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Real-time intelligent control of 3D-AFM using high-speed signal processing technology

Research Project

Project/Area Number 20K15172
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 29020:Thin film/surface and interfacial physical properties-related
Research InstitutionKanazawa University

Principal Investigator

Miyata Kazuki  金沢大学, ナノ生命科学研究所, 助教 (10788243)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords原子間力顕微鏡 / カルサイト / 高速信号処理 / 機械学習 / バクテリオロドプシン
Outline of Research at the Start

近年の原子間力顕微鏡(AFM)の高速化や3次元化により、固液界面の構造や動態を原子・分子スケールで捉えることが可能となったが、その制御手法は高速化・3次元化に対応しておらず、構造や性質の変化を常に最適な条件で計測することが困難だった。本研究では高速信号処理技術を用いたインテリジェントなリアルタイム測定条件制御機構を開発し、生体分子や高分子など幅広い試料の高速3次元分子スケール構造・動態解析を実現する。

Outline of Final Research Achievements

In this study, we developed an atomic force microscopy (AFM) image evaluation technique and evaluated its accuracy, which is one of the elemental technologies necessary to realize the intelligent real-time AFM control. In addition, in order to collect the training data for this technique and to demonstrate the practicality of the recently developed high-speed frequency modulation AFM, the etch pits formed on the surface of calcite were measured in pure water, and their dynamic behavior was successfully measured with atomic resolution.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したAFM画像評価技術を実際に高速信号処理回路(FPGA)を備えたAFM装置へ適用することで、取得中のAFM画像データに応じてリアルタイムに計測条件を最適化できるようになる。これにより、時間変化する表面・界面を正確に計測することが可能となり、結晶成長・溶解や自己組織化などの幅広い固液界面現象の高速サブナノスケール動態解析を実現することが期待される。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (4 results)

All 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] Aalto大学(フィンランド)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] High-Speed Atomic Force Microscopy of the Structure and Dynamics of Calcite Nanoscale Etch Pits2021

    • Author(s)
      Miyata Kazuki、Takeuchi Kazuyoshi、Kawagoe Yuta、Spijker Peter、Tracey John、Foster Adam S.、Fukuma Takeshi
    • Journal Title

      The Journal of Physical Chemistry Letters

      Volume: 12 Issue: 33 Pages: 8039-8045

    • DOI

      10.1021/acs.jpclett.1c02088

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Visualizing Atomic-scale Structures and Dynamics at Solid-liquid Interfaces by Frequency Modulation Atomic Force Microscopy2022

    • Author(s)
      K. Miyata
    • Organizer
      2nd WPI NanoLSI-iCeMS Joint Symposium on Nanometrology and Advanced Materials
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualizing Intracellular Structures with Sub-nanometer Scale Resolution by 3D-AFM in Liquid Environment2020

    • Author(s)
      K. Miyata, M. P. Garcia, K. Miyazawa, T. Shirokawa, A. M. Shahidul, C. Nakamura, T. Fukuma
    • Organizer
      The 28th International Colloquium on Scanning Probe Microscopy (ICSPM28)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2023-01-30  

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