Development of an objective MDD screening system adopting autonomic nervous responses to mental tasks

• Project/Area Number: 20K12603
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: Matsui Takemi 東京都立大学, システムデザイン研究科, 教授 (50404934)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生体医工学 / 生体情報 / ストレス

Outline of Research at the Start

うつ病は、医師の問診により診断されるため、その技量等に影響される。本申請研究協力者は、うつ病患者と健常者では精神負荷に対する自律神経応答が異なることを報告している。
本研究では、ニューラルネットワーク等の判別アルゴリズムを用い、うつ病か健常かの判別だけではなく、それらの程度の把握を試み、主観ではなく客観的な数値による、うつ病スクリーニング法の確立を目指す。自律神経応答は指尖光電脈波や心電図より把握できるため、試作するシステムは低コストでの製作が可能である。本システムは精神科を専門としない産業医の診療補助としての使用、また在宅での使用、潜在的うつ病患者の精神科受診促進への応用が期待される。

Outline of Final Research Achievements

In this research, we aimed to establish a method that screens patients with depression from healthy people without being influenced by the relationship between patients and doctors and a subjective diagnosis made by them based on their experiences.
We developed an automatic prototype system instructing subjects to speak out random numbers as a mental burden and obtained heart rate waves using a photoplethysmograph sensor. Also, we created an algorithm that discriminated patients with depression from healthy subjects using Linear Discriminant Analysis.We conducted the screening test with patients at a mental hospital and control subjects at our university. Due to unstable heart rate measurements, we had poor results, so we installed machine learning to our algorithm and successfully obtained high accuracy in discrimination.

Academic Significance and Societal Importance of the Research Achievements

うつ病診断は、アンケートや医師の問診により行われるが、主観に基づくアンケートの信頼性は高くなく、また問診は医師自身の経験に大きく左右される。そこで、本研究では、うつ病患者と健常者で異なる精神負荷に対する自律神経応答から、判別を行った。個人差が大きい自律神経応答に対し、機械学習を用いたアルゴリズムを構築することで、高精度な判別を可能とした。本システムは精神科のみならず、うつ病罹患者の在宅で自身の状態確認や、専門ではない産業医の診療補助として使用が考えられる。客観的数値により、産業医の精神科専門医への受診促進、潜在的うつ病患者の受診促進への応用が期待される。

Research Products

• [Journal Article] A medical radar system for non-contact vital sign monitoring and clinical performance evaluation in hospitalized older patients (2022)
  • Author(s): Yen Hoang Thi、Kurosawa Masaki、Kirimoto Tetsuo、Hakozaki Yukiya、Matsui Takemi、Sun Guanghao
  • Journal Title: Biomedical Signal Processing and Control Volume: 75 Pages: 103597-103597
  • DOI: 10.1016/j.bspc.2022.103597
  • Peer Reviewed / Open Access
• [Journal Article] Development of a Novel Vital-Signs-Based Infection Screening Composite-Type Camera With Truncus Motion Removal Algorithm to Detect COVID-19 Within 10 Seconds and Its Clinical Validation (2022)
  • Author(s): Unursaikhan B., Amarsanaa G., Sun G., Hashimoto K., Purevsuren O., Choimaa L., Matsui T.
  • Journal Title: Frontiers in Physiology, section Computational Physiology and Medicine Volume: 13: 905931
  • DOI: 10.3389/fphys.2022.905931
  • Peer Reviewed / Open Access
• [Journal Article] The development and clinical application of a novel schizophrenia screening system using yoga-induced autonomic nervous system responses (2022)
  • Author(s): Inoue T, Shinba T, Itokawa M, Sun G, Nishikawa M, Miyashita M, Suzuki K, Kariya N, Arai M, Matsui T.
  • Journal Title: Frontiers in Physiology Volume: 13 Pages: 902979-902979
  • DOI: 10.3389/fphys.2022.902979
  • Peer Reviewed / Open Access
• [Journal Article] Remote sensing of vital signs by medical radar time-series signal using cardiac peak extraction and adaptive peak detection algorithm: Performance validation on healthy adults and application to neonatal monitoring at an NICU (2022)
  • Author(s): Edanami K., Kurosawa M., Yen H. T., Kanazawa T., Abe Y., Kirimoto T., Yao Y., Matsui T., Sun G.
  • Journal Title: Computer Methods and Programs in Biomedicine Volume: 226: 107163 Pages: 107163-107163
  • DOI: 10.1016/j.cmpb.2022.107163
  • Peer Reviewed / Open Access
• [Journal Article] Development of a Novel Web Camera-Based Contact-Free Major Depressive Disorder Screening System Using Autonomic Nervous Responses Induced by a Mental Task and its Clinical Application (2021)
  • Author(s): Unursaikhan B, Tanaka N, Sun G, Watanabe S, Yoshii M, Funahashi K, Sekimoto F, Hayashibara F, Yoshizawa Y, Choimaa L, Matsui T
  • Journal Title: Frontiers in Physiology, section Computational Physiology and Medicine Volume: -
  • DOI: 10.3389/fphys.2021.642986
  • Peer Reviewed / Open Access
• [Journal Article] Return-to-Work Screening by Linear Discriminant Analysis of Heart Rate Variability Indices in Depressed Subjects. (2021)
  • Author(s): Shinba T, Murotsu K, Usui Y, Andow Y, Terada H, Kariya N, Tatebayashi Y, Matsuda Y, Mugishima G, Shinba Y, Sun G, Matsui T.
  • Journal Title: Sensors Volume: 21 Issue: 15 Pages: 5177-5177
  • DOI: 10.3390/s21155177
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Changes in Heart Rate Variability after Yoga are Dependent on Heart Rate Variability at Baseline and during Yoga: A Study Showing Normalization Effect in Yoga-Naive and Experienced Subject (2020)
  • Author(s): Shinba, T., Inoue, T., Matsui, T., Kimura, K. K., Itokawa, M, Arai, M.
  • Journal Title: International Journal of Yoga Volume: 13(2) Issue: 2 Pages: 160-167
  • DOI: 10.4103/ijoy.ijoy_39_19
  • Peer Reviewed / Open Access
• [Journal Article] 自律神経応答のみを用いたうつ病スクリーニング (2020)
  • Author(s): 松井岳巳
  • Journal Title: 日本官能評価学会 Volume: 24(1) Pages: 1-4
• [Journal Article] Contactless vital signs measurement system using RGB-thermal image sensors and its clinical screening test on patients with seasonal influenza (2020)
  • Author(s): Negishi, T., Abe, S., Matsui, T., Liu, H., Kurosawa, M., Kirimoto, T., Sun, G.
  • Journal Title: Sensors (Basel) Volume: 20(8) Issue: 8 Pages: 2171-2171
  • DOI: 10.3390/s20082171
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Usefulness of heart rate variability indices in assessing the risk of an unsuccessful return to work after sick leave in depressed patients (2020)
  • Author(s): Shinba, T., Murotsu, K., Usui, Y., Andow, Y., Terada, H., Takahashi, M., Takii, R., Urita, M., Sakuragawa, S., Mochizuki, M., Kariya, N., Matsuda, S., Obara, Y., Matsuda, H., Tatebayashi, Y., Matsuda, Y., Mugishima, G., Nedachi, T., Sun, G., Inoue, T., Matsui, T.
  • Journal Title: Neuropsychopharmacology Reports Volume: 40 Issue: 3 Pages: 239-245
  • DOI: 10.1002/npr2.12121
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Pneumonia Screening System based on Parasympathetic Activity Monitoring in Non-contact Way using Compact Radars Beneath the Bed Mattress. (2020)
  • Author(s): Matsui, T., Kobayashi, T., Hirano, M., Kanda, M., Sun, G., Otake, Y., Okada, M., Watanabe, S., Hakozaki, Y.
  • Journal Title: Journal of Infection Volume: 81(2) Issue: 2 Pages: 142-144
  • DOI: 10.1016/j.jinf.2020.06.002
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of Epidemiological Map using an Internet of Things Infectious Disease Surveillance Platform (2020)
  • Author(s): Sun, G., Nguyen, V. T., Le, T. H., Pham, T. H., Ishibashi, K., Matsui, T.
  • Journal Title: Critical Care Volume: 24 Issue: 1 Pages: 400-400
  • DOI: 10.1186/s13054-020-03132-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development and Clinical Application of a Novel Non-contact Early Airflow Limitation Screening System using an Infrared Time-of-flight Depth Image Sensor (2020)
  • Author(s): Takamoto, H., Nishine, H., Sato, S., Sun, G., Watanabe, S., Seokjin, K., Asai, M., Mineshita, M., Matsui, T.
  • Journal Title: Frontiers in Physiology Volume: 11 Pages: 552942-552942
  • DOI: 10.3389/fphys.2020.552942
  • Peer Reviewed / Open Access
• [Presentation] 心拍変動指数を用いた判別分析によるうつ病診断とシステム開発 (2022)
  • Author(s): 松井岳巳
  • Organizer: 第118回日本精神神経学会学術総会
• [Presentation] 在宅高齢者看取り支援のためのチェーンストークス呼吸非接触・自動検出システムの開発と臨床応用 (2022)
  • Author(s): 齋藤晶斗，神田雅大，孫光鎬，箱崎幸也，松井岳巳
  • Organizer: 第61回日本生体医工学会大会
• [Presentation] スマートフォンカメラで求めた子猫動画視聴時の自律神経応答を用いたうつ病スクリーニングシステムの開発 (2022)
  • Author(s): 劉双語，井上智子，宮崎伸一，林原史明，佐藤正平，榛葉俊一，仮屋暢聡，孫光鎬，松井岳巳
  • Organizer: 第52回人間工学会関東支部大会
• [Presentation] 精神負荷時の自律神経応答を用いたうつ病・統合失調症スクリーニング--精神負荷としてのヨーガ (2021)
  • Author(s): 松井岳巳
  • Organizer: 第19回日本ヨーガ療法学会研究総会沖縄大会
• [Presentation] 睡眠中の自律神経応答を用いた腕時計・24 時間・メンタルホルターの開発と治療効果推定 (2021)
  • Author(s): 平塚巧真，小原右輔，仮屋暢聡，孫光縞，榛葉俊一，井上智子，松井岳巳
  • Organizer: 第60回日本生体医工学会
• [Presentation] ヨーガ療法による自律神経応答を用いた統合失調症の新規スクリーニングシステムの開発 (2021)
  • Author(s): 井上智子，榛葉俊一，糸川昌成，孫光鎬，西川真帆，仮屋暢聡，宮下光弘，鈴木浩一，堀内泰江，鳥海和也，吉川茜，宮野康寛，石田裕昭，新井誠，松井岳巳
  • Organizer: 第62回日本心身医学会総会
• [Presentation] 汗腺支配の交感神経バーストと末梢皮膚温に着目した腕時計型うつ病スクリーニングシステムの臨床応用 (2021)
  • Author(s): 長谷川拳也，松井岳巳，小原右輔，仮屋暢聡，孫光縞，榛葉俊一，井上智子
  • Organizer: 第117回日本精神神経学会学術総会
• [Presentation] A Non-contact Spirometer with Time-of-Flight Sensor for Assessment of Pulmonary Function (2020)
  • Author(s): Sakamoto, H., Sun, G., Takamoto, H., Matsui, T., Kirimoto T.
  • Organizer: The 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society
• [Presentation] 独立成分分析による10GHz帯と24GHz帯域ドップラーレーダから計測された心拍・呼吸信号の分離法 (2020)
  • Author(s): 枝並佳佑，孫光鎬，桐本哲郎，黒沢正樹，松井岳巳
  • Organizer: 第59回 日本生体医工学会大会
• [Presentation] CCDカメラのRGB3信号を用いた非接触脈波信号の計測法 (2020)
  • Author(s): 西川真帆，孫光鎬，榛葉俊一，松井岳巳，桐本哲郎
  • Organizer: 第59回 日本生体医工学会大会
• [Presentation] 睡眠中の自律神経応答を用いた腕時計型・24 時間メンタル・ホルターの開発とうつ病スクリーニング精度評価 (2020)
  • Author(s): 平塚巧真，松井岳巳，小原右輔，仮屋暢聡，孫光縞，榛葉俊一，井上智子
  • Organizer: 第116回日本精神神経学会学術総会
• [Remarks] 松井研究室ホームページ
  • URL: https://www.comp.sd.tmu.ac.jp/matsui-lab/index.html