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An approach to increase the gut-derived maternal immunoglobulin A (IgA) production using dietary tryptophan via aryl hydrocarbon receptor

Research Project

Project/Area Number 20K15478
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 38050:Food sciences-related
Research InstitutionTohoku University

Principal Investigator

Jahidul Islam  東北大学, 農学研究科, 特任助教 (20805569)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsIgA / 腸管 / トリプトファン / Immunoglobulin A / Mammary gland / Tryptophan / AHR / Plasma cells / Ahr
Outline of Research at the Start

This study will illustrate that gut derived maternal IgA produced by dietary tryptophan shapes the infants immune system and their gut microbiota.

Outline of Final Research Achievements

Feces of mice fed with 0.5% Trp-added basal feed or basal feed over time were collected and the IgA concentration in the feces was measured. Six weeks after the start of feeding, the large intestine was collected to address the number of plasma cells. In addition, using mice born 6 to 8 weeks after the start of feeding, feces and milk were collected to measure IgA concentration. The large intestine and mammary gland were collected in the second week of breastfeeding, to investigate the number of plasma cells. Fecal IgA levels increased significantly in the Trp group after 4 weeks of feeding bottom. However, there was no significant difference in the number of plasma cells in the large intestine 6 weeks after the start of feeding. Fecal IgA levels also increased significantly in the Trp group during early and late pregnancy. Trp is highly demanding, suggesting that Trp can enhance immunity in the intestinal tract.

Academic Significance and Societal Importance of the Research Achievements

Most of the changes in the amount of intestinal IgA and its role during the perinatal period is still unknown. This study for the first time investigated the intestinal IgA production and its role in strengthening immunity during the perinatal period through tryptophan (Trp) supplementation.

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (6 results)

All 2022 2021

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Fermented rice bran supplementation attenuates chronic colitis-associated extraintestinal manifestations in female C57BL/6N mice2022

    • Author(s)
      Islam Jahidul、Agista Afifah Zahra、Watanabe Kouichi、Nochi Tomonori、Aso Hisashi、Ohsaki Yusuke、Koseki Takuya、Komai Michio、Shirakawa Hitoshi
    • Journal Title

      The Journal of Nutritional Biochemistry

      Volume: 99 Pages: 108855-108855

    • DOI

      10.1016/j.jnutbio.2021.108855

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a rational framework for the therapeutic efficacy of fecal microbiota transplantation for calf diarrhea treatment2022

    • Author(s)
      Islam Jahidul、Tanimizu Masae、Shimizu Yu、Goto Yoshiaki、Ohtani Natsuki、Sugiyama Kentaro、Tatezaki Eriko、Sato Masumi、Makino Eiji、Shimada Toru、Ueda Chise、Matsuo Ayumi、Suyama Yoshihisa、Sakai Yoshifumi、Furukawa Mutsumi、Usami Katsuki、Yoneyama Hiroshi、Aso Hisashi、Tanaka Hidekazu、Nochi Tomonori
    • Journal Title

      Microbiome

      Volume: 10 Issue: 1 Pages: 31-31

    • DOI

      10.1186/s40168-021-01217-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk2021

    • Author(s)
      Usami Katsuki、Niimi Kanae、Matsuo Ayumi、Suyama Yoshihisa、Sakai Yoshifumi、Sato Shintaro、Fujihashi Kohtaro、Kiyono Hiroshi、Uchino Saeka、Furukawa Mutsumi、Islam Jahidul、etc
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 10 Pages: 109655-109655

    • DOI

      10.1016/j.celrep.2021.109655

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fermented Rice Bran Supplementation Prevents the Development of Intestinal Fibrosis Due to DSS-Induced Inflammation in Mice2021

    • Author(s)
      Agista Afifah Zahra、Rusbana Tubagus Bahtiar、Islam Jahidul、Ohsaki Yusuke、Sultana Halima、Hirakawa Ryota、Watanabe Kouichi、Nochi Tomonori、Ardiansyah、Budijanto Slamet、Yang Suh-Ching、Koseki Takuya、Aso Hisashi、Komai Michio、Shirakawa Hitoshi
    • Journal Title

      Nutrients

      Volume: 13 Issue: 6 Pages: 1869-1869

    • DOI

      10.3390/nu13061869

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 難治性下痢症発症牛に対する糞便移植の有効性評価2022

    • Author(s)
      Jahidul Islam, 谷水優江, 清水優, 五島可祥, 大谷夏輝, 大谷夏輝, 舘崎恵理子, 佐藤茉純, 牧野英司, 島田亘, 上田千世, 田中秀和, 野地智法
    • Organizer
      日本無菌生物ノートバイオロジー学会
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 下痢治療剤および牛の下痢治療方法2021

    • Inventor(s)
      野地智法、Jahidul Islam、田中秀和
    • Industrial Property Rights Holder
      野地智法、Jahidul Islam、田中秀和
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-196413
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2023-01-30  

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