| Project/Area Number |
20K14785
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 21060:Electron device and electronic equipment-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Xiao Tinghui 東京大学, 大学院理学系研究科(理学部), 客員共同研究員 (50869675)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | silicon photonics / optical sensor / Raman spectroscopy / optical biosensor / Raman optical activity |
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| Outline of Research at the Start |
Raman optical activity (ROA) is an effective optical tool for detection of chiral biomolecules but suffers from low sensitivity. Here the PI proposes an on-chip chiral biosensor that enables reliable, high-sensitivity ROA measurement of chiral biomolecules with negligible artifacts.
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| Outline of Final Research Achievements |
Raman optical activity (ROA) is effective for studying the conformational structure and behavior of chiral molecules in aqueous solutions and is advantageous over X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy in sample preparation and cost performance. However, ROA signals are inherently minuscule; 3-5 orders of magnitude weaker than spontaneous Raman scattering due to the weak chiral light-matter interaction. In this project, we demonstrated on-chip chiral biosensor by devising a silicon nanodisk array and exploiting its dark mode to overcome these limitations. Specifically, we use it with pairs of chemical and biological enantiomers to show >100x enhanced chiral light-molecule interaction with negligible artifacts for ROA measurements.
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| Academic Significance and Societal Importance of the Research Achievements |
このプロジェクトにより、X 線結晶構造解析法やNMR 分光法では不可能な、微量のキラル分子の絶対構造解析を、簡便・迅速・安価・安定的に行うことができる。分析化学、構造生物学、物質科学、薬学、量子生命科学などの多様な分野への応用展開が期待される。
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