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Elucidation of the role of Oleic acid metabolism in the glioma tumor biology

Research Project

Project/Area Number 20K11527
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionTohoku University

Principal Investigator

Kagawa Yoshiteru  東北大学, 医学系研究科, 助教 (30728887)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脂肪酸結合蛋白質 / FABP7 / 脳腫瘍 / 脂肪酸代謝 / エピゲノム / ヒストンアセチル化 / 脂肪滴 / グリオーマ / オレイン酸 / アセチルCoA / ATP-citrate lyase (ACLY) / 核内脂肪滴 / PML小体 / 脂質ラフト / イソクエン酸脱水素酵素 (IDH) / イソクエン酸脱水素酵素 / 脂肪酸 / Idh1遺伝子 / 脂質代謝
Outline of Research at the Start

グリオブラストーマは最も悪性度の高い脳腫瘍の一つであるが、未だ有効な診断マーカーや治療法は確立されていない。近年、グリオブラストーマの細胞内代謝系と腫瘍生物学的特性との関連が注目されているが、詳細は明らかになっていない。
これまでに我々は様々な脂肪酸の中で特にオレイン酸がグリオブラストーマの増殖を促進することを見出している。本申請では、オレイン酸に強い親和性を持ち、グリオブラストーマに高い発現を示す脂肪酸結合蛋白質 (FABP7) に着目し、“脳腫瘍増殖の病態メカニズムにおけるオレイン酸代謝の意義”を明確にすることを目指す。

Outline of Final Research Achievements

Glioblastoma is one of the malignant brain tumors. In this study, we have examined the role of oleic acid metabolism in the brain tumor pathology focusing on the relation between fatty acid binding protein 7, which has high affinity with oleic acid and is dominantly expressed by glioblastoma, and the presence of IDH mutation, which is involved in the survival of glioma patients.
We have demonstrated that FABP7 is highly expressed in nucleus of IDH1 wild type glioblastoma, that nuclear localization of FABP7 increases nuclear acetyl-CoA levels and histone acetylation levels, and that oleic acid induces nuclear localization of FABP7, which leads to the formation of nuclear lipid droplet and contributes to the transcriptional regulation.

Academic Significance and Societal Importance of the Research Achievements

グリオブラストーマは最も悪性度の高い脳腫瘍の一つであるが、未だ有効な診断マーカーや治療法は確立されていない。近年、グリオブラストーマの細胞内代謝系と腫瘍生物学的特性との関連が注目されているが、詳細は明らかになっていなかった。本研究では、予後不良の野生型IDH1グリオブラストーマでFABP7の発現が高く、特に核に強く発現することを見出した。この結果より、FABP7を標的としたグリオブラストーマの病態診断の確立が期待できる。また、FABP7機能を介したオレイン酸代謝がグリオブラストーマの病態進行を促進させることから、オレイン酸を標的にした栄養学的な治療指針の確立を期待することが出来る。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (50 results)

All 2022 2021 2020 Other

All Int'l Joint Research (3 results) Journal Article (17 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 17 results,  Open Access: 13 results) Presentation (28 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] The University of Melbourne/Monash University(オーストラリア)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] University at Buffalo(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] メルボルン大学/モナッシュ大学(オーストラリア)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Environmental enrichment sex-dependently rescues memory impairment in FABP5 KO mice not mediated by brain-derived neurotrophic factor.2022

    • Author(s)
      Marion M, Hamilton J, Richardson B, Roeder N, Figueiredo A, Nubelo A, Hetelekides E, Penman S, Owada Y, Kagawa Y, Thanos PK.
    • Journal Title

      Behav Brain Res

      Volume: 425, Pages: 113814-113827

    • DOI

      10.1016/j.bbr.2022.113814

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unpredictable chronic mild stress differentially impacts resting brain glucose metabolism in fatty acid-binding protein 7 deficient mice2022

    • Author(s)
      Hamilton John、Roeder Nicole、Richardson Brittany、Hammond Nikki、Sajjad Munawwar、Yao Rutao、Owada Yuji、Kagawa Yoshiteru、Thanos Panayotis K.
    • Journal Title

      Psychiatry Research: Neuroimaging

      Volume: 323 Pages: 111486-111486

    • DOI

      10.1016/j.pscychresns.2022.111486

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Oleic acid‐bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation2022

    • Author(s)
      Umaru Banlanjo Abdulaziz、Kagawa Yoshiteru、Ohsaki Yuki、Pan Yijun、Chen Chuck T.、Chen Daniel K.、Abe Toshiaki、Shil Subrata Kumar、Miyazaki Hirofumi、Kobayashi Shuhei、Maekawa Motoko、Yamamoto Yui、Wannakul Tunyanat、Yang Shuhan、Bazinet Richard P.、Owada Yuji
    • Journal Title

      The FEBS Journal

      Volume: 290 Issue: 7 Pages: 1798-1821

    • DOI

      10.1111/febs.16672

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Altered Blood?Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis2022

    • Author(s)
      Pan Yijun、Kagawa Yoshiteru、Sun Jiaqi、Turner Bradley J.、Huang Cheng、Shah Anup D.、Schittenhelm Ralf B.、Nicolazzo Joseph A.
    • Journal Title

      Pharmaceutics

      Volume: 14 Issue: 12 Pages: 2803-2803

    • DOI

      10.3390/pharmaceutics14122803

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae function.2022

    • Author(s)
      Kagawa Y, Umaru BA, Kanamori M, Zama R, Shil SK, Miyazaki H, Kobayashi S, Wannakul T, Yang S, Tominaga T, Owada Y.
    • Journal Title

      Mol Oncol

      Volume: 16 Issue: 1 Pages: 289-306

    • DOI

      10.1002/1878-0261.13130

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/β-Catenin Signaling2021

    • Author(s)
      Umaru Banlanjo Abdulaziz、Kagawa Yoshiteru、Shil Subrata Kumar、Arakawa Naoki、Pan Yijun、Miyazaki Hirofumi、Kobayashi Shuhei、Yang Shuhan、Cheng An、Wang Yifei、Shinoda Yasuharu、Kiniwa Yukiko、Okuyama Ryuhei、Fukunaga Kohji、Owada Yuji
    • Journal Title

      Pharmaceutical Research

      Volume: 38 Issue: 3 Pages: 479-490

    • DOI

      10.1007/s11095-021-03009-9

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fatty acid‐binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung2021

    • Author(s)
      Yang Shuhan、Kobayashi Shuhei、Sekino Kaname、Kagawa Yoshiteru、Miyazaki Hirofumi、Kumar Shil Subrata、Abdulaziz Umaru Banlanjo、Wannakul Tunyanat、Owada Yuji
    • Journal Title

      FEBS Letters

      Volume: 595 Issue: 13 Pages: 1797-1805

    • DOI

      10.1002/1873-3468.14106

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ndufs4 ablation decreases synaptophysin expression in hippocampus2021

    • Author(s)
      Shil Subrata Kumar、Kagawa Yoshiteru、Umaru Banlanjo Abdulaziz、Nanto-Hara Fumika、Miyazaki Hirofumi、Yamamoto Yui、Kobayashi Shuhei、Suzuki Chitose、Abe Takaaki、Owada Yuji
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-90127-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] SGLT-1-specific inhibition ameliorates renal failure and alters the gut microbial community in mice with adenine-induced renal failure2021

    • Author(s)
      Ho Hsin‐Jung、Kikuchi Koichi、Oikawa Daiki、Watanabe Shun、Kanemitsu Yoshitomi、Kagawa Yoshiteru、その他19名
    • Journal Title

      Physiological Reports

      Volume: 9 Issue: 24 Pages: 15092-15092

    • DOI

      10.14814/phy2.15092

    • URL

      https://pure.teikyo.jp/en/publications/300ec1cb-3d12-473d-9e04-cbdc70be0195

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acid‐binding protein 5 limits the generation of Foxp3+ regulatory T cells through regulating plasmacytoid dendritic cell function in the tumor microenvironment2021

    • Author(s)
      Kobayashi Shuhei、Wannakul Tunyanat、Sekino Kaname、Takahashi Yu、Kagawa Yoshiteru、Miyazaki Hirofumi、Umaru Banlanjo Abdulaziz、Yang Shuhan、Yamamoto Yui、Owada Yuji
    • Journal Title

      International Journal of Cancer

      Volume: 150 Issue: 1 Pages: 152-163

    • DOI

      10.1002/ijc.33777

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acid binding protein 3 regulates differentiation of IgM-producing plasma cells.2020

    • Author(s)
      Shuhei Kobayashi, Hai The Phung, Shunichi Tayama, Yoshiteru Kagawa, Hirofumi Miyazaki, Yui Yamamoto, Takashi Maruyama, Naoto Ishii, Yuji Owada
    • Journal Title

      The FEBS Journal

      Volume: In Press Issue: 4 Pages: 1130-1141

    • DOI

      10.1111/febs.15460

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination2020

    • Author(s)
      Foerster Sarah、Guzman de la Fuente Alerie、Kagawa Yoshiteru、Bartels Theresa、Owada Yuji、Franklin Robin J. M.
    • Journal Title

      Glia

      Volume: 68 Issue: 7 Pages: 1410-1420

    • DOI

      10.1002/glia.23789

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty Acid Binding Protein 7 is Involved in the Proliferation of Reactive Astrocytes, but not in Cell Migration and Polarity2020

    • Author(s)
      Hara Tomonori、Abdulaziz Umaru Banlanjo、Sharifi Kazem、Yoshikawa Takeo、Owada Yuji、Kagawa Yoshiteru
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 53 Issue: 4 Pages: 73-81

    • DOI

      10.1267/ahc.20001

    • NAID

      130007891194

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial dysfunction in GnRH neurons impaired GnRH production2020

    • Author(s)
      Kagawa Yoshiteru、Umaru Banlanjo Abdulaziz、Shil Subrata Kumar、Hayasaka Ken、Zama Ryo、Kobayashi Yuta、Miyazaki Hirofumi、Kobayashi Shuhei、Suzuki Chitose、Katori Yukio、Abe Takaaki、Owada Yuji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 530 Issue: 1 Pages: 329-335

    • DOI

      10.1016/j.bbrc.2020.07.090

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes2020

    • Author(s)
      Kagawa Y, Umaru BA, Shima H, Ito R, Zama R, Islam A, Kanno S, Yasui A, Sato S, Jozaki K, Shil SK, Miyazaki H, Kobayashi S, Yamamoto Y, Kogo H, Shimamoto-Mitsuyama C, Sugawara A, Sugino N, Kanamori M, Tominaga T, Yoshikawa T, Fukunaga K, Igarashi K, Owada Y
    • Journal Title

      Molecular Neurobiology

      Volume: 57 Issue: 12 Pages: 4891-4910

    • DOI

      10.1007/s12035-020-02057-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty acid-binding protein 5 limits ILC2-mediated allergic lung inflammation in a murine asthma model.2020

    • Author(s)
      Kobayashi S, Tayama S, Phung TH, Kagawa Y, Miyazaki H, Takahashi Y, Maruyama T, Ishii N, Owada Y
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 16617-16617

    • DOI

      10.1038/s41598-020-73935-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acid‐binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4 + γ/δ T cell in a murine model2020

    • Author(s)
      Kobayashi Shuhei、Phung Hai The、Kagawa Yoshiteru、Miyazaki Hirofumi、Takahashi Yu、Asao Atsuko、Maruyama Takashi、Yoshimura Akihiko、Ishii Naoto、Owada Yuji
    • Journal Title

      Allergy

      Volume: - Issue: 6 Pages: 1776-1788

    • DOI

      10.1111/all.14630

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] オレイン酸がミクログリアのアミロイドβ取り込み機能に及ぼす影響2022

    • Author(s)
      天羽 瑛子, Shuhan Yang, 宮崎 啓史, 香川 慶輝, 前川 素子, 大和田 祐二
    • Organizer
      NEURO2022 第45回日本神経科学大会(沖縄コンベンションセンター, ハイブリット開催)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Should oral medication dose be adjusted in Alzheimer's disease?2022

    • Author(s)
      Yijun Pan, Jiaqi Sun, Liang Jin, Yoshiteru Kagawa, Yuji Owada, Joseph Nicolazzo
    • Organizer
      Alzheimer's Association International Conference 2022(SAN DIEGO, USA)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microglia with fatty acid-binding protein 5 deficiency exhibit proinflammatory phenotype contributing to neuroinflammation2022

    • Author(s)
      Yoshiteru Kagawa, Liang Jin, Jiaqi Sun, Joseph Nicolazzo, Yuji Owada, Yijun Pan
    • Organizer
      Alzheimer's Association International Conference 2022(SAN DIEGO, USA)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳腫瘍における異常脂質代謝とフェロトーシス耐性獲得機構の関連性とその治療応用2022

    • Author(s)
      香川慶輝, Umaru Banlanjo Abdulaziz, 須田朱音, 大和田祐二
    • Organizer
      日本解剖学会 第68回東北・北海道連合支部学術集会(北海道大学, ハイブリッド開催)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Polyunsaturated fatty acids suppress the growth of pancreatic cancer cells via ferroptosis2022

    • Author(s)
      Akane Suda , Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Yuji Owada
    • Organizer
      第45回日本分子生物学会年会(幕張メッセ, 千葉市)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Overformation of lipid droplet by altered lipid metabolism in glioma induce ferroptosis-resistance2022

    • Author(s)
      Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Yijun Pan, Jiaqi Sun, Akane Suda, Joseph Nicolazzo, Yuji Owada
    • Organizer
      第45回日本分子生物学会年会(幕張メッセ, 千葉市)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 核内FABP7はカベオラ機能調節を介してIDH1野生型グリオーマの増殖を制御する2022

    • Author(s)
      香川慶輝, Banlanjo Abdulaziz Umaru, 大和田祐二
    • Organizer
      第127回日本解剖学会全国学術集会(大阪大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] FABP7-Oleic acid interaction potently drives glioma cell proliferation via nuclear lipid droplet formation and epigenetic regulation2022

    • Author(s)
      Banlanjo Abdulaziz Umaru, Yoshiteru Kagawa, Yuji Owada
    • Organizer
      第127回日本解剖学会全国学術集会(大阪大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] Oleic acid increased survivability and invasion of melanoma cells2022

    • Author(s)
      Tunyanat Wannakul, Hirofumi Miyazaki, Yoshiteru Kagawa, Motoko Maekawa, Yuji Owada
    • Organizer
      第127回日本解剖学会全国学術集会(大阪大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] 多価不飽和脂肪酸はFerroptosisを介して膵がん病態を抑制する2022

    • Author(s)
      須田朱音、香川慶輝、大和田祐二
    • Organizer
      第127回日本解剖学会全国学術集会(大阪大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] 腫瘍増殖メカニズムにおける核内脂質動態の意義の解明2021

    • Author(s)
      香川 慶輝
    • Organizer
      第126回日本解剖学会学術総会全国学術集会・第98回日本生理学会大会合同大会 日本解剖学会奨励賞受賞講演 (名古屋大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] FABP7はIDH1野生型グリオーマの増殖に関与する2021

    • Author(s)
      香川 慶輝, Banlanjo Abdulaziz Umaru, 大和田 祐二
    • Organizer
      第126回日本解剖学会全国学術集会・第98回日本生理学会大会合同大会(名古屋大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] Ndufs4 regulates synaptophysin expression in hippocampus2021

    • Author(s)
      Subrata Kumar Shil, Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Takaaki Abe, Yuji Owada
    • Organizer
      第126回日本解剖学会全国学術集会・第98回日本生理学会大会合同大会(名古屋大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] Fatty Acid Binding Protein 7 (FABP7) / oleic acid mediated epigenetic regulation drives glioma cell proliferation2021

    • Author(s)
      Banlanjo Abdulaziz Umaru, Yoshiteru Kagawa, Yuji Owada
    • Organizer
      第126回日本解剖学会全国学術集会・第98回日本生理学会大会合同大会(名古屋大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] Fatty acid-binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4+ γ/δ T cell development.2021

    • Author(s)
      Shuhei Kobayashi, Yoshiteru Kagawa, Hirofumi Miyazaki, Yuji Owada
    • Organizer
      第126回日本解剖学会全国学術集会・第98回日本生理学会大会合同大会(名古屋大学, オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] Nuclear FABP7 is involved in cell proliferation of IDH1 wild-type glioblastoma.2021

    • Author(s)
      Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Yuji Owada
    • Organizer
      第44回日本分子生物学会(パシフィコ横浜)
    • Related Report
      2021 Research-status Report
  • [Presentation] Interaction between Fatty acid binding protein 7 (FABP7)/oleic acid drives glioma cell proliferation2021

    • Author(s)
      Banlanjo A Umaru, Yoshiteru Kagawa, and Yuji Owada
    • Organizer
      第44回日本分子生物学会(パシフィコ横浜)
    • Related Report
      2021 Research-status Report
  • [Presentation] Ndufs4 ablation results in presynaptic loss in hippocampus2020

    • Author(s)
      Subrata Kumar Shil, Yoshiteru Kagawa, Umaru Banlanjo Abdulaziz, Hirofumi Miyazaki, Yui Yamamoto, Shuhei Kobayashi, Takaaki Abe, Yuji Owada
    • Organizer
      日本解剖学会 第66回東北・北海道連合支部学術集会(岩手医科大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Presentation] Fatty acid binding protein 7 (FABP7)/oleic acid interaction potently drives glioma cell proliferation.2020

    • Author(s)
      Umaru Banlanjo Abdulaziz, Yoshiteru Kagawa, Subrata Kumar Shil, Hirofumi Miyazaki, Shuhei Kobayashi, Yuji Owada
    • Organizer
      日本解剖学会 第66回東北・北海道連合支部学術集会(岩手医科大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Presentation] Ndufs4 ablation results in decrease of synaptophysin expression in mouse hippocampus2020

    • Author(s)
      Subrata Kumar Shil, Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Takaaki Abe, Yuji Owada
    • Organizer
      第47回日本脳科学会(東北大学川内北キャンパス, 仙台市)
    • Related Report
      2020 Research-status Report
  • [Presentation] FABP7 regulates nuclear acetyl-CoA metabolism in astrocytes2020

    • Author(s)
      Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Yuji Owada
    • Organizer
      第43回日本分子生物学会(京都大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Presentation] Fatty acid binding protein 7 (FABP7) drives melanoma cell proliferation via modulation of Wnt/β-catenin signaling2020

    • Author(s)
      Banlanjo Abdulaziz Umaru, Yoshiteru Kagawa, Subrata Kumar Shil, Yuji Owada
    • Organizer
      第43回日本分子生物学会(京都大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Presentation] Ndufs4 deficiency shows a decreased expression of synaptophysin in hippocampus2020

    • Author(s)
      Subrata Kumar Shil, Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Takaaki Abe, Yuji Owada
    • Organizer
      第43回日本分子生物学会(京都大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Presentation] Ndufs4 regulates synaptophysin expression in hippocampus2020

    • Author(s)
      Subrata Kumar Shil, Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Takaaki Abe, Yuji Owada
    • Organizer
      第126回日本解剖学会全国学術集会・第98回日本生理学会大会合同大会(名古屋大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Presentation] 腫瘍増殖メカニズムにおける核内脂質動態の意義の解明2020

    • Author(s)
      香川 慶輝
    • Organizer
      第126回日本解剖学会学術総会全国学術集会・第98回日本生理学会大会合同大会 日本解剖学会奨励賞受賞講演 (名古屋大学, オンライン開催)
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] FABP7はIDH1野生型グリオーマの増殖に関与する2020

    • Author(s)
      香川 慶輝, Banlanjo Abdulaziz Umaru, 大和田 祐二
    • Organizer
      第126回日本解剖学会全国学術集会・第98回日本生理学会大会合同大会(名古屋大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Presentation] Fatty Acid Binding Protein 7 (FABP7) / oleic acid mediated epigenetic regulation drives glioma cell proliferation2020

    • Author(s)
      Banlanjo Abdulaziz Umaru, Yoshiteru Kagawa, Yuji Owada
    • Organizer
      第126回日本解剖学会全国学術集会・第98回日本生理学会大会合同大会(名古屋大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Presentation] Fatty acid-binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4+ γ/δ T cell development.2020

    • Author(s)
      Shuhei Kobayashi, Yoshiteru Kagawa, Hirofumi Miyazaki, Yuji Owada
    • Organizer
      第126回日本解剖学会全国学術集会・第98回日本生理学会大会合同大会(名古屋大学, オンライン開催)
    • Related Report
      2020 Research-status Report
  • [Remarks] 東北大学大学院医学系研究科 器官解剖学分野

    • URL

      https://organ-anatomy.med.tohoku.ac.jp/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
  • [Remarks] 東北大学大学院医学系研究科器官解剖学分野

    • URL

      https://organ-anatomy.med.tohoku.ac.jp/

    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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