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Distribution of periodontopathogenic bacteria in major systemic blood vessel walls - based on a case of death due to cerebrovascular accident

Research Project

Project/Area Number 20K10287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionHokkaido University

Principal Investigator

Takeuchi Akiko  北海道大学, 医学研究院, 特任助教 (00867179)

Co-Investigator(Kenkyū-buntansha) 的場 光太郎  北海道大学, 医学研究院, 教授 (00466450)
箕輪 和行  北海道大学, 歯学研究院, 教授 (30209845)
兵頭 秀樹  福井大学, 学術研究院医学系部門, 教授 (30306154)
亀田 浩之  北海道大学, 歯学研究院, 助教 (70829887)
長谷部 晃  北海道大学, 歯学研究院, 教授 (90281815)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯周病原菌 / 死後画像 / PCR / P. gingivalis / 歯周病菌 / PCR / 歯周病 / 脳血管障害 / 定量的PCR / P.gingivalis / 歯周病原性菌
Outline of Research at the Start

慢性炎症としての歯周病は、糖尿病や心・冠動脈疾患、関節リウマチなどの全身疾患のリスク因子となることが知られている。これまでの研究により、歯周病と心・冠動脈疾患や頸部血管などの動脈硬化との関連が明らかになりつつある。しかし、歯周病と脳血管障害の関連や、歯周病の進行が全身血管に与える影響についての検討は十分ではない。本研究では、脳血管障害による死亡症例で、脳血管を含む全身の主要血管における歯周病原性菌の存在分布と歯周病進行度を対比し、歯周病進行度と血管障害発症リスクとの関連性を明らかにする。

Outline of Final Research Achievements

We examined periodontal bacteria in the oral cavity and their effects on major systemic blood vessels. Bacteria were collected from the oral cavity of forensic autopsies, and periodontal bacteria were identified by PCR testing. In 77.3% of the cases, multiple periodontal pathogens were detected. Porphyromonas gingivalis (P.g) was found in 50% of the cases in which periodontopathic bacteria were detected. Comparison of the presence of P.g in the oral cavity with the calcified areas of major large blood vessels extracted by postmortem whole-body CT showed that the presence of P.g in the oral cavity was associated with more calcified areas in the large blood vessels throughout the body, suggesting a high likelihood of vascular atherosclerosis. Detection of P.g within the walls of these vessels was difficult, and the distribution of its presence within the vessel walls could not be verified.

Academic Significance and Societal Importance of the Research Achievements

慢性炎症としての歯周病は、口腔内に存在する歯周病原菌による細菌感染により起こり、糖尿病や心・冠動脈疾患などのさまざまな全身疾患のリスク因子と考えられている。歯周病原菌の一種であるPorphyromonas gingivalis(P.g)は、血管内皮に付着することから、アテローム性動脈硬化との関連が考えられている。今回、口腔内におけるP.gの存在と全身主要血管における石灰化領域の比較から、歯周病原菌(P.g)と血管の動脈硬化の程度に正の相関があることが示唆された。ただし、血管壁におけるP.g存在分布の比較として有意な結果は得られず、今後さらなる検討が必要と考えられた。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (11 results)

All 2024 2023 2022 2021

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Objective Evaluation of Oral and Pharyngeal Areas in Autopsy Cases ofObstructive Sleep Apnea Syndrome via Postmortem CT2023

    • Author(s)
      Takeuchi Akiko、Hyodoh Hideki、Jin Shigeki、Tanaka Satoshi、Murakami Manabu、Minowa Kazuyuki、Matoba Kotaro
    • Journal Title

      Current Medical Imaging Formerly Current Medical Imaging Reviews

      Volume: - Pages: 7-7

    • DOI

      10.2174/1573405620666230328082804

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-Gaussian model-based diffusion-weighted imaging of oral squamous cell carcinoma: associations with Ki-67 proliferation status2023

    • Author(s)
      Shima Tomoka、Fujima Noriyuki、Yamano Shigeru、Kameda Hiroyuki、Suzuka Masaaki、Takeuchi Akiko、Kinoshita Yurika、Iwai Nanami、Kudo Kohsuke、Minowa Kazuyuki
    • Journal Title

      Oral Radiology

      Volume: - Issue: 4 Pages: 661-667

    • DOI

      10.1007/s11282-023-00682-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Objective evaluation of chest findings in infants by postmortem computed tomography2023

    • Author(s)
      Shimbashi Shogo、Hayata Rina、Matoba Kotaro、Saito Atsuko、Matoba Tomoko、Takeuchi Akiko、Jin Shigeki、Hyodoh Hideki
    • Journal Title

      Legal Medicine

      Volume: 60 Pages: 102178-102178

    • DOI

      10.1016/j.legalmed.2022.102178

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Objective skull fracture evaluation by using the postmortem 3D-CT skull fracture score in fatal falls2022

    • Author(s)
      Hyodoh Hideki、Takeuchi Akiko、Matoba Kotaro、Murakami Manabu、Matoba Tomoko、Saito Atsuko、Jin Shigeki
    • Journal Title

      Legal Medicine

      Volume: 56 Pages: 102048-102048

    • DOI

      10.1016/j.legalmed.2022.102048

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] The usefulness of measuring n-butyric acid concentration as a new indicator of blood decomposition in forensic autopsy2022

    • Author(s)
      Matoba Kotaro、Murakami Manabu、Fujita Emi、Jin Shigeki、Ogasawara Ryosuke、Matoba Tomoko、Takeuchi Akiko、Haga Sanae、Ozaki Michitaka、Hyodoh Hideki
    • Journal Title

      Legal Medicine

      Volume: 57 Pages: 102071-102071

    • DOI

      10.1016/j.legalmed.2022.102071

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent2022

    • Author(s)
      Jin Zhiping、Fan Hailong、Osanai Toshiya、Nonoyama Takayuki、Kurokawa Takayuki、Hyodoh Hideki、Matoba Kotaro、Takeuchi Akiko、Gong Jian Ping、Fujimura Miki
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 42 Pages: 1-9

    • DOI

      10.1073/pnas.2206685119

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of oral air space volume in obstructive sleep apnea syndrome using clinical and postmortem CT imaging2022

    • Author(s)
      Akiko Takeuchi, Hideki Hyodoh, Kotaro Matoba, Manabu Murakami, Kohsuke Kudo, Kazuyuki Minowa owa
    • Journal Title

      Oral Radiology

      Volume: 38 Issue: 1 Pages: 29-36

    • DOI

      10.1007/s11282-021-00520-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] 法医解剖事例における口腔内の歯周病菌(P.g菌)の存在と動脈硬化の程度に関する検討2024

    • Author(s)
      竹内明子
    • Organizer
      日本法歯科医学会第18会学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] A case of postmortem CT scan useful in identifying the cause of colonic perforation.2022

    • Author(s)
      Matoba K, Jin S, Hyodoh H
    • Organizer
      11th Congress of International Society of Forensic Radiology and Imaging (ISFRI)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Volume rendering による頭蓋冠骨折の客観的評価法2022

    • Author(s)
      兵頭秀樹. 竹内明子. 的場光太郎, 村上学, 的場智子, 齋藤厚子, 神繁樹
    • Organizer
      106 次日本法医学会学術全国集 会
    • Related Report
      2022 Research-status Report
  • [Presentation] Objective fracture evaluation by postmortem3D-CTFractureScore.2021

    • Author(s)
      Hideki Hyodoh, Akiko Takeuchi, Kotaro Matoba, Manabu Murakami, Tomoko Matoba, Atsuko Saito, Nahoko Okuya, Shigeki Jin.
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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