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Research on best dosage forms for deglutition disorders

Research Project

Project/Area Number 20K11236
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Yamawaki Masanaga  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30302855)

Co-Investigator(Kenkyū-buntansha) 檀 一平太  中央大学, 理工学部, 教授 (20399380)
鈴木 健嗣  筑波大学, システム情報系, 教授 (30350474)
鈴木 孝禎  大阪大学, 産業科学研究所, 教授 (90372838)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords嚥下障害 / 薬剤剤型 / brain mapping / 嚥下聴診器 / polypharmacy / 嚥下音 / 簡易検査 / 脳機能画像
Outline of Research at the Start

本研究は薬剤の嚥下運動について、1)薬剤dosage formsの嚥下運動への影響の分析、2)種々のdosage formsによる嚥下運動の脳内表象の解明、3)高齢者の服薬状況に関するコホート研究との比較分析、4)加齢変化及び嚥下障害にふさわしい薬剤内服戦略の開発、を目的とする。
本研究は薬剤嚥下運動の分析及びその脳内表象(脳内コネクトーム:大脳・延髄ネットワークを含む)を解析することにより、嚥下運動に効率的な薬剤dosage formsを解明し、DDS (drug delivery system)も含めた新たな薬剤dosage formsの開発につなげようというものである。

Outline of Final Research Achievements

This study aims to 1) analyze the effects of drug dosage forms (dosage form, lubricity, solubility, etc.) on swallowing movements, and 2) examine the brain representations of swallowing movements by various drug dosage forms. 3) Comparative analysis with ongoing cohort studies on medication status in the elderly, and 4) Development of oral drug administration strategies appropriate for age-related changes and dysphagia.
By 2022, a) analysis of swallowing movements for various dosage forms using the wearable swallowing measuring device Gokuri, b) analysis of brain representations of swallowing for various dosage forms using fNIRS, and c) analysis of elderly people through cohort studies, were performed. From 2022, we have carried out the projects: d) analysis of dysphagia patterns and drug dosage forms, and e) preparation for clinical trials.

Academic Significance and Societal Importance of the Research Achievements

高齢化が進んでいる我が国において、嚥下障害の克服は喫緊の課題であるが、薬剤の嚥下についての研究はほとんどないのが現状である。我々は大脳嚥下中枢から延髄嚥下中枢への抑制シグナルの関与、感覚入力による運動野制御、及び大脳嚥下中枢における嚥下困難の脳内表象(脳内表現)を明らかにし、さらに薬剤嚥下運動の分析及びその脳内表象(脳内コネクトーム:大脳・延髄ネットワークを含む)を解析し、嚥下運動に効率的な薬剤dosageformsを明らかにし、DDS (drug delivery system)も含めた新たな薬剤dosage formsの開発につながることが期待された。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (13 results)

All 2024 2023 2021 2020

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Sliced Jelly Whole Swallowing Reduces Deglutition Risk: A Novel Feeding Method for Patients with Dysphagia2024

    • Author(s)
      Seijiro Aii, M.D. Ichiro Fujishima, M.D., Ph.D. Takashi Shigematsu, M.D., Ph.D. Tomohisa Ohno, D.D.S., Ph.D. Kenjiro Kunieda, M.D., Ph.D. Masanaga Yamawaki, M.D., Ph.D.
    • Journal Title

      Dysphagia

      Volume: 280

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elucidation of the needs for telecritical care services in Japan: a qualitative study2023

    • Author(s)
      Morimoto Mizuki、Nawa Nobutoshi、Okada Eriko、Itsui Yasuhiro、Kashimada Ayako、Yamamoto Kouhei、Akaishi Yu、Yamawaki Masanaga
    • Journal Title

      BMJ Open

      Volume: 13 Issue: 11 Pages: e072065-e072065

    • DOI

      10.1136/bmjopen-2023-072065

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study2023

    • Author(s)
      Akaishi Yu、Nawa Nobutoshi、Kashimada Ayako、Itsui Yasuhiro、Okada Eriko、Yamawaki Masanaga
    • Journal Title

      Medical Education Online

      Volume: 28 Issue: 1 Pages: 00-00

    • DOI

      10.1080/10872981.2023.2225886

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cricopharyngeal muscle origin transection for oropharyngeal dysphagia, a novel surgical technique.2023

    • Author(s)
      Kanazawa H, Fujishima I, Ohno T, Kunieda K, Shigematu T, Yamawaki M.
    • Journal Title

      Eur Arch Oto-Rhino-Laryngol

      Volume: 280 Issue: 1 Pages: 483-486

    • DOI

      10.1007/s00405-022-07588-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of Reliability and Validity regarding the “Structural Items of Protocol for Percutaneous Endoscopic Gastrostomy Removal for Older People” in Nursing Practice2021

    • Author(s)
      千葉 由美, 山田 律子, 市村 久美子, 古田 愛子, 椎橋 依子, 中島 聖子, 戸原 玄, 山脇 正永, 石田 瞭, 唐帆 健浩, 植田 耕一郎, 平野 浩彦, 許 俊鋭
    • Journal Title

      The Japanese Journal of Dysphagia Rehabilitation

      Volume: 25 Issue: 3 Pages: 190-207

    • DOI

      10.32136/jsdr.25.3_190

    • NAID

      40022815333

    • ISSN
      1343-8441, 2434-2254
    • Year and Date
      2021-12-31
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of hereditary hemorrhagic telangiectasia complaining of shunt encephalopathy diagnosed by fast Fourier transform and contrast-enhanced ultrasonography2021

    • Author(s)
      Sakagami Junichi, Sogame Yoshio, Yasuda Hiroaki, Sakai Takamitsu, Kitano Satomi, Yamawaki Masanaga, Itoh Yoshito, Kagawa Keizo
    • Journal Title

      Journal of Hospital General Medicine

      Volume: 3 Pages: 49-53

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 症例 私の治療方針(series 19) 球症状を呈し、重症筋無力症と筋萎縮性側索硬化症の鑑別を要した76歳女性例2021

    • Author(s)
      谷口 洋, 向井 泰司, 金沢 英哲, 山脇 正永, 向井 泰司
    • Journal Title

      嚥下医学

      Volume: 10 Pages: 53-61

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two cases of novel coronavirus infection (COVID-19) with transient viral elevation using semi-quantitative real-time reverse transcription PCR and symptom relapse after completion of 10 days of favipiravir treatment2020

    • Author(s)
      Hajime TKunimitsu suboi , Yu Kasamatsu , Shin Matsubara , Akifumi Sasao , Katsutomo , Nana Munakata , Takamasa Ito , Yasuhiro Tsuchido , Masanaga Yamawaki , Naohisa Fujita
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 23 Issue: 7 Pages: 1072-1075

    • DOI

      10.1016/j.jiac.2020.12.018

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Future trend in medical curriculum.2023

    • Author(s)
      Masanaga Yamawaki
    • Organizer
      Siriraj International in Medicine and Public Health.
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of evaluation system from undergraduate to postgraduate clinical training : a nation-wide EPOC (E-POrtfolio of Clinical training) in Japan.2023

    • Author(s)
      Masanaga Yamawaki, Eriko Okada, Nobutoshi Nawa, Makoto Takahashi, Ayako Kashimada, Yu Akaishi, Shouko Yoshida, Yujiro Tanaka.
    • Organizer
      AMEE 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Swallowing Rehabilitation for Neurodegenerative Diseases2021

    • Author(s)
      Masanaga Yamawaki
    • Organizer
      2nd International Dysphagia Course "Clinically Oriented Dysphagia Rehabilitation Lectures & Workshop"
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 高次脳機能障害と嚥下障害:メカニズムとエビデンス2021

    • Author(s)
      山脇正永
    • Organizer
      第44回日本嚥下医学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Book] 認知症診療実践ハンドブック2021

    • Author(s)
      清水充子、山脇正永
    • Total Pages
      439
    • Publisher
      中外医学社
    • ISBN
      9784498228931
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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