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On-chip chiral biosensor based on superchiral-field-enhanced Raman optical activity

Research Project

Project/Area Number 20K14785
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 21060:Electron device and electronic equipment-related
Research InstitutionThe University of Tokyo

Principal Investigator

Xiao Tinghui  東京大学, 大学院理学系研究科(理学部), 客員共同研究員 (50869675)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordssilicon photonics / optical sensor / Raman spectroscopy / optical biosensor / Raman optical activity
Outline of Research at the Start

Raman optical activity (ROA) is an effective optical tool for detection of chiral biomolecules but suffers from low sensitivity. Here the PI proposes an on-chip chiral biosensor that enables reliable, high-sensitivity ROA measurement of chiral biomolecules with negligible artifacts.

Outline of Final Research Achievements

Raman optical activity (ROA) is effective for studying the conformational structure and behavior of chiral molecules in aqueous solutions and is advantageous over X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy in sample preparation and cost performance. However, ROA signals are inherently minuscule; 3-5 orders of magnitude weaker than spontaneous Raman scattering due to the weak chiral light-matter interaction. In this project, we demonstrated on-chip chiral biosensor by devising a silicon nanodisk array and exploiting its dark mode to overcome these limitations. Specifically, we use it with pairs of chemical and biological enantiomers to show >100x enhanced chiral light-molecule interaction with negligible artifacts for ROA measurements.

Academic Significance and Societal Importance of the Research Achievements

このプロジェクトにより、X 線結晶構造解析法やNMR 分光法では不可能な、微量のキラル分子の絶対構造解析を、簡便・迅速・安価・安定的に行うことができる。分析化学、構造生物学、物質科学、薬学、量子生命科学などの多様な分野への応用展開が期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (18 results)

All 2023 2022 2021 2020

All Journal Article (7 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 7 results,  Open Access: 7 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (2 results)

  • [Journal Article] Studying the efficacy of antiplatelet drugs on atherosclerosis by optofluidic imaging on a chip2023

    • Author(s)
      Deng Yunjie、Tay Hui Min、Zhou Yuqi、Fei Xueer、Tang Xuke、Nishikawa Masako、Yatomi Yutaka、Hou Han Wei、Xiao Ting-Hui、Goda Keisuke
    • Journal Title

      Lab on a Chip

      Volume: 23 Issue: 3 Pages: 410-420

    • DOI

      10.1039/d2lc00895e

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ultracompact Vernier-effect-improved sensor by a single microfiber-knot resonator2023

    • Author(s)
      Yu Yang、Yu Ya-Nan、Chen Zhao-Kun、Li Chun-Ran、Tian Nong、Yan Hao-Chen、Luo Jian-Yi、Xiao Ting-Hui
    • Journal Title

      Optics Express

      Volume: 31 Issue: 4 Pages: 6917-6917

    • DOI

      10.1364/oe.481253

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Highly Scalable, Wearable Surface-Enhanced Raman Spectroscopy2022

    • Author(s)
      Limei Liu, Pablo Martinez Pancorbo, Ting-Hui Xiao, Saya Noguchi, Machiko Marumi, Hiroki Segawa, Siddhant Karhadkar, Julia Gala de Pablo, Kotaro Hiramatsu, Yasutaka Kitahama, Tamitake Itoh, Junle Qu, Kuniharu Takei, Keisuke Goda
    • Journal Title

      Advanced Optical Materials

      Volume: 10 Issue: 17 Pages: 2200054-2200054

    • DOI

      10.1002/adom.202200054

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] All-dielectric chiral-field-enhanced Raman optical activity2021

    • Author(s)
      Xiao Ting-Hui、Cheng, Zhenzhou、Luo Zhenyi、Isozaki Akihiro、Hiramatsu Kotaro、Itoh Tamitake、Nomura Masahiro、Iwamoto Satoshi、Goda Keisuke
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41467-021-23364-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optical force induced by strong exciton-plasmon coupling2021

    • Author(s)
      Li Wanjun、Yu Yang、Yan Haochen、Zeng Qingguang、Xiao Ting-Hui
    • Journal Title

      Optics Express

      Volume: 29 Issue: 25 Pages: 41600-41600

    • DOI

      10.1364/oe.443686

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metal-free SERS: Where we are now, where we are heading2021

    • Author(s)
      Martinez Pancorbo Pablo、Zhang Huanhuan、Yu Xingxing、Xiao Ting-Hui、Goda Keisuke
    • Journal Title

      Europhysics Letters

      Volume: 136 Issue: 3 Pages: 34001-34001

    • DOI

      10.1209/0295-5075/ac4d40

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Porous carbon nanowire array for surface-enhanced Raman spectroscopy2020

    • Author(s)
      Chen Nan、Xiao Ting-Hui、Luo Zhenyi、Kitahama Yasutaka、Hiramatsu Kotaro、Kishimoto Naoki、Itoh Tamitake、Cheng Zhenzhou、Goda Keisuke
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 4772-4772

    • DOI

      10.1038/s41467-020-18590-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] On-chip chiral-field-enhanced Raman optical activity for biosensing2022

    • Author(s)
      Ting-Hui Xiao
    • Organizer
      CLEO-PR
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Porous carbon nanowires for plasmon-free SERS2021

    • Author(s)
      T. Xiao, N. Chen, Z. Luo, Y. Kitahama, K. Hiramatsu, N. Kishimoto, T. Itoh, Z. Cheng, and K. Goda
    • Organizer
      SPIE Photonics West
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Chiral-field-enhanced Raman optical activity by a silicon nanodisk array2021

    • Author(s)
      T. Xiao, Z. Luo, K. Hiramatsu, A. Isozaki, T. Itoh, Z. Cheng, M. Nomura, S. Iwamoto, and K. Goda
    • Organizer
      SPIE Photonics West
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Enhanced Raman spectroscopy by metal-free nanostructures2021

    • Author(s)
      Tinghui Xiao
    • Organizer
      Optics & Photonics Japan 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mid-infrared germanium photonic devices and beyond2021

    • Author(s)
      Tinghui Xiao
    • Organizer
      PIERS 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Measurement and manipulation of light-matter interaction towards quantum bioengineering2021

    • Author(s)
      Tinghui Xiao
    • Organizer
      量子生命科学会第3回大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] キラルな生体分子における振動状態の縮退の観測2020

    • Author(s)
      Ting-Hui Xiao、合田圭介
    • Organizer
      量子生命科学会第2回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] バンドエンジニアリングによる光合成過程中の振動を利用した電荷移動の制御2020

    • Author(s)
      野口沙耶 、Ting-Hui Xiao、合田圭介
    • Organizer
      量子生命科学会第2回大会
    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] センサ基板の製造方法、センサ基板、センサシステム、及びラマン散乱2021

    • Inventor(s)
      合田圭介、シヤオ テインフイ、リウ リメイ、平松光太郎
    • Industrial Property Rights Holder
      合田圭介、シヤオ テインフイ、リウ リメイ、平松光太郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-055087
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report
  • [Funded Workshop] PIERS 20212021

    • Related Report
      2021 Research-status Report
  • [Funded Workshop] SPIE Photonics West2021

    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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