Manganese-catalyzed synthesis of fluorinated organic compounds and hydrogenation/dehydrogenation catalysis
| Project/Area Number |
20K15305
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 34010:Inorganic/coordination chemistry-related
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
HE YuTao 沖縄科学技術大学院大学, 錯体化学・触媒ユニット, 研究員 (70868140)
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| Project Period (FY) |
2020-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | manganese / coupling / oxidative addition |
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| Outline of Research at the Start |
Utilizing low price, non-toxic Mn catalysts provides safer and more economical routes for synthesis of these valuable products. This will eventually have a large impact on synthetic organic chemistry and closely related pharmaceutical/agrochemical/materials/medical industries.
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| Outline of Annual Research Achievements |
Until now, the following research achievements have been achieved.
1. The synthesis of stable Mn(III) aryl complexes obtained by oxidative addition of aryl bromide or aryl chloridehas been finished.
2. The reactions of our synthesized complexes with a range of organometallic alkylating or arylating reagents (alkyl and aryl Grignard reagents, MeLi, ZnMe2) to undergo C(sp2)-C(sp3) or C(sp2)-C(sp2) bond coupling has been carried out and a preliminary catalytic system has been demonstrated.
3.The reagent scope and yield of the C(sp2)-C(sp3) coupled product can be increased by addition of TEMPO as an oxidant generating alkyl radicals.
4.Except aryl bromide, the type of Ar-Cl is also a good pre-cursor in oxidative addition to MnI species for construc-tion of new C-C bond.
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Report
(1 results)
Research Products
(1 results)
