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Exploration of environmental and genetic factors associated with prognosis in gastric and colorectal cancer survivors

Research Project

Project/Area Number 20K10463
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

Oze Isao  愛知県がんセンター(研究所), がん予防研究分野, 主任研究員 (00584509)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords胃がん / 大腸がん / がんサバイバー / がんサバイバーシップ / 縦断研究 / 遺伝子多型 / microRNA
Outline of Research at the Start

胃がん・大腸がんに罹患した後、生存している人(がんサバイバー)において、がんの再発や死亡のリスクと関連する遺伝子多型やmicroRNAなどのバイオマーカーや生活習慣を明らかにすることを目的に本研究を行う。そのため、2015年から2018年に愛知県がんセンターで初回治療を行った胃がん・大腸がんサバイバーを診断時から定期的に臨床情報、生活習慣、血液試料の収集をしたデータを利用する。本研究により、がん罹患後に気をつけるべき生活習慣の発見や、がんの再発や進行に影響する遺伝子やエピジェネティクスに関する知見の集積が見込まれる。

Outline of Final Research Achievements

We examined the associations between psychological states, such as depression, and socioeconomic factors among gastric and colorectal cancer survivors. At the time of cancer diagnosis, the prevalence of depression, as measured by the K6 questionnaire with a score of 10 or above, was 10.1%. This percentage decreased to 7.4% at the one-year follow-up. However, the proportion of individuals experiencing latent anxiety increased from 20.1% to 36.9% during the same period. The number of individuals providing social support was associated with lower depression scores. Interestingly, female patients consistently maintained their levels of social support after their cancer diagnosis. In contrast, male survivors showed a tendency for a decrease in the number of supporters.

Academic Significance and Societal Importance of the Research Achievements

胃がん・大腸がんは現在日本で最も罹患者数の多いがんであり、がんと診断された後に生存しているがんサバイバーの数も多い。がんサバイバーの抱える問題のうち、しばしば問題になるのが抑うつである。本研究結果は社会的サポートの充実の大切さを示すものであり、病院の相談支援体制やがんサバイバー同士のピアサポートなどの取り組みが重要であることを示唆する。また、社会的サポートが不十分な人を見逃さないような支援体制が必要であることも示した。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (11 results)

All 2023 2022 2021 2020

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (1 results)

  • [Journal Article] Helicobacter pylori, homologous-recombination genes, and gastric cancer2023

    • Author(s)
      Usui Yoshiaki, Taniyama Yukari, Hatakeyama Masanori, Matsuo Keitaro, Momozawa Yukihide, etal.
    • Journal Title

      The New England Journal of Medicine

      Volume: 388 Issue: 13 Pages: 1181-1190

    • DOI

      10.1056/nejmoa2211807

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of socioeconomic status and sibling number on the prevalence of Helicobacter pylori infection: a cross-sectional study in a Japanese population2022

    • Author(s)
      Elshair M, Ugai T, Oze I, Kasugai Y, Koyanagi YN, Hara K, Ito H, Matsuo K.
    • Journal Title

      Nagoya Journal of Medical Science

      Volume: 84 Issue: 2 Pages: 374-387

    • DOI

      10.18999/nagjms.84.2.374

    • ISSN
      0027-7622
    • URL

      https://nagoya.repo.nii.ac.jp/records/2002887

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 胃がん・大腸がんサバイバーシップ実現を目指した研究基盤作成の試み2022

    • Author(s)
      尾瀬功
    • Journal Title

      Medical Science Digest

      Volume: 48 Pages: 147-147

    • Related Report
      2021 Research-status Report
  • [Journal Article] Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study2021

    • Author(s)
      Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, et al
    • Journal Title

      Journal of Epidemiology

      Volume: 31 Issue: 3 Pages: 172-179

    • DOI

      10.2188/jea.JE20190296

    • NAID

      130007995132

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2021-03-05
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Personal Breast Cancer Risk Stratification Model Using Common Variants and Environmental Risk Factors in Japanese Females2021

    • Author(s)
      Oze Isao、Ito Hidemi、Kasugai Yumiko、Yamaji Taiki、Kijima Yuko、Ugai Tomotaka、Kasuga Yoshio、Ouellette Tomoyo K.、Taniyama Yukari、Koyanagi Yuriko N.、Imoto Issei、Tsugane Shoichiro、Koriyama Chihaya、Iwasaki Motoki、Matsuo Keitaro
    • Journal Title

      Cancers

      Volume: 13 Issue: 15 Pages: 3796-3796

    • DOI

      10.3390/cancers13153796

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating immune- and inflammation-related biomarkers and early-stage noncardia gastric cancer risk2021

    • Author(s)
      Song Minkyo、Rabkin Charles S.、Ito Hidemi、Oze Isao、Koyanagi Yuriko N.、Pfeiffer Ruth M.、Kasugai Yumiko、Matsuo Keitaro、Camargo M. Constanza
    • Journal Title

      European Journal of Cancer Prevention

      Volume: 31 Issue: 3 Pages: 270-273

    • DOI

      10.1097/cej.0000000000000706

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 食道がんの疫学とリスク因子2021

    • Author(s)
      尾瀬功
    • Journal Title

      臨牀消化器内科

      Volume: 36 Pages: 57-57

    • Related Report
      2021 Research-status Report
  • [Journal Article] Alcohol Drinking and Bladder Cancer Risk From a Pooled Analysis of Ten Cohort Studies in Japan2020

    • Author(s)
      Masaoka Hiroyuki、Matsuo Keitaro、Oze Isao、Ito Hidemi、Naito Mariko、Wada Keiko、Nagata Chisato、Nakayama Tomio、Kitamura Yuri、Sadakane Atsuko、Tamakoshi Akiko、Tsuji Ichiro、Sugawara Yumi、Sawada Norie、Mizoue Tetsuya、Inoue Manami、Tanaka Keitaro、Tsugane Shoichiro、Shimazu Taichi
    • Journal Title

      Journal of Epidemiology

      Volume: 30 Issue: 7 Pages: 309-313

    • DOI

      10.2188/jea.JE20190014

    • NAID

      130007870960

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2020-07-05
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis2020

    • Author(s)
      Koyanagi Yuriko N.、Suzuki Etsuji、Imoto Issei、Kasugai Yumiko、Oze Isao、Ugai Tomotaka、Iwase Madoka、Usui Yoshiaki、Kawakatsu Yukino、Sawabe Michi、Hirayama Yutaka、Tanaka Tsutomu、Abe Tetsuya、Ito Seiji、Komori Koji、Hanai Nobuhiro、Tajika Masahiro、Shimizu Yasuhiro、Niwa Yasumasa、Ito Hidemi、Matsuo Keitaro
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 7 Pages: 1601-1610

    • DOI

      10.1158/0008-5472.can-19-2685

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between Socioeconomic Status and Digestive Tract Cancers: A Case-Control Study2020

    • Author(s)
      Kawakatsu Yukino、Koyanagi Yuriko N.、Oze Isao、Kasugai Yumiko、Morioka Hisayoshi、Yamaguchi Rui、Ito Hidemi、Matsuo Keitaro
    • Journal Title

      Cancers

      Volume: 12 Issue: 11 Pages: 3258-3258

    • DOI

      10.3390/cancers12113258

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 胃がん・大腸がんサバイバーの治療後のうつと関連する社会的・経済的要因の探索2021

    • Author(s)
      尾瀬功 伊藤秀美 伊藤誠二 小森康司 田中努 田近正洋 春日井由美子 小栁友理子 谷山由佳里 松尾恵太郎
    • Organizer
      第31回日本疫学会学術総会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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