
      Nakahodo Naoko、Nomura Yoshiaki、Oshiro Takumi、Otsuka Ryoko、Kakuta Erika、Okada Ayako、Inai Yuko、Takei Noriko、Hanada Nobuhiro
    • Journal Title

      Medicina

      Volume: 56 Issue: 10 Pages: 549-549

    • DOI

      10.3390/medicina56100549

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Supplied Food Consistency and Oral Functions of Institutionalized Elderly2020

    • Author(s)
      Nomura Y, Tsutsumi I, Nagasaki M, Tsuda H, Koga F, Kashima N, Uraguchi M, Okada A, Kakuta E, Hanada N.
    • Journal Title

      Int J Dent.

      Volume: 2020 Pages: 3463056-3463056

    • DOI

      10.1155/2020/3463056

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 口腔プロバイオティクス候補菌 Lactobacillus gasseri YIT 12321の資化性について2023

    • Author(s)
      岡田彩子,今井 奬,菊地朋宏,大塚良子,曽我部 薫,有吉芽生,マティン カイルール,寺井智彦,奥村剛一,花田信弘.
    • Organizer
      第72回日本口腔衛生学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] 炎症性腸疾患寛解期における専門的口腔ケアの口腔と腸内細菌叢への影響について2023

    • Author(s)
      大塚良子,マティン カイルール,岡田彩子,根深研一,花田信弘.
    • Organizer
      第72回日本口腔衛生学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] 全身的な健康を歯科から考える “予防医学”としての概念を歯科へ.「3DS除菌外来」の試み 第九報2023

    • Author(s)
      山田秀則,宮之原真由,村田貴俊,岡田彩子,花田信弘.
    • Organizer
      第72回日本口腔衛生学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] 口腔プロバイオティクス候補菌Lactobacillus gasseri YIT 12321のう蝕原性について2022

    • Author(s)
      岡田彩子、今井 奬、寺井智彦、奥村剛一、山本雄嗣、花田信弘
    • Organizer
      日本歯科保存学会2022年度秋季学術大会(第157回) 第24回日韓歯科保存学会学術大会
    • Related Report
      2022 Research-status Report

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Published: 2020-04-28   Modified: 2024-12-25  

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