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Strategies to control insulin resistance based on prevention of weakened immunoglobulin A coating of commensal gut bacteria

Research Project

Project/Area Number 20K11580
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionOkayama University

Principal Investigator

Tsuruta Takeshi  岡山大学, 環境生命科学学域, 准教授 (90728411)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsインスリン抵抗性 / 免疫グロブリンA / 腸内細菌 / 食物繊維 / 油脂 / 分泌型免疫グロブリンA / インスリン感受性
Outline of Research at the Start

2型糖尿病はインスリンの分泌やインスリン感受性が低下することにより、血糖調節に異常をきたす疾患である。本研究では、腸内細菌に対する腸管IgAの反応性の低下がインスリン感受性の低下に関係していることに着目し、腸管IgAの反応性の低下を抑制する食品素材がインスリン感受性の低下予防に有効であるかを検証する。本研究を実施することにより、インスリン感受性の低下を予防する食品素材を新たな観点から探索することが可能となり、2型糖尿病の発症予防の新たな戦略を提示できる。

Outline of Final Research Achievements

Insulin resistance, a major factor in the pathogenesis of type 2 diabetes, is associated with a disturbance in the relationship between IgA, a major antibody in gut, and commensal gut bacteria. In this study, we searched for food materials that eliminate the disturbance and verified the effect on prevention of insulin resistance. As a result, while high intake of animal fat causes a disturbance in the relationship between IgA and gut bacteria, replacing the fatty acid composition of animal fat with medium-chain fatty acids alleviated the disturbance and also alleviated the symptoms of insulin resistance. It was also found that consumption of a dietary fiber together with animal fat improved the disturbance in the relationship between IgA and gut bacteria, as well as insulin resistance.

Academic Significance and Societal Importance of the Research Achievements

本研究成果から一部の難消化性糖質の摂取や動物性油脂の代替油脂として消化吸収性の高い油脂を摂取することにより腸内細菌に結合する腸管IgA量が増加し、特定の腸内細菌に対する腸管IgAの結合性が変化することが明らかとなった。また、これらの作用が糖代謝機能の低下抑制に関与していることが示された。本知見を応用し、腸内細菌と腸管IgAの正常な関係性を維持し、2型糖尿病予防に有用な食品素材の探索やその組み合わせを提案していくことが期待できる。

Report

(3 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (15 results)

All 2022 2021 2020

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Local free fatty acids trigger the expression of lipopolysaccharide-binding protein in murine white adipose tissue2022

    • Author(s)
      SEKI Manami、MIWA Akiho、OHSAKA Fumina、KARATSU Yugo、TSURUTA Takeshi、HINO Shingo、MORITA Tatsuya、SONOYAMA Kei
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 41 Issue: 2 Pages: 54-65

    • DOI

      10.12938/bmfh.2021-061

    • NAID

      130008145462

    • ISSN
      2186-3342
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bacterial and fungal microbiota of total mixed ration silage stored at various temperatures2022

    • Author(s)
      Wali, A., Hou, J., Tsuruta, T., and Nishino, N.
    • Journal Title

      Journal of Applied Microbiology

      Volume: - Issue: 2 Pages: 1-12

    • DOI

      10.1111/jam.15582

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aicda deficiency exacerbates high-fat diet-induced hyperinsulinemia but not gut dysbiosis in mice2021

    • Author(s)
      Tsuruta Takeshi、Muhomah Teresia Aluoch、Sonoyama Kei、Nguyen Qui D.、Takase Yurika、Nishijima Aoi、Himoto Shiori、Katsumata Emiko、Nishino Naoki
    • Journal Title

      Nutrition Research

      Volume: 93 Pages: 15-26

    • DOI

      10.1016/j.nutres.2021.06.009

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cecum microbiota in rats fed soy, milk, meat, fish, and egg proteins with prebiotic oligosaccharides2021

    • Author(s)
      Sivixay Souliphone、Department of Animal Science, Graduate School of Life and Environmental Science, Okayama University, Okayama, Japan、Bai Gaowa、Tsuruta Takeshi、Nishino Naoki、Department of Health Science and Social Welfare, Takahashi, Japan
    • Journal Title

      AIMS Microbiology

      Volume: 7 Issue: 1 Pages: 1-12

    • DOI

      10.3934/microbiol.2021001

    • NAID

      120006956806

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Consumption of indigestible saccharides and administration of Bifidobacterium pseudolongum reduce mucosal serotonin in murine colonic mucosa2021

    • Author(s)
      Tatsuoka Misa、Osaki Yosuke、Ohsaka Fumina、Tsuruta Takeshi、Kadota Yoshihiro、Tochio Takumi、Hino Shingo、Morita Tatsuya、Sonoyama Kei
    • Journal Title

      British Journal of Nutrition

      Volume: in press Issue: 4 Pages: 513-525

    • DOI

      10.1017/s0007114521001306

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cyclic nigerosylnigerose ameliorates DSS-induced colitis with restoration of goblet cell number and increase in IgA reactivity against gut microbiota in mice2020

    • Author(s)
      TSURUTA Takeshi、KATSUMATA Emiko、MIZOTE Akiko、JIAN JIAN Hou、MUHOMAH Teresia Aluoch、NISHINO Naoki
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 39 Issue: 3 Pages: 188-196

    • DOI

      10.12938/bmfh.2020-012

    • NAID

      130007881582

    • ISSN
      2186-3342
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Examination of milk microbiota, fecal microbiota, and blood metabolites of Jersey cows in cool and hot seasons2020

    • Author(s)
      Nguyen Dang Qui, Tsuruta Takeshi, Nishino Naoki, Q.D., Tsuruta, T., Nishino, N.
    • Journal Title

      Animal Science Journal

      Volume: 1 Issue: 1

    • DOI

      10.1111/asj.13441

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine2020

    • Author(s)
      Okumura Motoshi、Hamada Akihiro、Ohsaka Fumina、Tsuruta Takeshi、Hira Tohru、Sonoyama Kei
    • Journal Title

      Pfl?gers Archiv - European Journal of Physiology

      Volume: 472 Issue: 10 Pages: 1521-1532

    • DOI

      10.1007/s00424-020-02453-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 殺菌乳酸菌(Lactobacillus plantarum SNK株)の摂取が高齢マウスの小腸膜消化酵素活性に及ぼす影響2021

    • Author(s)
      西島葵、渡辺卓巳、池田暁仁、西野直樹、鶴田剛司
    • Organizer
      日本栄養食糧学会 中四国支部大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Role of gut immunoglobulin A in the pathogenesis of high fat diet-induced disorders2021

    • Author(s)
      Takeshi Tsuruta
    • Organizer
      International Symposium on Animal Bioscience
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of lard-, olive oil- and soybean oil-enriched diet on immunoglobulin A coating of gut bacteria2021

    • Author(s)
      Mao Teraoka, Naoki Nishino, Takeshi Tsuruta
    • Organizer
      International Symposium on Animal Bioscience
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of heat-killed Lactobacillus plantarum SNK strain on mucosal digestive enzymes activity in small intestine of aged mice2021

    • Author(s)
      Aoi NISHIJIMA, Takumi WATANABE, Akihito IKEDA, Naoki NISHINO, Takeshi TSURUTA
    • Organizer
      International Symposium on Animal Bioscience
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 環状四糖(CNN)の摂取が高脂肪食誘導性肥満マウスのインスリン抵抗性に及ぼす影響2021

    • Author(s)
      鶴田 剛司、溝手 晶子、塩津 萌々子、佐相 晴香、西野 直樹
    • Organizer
      農芸化学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 腸管免疫(分泌型IgA)と腸内細菌の相互作用に油脂の摂取が及ぼす影響2020

    • Author(s)
      鶴田 剛司
    • Organizer
      日本栄養食糧学会中四国支部会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 高脂肪食の摂取にともなう腸管IgAの腸内細菌に対する反応性の低下と肥満病態の関係性2020

    • Author(s)
      鶴田 剛司、園山 慶、西野 直樹
    • Organizer
      日本栄養食糧学会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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