| Project/Area Number |
20K11554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Sasaki Masaya 滋賀医科大学, 医学部, 教授 (40242979)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 心不全 / 栄養代謝病態 / 腸内環境 / 腸内細菌叢 / 栄養状態 / 炎症性サイトカイン / エネルギー代謝 |
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| Outline of Research at the Start |
申請者は、慢性心不全患者においても、重症化とともに低栄養からサルコペニアを呈すること、また、慢性心不全の栄養代謝病態にも炎症性サイトカインTNF-αやIL-6が深く関与するという新たな知見を発表した（Ann Nutr Metab in press）。そして、慢性心不全においては、腸管の血流障害や浮腫により腸管のバリア機能が低下し、ここに腸内細菌叢の乱れも相まって、バクテリアルトランスロケーションから炎症性サイトカインが誘導されるとの仮説を立てた。本研究では、心不全の栄養代謝病態における心腸相関をエネルギー代謝と腸内細菌叢の視点から検討する。
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| Outline of Final Research Achievements |
The subjects were 20 patients with heart failure who underwent inpatient treatment at a cardiology department. Positive correlations were observed between serum BNP levels and serum CRP or TNF-α levels, but neither was significant. We divided into two groups, BNP≧200 (severe group) and BNP<200 (mild group), Serun TNF-α and IL-6 levels tended to be high in high BNP group, but no significant difference was observed.
Decreased α-diversity (observed species and Chao1 index) was found in severe group. On the other hand, there was no difference in the β-diversity. In the phylum-level analysis, the severe group tended to have a lower occupancy rate of Firmicutes and Bacteroidetes compared to the mild group. Genus-level analysis showed that the severe group had high occupancy rates of Dickeya and Enterococcus, and decreased occupancy rates of Paraprevotella, Clostridium, and Butyricococcus.
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| Academic Significance and Societal Importance of the Research Achievements |
重症の心不全患者では、腸内細菌叢の調整が低下し、腸内環境が悪化している傾向が認められた。しかし、栄養状態との関連について明らかでなかった。
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