An approach to increase the gut-derived maternal immunoglobulin A (IgA) production using dietary tryptophan via aryl hydrocarbon receptor
| Project/Area Number |
20K15478
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Tohoku University |
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Principal Investigator |
Jahidul Islam 東北大学, 農学研究科, 特任助教 (20805569)
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | IgA / 腸管 / トリプトファン / Immunoglobulin A / Mammary gland / Tryptophan / AHR / Plasma cells / Ahr |
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| Outline of Research at the Start |
This study will illustrate that gut derived maternal IgA produced by dietary tryptophan shapes the infants immune system and their gut microbiota.
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| Outline of Final Research Achievements |
Feces of mice fed with 0.5% Trp-added basal feed or basal feed over time were collected and the IgA concentration in the feces was measured. Six weeks after the start of feeding, the large intestine was collected to address the number of plasma cells. In addition, using mice born 6 to 8 weeks after the start of feeding, feces and milk were collected to measure IgA concentration. The large intestine and mammary gland were collected in the second week of breastfeeding, to investigate the number of plasma cells. Fecal IgA levels increased significantly in the Trp group after 4 weeks of feeding bottom. However, there was no significant difference in the number of plasma cells in the large intestine 6 weeks after the start of feeding. Fecal IgA levels also increased significantly in the Trp group during early and late pregnancy. Trp is highly demanding, suggesting that Trp can enhance immunity in the intestinal tract.
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| Academic Significance and Societal Importance of the Research Achievements |
Most of the changes in the amount of intestinal IgA and its role during the perinatal period is still unknown. This study for the first time investigated the intestinal IgA production and its role in strengthening immunity during the perinatal period through tryptophan (Trp) supplementation.
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Report
(3 results)
Research Products
(6 results)
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[Presentation] 難治性下痢症発症牛に対する糞便移植の有効性評価2022
Author(s)
Jahidul Islam, 谷水優江, 清水優, 五島可祥, 大谷夏輝, 大谷夏輝, 舘崎恵理子, 佐藤茉純, 牧野英司, 島田亘, 上田千世, 田中秀和, 野地智法
Organizer
日本無菌生物ノートバイオロジー学会
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