RAPID support system using perfusion imaging in endovascular suite to acute stroke

• Project/Area Number: 20K12707
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: INOUE MANABU 国立研究開発法人国立循環器病研究センター, 病院, 医長 (60439362)
• Co-Investigator(Kenkyū-buntansha): 古賀 政利 国立研究開発法人国立循環器病研究センター, 病院, 部長 (30512230) ; 豊田 一則 国立研究開発法人国立循環器病研究センター, 病院, 副院長 (50275450)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳梗塞 / 画像診断 / 灌流画像 / CT / MRI / 急性期脳梗塞 / CT灌流画像 / 血管造影検査 / 再灌流療法 / 血栓回収療法

Outline of Research at the Start

急性期脳梗塞症例を脳血管撮影室内にて必要とされる全ての画像診断を行い、最短で診断/治療につながる診療支援システムを構築することにある。本研究で構築されたシステム（DSA室内で全て完結）と従来の診療システム(頭部単純CTからDSA室もしくは頭部MRIからDSA室)を比較検討する。両者の90日後の脳梗塞の重症度を示すNational Institutes of Health Stroke Scale(NIHSS)と日常生活自立度であるmodifid Rankin Scale (ｍRS)、生活の質を評価するNeuro-QOLをもって、最終的な予後転帰を比較検討する。

Outline of Final Research Achievements

The research was to construct a system to transport suspected acute stroke patients directly to the catheterization room using the RAPID system, perform perfusion image analysis, and determine the indication for reperfusion therapy. However, the global coronary disaster forced the center to change its emergency consultation system in the emergency department. Therefore, we studied an IT system to share the results of analysis using CT perfusion images to the staff waiting in the catheterization room, and constructed an in-hospital system using a system that can be viewed with portable devices (smart phones and tablets).

Academic Significance and Societal Importance of the Research Achievements

本研究内容の灌流画像解析と合わせて、第47回日本脳卒中学会学術集会、第37回日本脳神経血管内治療学会学術総会、第64回日本脳循環代謝学会学術集会、第37回日本脳神経血管内治療学会学術総会で発表し，　J Am Heart Assocに論文発表した。

Research Products

• [Journal Article] Intravenous Alteplase at 0.6 mg/kg for Unknown Onset Stroke with Prior Antithrombotic Medication: THAWS Randomized Clinical Trial (2023)
  • Author(s): Koga Masatoshi、Inoue Manabu、Miwa Kaori、Yoshimura Sohei、Fukuda-Doi Mayumi、et al.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Issue: 1 Pages: 15-22
  • DOI: 10.5551/jat.63337
  • NAID: 130008163472
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2023-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Workflow Delays in Stroke Reperfusion Therapy: A Comparison between the Year-Long Pre-COVID-19 Period and the with-COVID-19 Period (2022)
  • Author(s): Yoshimoto Takeshi、Shiozawa Masayuki、Koge Junpei、Inoue Manabu、Koga Masatoshi、Ihara Masafumi、Toyoda Kazunori
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 7 Pages: 1095-1107
  • DOI: 10.5551/jat.63090
  • NAID: 130008074053
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-07-01
  • Peer Reviewed
• [Journal Article] Tenecteplase versus alteplase for large vessel occlusion recanalization (T-FLAVOR): Trial protocol (2022)
  • Author(s): Kawano H, Hirano T, Inoue M, Fukuda-Doi M, Iwasaki K, Omae K, Tanaka K, Yamamoto H, Koga M, Sakai N, Nagao T, Sasaki M, Hayakawa N, Toyoda K.
  • Journal Title: Eur Stroke J Volume: 7 Issue: 1 Pages: 71-75
  • DOI: 10.1177/23969873211070455
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endovascular Therapy for Acute Stroke with a Large Ischemic Region (2022)
  • Author(s): Yoshimura Shinichi、Sakai Nobuyuki、Yamagami Hiroshi、et al.
  • Journal Title: New England Journal of Medicine Volume: 386 Issue: 14 Pages: 1303-1313
  • DOI: 10.1056/nejmoa2118191
  • Peer Reviewed
• [Journal Article] Association Between Alberta Stroke Program Early Computed Tomography Score and Efficacy and Safety Outcomes With Endovascular Therapy in Patients With Stroke From Large-Vessel Occlusion (2022)
  • Author(s): Uchida Kazutaka、Shindo Seigo、Yoshimura Shinichi、Tet al.
  • Journal Title: JAMA Neurology Volume: 79 Issue: 12 Pages: 1260-1260
  • DOI: 10.1001/jamaneurol.2022.3285
  • Peer Reviewed
• [Journal Article] Oral Anticoagulants in the Oldest Old with Recent Stroke and Atrial Fibrillation (2021)
  • Author(s): Polymeris Alexandros A.、Macha Kosmas,,, Inoue Manabu ,,, et al
  • Journal Title: Annals of Neurology Volume: 91 Issue: 1 Pages: 78-88
  • DOI: 10.1002/ana.26267
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mechanical Thrombectomy Up to 24?Hours in Large Vessel Occlusions and Infarct Velocity Assessment (2021)
  • Author(s): Inoue Manabu、Yoshimoto Takeshi、Tanaka Kanta、Koge Junpei、Shiozawa Masayuki、Nishii Tatsuya、Ohta Yasutoshi、Fukuda Tetsuya、Satow Tetsu、Kataoka Hiroharu、Yamagami Hiroshi、Ihara Masafumi、Koga Masatoshi、Mlynash Michael、Albers Gregory W.、Toyoda Kazunori
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 24
  • DOI: 10.1161/jaha.121.022880
  • Peer Reviewed / Open Access
• [Journal Article] Blind Exchange With Mini-Pinning Technique Using the Tron Stent Retriever for Middle Cerebral Artery M2 Occlusion Thrombectomy in Acute Ischemic Stroke (2021)
  • Author(s): Yoshimoto Takeshi、Tanaka Kanta、Koge Junpei、Shiozawa Masayuki、Yamagami Hiroshi、Inoue Manabu、Kamogawa Naruhiko、Satow Tetsu、Kataoka Hiroharu、Toyoda Kazunori、Ihara Masafumi、Koga Masatoshi
  • Journal Title: Frontiers in Neurology Volume: 12
  • DOI: 10.3389/fneur.2021.667835
  • Peer Reviewed / Open Access
• [Journal Article] Mechanical Thrombectomy in Patients with a Large Ischemic Volume at Presentation: Systematic Review and Meta-Analysis (2021)
  • Author(s): Kerleroux Basile、Janot Kevin,,, Inoue Manabu,,, et al
  • Journal Title: Journal of Stroke Volume: 23 Issue: 3 Pages: 358-366
  • DOI: 10.5853/jos.2021.00724
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intensive blood pressure lowering with nicardipine and outcomes after intracerebral hemorrhage: An individual participant data systematic review (2021)
  • Author(s): Toyoda Kazunori、Yoshimura Sohei、Fukuda-Doi Mayumi,,, Inoue Manabu,,, et al
  • Journal Title: International Journal of Stroke Volume: N/A Issue: 5 Pages: 494-505
  • DOI: 10.1177/17474930211044635
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cerebral microbleeds development after stroke thrombolysis: A secondary analysis of the THAWS randomized clinical trial (2021)
  • Author(s): Kaori Miwa, Masatoshi Koga, Manabu Inoue, Sohei Yoshimura, Makoto Sasaki, Yusuke Yakushiji, Mayumi Fukuda-Doi, Yasushi Okada, Taizen Nakase, Masafumi Ihara, Yoshinari Nagakane, Shunya Takizawa, Koko Asakura, Junya Aoki, Kazumi Kimura, Haruko Yamamoto, Kazunori Toyoda
  • Journal Title: Int J Stroke Volume: - Issue: 6 Pages: 628-636
  • DOI: 10.1177/17474930211035023
  • Peer Reviewed / Open Access
• [Journal Article] Guidelines for Mechanical Thrombectomy in Japan, the Fourth Edition, March 2020: A Guideline from the Japan Stroke Society, the Japan Neurosurgical Society, and the Japanese Society for Neuroendovascular Therapy (2021)
  • Author(s): YAMAGAMI Hiroshi、HAYAKAWA Mikito、INOUE Manabu、IIHARA Koji、OGASAWARA Kuniaki、TOYODA Kazunori、HASEGAWA Yasuhiro、OHATA Kenji、SHIOKAWA Yoshiaki、NOZAKI Kazuhiko、EZURA Masayuki、IWAMA Toru、JSS/JNS/JSNET Joint Guideline Authoring Committee
  • Journal Title: Neurologia medico-chirurgica Volume: 61 Issue: 3 Pages: 163-192
  • DOI: 10.2176/nmc.nmc.st.2020-0357
  • NAID: 130007998630
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Magnetic Resonance Imaging?Guided Thrombolysis (0.6 mg/kg) Was Beneficial for Unknown Onset Stroke Above a Certain Core Size (2021)
  • Author(s): Toyoda Kazunori、Inoue Manabu、Yoshimura Sohei、et al
  • Journal Title: Stroke Volume: 52 Issue: 1 Pages: 12-19
  • DOI: 10.1161/strokeaha.120.030848
  • Peer Reviewed
• [Journal Article] 特集 急性期脳梗塞診断と治療法の進歩─ Time is brain からImaging is brain へ─ 急性期脳梗塞の画像診断における灌流画像の意義 (2020)
  • Author(s): 井上 学
  • Journal Title: 画像診断 Volume: 40 Issue: 14 Pages: 1437-1448
  • DOI: 10.15105/GZ.0000002005
  • ISSN: 0285-0524, 2432-1281
  • Year and Date: 2020-11-25
• [Journal Article] A nomogram to predict unfavourable outcome in patients receiving oral anticoagulants for atrial fibrillation after stroke (2020)
  • Author(s): Cappellari Manuel、Seiffge David J、Koga Masatoshi、...、Inoue Manabu、lToyoda Kazunori、Engelter Stefan T、De Marchis GM、on behalf of the SAMURAI-NVAF, RAF-NOAC, NOACISP LONG-TERM, and Verona Study Groups
  • Journal Title: European Stroke Journal Volume: 5 Issue: 4 Pages: 384-393
  • DOI: 10.1177/2396987320945840
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identifying large ischemic core volume ranges in acute stroke that can benefit from mechanical thrombectomy (2020)
  • Author(s): Yoshimoto Takeshi、Inoue Manabu、Tanaka Kanta、Kanemaru Kodai、Koge Junpei、Shiozawa Masayuki、Kamogawa Naruhiko、Kimura Shunsuke、Chiba Tetsuya、Satow Tetsu、Takahashi Jun C、Toyoda Kazunori、Koga Masatoshi、Ihara Masafumi
  • Journal Title: Journal of NeuroInterventional Surgery Volume: 0 Issue: 12 Pages: 0-0
  • DOI: 10.1136/neurintsurg-2020-016934
  • Peer Reviewed
• [Journal Article] Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data (2020)
  • Author(s): Thomalla Gotz、Boutitie Florent、Ma Henry、Koga Masatoshi、Ringleb Peter、Schwamm Lee H、Wu Ona、Bendszus Martin、Bladin Christopher F、Campbell Bruce C V、Cheng Bastian、Churilov Leonid、Ebinger Martin、Endres Matthias、Fiebach Jochen B、Fukuda-Doi Mayumi、Inoue Manabu、et al
  • Journal Title: The Lancet Volume: 396 Issue: 10262 Pages: 1574-1584
  • DOI: 10.1016/s0140-6736(20)32163-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Left Atrial Size and Ischemic Events after Ischemic Stroke or Transient Ischemic Attack in Patients with Nonvalvular Atrial Fibrillation (2020)
  • Author(s): Tokunaga Keisuke、Koga Masatoshi、Yoshimura Sohei、Okada Yasushi、Yamagami Hiroshi、Todo Kenichi、Itabashi Ryo、Kimura Kazumi、Sato Shoichiro、Terasaki Tadashi、Inoue Manabu、et al
  • Journal Title: Cerebrovascular Diseases Volume: 49 Issue: 6 Pages: 619-624
  • DOI: 10.1159/000511393
  • Peer Reviewed
• [Journal Article] Stroke Care Trends During COVID-19 Pandemic in Zanjan Province, Iran. From the CASCADE Initiative: Statistical Analysis Plan and Preliminary Results (2020)
  • Author(s): Ghoreishi Abdoreza、Arsang-Jang Shahram、Sabaa-Ayoun Ziad、... 、Inoue Manabu、... 、et al
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 29 Issue: 12 Pages: 105321-105321
  • DOI: 10.1016/j.jstrokecerebrovasdis.2020.105321
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Treatment Outcomes by Initial Neurological Deficits in Acute Stroke Patients with Basilar Artery Occlusion: The RESCUE Japan Registry 2 (2020)
  • Author(s): Yoshimoto Takeshi、Tanaka Kanta、Yamagami Hiroshi、Uchida Kazutaka、Inoue Manabu、Koge Junpei、Ihara Masafumi、Toyoda Kazunori、Imamura Hirotoshi、Ohara Nobuyuki、Morimoto Takeshi、Sakai Nobuyuki、Yoshimura Shinichi
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 29 Issue: 11 Pages: 105256-105256
  • DOI: 10.1016/j.jstrokecerebrovasdis.2020.105256
  • Peer Reviewed
• [Journal Article] MRI and intravenous thrombolysis for unclear-onset stroke during the COVID-19 pandemic: a case report (2020)
  • Author(s): Kamogawa Naruhiko、Egashira Shuhei、Tanaka Kanta、Shiozawa Masayuki、Inoue Manabu、Ohta Yasutoshi、Nishii Tatsuya、Fukuda Tetsuya、Koga Masatoshi
  • Journal Title: Rinsho Shinkeigaku Volume: 60 Issue: 10 Pages: 706-711
  • DOI: 10.5692/clinicalneurol.cn-001481
  • NAID: 130007929892
  • ISSN: 0009-918X, 1882-0654
  • Peer Reviewed
• [Journal Article] Cerebral embolism accompanied by remarkable diffusion-weighted imaging reversal in a 10?month-old infant with congenital heart disease (2020)
  • Author(s): Ikenouchi Hajime、Inoue Manabu、Miwa Kaori、Yi Kenichiro、Suzuki Dai、Iwasa Toru、Toyoda Kazunori、Koga Masatoshi
  • Journal Title: eNeurologicalSci Volume: 20 Pages: 100260-100260
  • DOI: 10.1016/j.ensci.2020.100260
  • Peer Reviewed
• [Journal Article] Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE) (2020)
  • Author(s): Abootalebi Shahram, Aertker Benjamin M, Andalibi Mohammad Sobhan, Hirano Teruyuki, et al.
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 29 Issue: 9 Pages: 104938-104938
  • DOI: 10.1016/j.jstrokecerebrovasdis.2020.104938
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset (2020)
  • Author(s): Koga Masatoshi、Yamamoto Haruko、Inoue Manabu、et al.
  • Journal Title: Stroke Volume: 51 Issue: 5 Pages: 1530-1538
  • DOI: 10.1161/strokeaha.119.028127
  • Peer Reviewed
• [Journal Article] Acute cerebrovascular imaging for stroke management: a literature review (2020)
  • Author(s): Koga Masatoshi、Inoue Manabu、Sonoda Kazutaka、Tanaka Kanta、Shiozawa Masayuki、Okada Takashi、Ikenouchi Hajime、Fukuda Tetsuya、Satow Tetsu、Ihara Masafumi、Itabashi Ryo、Kudo Kohsuke、Yamagami Hiroshi、Toyoda Kazunori
  • Journal Title: Japanese Journal of Stroke Volume: 42 Issue: 6 Pages: 495-501
  • DOI: 10.3995/jstroke.10776
  • NAID: 130007942500
  • ISSN: 0912-0726, 1883-1923
  • Peer Reviewed
• [Presentation] Mechanical Thrombectomy Up to 24 Hours in Large Vessel Occlusions and COVID-19 Plenary Symposium 05 AIS1; Pre-TX Imaging debate (2022)
  • Author(s): 井上 学
  • Organizer: WFITN 2022
  • Int'l Joint Research / Invited
• [Presentation] RNF213 p.R4810K多型保有脳主幹動脈閉塞症に対する血管内治療の治療反応性 (2022)
  • Author(s): 吉本 武史,田中 寛大, 高下 純平, 齊藤 聡, 山上 宏, 中奥 由里子, 西村 邦宏, 山口 枝里子, 川上 大輔, 鴨川 徳彦, 太田 剛史, 佐藤 徹, 井上 学, 服部 頼都, 鷲田 和夫, 片岡 大治, 豊田 一則, 古賀 政利, 丸山 博文, 猪原 匡史
  • Organizer: 第51回日本脳卒中の外科学会学術集会
  • Invited
• [Presentation] シンポジウム血管内治療デバイスと医用画像解析ソフトの診療報酬 (2022)
  • Author(s): 坂井 信幸,小笠原 邦昭, 橋本 洋一郎, 藤本 茂, 佐々木 真理, 井上 学, 宮本 享, 宮地 茂, 松丸 祐司, 大石 英則, 石井 暁, 今村 博敏, 坂井 千秋
  • Organizer: 第47回日本脳卒中学会学術集会
  • Invited
• [Presentation] 急性期脳梗塞における画像診断ーbasicからadvanced imagingまでー (2022)
  • Author(s): 井上 学
  • Organizer: 第47回日本脳卒中学会学術集会
  • Invited
• [Presentation] 灌流画像を使用した主幹動脈閉塞における24時間までの機械的血栓回収術と梗塞拡大速度の評価 (2022)
  • Author(s): 井上 学
  • Organizer: 第47回日本脳卒中学会学術集会
  • Invited
• [Presentation] COVID-19蔓延下のCTに基づくRAPIDでの血栓回収療法の適応判断の妥当性 (2022)
  • Author(s): 太田 剛史，佐藤 徹, 田中 寛大, 高下 純平, 吉本 武史, 井上 学, 豊田 一則, 濱野 栄佳, 池堂 太一, 角 真佐武, 下永 皓司, 櫛 裕史, 森 久恵, 飯原 弘二, 片岡 大治
  • Organizer: 第47回日本脳卒中学会学術集会
• [Presentation] 急性期脳梗塞の画像診断新時代 - 何が有用 ? 何が必要 ? (2021)
  • Author(s): 井上 学
  • Organizer: 第37回NPO法人日本脳神経血管内治療学会学術総会
  • Invited
• [Presentation] 脳血栓回収療法に脳血流検査は必要か？治療前検査必要派 (2021)
  • Author(s): 井上 学
  • Organizer: 第64回日本脳循環代謝学会学術集会
  • Invited
• [Presentation] 変わりゆく脳卒中診療と画像診断 (2021)
  • Author(s): 井上 学
  • Organizer: 第34回日本脳神経血管内治療学会九州地方会
  • Invited
• [Presentation] 再灌流療法のための画像診断の要点 (2021)
  • Author(s): 井上 学
  • Organizer: 第62回日本神経学会総会
  • Invited
• [Presentation] Prior Antithrombotic Medication May Affect Outcomes Following Alteplase at 0.6mg for Unknown Onset Stroke: THAWS Randomized Clinical Trial (2021)
  • Author(s): Koga M, Inoue M, Miwa K, Yoshimura S, Fukuda-doi M, Aoki J, Asakura K, Ohtaki M, Kamiyama K, Igarashi S, Doijiri R, Ito Y, Takagi Y, Ihara M, Sasaki M, Kitazono T, Kimura K, Minematsu K, Yamamoto H, Toyoda K
  • Organizer: International Stroke Conference
  • Int'l Joint Research
• [Presentation] Thrombolysis for Acute Wake-Up And Unclear Onset Strokes With Alteplase at 0.6mg /kg in Clinical Practice: THAWS2 Study (2021)
  • Author(s): Yoshimura S, Koga M, Okada T, Inoue M, Miwa K, Fukuda-doi M, Kondo R, Inoue T, Ichijo M, Ohtaki M, Nagakane Y, Itabashi R, Sakai N, Aoki J, Shiokawa Y, Yagita Y, Iwama T, Yakushiji Y, Kusumi M, Kamiyama K, Doijiri R, Igarashi S, Kanzawa T, Matsumoto S, Ito Y, Yoshimura S, Ohsaki M, Ihara M, Toyoda K
  • Organizer: International Stroke Conference
  • Int'l Joint Research
• [Presentation] 中大脳動脈M2閉塞に対するTronステントリトリーバーを用いたBEMPテクニックの報告 (2021)
  • Author(s): 吉本武史，田中寛大，高下純平，塩澤真之，山上 宏，井上 学，鴨川徳彦，佐藤 徹，片岡大治，豊田一則，古賀政利，猪原匡史
  • Organizer: 第2回日本脳神経内科血管治療研究会学術集会
• [Presentation] 急性期脳梗塞に対する血栓吸引テクニックと血栓吸引併用ステントリトリバーテクニックのランダム化比較試験：試験プロトコル (2021)
  • Author(s): 田中寛大，高下純平，吉本武史，太田剛，佐藤徹，井上 学，塩澤真之，福田哲也，片岡広治，猪原匡史，古賀政利，豊田一則
  • Organizer: 第2回日本脳神経内科血管治療研究会学術集会
• [Presentation] アテトーゼ型脳性麻痺に関連した頸椎症が原因と考えられた両側Bow-hunter症候群の一例 (2021)
  • Author(s): 小椋史織，高下純平，井上 学，田中寛大，吉本武史，塩澤真之，豊田一則，古賀政利
  • Organizer: 第119回日本神経学会近畿地方会
• [Presentation] 脳灌流画像を用いた tissue-based imaging によるLate presenting stroke の治療戦略 (2020)
  • Author(s): 井上 学
  • Organizer: 第36回NPO法人日本脳神経血管内治療学会学術総会
  • Invited
• [Presentation] 超急性期広範梗塞に血栓回収をすべきか：No (2020)
  • Author(s): 井上 学
  • Organizer: 第45回日本脳卒中学会学術集会
  • Invited
• [Presentation] Brain tissue から見た脳梗塞治療時間枠の限界 (2020)
  • Author(s): 井上 学
  • Organizer: 第45回日本脳卒中学会学術集会
  • Invited
• [Presentation] 灌流画像を使用した脳梗塞診断と抗凝固療法 (2020)
  • Author(s): 井上 学
  • Organizer: 日本脳神経外科学会 第79回学術総会
  • Invited
• [Book] 脳卒中治療Controversy (2023)
  • Author(s): 井上 学
  • Total Pages: 388
  • Publisher: 中外医学社
• [Book] 内科臨床誌メディチーナ60巻3号 (2023)
  • Author(s): 井上 学
  • Total Pages: 184
  • Publisher: 医学書院
• [Book] 「RadFan」第20巻15号 (2023)
  • Author(s): 井上 学
  • Total Pages: 82
  • Publisher: 株式会社メディカルアイ
• [Book] 発展する脳卒中診療の最前線 3月第1土曜特集 (2022)
  • Author(s): 井上 学
  • Total Pages: 160
  • Publisher: 医歯薬出版株式会社
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  • ISBN: 9784780905403
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  • Total Pages: 88
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