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Computer modeling of cardiac conduction system for arrhythmia research and implantable device testing

Research Project

Project/Area Number 20K12046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 62010:Life, health and medical informatics-related
Research InstitutionThe University of Aizu

Principal Investigator

Maxim・V Ryzhii  会津大学, コンピュータ理工学部, 上級准教授 (50254082)

Project Period (FY) 2020-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsatrioventricular node / rabbit heart model / Aliev-Panfilov model / dual pathway / AVNRT / Wenckebach periodicity / ECG / MATLAB / cardiac conduction curve / coupling asymmetry / retrograde conduction / ladder diagram / Corrado-Niederer / Aliev-Panfilov / "natural pacemaker" / "nonlinear equation" / "dual pathway" / "cardiac model" / intestine / "sinoatrial node" / Mitchell-Schaeffer / pacemaker / nonlinear equation / oscillator / cardiac model / arrhythmia / computer modeling / conduction system / implantable device
Outline of Research at the Start

We are going to develop a simple comprehensive computer model of conduction system of the heart for implantable pacemaker testing and cardiac arrhythmia study. Using the developed model, we will perform various computer simulations of the cardiac rhythm disturbances, and investigate possible methods of their control.

Outline of Annual Research Achievements

* Using our AV node model we studied the onset of typical and atypical forms of atrioventricular nodal reentrant tachycardia (AVNRT) and revealed their origin and clinical incidence. We demonstrated for the first time using computer simulations that differences in the effective refractory periods of slow and fast pathways during anterograde and retrograde conduction determine
the type of AVNRT. The obtained results explain significant prevalence of the typical type over atypical one.
* We simulated Wenckebach patterns with our AV node model and revealed the domination of atypical Wenckebach forms with high AV conduction ratios at lower atrial pacing rates. We observed that Wenckebach phenomenon occurs at regular atrial pacing rhythms with cycles shorter than effective refractory periods of fast pathway, more precisely, shorter than the point of transition of conduction from fast to slow pathway. The Wenckebach patterns are formed around the penetrating bundle, where the most pronounced increase of atria-His and His-His interval delays occur.
* We proposed a novel model for generating synthetic ECG, combining AV node with dual pathways, Bachmann’s bandle, and muscle responses. Using the model, we reproduced several cardiac scenarios: tachycardia, AVNRT, atrial fibrillation, and atrial flutter with Wenckebach patterns formation. The model provides a unique possibility to reproduce cardiac conduction scenarios simultaneously as electrical signals inside the cardiac conduction system and outside the body in the form of ECG for better understanding of cardiac electrophysiology.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

Using our previously developed model for pacemaking variant of excitable Aliev-Panfilov cardiac cell model, and our compact atrioventricular node (AVN) model for rabbit heart with dual pathway structure, we performed preliminary study of atrioventricular reentrant tachycardia (AVNRT) and formation of Wenckebach periodicity. We also developed a new model for synthetic ECG simulation based on the combination of our compact AVN model for rabbit heart and previously developed cardiac muscle response model. The results were presented at Computing in Cardiology 2023 and IEEE Int. Conference on Bioinformatics and Biomedicine (BIBM 2023). The pertinent inhouse MATLAB software was developed.

Strategy for Future Research Activity

We are in a process of a new improved model development for the rabbit AV node under the influence of autonomic nervous system (ANS). Using the improved AV node model, we are going to consider and simulate the following cardiac phenomena: (a) the onset, sustainability and spontaneous termination of the atrioventricular nodal reentrant tachycardia (AVNRT), (b) influence of ANS on the AV node filtering properties during atrial fibrillation, (c) transformation of Wenckebach patterns under the influence of ANS, (d) further development of our ECG simulation models, including simplest human three-oscillator model and more detailed rabbit AV node model based on modified Aliev-Panfilov equation, to provide wider functionality and detalization with the aim of their future hardware implementation.

Report

(4 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (21 results)

All 2023 2022 2021 2020 Other

All Journal Article (9 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (6 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Remarks (6 results)

  • [Journal Article] Revealing the Origin of Typical and Atypical Forms of Atrioventricular Nodal Reentrant Tachycardia with a Compact Computer Model of Rabbit AV Node2023

    • Author(s)
      Ryzhii Maxim、Ryzhii Elena
    • Journal Title

      IEEE Conference Proceedings (IEEE Conf Proc)

      Volume: 2023 Pages: 1-4

    • DOI

      10.22489/cinc.2023.080

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Formation of the Wenckebach Periodicity in a Mathematical Model of Rabbit AV Node2023

    • Author(s)
      E. Ryzhii and M. Ryzhii
    • Journal Title

      IEEE Conference Proceedings (IEEE Conf Proc)

      Volume: 2023 Pages: 1-4

    • DOI

      10.22489/cinc.2023.320

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simulation of ECG Using a Rabbit Cardiac Conduction Model with Dual-Pathway Atrioventricular Node2023

    • Author(s)
      Ryzhii Maxim、Ryzhii Elena
    • Journal Title

      Proceedings - 2023 IEEE Int. Conf. on Bioinformatics and Biomedicine, BIBM 2023

      Volume: 196805 Pages: 2197-2200

    • DOI

      10.1109/bibm58861.2023.10385295

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A compact multi-functional model of the rabbit atrioventricular node with dual pathways2023

    • Author(s)
      M. Ryzhii and E. Ryzhii
    • Journal Title

      Frontiers in Physiology

      Volume: 14 Pages: 1126648-1126648

    • DOI

      10.3389/fphys.2023.1126648

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pacemaking function of two simplified cell models2022

    • Author(s)
      M. Ryzhii and E. Ryzhii
    • Journal Title

      PLOS One

      Volume: 17(4) Issue: 4 Pages: e0257935-e0257935

    • DOI

      10.1371/journal.pone.0257935

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of Responses of Ion-Channel and Simplified Pacemaker Cell Models on External Stimulation2021

    • Author(s)
      M. Ryzhii and E. Ryzhii
    • Journal Title

      Proceedings - 2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021

      Volume: 176400 Pages: 2855-2861

    • DOI

      10.1109/bibm52615.2021.9669353

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pacemaking function of two simplified cell models2021

    • Author(s)
      M. Ryzhii and E. Ryzhii
    • Journal Title

      BioRxiv preprint server

      Volume: online

    • DOI

      10.1101/2021.09.14.460406

    • Related Report
      2021 Research-status Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Simulation of the Effect of AC stimulation on Atrioventricular Node with Nonlinear Model2020

    • Author(s)
      M. Ryzhii, E. Ryzhii
    • Journal Title

      Proc. of 11th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)

      Volume: - Pages: 9158159-9158159

    • DOI

      10.1109/esgco49734.2020.9158159

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simulation of ectopic activity onset in border zones between normal and damaged myocardium with minimal ionic models2020

    • Author(s)
      Ryzhii Maxim、Ryzhii Elena
    • Journal Title

      2020 Computing in Cardiology, CinC 2020

      Volume: 167094 Pages: 9344249-9344249

    • DOI

      10.22489/cinc.2020.142

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Revealing the Origin of Typical and Atypical Forms of Atrioventricular Nodal Reentrant Tachycardia with a Compact Computer Model of Rabbit AV Node2023

    • Author(s)
      M. Ryzhii
    • Organizer
      Computing in Cardiology 2023, 50th Computing in Cardiology, CinC 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Formation of the Wenckebach Periodicity in a Mathematical Model of Rabbit AV Node2023

    • Author(s)
      M. Ryzhii
    • Organizer
      Computing in Cardiology 2023, 50th Computing in Cardiology, CinC 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simulation of ECG Using a Rabbit Cardiac Conduction Model with Dual-Pathway Atrioventricular Node2023

    • Author(s)
      M. Ryzhii
    • Organizer
      Proceedings - 2023 IEEE Int. Conf. on Bioinformatics and Biomedicine, BIBM 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of Responses of Ion-Channel and Simplified Pacemaker Cell Models on External Stimulation2021

    • Author(s)
      M. Ryzhii
    • Organizer
      2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Simulation of the Effect of AC stimulation on Atrioventricular Node with Nonlinear Model2020

    • Author(s)
      Ryzhii Maxim
    • Organizer
      11th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Simulation of Ectopic Activity Onset in Border Zones between Normal and Damaged Myocardium with Minimal Ionic Models2020

    • Author(s)
      Ryzhii Maxim
    • Organizer
      2020 Computing in Cardiology, CinC 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] MATLAB and CellML source codes for PLOS One, 2022

    • URL

      https://github.com/mryzhii/Simplified-pacemaker-cell-models

    • Related Report
      2022 Research-status Report
  • [Remarks] MATLAB source code for Front. Physiol. 2023

    • URL

      https://github.com/mryzhii/Compact-model-of-Rabbit-AV-node

    • Related Report
      2022 Research-status Report
  • [Remarks] MATLAB source code for Front. Physiol. 2023

    • URL

      https://doi.org/10.6084/m9.figshare.22015289.v1

    • Related Report
      2022 Research-status Report
  • [Remarks] Video presented at IEEE BIBM 2021 Conference

    • URL

      https://u-aizu.ac.jp/labs/cs-csm/mr/video/BIBM2021_presentation.mp4

    • Related Report
      2021 Research-status Report
  • [Remarks] MATLAB and CellML codes for models at GitHub

    • URL

      https://github.com/mryzhii/Simplified-pacemaker-cell-models

    • Related Report
      2021 Research-status Report
  • [Remarks] Video presentation at CinC 2020 Conference

    • URL

      https://www.u-aizu.ac.jp/labs/cs-csm/mr/video/CINC2020_142.mp4

    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-12-25  

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