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In search for nutritional biomarkers of 24-hour urine to prevent dementia

Research Project

Project/Area Number 20K10517
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionMukogawa Women's University

Principal Investigator

YAMORI Yukio  武庫川女子大学, 国際健康開発研究所, 教授 (80025600)

Co-Investigator(Kenkyū-buntansha) 森 真理  東海大学, 健康学部, 特任准教授 (70399343)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords長浜コホート研究 / 脊振研究 / 24時間尿中栄養バイオマーカー / 葉酸 / ホモシステイン / 認知機能 / 脳画像解析 / 予知・予防医学(先制医療) / 24時間尿分析 / 脳MRI健診 / 背振健診 / 脊振健診 / 長浜健診 / 24時間採尿分析 / 適塩和食
Outline of Research at the Start

世界保健機関の協力を得て60以上の地域で24時間尿を採取して分析し日本食の特色が大豆と魚の摂取で、これが心筋梗塞死が先進国中最低で日本人の平均寿命を世界一にしたが、食塩過剰摂取の為に脳卒中、脳血管性認知症がなお多く、健康寿命が平均寿命より10年も短い。従って適塩和食が健康寿命の延伸には勧められるが、大豆、魚の摂取は、脳萎縮抑制効果が期待される血中葉酸値を上昇させ、動脈硬化や糖尿病のリスク軽減効果も有る事を検証した。この新知見から24時間尿による栄養マーカーの成績と脳健診の画像解析から脳血管性認知症やアルツハイマー型認知症との関係性を分析し認知症の進行と予防に寄与する栄養因子を検証する。

Outline of Final Research Achievements

We could demonstrate the inverse association of soy isoflavones (Is) and fish taurine(T) in 24- hour urine samples with coronary heart diseases by WHO CARDIAC study to conclude, optimum salted soy and fish intakes were indispensable to extending healthy life expectancy. Is and T intakes in Japanese were epidemiologically associated with serum folate(F) elevation, and the epidemiological data of the reduction of dementia after the legal fortification of wheat powder by F in USA and the effective reduction of the brain atrophy in the elderly by the supplement intervention of F in England supported the potential effects of serum F elevation on dementia prevention.
We investigated the mechanisms of F elevation for reducing the risk of cognitive impairment, in Nagahama Cohort and particularly focused on the investigation of homocysteine association of the blood and urine in Seburi Study for detecting dementia risk by urinalysis for the prevention.

Academic Significance and Societal Importance of the Research Achievements

脳卒中モデルの開発に始まる大豆・魚の栄養の脳卒中の実験的予防栄養がヒトの疫学研究でもHDLを増加させ、動脈硬化の予防が可能で米国では葉酸(F)の法的添加後に認知症が低減し、英国ではFやビタミンB6、B12のサプリメントで高齢者の脳萎縮が抑えられたことから、Fを増加させる和食が勧められる。Fはホモシステイン(HC)を減少させるが、高齢者の健診で血中Hと尿中Hの相関を証明し、24時間採尿で尿中HをモニターしてFを増加させる適塩で大豆・魚を摂り、野菜からのカリウム摂取を勧めれば、食生活によって認知機能の低減を予防し得ると期待される。本研究は尿のモニターによる認知症の先制医療の進展に貢献しうる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (27 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 8 results) Presentation (14 results) (of which Int'l Joint Research: 4 results,  Invited: 9 results) Book (3 results)

  • [Int'l Joint Research] Poznan University of Life Sciences(ポーランド)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Relationship between Regional Distribution of Centenarians and Drinking Water Hardness in the Amami Islands, Kagoshima Prefecture, Japan2023

    • Author(s)
      Mai Suzuki, Siyuan Wu, Tomoki Ootawa, Henry Smith, Mitsuya Shiraishi, Atsushi Miyamoto, Yuki Matsuoka, Sawako Sawa, Mari Mori, Hideki Mori, Yukio Yamori
    • Journal Title

      Nutrients

      Volume: 15 Issue: 7 Pages: 1569-1569

    • DOI

      10.3390/nu15071569

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Grading of Japanese Diet Intakes by 24-Hour Urine Analysis of Taurine and Soy Isoflavones in Relation to Cardiovascular Risks2022

    • Author(s)
      Mari Mori, Miki Sagara, Hideki Mori, Yukio Yamori
    • Journal Title

      Taurine 12

      Volume: 12 Pages: 173-184

    • DOI

      10.1007/978-3-030-93337-1_17

    • ISBN
      9783030933364, 9783030933371
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of spot urine biomarkers and association with body weight in Japanese elementary schoolchildren2022

    • Author(s)
      Takemoto Nozomi、Millman Jasmine、Uema Tsugumi、Yamakawa Fusae、Okamoto Shiki、Mori Mari、Mori Hideki、Nakamura Koshi、Yamori Yukio、Masuzaki Hiroaki
    • Journal Title

      European Journal of Pediatrics

      Volume: 181 Issue: 11 Pages: 3879-3888

    • DOI

      10.1007/s00431-022-04604-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stroke-Prone SHR as Experimental Models for Cardiovascular Disease Risk Reduction in Humans2022

    • Author(s)
      Yukio Yamori, Miki Sagara, Hideki Mori, Mari Mori; CARDIAC Study Group
    • Journal Title

      Biomedicines

      Volume: 10 Issue: 11 Pages: 2974-2974

    • DOI

      10.3390/biomedicines10112974

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Health Effects of Soy Isoflavones and Green Tea Catechins on Cancer and Cardiovascular Diseases Based on Urinary Biomarker Levels2022

    • Author(s)
      Tomokazu Ohishi , Noriyuki Miyoshi, Mari Mori, Miki Sagara, Yukio Yamori
    • Journal Title

      Molecules

      Volume: 27 Issue: 24 Pages: 8899-8899

    • DOI

      10.3390/molecules27248899

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women2021

    • Author(s)
      Bajerska Joanna、Lagowska Karolina、Mori Mari、Regula Julita、Skoczek-Rubi?ska Aleksandra、Toda Toshiya、Mizuno Naho、Yamori Yukio
    • Journal Title

      The Journal of Nutrition

      Volume: 152 Issue: 1 Pages: 5-15

    • DOI

      10.1093/jn/nxab325

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome2021

    • Author(s)
      Yamagata Kazuo、Yamori Yukio
    • Journal Title

      Molecules

      Volume: 26 Issue: 19 Pages: 5863-5883

    • DOI

      10.3390/molecules26195863

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of the Soy Intake on Inflammatory Markers in Postmenopausal Women: A meta-analysis of Randomized Control Trials2021

    • Author(s)
      Joanna Bajerska, Karolina Lagowska, Mari Mori, Julita Regula, Aleksandra Skoczek-Robinska, Toshiya Toda, Yukio Yamori
    • Journal Title

      Nutrients (投稿中)

      Volume: 0 Pages: 0-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition of Endothelial Dysfunction by Dietary Flavonoids and Preventive Effects Against Cardiovascular Disease2020

    • Author(s)
      Yamagata Kazuo、Yamori Yukio
    • Journal Title

      Journal of Cardiovascular Pharmacology

      Volume: 75 Issue: 1 Pages: 1-9

    • DOI

      10.1097/fjc.0000000000000757

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 世界の24時間尿バイオマーカーの分析で分かった主要血管病の予防と健康長寿2022

    • Author(s)
      家森幸男
    • Organizer
      第76回日本栄養・食糧学会シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 令和食ー美しいバランス食を世界の長寿食に“適塩和食のすすめ”2022

    • Author(s)
      家森幸男
    • Organizer
      第22回日本抗加齢医学会総会シンポジウム講演
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Urinary Biomarker Analyses on Japanese, Mediterranean and Euro-Western Populations: Which is Better for Post-pandemic Longevity?2022

    • Author(s)
      Yukio Yamori
    • Organizer
      Hypertension Kyoto 2022(ISH 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Yukio Yamori, SHRSP Research For Cardiovascular Disease Prevention2022

    • Author(s)
      Yukio Yamori
    • Organizer
      Society for Hypertension Related Disease Model Research: Cardiovascular Diseases Model Satellite 2022.
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] How to Eat Wisely Our Asian Diet for Living Healthy Long Life with Less Cardiovascular Risks (CVR)2022

    • Author(s)
      Yukio Yamori
    • Organizer
      Hypertension Seoul 2022(KSH2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Improvement of Sodium/Potassium Ratio by Intervention Studies and Cardiovascular Risks2022

    • Author(s)
      Mari Mori
    • Organizer
      Hypertension Seoul 2022(KSH2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Magnesium and Taurine, first Proven to Be Preventive Nutrients in Stroke-prone Rat Models, Were 24-hour urinary Bio-Markers associated with Lower Cardiovascular Risks World-Widely and also in Japanese and Mediterranean Populations.2021

    • Author(s)
      Yukio Yamori,, Miki Sagara, Hideki Mori, Mari Mori
    • Organizer
      ESH-ISH2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 日本食と地中海食、どちらが世界一の長寿食か?2021

    • Author(s)
      家森 幸男
    • Organizer
      第21回日本抗加齢医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 24時間尿のマグネシウムとタウリンは心血管代謝リスクと和食摂取の評価指標となり得るか2021

    • Author(s)
      家森 幸男
    • Organizer
      第43回日本高血圧学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 日本食と地中海食、どちらか世界一の長寿食か?2021

    • Author(s)
      家森幸男、相良未木、荒井喜美、森英樹、森真理
    • Organizer
      日本抗加齢医学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 世界的規模で採取した24時間尿中タウリンとマグネシウム増加と循環器疾患リスク低減との関係2021

    • Author(s)
      森真理、相良未木、荒井喜美、森英樹、家森幸男
    • Organizer
      第7回国際タウリン研究会 日本部会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] "先制栄養”で薬剤師が拓く未来ー測って伸ばせる健康寿命2021

    • Author(s)
      家森幸男
    • Organizer
      第59回日本薬薬剤師会中国四国支部大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 「動脈硬化予防食としての日本食ー地中海食との共通の長所と短所2021

    • Author(s)
      家森幸男
    • Organizer
      日本循環器学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Magnesium and Taurine, First Person to Be Preventive Nutrients in Stroke-Prone Rat Models Were 24-Hour Urinary Bio-Markers Associated with Lower Cardiovascular Risks World-Wide and Also in Japanese and Mediterranean Populations2021

    • Author(s)
      Yukio Yamori, Miki Sagara, Hideki Mori, Mari Mori
    • Organizer
      International Society of Hypertension
    • Related Report
      2020 Research-status Report
  • [Book] 遺伝子が喜ぶ「奇跡の令和食」2021

    • Author(s)
      家森 幸男
    • Total Pages
      216
    • Publisher
      集英社インターナショナル
    • ISBN
      9784797673920
    • Related Report
      2021 Research-status Report
  • [Book] 健康長寿の「賢食」術2021

    • Author(s)
      家森幸男
    • Total Pages
      183
    • Publisher
      NHK出版
    • Related Report
      2020 Research-status Report
  • [Book] 奇跡の令和食2021

    • Author(s)
      家森幸男 監修、森真理
    • Total Pages
      216
    • Publisher
      集英社
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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