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Life events and frailty in older adults: effects by cognitive function and brain atrophy

Research Project

Project/Area Number 20K11276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

Lee Sangyoon  国立研究開発法人国立長寿医療研究センター, 研究所 老年学・社会科学研究センター, 副部長 (90466194)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsライフイベント / 高齢者 / フレイル / 認知機能 / 脳萎縮
Outline of Research at the Start

認知症の危険因子としてライフイベントのような社会心理的環境の影響が考えられているが、どのようなライフイベントが高齢者に発生し、その関連要因については、明らかにされていない。特に、発症時期の差をもたらす一因として高齢者のフレイル状態等、健康状態による対処の違いが考えられるが、エビデンスは少ない。さらに、ライフイベントの発生の脳萎縮および認知機能の変化における影響については、科学的根拠が乏しい。そこで本研究では、大規模高齢者機能健診を用い、高齢者におけるライフイベントの関連要因、フレイルとの関連を明らかにする。また、ライフイベントのパターンと脳萎縮、認知機能変化との関連を縦断的に検討する。

Outline of Final Research Achievements

Sociopsychological factors such as life events may be risk factors for dementia, but the relationship between life events and dementia is unclear. In particular, differences in health status, such as frailty in older people, may contribute to differences in the timing of dementia onset. However, there is little evidence of an association between frailty and life events.
The study used the Functional Health Check-up for the older adults to determine the relationship between life events and frailty among older people. The results showed that having negative life events and fewer positive life events was associated with frailty. Although the longitudinal study found no association with brain atrophy, further research is needed.

Academic Significance and Societal Importance of the Research Achievements

高齢者におけるフレイル、認知症発症は世界的にも緊要な課題である一方、ライフイベン
トとの研究は少なく科学的根拠が乏しい。ストレスの多いライフイベントは生涯で誰しも生じることであり、イベント発生後のアプローチはその後の障害発症を抑制・遅延できる重要な視点と考えられる。本研究が実施により、高齢者におけるライフイベントと身体機能について知見が提案できた。今後、老年学系のジャーナルに投稿を進める。
ライフイベント発生は高齢者における健康状態に影響する可能性があり、これらの発生による介入の必要性、また、国民への【ライフイベント発生後のアプローチ】に科学的な根拠の高い情報発信ができると考える。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (41 results)

All 2023 2022 2021 2020

All Journal Article (15 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 15 results,  Open Access: 11 results) Presentation (25 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] A non-pharmacological multidomain intervention of dual-task exercise and social activity affects the cognitive function in community-dwelling older adults with mild to moderate cognitive decline: A randomized controlled trial2023

    • Author(s)
      Lee Sangyoon、Harada Kenji、Bae Seongryu、Harada Kazuhiro、Makino Keitaro、Anan Yuya、Suzuki Takao、Shimada Hiroyuki
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 15 Pages: 1005410-1005410

    • DOI

      10.3389/fnagi.2023.1005410

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of social isolation and smartphone use on cognitive functions2022

    • Author(s)
      Morikawa M, Lee S, Makino K, Bae S, Chiba I, Harada K, Tomida K, Katayama O, Shimada H
    • Journal Title

      Arch Gerontol Geriatr

      Volume: 101 Pages: 104706-104706

    • DOI

      10.1016/j.archger.2022.104706

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of Dual Sensory Impairment with Cognitive Decline in Older Adults2022

    • Author(s)
      Tomida K, Lee S, Bae S, Harada K, Katayama O, Makino K, Chiba I, Morikawa M, Shimada H
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 51 Issue: 4 Pages: 322-330

    • DOI

      10.1159/000525820

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Light intensity physical activity is beneficially associated with brain volume in older adults with high cardiovascular risk2022

    • Author(s)
      Makino K, Lee S, Bae S, Harada K, Chiba I, Katayama O, Tomida K, Morikawa M, Yamashiro Y, Sudo M, Takayanagi N, Shimada H
    • Journal Title

      Front Cardiovasc Med

      Volume: 9 Pages: 882562-882562

    • DOI

      10.3389/fcvm.2022.882562

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isotemporal Substitution of Sedentary Behavior with Moderate- to Vigorous- Physical Activity Is Associated with Lower Risk of Disability: A Prospective Longitudinal Cohort Study2022

    • Author(s)
      Ippei Chiba, Sangyoon Lee, Seongryu Bae, Keitaro Makino, Yohei Shinkai, Osamu Katayama, Kenji Harada, Yukari Yamashiro, Naoto Takayanagi, Hiroyuki Shimada
    • Journal Title

      Physical Therapy

      Volume: - Issue: 5

    • DOI

      10.1093/ptj/pzac002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The association between social activity and physical frailty among community-dwelling older adults in Japan2022

    • Author(s)
      Katayama Osamu、Lee Sangyoon、Bae Seongryu、Makino Keitaro、Chiba Ippei、Harada Kenji、Shinkai Yohei、Shimada Hiroyuki
    • Journal Title

      BMC Geriatrics

      Volume: 22 Issue: 1 Pages: 870-870

    • DOI

      10.1186/s12877-022-03563-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of COVID-19 Pandemic Exacerbation of Depressive Symptoms for Social Frailty from the ORANGE Registry2022

    • Author(s)
      Kodama A, Kume Y, Lee S, Makizako H, Shimada H, Takahashi T, Ono T, Ota H
    • Journal Title

      Int J Environ Res Public Health

      Volume: 19 Issue: 2 Pages: 986-986

    • DOI

      10.3390/ijerph19020986

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simplified Decision-Tree Algorithm to Predict Falls for Community-Dwelling Older Adults2021

    • Author(s)
      Makino K, Lee S, Bae S, Chiba I, Harada K, Katayama O, Tomida K, Morikawa M, Shimada H
    • Journal Title

      J Clin Med

      Volume: 10 Issue: 21 Pages: 5184-5184

    • DOI

      10.3390/jcm10215184

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between self-reported night sleep duration and cognitive function among older adults with intact global cognition2021

    • Author(s)
      Kondo R, Miyano I, Lee S, Shimada H, Kitaoka H
    • Journal Title

      Int J Geriatr Psychiatry

      Volume: 36 Issue: 5 Pages: 766-774

    • DOI

      10.1002/gps.5476

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in sarcopenia characteristics associated with physical activity and disability incidences in older adults2021

    • Author(s)
      Chiba I, Lee S, Bae S, Makino K, Shinkai Y, Katayama O, Harada K, Takayanagi N, Shimada H
    • Journal Title

      J Cachexia Sarcopenia Muscle

      Volume: 12 Issue: 6 Pages: 1983-1994

    • DOI

      10.1002/jcsm.12801

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study2021

    • Author(s)
      Kume Y, Takahashi T, Itakura Y, Lee S, Makizako H, Ono T, Shimada H, Ota H
    • Journal Title

      Gerontology

      Volume: 67 Issue: 2 Pages: 184-193

    • DOI

      10.1159/000511986

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lifestyle Activity Patterns Related to Physical Frailty and Cognitive Impairment in Urban Community-Dwelling Older Adults in Japan2021

    • Author(s)
      Katayama Osamu、Lee Sangyoon、Bae Seongryu、Makino Keitaro、Shinkai Yohei、Chiba Ippei、Harada Kenji、Shimada Hiroyuki
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 22 Issue: 3 Pages: 583-589

    • DOI

      10.1016/j.jamda.2020.05.031

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between instrumental activities of daily living performance and incidence of mild cognitive impairment among older adults: A 48-month follow-up study2020

    • Author(s)
      Makino K, Lee S, Bae S, Shinkai Y, Chiba I, Shimada H
    • Journal Title

      Arch Gerontol Geriat

      Volume: Epub ahead of print Pages: 104034-104034

    • DOI

      10.1016/j.archger.2020.104034

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Behavioral Factors Related to the Incidence of Frailty in Older Adults2020

    • Author(s)
      Shimada Hiroyuki、Doi Takehiko、Tsutsumimoto Kota、Lee Sangyoon、Bae Seongryu、Arai Hidenori
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 10 Pages: 3074-3074

    • DOI

      10.3390/jcm9103074

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Engagement in lifestyle activities is associated with increased Alzheimer’s disease associated cortical thickness and cognitive performance in older adults2020

    • Author(s)
      Bae S, Lee S, Harada K, Harada K, Makino K, Chiba I, Katayama O, Shinkai Y, Park H, Shimada H
    • Journal Title

      J Clin Med

      Volume: 9 Issue: 5 Pages: 1424-1424

    • DOI

      10.3390/jcm9051424

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Prospects for social implementation of multifactorial interventions for dementia prevention」3. Is a health promotion program using IoT technology effective for older adults living in the community?2022

    • Author(s)
      Lee S
    • Organizer
      The 17th International Symposium on Geriatrics and Gerontology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Examining the factors that moderate progression from subjective cognitive decline to objective cognitive decline: a 4-year longitudinal study.2022

    • Author(s)
      Katayama O, Lee S, Bae S, Makino K, Chiba I, Harada K, Morikawa M, Tomida K, Shimada H.
    • Organizer
      Alzheimer's Association International Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 乳・乳製品摂取と認知機能低下との関連~地域在住高齢者の大規模コホート研究2022

    • Author(s)
      李相侖, 原田健次, 片山脩, 冨田浩輝, 森川将徳, 藤井一弥, 西島千陽, 山口亨, 見須裕香, 島田裕之.
    • Organizer
      第1回日本老年療法学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 地域在住高齢者を対象とした日常生活における活動と脳萎縮と認知機能との関連:cognitive resilience の検討2022

    • Author(s)
      李相侖, 裵成琉, 牧野圭太郎, 原田健次, 千葉一平, 片山脩, 冨田浩輝, 森川将徳, 島田裕之.
    • Organizer
      第64回日本老年医学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 非対面交流は抑うつ症状とフレイルの予防に有効な戦略となるか―観察的前向きコホート研究―.2022

    • Author(s)
      片山脩, 李相侖, 裵成琉, 牧野圭太郎, 千葉一平, 原田健次, 森川将徳, 冨田浩輝, 島田裕之.
    • Organizer
      第64回日本老年医学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高齢期における就労形態が要介護発生に与える影響. 第1回日本老年療法学会学術集会2022

    • Author(s)
      藤井一弥, 李相侖, 原田健次, 牧野圭太郎, 片山脩, 冨田浩輝, 山口亨, 西島千陽, 見須裕香, 島田裕之.
    • Organizer
      第1回日本老年療法学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Does combined participation in physical, cognitive, and social activities reduce the risk of disability among community-dwelling older adults?: NCGG- SGS study2021

    • Author(s)
      Lee S
    • Organizer
      The 7th Asian Conference For Frailty And Sarcopenia(ACFS 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sensorial frailty: association between audiovisual impairment and mild cognitive impairment in Japanese older adults2021

    • Author(s)
      Tomida K, Lee S, Bae S, Makino K, Harada K, Chiba I, Katayama O, Morikawa M, Shimada H
    • Organizer
      The 7th Asian Conference For Frailty And Sarcopenia(ACFS 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Life satisfaction is associated with the relationship between mild cognitive impairment and the incidence of disability2021

    • Author(s)
      Katayama O, Lee S, Bae S, Makino K, Chiba I, Harada K, Shinkai Y, Shimada H
    • Organizer
      Katayama O, Lee S, Bae S, Makino K, Chiba I, Harada K, Shinkai Y, Shimada H
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 独居高齢者の健康状態とフレイルとの関連:大規模地域コホートを用いた検討2021

    • Author(s)
      李相侖, 裵成琉, 牧野圭太郎, 原田健次, 千葉一平, 片山脩, 新海陽平, 島田裕之
    • Organizer
      第10回日本認知症予防学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] フレイル及び主観的認知機能低下の変化の軌跡とその関連要因の検討―オレンジレジストリ研究から―2021

    • Author(s)
      裵成琉, 李相侖, 牧野圭太郎, 千葉一平, 片山脩, 新海陽平, 原田健次, 島田裕之
    • Organizer
      第10回日本認知症予防学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 認知症リスク予測を目的とした電話インタビュースケール開発と機械学習を用いた予測精度の検証2021

    • Author(s)
      牧野圭太郎, 李相侖, 裵成琉, 千葉一平, 片山脩, 原田健次, 新海陽平, 島田裕之
    • Organizer
      第10回日本認知症予防学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 認知機能低下と要介護発生との関連の強さは生活満足度により異なる―地域在住高齢者による縦断的検討―2021

    • Author(s)
      片山脩, 李相侖, 裵成琉, 牧野圭太郎, 千葉一平, 原田健次, 新海陽平, 島田裕之
    • Organizer
      第10回日本認知症予防学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域在住高齢者における認知的フレイルと低栄養との関連2021

    • Author(s)
      千葉一平, 李相侖, 裵成琉, 原田健次, 牧野圭太郎, 新海陽平, 片山脩, 島田裕之
    • Organizer
      第10回日本認知症予防学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 手指の両側性協調運動制御に関わる神経基盤の加齢変化2021

    • Author(s)
      原田健次, 李相侖, 裵成琉, 牧野圭太郎, 千葉一平, 片山脩, 新海陽平, 島田裕之
    • Organizer
      第10回日本認知症予防学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 大規模地域コホートを用いた一人暮らしとフレイル:健康状態と外出による検討2021

    • Author(s)
      李相侖, 裵成琉, 牧野圭太郎, 千葉一平, 片山脩, 原田健次, 新海陽平, 島田裕之
    • Organizer
      第63回日本老年医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 心血管リスクレベルと認知機能低下の関連:認知ドメイン別の検討2021

    • Author(s)
      牧野圭太郎, 李相侖, 裵成琉, 千葉一平, 片山脩, 原田健次, 新海陽平, 島田裕之
    • Organizer
      第63回日本老年医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 身体的フレイルに関連する社会活動レベルの検証2021

    • Author(s)
      第63回日本老年医学会学術集会
    • Organizer
      第63回日本老年医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 対面・非対面の社会的ネットワークの新しいスケールは高齢者の抑うつ傾向を予測しうるか2021

    • Author(s)
      裵成琉, 李相侖, 牧野圭太郎, 千葉一平, 片山脩, 原田健次, 新海陽平, 島田裕之
    • Organizer
      第63回日本老年医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Frailty and Sarcopenia(I) Community-based Approach to Target Preventing Geriatric Syndrome: Findings from NCGGSGS.2020

    • Author(s)
      Sangyoon Lee
    • Organizer
      The Sixth ICAH-NCGG Symposium, Virtual conference
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 地域在住高齢者の認知症発症年齢に着目した危険因子の検討:老年症候群における大規模地域コホート縦断研究(NCGG-SGS)2020

    • Author(s)
      李相侖, 裵成琉, 牧野圭太郎, 原田健次, 千葉一平, 片山脩, 新海陽平, 島田裕之
    • Organizer
      第62回日本老年医学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 地域在住高齢者における身体的フレイルによる海馬内構造体の容積の違い2020

    • Author(s)
      原田健次, 裵成琉, 李相侖, 千葉一平, 牧野圭太郎, 片山脩, 新海陽平, 島田裕之
    • Organizer
      第62回日本老年医学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 地域在住高齢者における座位時間の身体活動時間への置き換えと要介護発生との関連-isotemporal substitution model による検討-2020

    • Author(s)
      千葉一平, 李相侖, 裵成琉, 牧野圭太郎, 新海陽平, 原田健次, 片山脩, 島田裕之
    • Organizer
      第7回日本予防理学療法学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 地域在住高齢者のライフスタイル活動パターンの検討―フレイルに着目した検討―2020

    • Author(s)
      片山脩, 李相侖, 裵成琉, 牧野圭太郎, 新海陽平, 千葉一平, 原田健次, 島田裕之
    • Organizer
      第62回日本老年医学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 地域高齢者の心理的フレイルと転倒恐怖感との関連:大規模コホートデータによる検討.2020

    • Author(s)
      牧野圭太郎, 李相侖, 裵成琉, 千葉一平, 片山脩, 原田健次, 新海陽平, 島田裕之
    • Organizer
      第7回日本予防理学療法学会学術大会
    • Related Report
      2020 Research-status Report
  • [Book] コグニサイズ入門 楽しく取り組む認知症予防2022

    • Author(s)
      島田裕之/李 相侖
    • Total Pages
      80
    • Publisher
      医歯薬出版株式会社
    • ISBN
      9784263266588
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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