Novel Physiological and Pathophysiological Roles of XOR in Insulin Resistance

• Project/Area Number: 20K11654
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Juntendo University
• Principal Investigator: Satoh HIroaki 順天堂大学, 医学部, 教授 (20323595)
• Co-Investigator(Kenkyū-buntansha): 森谷 千尋 順天堂大学, 医学部, 助教 (90645037)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: XOR / 糖尿病 / インスリン抵抗性 / 尿酸

Outline of Research at the Start

2型糖尿病の病態においてインスリン抵抗性の発症機序を解明することは糖尿病治療戦略において重要な課題である。高尿酸血症とインスリン抵抗性や肥満との間に正の相関を示すことが多くの観察研究で報告されているが、因果関係は不明である。
本研究では尿酸の産生に重要な酵素であるXOR (キサンチンオキシドレダクターゼ)に着目し，XORがインスリン抵抗性に及ぼす影響とその作用機序を解明する。インスリン抵抗性主要臓器である肝臓や筋肉への直接的なXOR生理活性を解明することで、新たなインスリン抵抗性発症機序が解明され、新たな糖尿病治療薬の開発に大きく貢献できると考える。

Outline of Final Research Achievements

Many observational studies have reported a positive correlation between hyperuricemia and insulin resistance, but the causal relationship is unknown. In this study, we focused on XOR, an enzyme important in the production of uric acid, and investigated the effect of XOR on insulin resistance using the XOR inhibitor febuxostat; XOR inhibitors significantly increased insulin sensitivity in peripheral tissues but did not significantly alter insulin sensitivity in the liver. We elucidated that XOR inhibitors enhance insulin sensitivity by directly inhibiting XOR in skeletal muscle.
These results suggest that XOR is not only involved in uric acid production but may also be closely related to the pathogenesis of insulin resistance in skeletal muscle.

Academic Significance and Societal Importance of the Research Achievements

本研究では、XORは尿酸産生に関与するばかりでなく、骨格筋でのインスリン抵抗性の病態にも深く関与していることを明らかにした。 本研究の成果により、骨格筋におけるXORとインスリン抵抗性との関連が解明され、インスリン抵抗性の新たな発症機序の解明につながると期待される。さらに今後ますます重要と考えられるインスリン抵抗性の治療薬の開発につながると期待される。

Research Products

• [Journal Article] Obesity and glucose metabolism abnormalities by post‐disaster evacuation (2023)
  • Author(s): Kawasaki Yukihiko、Nakano Hironori、Hayashi Fumikazu、Hosoya Mitsuaki、Yasumura Seiji、Ohira Tetsuya、Satoh Hiroaki、Suzuki Hitoshi、Takahashi Atsushi、Sakai Akira、Shimabukuro Michio、Ohto Hitoshi、Kamiya Kenji
  • Journal Title: Pediatrics International Volume: 65 Issue: 1
  • DOI: 10.1111/ped.15400
  • Peer Reviewed / Open Access
• [Journal Article] A 7 day inpatient diabetes education program improves quality of life and glycemic control 12?months after discharge (2023)
  • Author(s): Kurita Mika、Satoh Hiroaki、Kaga Hideyoshi、Kadowaki Satoshi、Someya Yuki、Tosaka Yuka、Nishida Yuya、Ikeda Fuki、Tamura Yoshifumi、Watada Hirotaka
  • Journal Title: Journal of Diabetes Investigation Volume: ‐ Issue: 6 Pages: 811-820
  • DOI: 10.1111/jdi.14008
  • Peer Reviewed / Open Access
• [Journal Article] Sex differences in risk factors for end‐stage kidney disease and death in type 2 diabetes: A retrospective cohort study. (2023)
  • Author(s): Oshima M, Iwata Y*, Toyama T, Kitajima S, Hara A, Sakai N, Shimizu M, Furuichi K, Haneda M, Babazono T, Yokoyama H, Iseki K, Araki S, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Makino H, Wada T
  • Journal Title: J Diabetes Volume: 15 Issue: 3 Pages: 246-254
  • DOI: 10.1111/1753-0407.13367
  • Peer Reviewed / Open Access
• [Journal Article] Trends in Lifestyle-related Diseases and Their Risk Factors After the Fukushima Daiichi Nuclear Power Plant Accident: Results of the Comprehensive Health Check in the Fukushima Health Management Survey (2022)
  • Author(s): Ohira Tetsuya、Nakano Hironori、Okazaki Kanako、Hayashi Fumikazu、Nagao Masanori、Sakai Akira、Hosoya Mitsuaki、Shimabukuro Michio、Takahashi Atsushi、Kazama Junichiro J.、Hashimoto Shigeatsu、Kawasaki Yukihiko、Satoh Hiroaki、Kobashi Gen、Yasumura Seiji、Ohto Hitoshi、Kamiya Kenji
  • Journal Title: Journal of Epidemiology Volume: 32 Issue: Supplement_XII Pages: S36-S46
  • DOI: 10.2188/jea.JE20210386
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2022-12-05
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship Between Risk of Hyper-Low-density Lipoprotein Cholesterolemia and Evacuation After the Great East Japan Earthquake (2022)
  • Author(s): Satoh H, Okazaki K, Ohira T, Sakai A, Hosoya M, Yasumura S, Kawasaki Y, Hashimmoto K, Ohtsuru A, Takahashi A, Watanabe K, Shimabukuro M, Kazama JJ, Hashimoto S, Kobashi G, Ohira H, Ohto H, Kamiya K
  • Journal Title: Journal of Epidemiology Volume: 32 Issue: 6 Pages: 277-282
  • DOI: 10.2188/jea.JE20200267
  • NAID: 130007967626
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2022-06-05
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of Risk Factors for Coronary Artery Disease in Asymptomatic Patients with Type 2 Diabetes Mellitus (2022)
  • Author(s): Takamura Kazuhisa、Fujimoto Shinichiro、Mita Tomoya、Kawaguchi Yuko Okano、Kurita Mika、Kadowaki Satoshi、Kamo Yuki、Aoshima Chihiro、Nozaki Yui Okada、Takahashi Daigo、Kudo Ayako、Hiki Makoto、Tomizawa Nobuo、Ikeda Fuki、Satoh Hiroaki、Watada Hirotaka、Minamino Tohru
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 5 Pages: 1226-1226
  • DOI: 10.3390/jcm11051226
  • Peer Reviewed / Open Access
• [Journal Article] A consensus statement from the Japan Diabetes Society (JDS): a proposed algorithm for pharmacotherapy in people with type 2 diabetes (2022)
  • Author(s): Bouchi Ryotaro、Kondo Tatsuya、Ohta Yasuharu、Goto Atsushi、Tanaka Daisuke、Satoh Hiroaki、Yabe Daisuke、Nishimura Rimei、Harada Norio、Kamiya Hideki、Suzuki Ryo、Yamauchi Toshimasa
  • Journal Title: Diabetology International Volume: 14 Issue: 1 Pages: 1-14
  • DOI: 10.1007/s13340-022-00605-x
  • Peer Reviewed / Open Access
• [Journal Article] A consensus statement from the Japan Diabetes Society: A proposed algorithm for pharmacotherapy in people with type 2 diabetes (2022)
  • Author(s): Bouchi Ryotaro、Kondo Tatsuya、Ohta Yasuharu、Goto Atsushi、Tanaka Daisuke、Satoh Hiroaki、Yabe Daisuke、Nishimura Rimei、Harada Norio、Kamiya Hideki、Suzuki Ryo、Yamauchi Toshimasa、JDS Committee on Consensus Statement Development
  • Journal Title: Journal of Diabetes Investigation Volume: 14 Issue: 1 Pages: 151-164
  • DOI: 10.1111/jdi.13960
  • Peer Reviewed / Open Access
• [Journal Article] Author Correction: Both higher fitness level and higher current physical activity level may be required for intramyocellular lipid accumulation in non-athlete men (2021)
  • Author(s): Yamasaki N, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Kaga H, Suzuki R, Sugimoto D, Kadowaki S, Sato M, Nakagata T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Satoh H, Kawamori R, Watada H.
  • Journal Title: Sci Rep Volume: 25 Issue: 1 Pages: 7304-7304
  • DOI: 10.1038/s41598-021-86892-x
  • Peer Reviewed / Open Access
• [Journal Article] A decrease in plasma glucose levels is required for increased endogenous glucose production with a single administration of a sodium‐glucose co‐transporter‐2 inhibitor tofogliflozin (2021)
  • Author(s): Yamasaki、Tamura Y、Kaga H、Sato M、Kiya M、Kadowaki S、Suzuki R、Furukawa Y、Sugimoto D、Funayama T、Someya Y、Kakehi S、Nojiri S、Satoh H、Kawamori R、Watada H
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 23 Issue: 5 Pages: 1092-1100
  • DOI: 10.1111/dom.14312
  • Peer Reviewed / Open Access
• [Journal Article] Effect of thyroxine treatment on pregnancy outcomes in infertile Japanese women with TSH levels between 2.5 μIU/mL and the upper reference limit: a retrospective study (2021)
  • Author(s): Tsunemi A、Uchida T、Kuroda K、Ikemoto Y、Ochiai A、Goto H、Sugiyama R、Satoh Hi、Itakura A、Watada Hi
  • Journal Title: Endocrine Journal Volume: 68 Issue: 2 Pages: 171-177
  • DOI: 10.1507/endocrj.EJ20-0380
  • NAID: 130007992473
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] A Pilot Study of Intervention With a Mobile Application Visualizing the Macronutrient Content for Type 2 Diabetes at a Japanese Center (2021)
  • Author(s): Tsunemi Asako、Sato Junko、Sugimoto Sakae、Iwagaki Yuko、Enomoto Mari、Someya Yuki、Kiya Mai、Matsuhashi Eiko、Wakabayashi Yuka、Funayama Takashi、Mita Tomoya、Uchida Toyoyoshi、Miyatsuka Takeshi、Azuma Kosuke、Shimizu Tomoaki、Kanazawa Akio、Satoh Hiroaki、Watada Hirotaka
  • Journal Title: Journal of Clinical Medicine Research Volume: 13 Issue: 8 Pages: 425-433
  • DOI: 10.14740/jocmr4558
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and Features of Impaired Glucose Tolerance in Young Underweight Japanese Women (2021)
  • Author(s): Sato M、Tamura Y、Nakagata T、Someya Y、Kaga H、Yamasaki N、Kiya M、Kadowaki S、Sugimoto D、Satoh H、Kawamori R、Watada H
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 106 Issue: 5 Pages: e2053-e2062
  • DOI: 10.1210/clinem/dgab052
  • Peer Reviewed
• [Journal Article] Short-Term SGLT2 Inhibitor Administration Does Not Alter Systemic Insulin Clearance in Type 2 Diabetes (2021)
  • Author(s): Sato M、Tamura Y、Kaga H、Yamasaki N、Kiya M、Kadowaki S、Sugimoto D、Funayama T、Someya Y、Kakehi S、Nojiri S、Satoh H、Kawamori R、Watada H
  • Journal Title: Biomedicines Volume: 9 Issue: 9 Pages: 1154-1154
  • DOI: 10.3390/biomedicines9091154
  • Peer Reviewed / Open Access
• [Journal Article] Combined changes in albuminuria and kidney function and subsequent risk for kidney failure in type 2 diabetes (2021)
  • Author(s): Oshima Megumi、ToyaIwata Yasunori、et. al
  • Journal Title: BMJ Open Diabetes Research & Care Volume: 9 Issue: 1 Pages: e002311-e002311
  • DOI: 10.1136/bmjdrc-2021-002311
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Short-Term Dietary and Therapeutic Iodine Restriction on the Therapeutic Effects of Radioactive Iodine Therapy in Patients with Graves' Disease (2021)
  • Author(s): Nishio R、Uchida T、Suzuki L、Onose Hi、Goto H、Yamada E、Satoh H、Watada H
  • Journal Title: Thyroid Volume: 31 Issue: 3 Pages: 439-445
  • DOI: 10.1089/thy.2020.0126
• [Journal Article] Adipose Insulin Resistance and Decreased Adiponectin Are Correlated With Metabolic Abnormalities in Nonobese Men (2021)
  • Author(s): Kiya M、Tamura Y、Takeno K、Someya Y、Kakehi S、Sato M、Yamasaki N、Kadowaki S、Suzuki R、Furukawa Y、Sugimoto D、Kaga H、Funayama T、Nishitani-Y M、Shimada K、Daida H、Aoki S、Satoh H、Kawamori R、Watada H
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 106 Issue: 5 Pages: e2228-e2238
  • DOI: 10.1210/clinem/dgab037
  • Peer Reviewed
• [Journal Article] Fast walking is a preventive factor against new-onset diabetes mellitus in a large cohort from a Japanese general population (2021)
  • Author(s): Iwasaki M, Kudo A, Asahi K, Machii N, Iseki K, Satoh H, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M
  • Journal Title: Sci Rep Volume: 11(1) Issue: 1 Pages: 716-716
  • DOI: 10.1038/s41598-020-80572-y
  • Peer Reviewed / Open Access
• [Journal Article] Influence of post-disaster evacuation on incidence of hyperuricemia in residents of Fukushima Prefecture: the Fukushima Health Management Survey (2020)
  • Author(s): Hashimoto S, Nagai M, Ohira T, Fukuma S, Hosoya M, Yasumura S, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Kawasaki Y, Takahashi A, Okazaki K, Kobashi G, Kamiya K, Yamashita S, Fukuhara SI, Ohto H
  • Journal Title: Clinical and Experimental Nephrology Volume: 24 Issue: 11 Pages: 1025-1032
  • DOI: 10.1007/s10157-020-01924-6
  • NAID: 120006890696
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non-obese men. (2020)
  • Author(s): Kaga H, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Suzuki R, Sugimoto D, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Sato H, Kawamori R, Watada H.
  • Journal Title: J Diabetes Investig. Volume: . Issue: 4 Pages: 874-877
  • DOI: 10.1111/jdi.13227
  • Peer Reviewed / Open Access
• [Journal Article] Conversion of pancreatic α cells into insulin-producing cells modulated by β-cell insufficiency and supplemental insulin administration (2020)
  • Author(s): Katahira T, Miyatsuka T, Miura M, Suzuki L, Himuro M, Nishida Y, Satoh H, Watada H
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 521 Issue: 1 Pages: 178-183
  • DOI: 10.1016/j.bbrc.2019.10.100
  • Peer Reviewed
• [Journal Article] Influence of Post-Disaster Evacuation on Childhood Obesity and Hyperlipidemia (2020)
  • Author(s): Kawasaki Y, Nakano H, Hosoya M, Yasumura S, Ohira T, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Takahashi A, Kobashi G, Kamiya K.
  • Journal Title: Pediatr Int Volume: - Issue: 6 Pages: 669-676
  • DOI: 10.1111/ped.14162
  • NAID: 120007118663
  • Peer Reviewed
• [Journal Article] Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes (2020)
  • Author(s): Kobayashi M, Satoh H, Matsuo T, Kusunoki Y, Tokushima M, Watada H, Namba M, Kitamura T
  • Journal Title: Endocrine Journal Volume: 67 Issue: 9 Pages: 903-922
  • DOI: 10.1507/endocrj.EJ20-0079
  • NAID: 130007910110
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Lower intake of saturated fatty acids is associated with persistently higher arterial stiffness in patients with type 2 diabetes (2020)
  • Author(s): Mita T, Someya Y, Osonoi Y, Osonoi T, Saito M, Nakayama S, Ishida H, Sato H, Gosho M, Watada H
  • Journal Title: Journal of Diabetes Investigation Volume: 12 Issue: 2 Pages: 226-233
  • DOI: 10.1111/jdi.13347
  • Peer Reviewed
• [Journal Article] Ingestion of an exogenous ketone monoester improves the glycemic response during oral glucose tolerance test in individuals with impaired glucose tolerance: A cross‐over randomized trial (2020)
  • Author(s): Nakagata T, Tamura Y, Kaga H, Sato M, Yamasaki N, Someya Y, Kadowaki S, Sugimoto D, Satoh H, Kawamori R, Watada H
  • Journal Title: Journal of Diabetes Investigation Volume: － Issue: 5 Pages: 756-762
  • DOI: 10.1111/jdi.13423
  • Peer Reviewed
• [Journal Article] Fukushima Health Management Survey. Relationship between the prevalence of polycythemia and factors observed in the mental health and lifestyle survey after the Great East Japan Earthquake. (2020)
  • Author(s): Sakai A, Nakano H, Ohira T, Maeda M, Okazaki K, Takahashi A, Kawasaki Y, Satoh H, Ohtsuru A, Shimabukuro M, Kazama J, Hashimoto S, Hosoya M, Yasumura S, Yabe H, Ohto H, Kamiya K
  • Journal Title: Medicine (Baltimore) Volume: 99 Issue: 1 Pages: e18486-e18486
  • DOI: 10.1097/md.0000000000018486
  • Peer Reviewed
• [Journal Article] Characteristics associated with elevated 1-h plasma glucose levels during a 75-g oral glucose tolerance test in non-obese Japanese men. (2020)
  • Author(s): Sato M, Tamura Y, Someya Y, Takeno K, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Nakagata T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Sato H, Kawamori R, Watada H.
  • Journal Title: J Diabetes Investig Volume: . Issue: 6 Pages: 1520-1523
  • DOI: 10.1111/jdi.13245
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Plasma Exchange in Thyroid Storm With Consideration of Its Distribution Into the Extravascular Space (2020)
  • Author(s): Shinohara M, Uchida T, Funayama T, Watanabe M, Kusaoi M, Yamaji K, Tamura N, Goto H, Sato H, Watada H
  • Journal Title: Journal of the Endocrine Society Volume: 4 Issue: 4
  • DOI: 10.1210/jendso/bvaa023
  • Peer Reviewed
• [Journal Article] Effect of real‐life insulin pump with predictive low‐glucose management use for 3 months: Analysis of the patients treated in a Japanese center (2020)
  • Author(s): Tsunemi A, Sato J, Kurita M, Wakabayashi Y, Waseda N, Koshibu M, Shinohara M, Ozaki A, Nakamura H, Hirano N, Ikeda F, Satoh H, Watada H
  • Journal Title: Journal of Diabetes Investigation Volume: 11 Issue: 6 Pages: 1564-1569
  • DOI: 10.1111/jdi.13288
  • Peer Reviewed
• [Journal Article] Both higher fitness level and higher current physical activity level may be required for intramyocellular lipid accumulation in non-athlete men. (2020)
  • Author(s): Yamasaki N, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Kaga H, Suzuki R, Sugimoto D, Kadowaki S, Sato M, Nakagata T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Sato H, Kawamori R, Watada H.
  • Journal Title: Sci Rep. Volume: 10 Issue: 1 Pages: 4102-4102
  • DOI: 10.1038/s41598-020-61080-5
  • Peer Reviewed / Open Access
• [Presentation] 糖尿病患者を対象とした教育入院の長期的な血糖コントロール効果の検討 (2023)
  • Author(s): 松村尚美、松井亮太、高橋徳江、岩崎裕子、田村尚子、笹渕有布、新タ記久乃、佐藤博亮
  • Organizer: 第26回日本病態栄養学会年次学術集会
• [Presentation] 1型糖尿病：血糖マネージメントに難渋した症例 ―生活環境に流されやすい患者さんへの療養支援― (2023)
  • Author(s): 佐藤博亮、北島菜緒、松村尚美、岩崎裕子、高橋徳江
  • Organizer: 第26回日本病態栄養学会年次学術集会
• [Presentation] 治療自己中断後に、膿胸を併発し甲状腺クリーゼを発症したBasedow病の１例 (2023)
  • Author(s): 江川勇太，安永光毅，関根直樹，佐藤綾子，片平雄大，小田切史徳，金森幸一郎，小谷野肇，佐藤博亮
  • Organizer: 第684回日本内科学会関東地方会
• [Presentation] SGLT2阻害薬を投与した直後に糖尿病ケトアシドーシスを発症した肥満を伴った糖尿病の１例 (2023)
  • Author(s): 中村理人，関根直樹，佐藤綾子，片平雄大，小谷野肇，佐藤博亮
  • Organizer: 第684回日本内科学会関東地方会
• [Presentation] 人工肛門の増設後に低Ca血症を来した2型糖尿病の１例 (2023)
  • Author(s): 中村理人，関根直樹，佐藤綾子，片平雄大，小谷野肇，佐藤博亮
  • Organizer: 第685回日本内科学会関東地方会
• [Presentation] 糖尿病教育入院が患者QOLと1年後の血糖コントロールに及ぼす影響についての検討 (2022)
  • Author(s): 栗田実佳，佐藤博亮，門脇聡，池田富貴，綿田裕孝
  • Organizer: 第95回日本内分泌学会学術総会
• [Presentation] 低体温症，糖尿病性ケトアシドーシスを契機に入院し，経過中に虚血性大腸炎を併発した劇症1型糖尿病の1例 (2022)
  • Author(s): 神後宏一，池田恒基，高木理恵，古屋翔子，松橋瑛子，登坂祐佳，小谷野肇，佐藤博亮
  • Organizer: 第678回日本内科学会関東地方会
• [Presentation] A case of isolated ACTH deficiency without adrenal Insufficiency due to concomitant with subclinical Cushing’s syndrome (2022)
  • Author(s): Koki Ikeda, Shoko Furuya, Eri Takagi, Eiko Matsuhashi, Yuka Tosaka, Hajime Koyano, Hiroaki Satoh
  • Organizer: ACP (米国内科学会) 日本支部年次総会2022
• [Presentation] 低体重のためCOX-2選択的阻害薬により急性腎不全を発症した緩徐進行1型糖尿病の1例 (2022)
  • Author(s): 綾目達宏，池田恒基，高木理恵，古屋翔子，松橋瑛子，登坂祐佳，小谷野肇，佐藤博亮
  • Organizer: 第679回日本内科学会関東地方会
• [Presentation] 健診で肝機能障害を指摘されたのを契機に診断に至ったSheehan症候群の1例 (2022)
  • Author(s): 前川耀一郎，池田恒基，関根直樹，佐藤綾子，登坂祐佳，小谷野肇，佐藤博亮
  • Organizer: 第680回日本内科学会関東地方会
• [Presentation] 左腎癌に対するニボルマブ+イピリムマブ併用療法中に発症したACTH単独欠損症の1例 (2022)
  • Author(s): 月岡雄生，池田恒基，関根直樹，佐藤綾子，登坂祐佳，小谷野肇，佐藤博亮
  • Organizer: 第681回日本内科学会関東地方会
• [Presentation] 腫瘍の局在診断に苦慮した先端巨大症の1例 (2022)
  • Author(s): 高木恵理，古屋翔子，安永光毅，関根直樹，佐藤綾子，松橋瑛子，登坂祐佳，小谷野肇，佐藤博亮
  • Organizer: 第681回日本内科学会関東地方会
• [Presentation] 複合的な要因で出現した低Na血症の1例 (2022)
  • Author(s): 飯島柚香，池田恒基，関根直樹，佐藤綾子，片平雄大，登坂祐佳，小谷野肇，佐藤博亮
  • Organizer: 第682回日本内科学会関東地方会
• [Presentation] 新型コロナウイルス感染症拡大予防のためのマスク着用生活により発見が遅れた先端巨大症の1例 (2022)
  • Author(s): 金井彩音，安永光毅，関根直樹，佐藤綾子，片平雄大，小谷野肇，佐藤博亮
  • Organizer: 第683回日本内科学会関東地方会
• [Presentation] 局在診断に難渋した褐色細胞腫の1例 (2022)
  • Author(s): 関根直樹，安永光毅，佐藤綾子，片平雄大，小谷野肇，佐藤博亮
  • Organizer: 第683回日本内科学会関東地方会
• [Presentation] Basedow病加療中に急性発症1型糖尿病を発症した多先性自己免疫症候群3A型の1例 (2022)
  • Author(s): 川角佑，登坂祐佳，高木理恵，古屋翔子，松橋瑛子，小谷野肇，佐藤博亮
  • Organizer: 第676回日本内科学会関東地方会
• [Presentation] 1型糖尿病患者の食事，睡眠，身体活動量，治療実態とQuality of Life (QOL)との関連性のコホート調査 (2021)
  • Author(s): 小澁真実，佐藤淳子，栗田実佳，常見亜佐子，若林侑香，氷室美和，鵜澤博嗣，門脇聡，中島健一，青山周平，古川康彦，加賀英義，飯田雅，舩山崇，後藤広昌，西田友哉，三田智也，内田豊義，田村好史，宮塚健，清水友章，荻原健，金澤昭雄，麻生克己，佐藤博亮，綿田裕孝
  • Organizer: 第64回日本糖尿病学会年次学術集会
• [Presentation] 低左心機能を呈したカテコラミン心筋症合併褐色細胞腫の1例 (2021)
  • Author(s): 登坂祐佳、林祐未、松橋瑛子、森谷千尋、小谷野肇、佐藤博亮
  • Organizer: 第31回臨床内分泌Update
• [Presentation] 糖尿病教育入院と栄養指導の効果について (2021)
  • Author(s): 松村尚美、高橋徳江、岩崎裕子、田村尚子、笹渕有布、上野千佳子、岩崎美咲、佐藤めぐみ、佐藤博亮、小谷野肇、登坂祐佳
  • Organizer: 第24回・第25回日本病態栄養学会年次学術集会
• [Presentation] 糖尿病教育入院中に発見された副腎偶発腫瘍を契機に診断に至ったサブクリニカルCusing症候群の1例 (2021)
  • Author(s): 古屋翔子，佐藤博亮，栗田実佳、門脇聡，綿田裕孝
  • Organizer: 第674回日本内科学会関東地方会
• [Presentation] The 7-Day Diabetes Education Hospitalization Program Improves Quality of Life and Treatment Satisfaction (2020)
  • Author(s): Kurita M, Satoh H, Kadowaki S, Watada H
  • Organizer: 80th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] The Impact of Visulalizing Macronutrient content via Food-Long App “Calomeal” on glycemic Control and QoL in People with Thpe 2 Diabetes (2020)
  • Author(s): Tsunemi A, Sato J, Enomoto M, Iwagaki Y, Sugimoto S, Someya Y, Kiya M, Matsuhashi E, Wakabayashi Y, Funayama T, Uchida T, Miyatsuka T, Azuma K, Shimizu T, Satoh H, Kanazawa A, Watada H
  • Organizer: 80th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Coexistence of Hypoadiponectinemia and Impaired Adipose Tissue Insulin Sensitivity Increases the Risk of Metabolic Abnomality Due to Muscle Insulin Resistance in Nonobese Japanese Men (2020)
  • Author(s): Kiya M, Tamura Y, Takeno K, Someya Y, Kakehi S, Sato M, Yamasaki N, Kadowaki S, Suzuki R, Furukawa Y, Sugimoto D, Kaga H, Funayama T, Satoh H, Kawamori R, Watada H
  • Organizer: 80th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] 糖尿病教育入院中に血清Cペプチド・インスリン濃度の乖離から発見されたインスリン抗体陽性の2型糖尿病の1例 (2020)
  • Author(s): 金井晶子，佐藤博亮，栗田実佳、吉田千紗，綿田裕孝
  • Organizer: 第662回日本内科学会関東地方会
• [Presentation] 糖尿病教育入院がQOLに及ぼす影響についての検討 (2020)
  • Author(s): 栗田実佳，佐藤博亮，吉田千紗，門脇聡，綿田裕孝
  • Organizer: 第63回日本糖尿病学会年次学術集会
• [Presentation] 食事記録アプリが2型糖尿病患者の食習慣および血糖コントロールに与える影響 (2020)
  • Author(s): 常見亜佐子，佐藤淳子，杉本栄，幸由布子，榎本真理，木屋舞，松橋瑛子，若林侑香，船山崇，内田豊義，宮塚健，東浩介，清水友章，佐藤博亮，金澤昭雄，綿田裕孝
  • Organizer: 第63回日本糖尿病学会年次学術集会
• [Presentation] 非肥満男性の脂肪機能異常（低アディポネクチン血症と脂肪インスリン抵抗性の併存）は，脂肪肝や筋インスリン抵抗性と関連する (2020)
  • Author(s): 木屋舞，田村好史，竹野影海，染谷由希，筧佐織，佐藤元律，山崎望，門脇聡，鈴木瑠璃子，古川康彦，杉本大介，加賀英義，船山崇，佐藤博亮，河盛隆造，綿田裕孝
  • Organizer: 第63回日本糖尿病学会年次学術集会
• [Presentation] 糖尿病教育入院中にKallman症候群の診断に至った糖尿病の1症例 (2020)
  • Author(s): 門脇聡，佐藤博亮，栗田実佳，尾崎敦子，綿田裕孝
  • Organizer: 第30回臨床内分泌代謝Update