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Development of propensity score models in large epidemiologic studies: causal inference and AI

Research Project

Project/Area Number 20K10471
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionOkayama University

Principal Investigator

SUZUKI Etsuji  岡山大学, 医歯薬学域, 研究准教授 (10627764)

Co-Investigator(Kenkyū-buntansha) 頼藤 貴志  岡山大学, 医歯薬学域, 教授 (00452566)
篠崎 智大  東京理科大学, 工学部情報工学科, 講師 (60644482)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords因果推論 / 因果関係 / AI / 傾向スコア / 疫学
Outline of Research at the Start

交絡バイアスなどを制御するため、多くの疫学研究では「傾向スコア」モデルが用いられている。本研究の目的は、傾向スコアモデルの理論的問題を明らかにして、交絡バイアスなどを制御するための新たな因果推論手法を構築し、その有用性を実データで検証することである。さらに、機械学習などのAI技術も応用することで、疫学研究の質の向上に資することをめざす。

Outline of Final Research Achievements

We evaluated the usefulness of the marginal sufficient component cause model, a newly proposed causal model, by discussing its theoretical problems and limitations. Furthermore, we examined the Hill’s viewpoints from the perspective of causal mechanisms and showed the importance of using appropriate causal models in a complementary manner to evaluate causality. Moreover, we developed measures for assessing intervention effects within the framework of causal inference. We developed theories regarding the assessment of causal mechanisms and confounding, offering a prospect for the field of epidemiology in the AI era.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、近年注目されている因果推論手法を活用したものであり、リアルワールドデータから因果関係を評価する上で有用な理論的知見である。これらの知見は、十分原因モデルと潜在アウトカムモデルいう重要な2種類の因果モデルの対応を発展させており、傾向スコアモデルを開発する基盤となる。また、交絡バイアスなどを適切に制御し、因果メカニズムを評価するために重要な研究成果である。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (48 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (6 results) Journal Article (23 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 21 results,  Open Access: 14 results) Presentation (17 results) (of which Int'l Joint Research: 8 results,  Invited: 6 results) Remarks (2 results)

  • [Int'l Joint Research] ハーバード大学/マサチューセッツ工科大学/ロードアイランド大学(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] マギル大学(カナダ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ハーバード大学(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] マギル大学(カナダ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] ハーバード大学(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] マギル大学(カナダ)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Exchangeability of Measures of Association Before and After Exposure Status Is Flipped: Its Relationship With Confounding in the Counterfactual Model2023

    • Author(s)
      Suzuki Etsuji、Yamamoto Michio、Yamamoto Eiji
    • Journal Title

      Journal of Epidemiology

      Volume: 33 Issue: 8 Pages: 385-389

    • DOI

      10.2188/jea.JE20210352

    • NAID

      130008143828

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2023-08-05
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attributable fraction and related measures: Conceptual relations in the counterfactual framework2023

    • Author(s)
      Suzuki Etsuji、Yamamoto Eiji
    • Journal Title

      Journal of Causal Inference

      Volume: 11 Issue: 1

    • DOI

      10.1515/jci-2021-0068

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal exposure to opioids and neurodevelopmental disorders in children: a Bayesian mediation analysis2023

    • Author(s)
      Wang S, Puggioni G, Wu J, Meador KJ, Caffrey A, Wyss R, Slaughter JL, Suzuki E, Ward KE, Lewkowitz AK, Wen X
    • Journal Title

      American Journal of Epidemiology

      Volume: -

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Do Complementary and Alternative Medicine Users Also Use Conventional Medicine? A Repeated Cross-Sectional Study in Japan from 1995 to 20132023

    • Author(s)
      Matsuki Nobuyoshi、Suzuki Etsuji、Mitsuhashi Toshiharu、Takao Soshi、Yorifuji Takashi
    • Journal Title

      Journal of Integrative and Complementary Medicine

      Volume: 29 Issue: 2 Pages: 119-126

    • DOI

      10.1089/jicm.2022.0631

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat Exposure Following the Rainy Season Is Associated With an Increased Risk of Cardiovascular Emergency Among the Elderly in Japan2023

    • Author(s)
      Fujimoto Ryohei、Suzuki Etsuji、Kashima Saori、Nakamura Kazufumi、Naito Hiromichi、Nakao Atsunori、Ito Hiroshi、Yorifuji Takashi
    • Journal Title

      Journal of the American Heart Association

      Volume: 12 Issue: 6

    • DOI

      10.1161/jaha.122.027046

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The primary importance of the research question: implications for understanding natural versus controlled direct effects2022

    • Author(s)
      Shrier Ian、Suzuki Etsuji
    • Journal Title

      International Journal of Epidemiology

      Volume: 51 Issue: 4 Pages: 1041-1046

    • DOI

      10.1093/ije/dyac090

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A general explanation of the counterfactual definition of confounding2022

    • Author(s)
      Suzuki Etsuji、Yamamoto Michio、Yamamoto Eiji
    • Journal Title

      Journal of Clinical Epidemiology

      Volume: - Pages: 189-192

    • DOI

      10.1016/j.jclinepi.2022.02.002

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of nighttime sleep with behaviors in Japanese early childhood.2022

    • Author(s)
      Yamauchi Y, Takao S, Matsumoto N, Yorifuji T.
    • Journal Title

      Pediatr Int.

      Volume: 64(1) Issue: 1

    • DOI

      10.1111/ped.15354

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early childhood exposure to maternal smoking and obesity: A nationwide longitudinal survey in Japan.2022

    • Author(s)
      Yamashita M, Yorifuji T, Matsumoto N, Kubo T, Tsukahara H.
    • Journal Title

      Clin Obes.

      Volume: - Issue: 3

    • DOI

      10.1111/cob.12572

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal sepsis and Kawasaki disease2022

    • Author(s)
      Takeuchi Akihito、Sugino Noriko、Namba Takahiro、Tamai Kei、Nakamura Kazue、Nakamura Makoto、Kageyama Misao、Yorifuji Takashi、Bonno Motoki
    • Journal Title

      European Journal of Pediatrics

      Volume: 181 Issue: 8 Pages: 2927-2933

    • DOI

      10.1007/s00431-022-04501-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bias amplification in the g-computation algorithm for time-varying treatments: a case study of industry payments and prescription of opioid products2022

    • Author(s)
      Inoue, K., Goto, A., Kondo, N. and Shinozaki, T.
    • Journal Title

      BMC Medical Research Methodology

      Volume: 22 Issue: 1

    • DOI

      10.1186/s12874-022-01563-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ビッグデータ論文を読む際の10か条2022

    • Author(s)
      篠崎智大
    • Journal Title

      薬理と治療

      Volume: 50 Pages: 187-192

    • Related Report
      2021 Research-status Report
  • [Journal Article] Artificial intelligence and epidemiology in data science : Prediction and causal inference2021

    • Author(s)
      Yorifuji Takashi、Suzuki Etsuji
    • Journal Title

      Okayama Igakkai Zasshi (Journal of Okayama Medical Association)

      Volume: 133 Issue: 1 Pages: 55-57

    • DOI

      10.4044/joma.133.55

    • NAID

      130008034822

    • ISSN
      0030-1558, 1882-4528
    • Year and Date
      2021-04-01
    • Related Report
      2020 Research-status Report
    • Open Access
  • [Journal Article] Preterm birth and Kawasaki disease: a nationwide Japanese population-based study2021

    • Author(s)
      Takeuchi A, Namba T, Matsumoto N, Tamai K, Nakamura K, Nakamura M, Kageyama M, Kubo T, Tsukahara H, Yorifuji T
    • Journal Title

      Pediatr Res

      Volume: Oct 8 Issue: 2 Pages: 557-562

    • DOI

      10.1038/s41390-021-01780-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sports participation and preterm birth: a nationwide birth cohort in Japan2021

    • Author(s)
      Tamai Kei、Matsumoto Naomi、Takeuchi Akihito、Nakamura Makoto、Nakamura Kazue、Kageyama Misao、Washio Yosuke、Tsukahara Hirokazu、Yorifuji Takashi
    • Journal Title

      Pediatric Research

      Volume: - Issue: 2 Pages: 572-579

    • DOI

      10.1038/s41390-021-01808-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early childhood exposure to maternal smoking and behavioral development2021

    • Author(s)
      Ariyoshi Makiko、Mitsuhashi Toshiharu、Matsumoto Naomi、Nakamura Kazue、Yorifuji Takashi
    • Journal Title

      Archives of Environmental Occupational Health

      Volume: - Issue: 7 Pages: 1-8

    • DOI

      10.1080/19338244.2021.1972278

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Marginal Sufficient Component Cause Model: An Emerging Causal Model With Merits?2021

    • Author(s)
      Suzuki Etsuji、Yamamoto Eiji
    • Journal Title

      Epidemiology

      Volume: 32 Issue: 6 Pages: 838-845

    • DOI

      10.1097/ede.0000000000001411

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Strength in causality: discerning causal mechanisms in the sufficient cause model2021

    • Author(s)
      Suzuki Etsuji、Yamamoto Eiji
    • Journal Title

      European Journal of Epidemiology

      Volume: 36 Issue: 9 Pages: 899-908

    • DOI

      10.1007/s10654-021-00798-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between Early Surgery and Postoperative Outcomes in Elderly Patients with Distal Femur Fracture: A Retrospective Cohort Study2021

    • Author(s)
      Yamamoto Norio、Ohbe Hiroyuki、Tomita Yosuke、Yorifuji Takashi、Nakajima Mikio、Sasabuchi Yusuke、Miyamoto Yuki、Matsui Hiroki、Noda Tomoyuki、Yasunaga Hideo
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 24 Pages: 5800-5800

    • DOI

      10.3390/jcm10245800

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Body Mass Index and Ventilator Dependence in Critically Ill Subjects in Japan: A Cohort Study Using a Nationwide Database2021

    • Author(s)
      Fujinaga Jun、Suzuki Etsuji、Irie Hiromasa、Onodera Mutsuo
    • Journal Title

      Respiratory Care

      Volume: - Issue: 9 Pages: 1433-1439

    • DOI

      10.4187/respcare.08660

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Is a sense of community belonging associated with problem gambling in Canada?2021

    • Author(s)
      Izutsu Masato、Suzuki Etsuji
    • Journal Title

      Social Psychiatry and Psychiatric Epidemiology

      Volume: - Issue: 10 Pages: 1871-1880

    • DOI

      10.1007/s00127-021-02040-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Understanding Marginal Structural Models for Time-Varying Exposures: Pitfalls and Tips2020

    • Author(s)
      Shinozaki Tomohiro、Suzuki Etsuji
    • Journal Title

      Journal of Epidemiology

      Volume: 30 Issue: 9 Pages: 377-389

    • DOI

      10.2188/jea.JE20200226

    • NAID

      130007896982

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2020-09-05
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Re: A graphical description of partial exchangeability2020

    • Author(s)
      Suzuki Etsuji、Yamamoto Eiji
    • Journal Title

      Epidemiology

      Volume: 32 Issue: 2 Pages: e7-e9

    • DOI

      10.1097/ede.0000000000001306

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Attributable fraction and related measures: conceptual relations in the counterfactual framework2023

    • Author(s)
      Suzuki E, Yamamoto E
    • Organizer
      The 2023 American Causal Inference Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Understanding vaccine efficacy in the counterfactual framework2023

    • Author(s)
      Suzuki E, Yamamoto T, Yamamoto E
    • Organizer
      56th Annual Meeting of the Society for Epidemiologic Research
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] データから因果関係に迫る疫学理論の開発と実践2023

    • Author(s)
      鈴木越治
    • Organizer
      第33回日本疫学会学術総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Attributable fraction and related measures: conceptual relations in the counterfactual framework2022

    • Author(s)
      Suzuki E, Yamamoto E
    • Organizer
      55th Annual Meeting of the Society for Epidemiologic Research
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanisms and sufficient causes: a theoretical perspective to understand the etiology of suicide2022

    • Author(s)
      Suzuki E
    • Organizer
      19th Congress of the WPA Epidemiology and Public Health Section
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 因果媒介分析2022

    • Author(s)
      篠崎智大
    • Organizer
      ヘルスデータサイエンス学会第1回学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 標的学習の基礎2022

    • Author(s)
      篠崎智大
    • Organizer
      2022年度統計関連学会連合大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 観察研究の効果推定値を標的集団に一般化/移送する方法の検討2022

    • Author(s)
      堀江悠生、篠崎智大
    • Organizer
      2022年度統計関連学会連合大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] One-step approximation of covariate balancing propensity score using generalized linear models2022

    • Author(s)
      Tomohiro Shinozaki
    • Organizer
      The 11th Conference of the Asian Regional Section of the International Association for Statistical Computing (IASC-ARS)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Marginal sufficient component cause model: an emerging causal model with authenticity?2021

    • Author(s)
      Suzuki E, Yamamoto E
    • Organizer
      54th Annual Meeting of the Society for Epidemiologic Research
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 交絡はバイアスと区別すべきか―AI時代における疫学の展望2021

    • Author(s)
      鈴木越治,篠崎智大,三橋利晴,津田敏秀,山本英二
    • Organizer
      第94回日本産業衛生学会
    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Presentation] 反事実因果モデルと RWEとの架橋2021

    • Author(s)
      篠崎智大
    • Organizer
      2021年度統計関連学会連合大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 曝露と非曝露を入れ替えた場合に関連指標が変わるか否か―反事実モデルにおける交絡との関係2021

    • Author(s)
      鈴木越治,山本倫生,山本英二
    • Organizer
      第31回日本疫学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 重症患者のBody Mass Indexと人工呼吸器依存の関係―JIPADデータを用いたコホート研究2021

    • Author(s)
      藤永潤,鈴木越治,入江洋正,小野寺睦雄
    • Organizer
      第48回日本集中治療医学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 高齢者における雨季後の気温変動と心血管疾患による救急搬送との関連2021

    • Author(s)
      藤本竜平,鈴木越治,中村一文,伊藤浩,頼藤貴志
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] The meaning of arrows: reflections on the assumption of faithfulness in causal directed acyclic graphs2020

    • Author(s)
      Suzuki E, Shinozaki T, Yamamoto E
    • Organizer
      53rd Annual Meeting of the Society for Epidemiologic Research
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] A different perspective of “cross-world independence assumption” and the utility of natural effects compared to controlled effects2020

    • Author(s)
      Shrier I, Suzuki E
    • Organizer
      53rd Annual Meeting of the Society for Epidemiologic Research
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Remarks] 岡山大学大学院医歯薬学総合研究科疫学・衛生学分野ホームページ

    • URL

      https://www.unit-gp.jp/eisei/wp/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
  • [Remarks] 岡山大学大学院医歯薬学総合研究科疫学・衛生学分野ホームページ

    • URL

      http://www.unit-gp.jp/eisei/wp/

    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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