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Right heart function assessed by myocardial strain: Study of the chronic pulmonary hypertension model

Research Project

Project/Area Number 20K15667
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

Suzuki Ryohei  日本獣医生命科学大学, 獣医学部, 助教 (80825216)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肺高血圧 / 右心機能 / 心筋ストレイン / 心エコー図検査 / 心不全 / 心臓カテーテル / イヌ / イヌモデル / 心エコー / 犬
Outline of Research at the Start

肺高血圧の病態における右心機能評価は、重症度や予後判定において重要である。心筋ストレインとは心エコー図検査により心筋運動を数値化した新しい心機能指標であり、観血的心機能指標を非観血的に反映する感度の良い指標である。
本研究は、肺高血圧症の病態における非観血的で鋭敏な右心機能評価を心筋ストレインにより確立するために、①心筋ストレインは観血的な右心機能指標と相関するか? ②慢性肺高血圧症モデルの右心機能変化は心筋ストレインにより検出できるか? を明らかにする。
本研究により、心疾患症例に対する非観血的な右心機能評価、右心機能を考慮した治療方針の策定、良好な臨床転帰や予後が実現できる可能性がある。

Outline of Final Research Achievements

This study targets the intractable disease of pulmonary hypertension, which can be life-threatening for patients, including dogs and humans. In addition, the purpose was to establish a non-invasive evaluation method by echocardiography called myocardial strain. As a research result, detailed pathophysiological evaluation using model animals was performed, and it was demonstrated that myocardial strain is useful for evaluation of the progression process and severity of pulmonary hypertension. We also established a new echocardiographic index that seems to be more useful than the conventional index, and published some academic papers. Furthermore, in the case of heart disease in cats, we examined the relationship between pulmonary hypertension and myocardial strain and worsening of the condition, and reported the usefulness of myocardial strain as a predictor of severity evaluation and the onset of heart failure.

Academic Significance and Societal Importance of the Research Achievements

本研究の主要な成果として、心筋ストレインという非侵襲的な心エコー図検査による指標を用いることで、詳細にかつ鋭敏に、肺高血圧症の病態進行が評価できることを報告した。このことは、難治性かつ生命を脅かす重要な循環器疾患である肺高血圧症の病態において、非侵襲的な心機能評価、治療方針の策定、また将来的には良好な臨床転帰や予後に貢献する可能性がある。また獣医療において、犬と並んで飼育頭数が多く、かつ循環器疾患が多発する猫の心筋症病態においても、心筋ストレインの有用性を複数実証した。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (23 results)

All 2022 2021 2020

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (15 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Right Ventricular Myocardial Adaptation Assessed by Two-Dimensional Speckle Tracking Echocardiography in Canine Models of Chronic Pulmonary Hypertension2021

    • Author(s)
      Yuchi Yunosuke、Suzuki Ryohei、Kanno Haruka、Teshima Takahiro、Matsumoto Hirotaka、Koyama Hidekazu
    • Journal Title

      Frontiers in Veterinary Science

      Volume: 8

    • DOI

      10.3389/fvets.2021.727155

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of the influence of manual ventilation-controlled respiration on right ventricular pressure-volume loops and echocardiographic variables in healthy anesthetized dogs2021

    • Author(s)
      Yuchi Yunosuke、Suzuki Ryohei、Teshima Takahiro、Matsumoto Hirotaka、Koyama Hidekazu
    • Journal Title

      American Journal of Veterinary Research

      Volume: 82 Issue: 11 Pages: 865-871

    • DOI

      10.2460/ajvr.82.11.865

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Right ventricular systolic and diastolic function assessed by two-dimensional speckle tracking echocardiography in dogs with myxomatous mitral valve disease2021

    • Author(s)
      YUCHI Yunosuke、SUZUKI Ryohei、TESHIMA Takahiro、MATSUMOTO Hirotaka、KOYAMA Hidekazu
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 83 Issue: 12 Pages: 1918-1927

    • DOI

      10.1292/jvms.21-0195

    • NAID

      130008127563

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pulmonary Vascular Resistance Estimated by Echocardiography in Dogs With Myxomatous Mitral Valve Disease and Pulmonary Hypertension Probability2021

    • Author(s)
      Suzuki Ryohei、Yuchi Yunosuke、Kanno Haruka、Saito Takahiro、Teshima Takahiro、Matsumoto Hirotaka、Koyama Hidekazu
    • Journal Title

      Frontiers in Veterinary Science

      Volume: 8

    • DOI

      10.3389/fvets.2021.771726

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Left and Right Myocardial Functionality Assessed by Two-Dimensional Speckle-Tracking Echocardiography in Cats with Restrictive Cardiomyopathy2021

    • Author(s)
      Suzuki Ryohei、Yuchi Yunosuke、Kanno Haruka、Teshima Takahiro、Matsumoto Hirotaka、Koyama Hidekazu
    • Journal Title

      Animals

      Volume: 11 Issue: 6 Pages: 1578-1578

    • DOI

      10.3390/ani11061578

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early detection of myocardial dysfunction in a cat that gradually progressed to endomyocardial form of restrictive cardiomyopathy2021

    • Author(s)
      Saito Takahiro、Suzuki Ryohei、Yuchi Yunosuke、Teshima Takahiro、Matsumoto Hirotaka、Koyama Hidekazu
    • Journal Title

      BMC Veterinary Research

      Volume: 17 Issue: 1 Pages: 274-274

    • DOI

      10.1186/s12917-021-02987-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of Congestive Heart Failure and Myocardial Dysfunction in Cats With Cardiomyopathy by Using Two-Dimensional Speckle-Tracking Echocardiography2021

    • Author(s)
      Suzuki Ryohei、Saito Takahiro、Yuchi Yunosuke、Kanno Haruka、Teshima Takahiro、Matsumoto Hirotaka、Koyama Hidekazu
    • Journal Title

      Frontiers in Veterinary Science

      Volume: 8

    • DOI

      10.3389/fvets.2021.771244

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of tricuspid annular plane systolic excursion normalized by right ventricular size indices in dogs with postcapillary pulmonary hypertension2021

    • Author(s)
      Yunosuke Yuchi, Ryohei Suzuki, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
    • Journal Title

      Journal of veterinary internal medicine

      Volume: 35 Issue: 1 Pages: 107-119

    • DOI

      10.1111/jvim.15984

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 呼吸器疾患に続発した肺高血圧症罹患犬における心機能解析2022

    • Author(s)
      湯地 勇之輔, 鈴木 亮平, 齊藤 尭大, 手嶋 隆洋, 松本 浩毅, 小山 秀一
    • Organizer
      第18回日本獣医内科学アカデミー
    • Related Report
      2021 Annual Research Report
  • [Presentation] 後毛細血管性肺高血圧症罹患犬における高用量ベラプロストナトリウムの臨床的有用性の検討2022

    • Author(s)
      湯地 勇之輔, 鈴木 亮平, 齊藤 尭大, 手嶋 隆洋, 松本 浩毅, 小山 秀一
    • Organizer
      第18回日本獣医内科学アカデミー
    • Related Report
      2021 Annual Research Report
  • [Presentation] Phlebotomy and hydroxycarbamide administration for polycythemia caused by Eisenmenger's syndrome in a dog2022

    • Author(s)
      Takahiro Saito, Ryohei Suzuki, Yunosuke Yuchi, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
    • Organizer
      The 8th AiSVIM meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prognostic utility of pulmonary vascular resistance estimated by echocardiography in dogs with post-capillary pulmonary hypertension2022

    • Author(s)
      Yunosuke Yuchi, Ryohei Suzuki, Takahiro Saito, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
    • Organizer
      The 8th AiSVIM meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myocardial function assessed by two dimensional speckle tracking echocardiography in cats with cardiomyopathy and congestive heart failure2021

    • Author(s)
      Ryohei Suzuki, Yunosuke Yuchi, Haruka Kanno, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
    • Organizer
      ACVIM Forum 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influence of heart rate on right ventricular function in healthy dogs2021

    • Author(s)
      Yunosuke Yuchi , Ryohei Suzuki, Takahiro Teshima , Hirotaka Matsumoto, Hidekazu Koyama
    • Organizer
      ACVIM Forum 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心筋症に罹患した猫におけるうっ血性心不全の有無と心筋運動指標を含む心エコー図検査指標の関係性2021

    • Author(s)
      鈴木 亮平, 湯地 勇之輔, 菅野 はるか, 斎藤 堯大, 手嶋 隆洋, 松本 浩毅, 小山 秀一
    • Organizer
      第114回日本獣医循環器学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 心拍数の変化が健常犬の右心機能に及ぼす影響の検討2021

    • Author(s)
      湯地 勇之輔, 鈴木 亮平, 手嶋 隆洋, 松本 浩毅, 小山 秀一
    • Organizer
      第114回日本獣医循環器学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Real-time 3D心エコー法による右室形態および機能評価の有用性2021

    • Author(s)
      湯地 勇之輔, 鈴木 亮平, 齊藤 尭大, 手嶋 隆洋, 松本 浩毅, 小山 秀一
    • Organizer
      第115回日本獣医循環器学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 慢性肺高血圧症モデル犬に対するベラプロストナトリウムの薬用量の検討2021

    • Author(s)
      湯地 勇之輔, 鈴木 亮平, 手嶋 隆洋, 松本 浩毅, 小山 秀一
    • Organizer
      第17回日本獣医内科学アカデミー 学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 呼吸に伴う静脈還流量の変化が健常犬の右心機能に及ぼす影響の検討2021

    • Author(s)
      湯地 勇之輔, 鈴木 亮平, 手嶋 隆洋, 松本 浩毅, 小山 秀一
    • Organizer
      第17回日本獣医内科学アカデミー 学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Left and Right Myocardial Function in Dogs with Pulmonary Hypertension Secondary to Mitral Valve Disease2020

    • Author(s)
      Ryohei Suzuki, Yunosuke Yuchi, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
    • Organizer
      The American College of Veterinary Internal Medicine Forum On Demand
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Layer specific Myocardial Function Assessed by Two dimensional Speckle tracking Echocardiography in Cats with Restrictive Cardiomyopathy2020

    • Author(s)
      Ryohei Suzuki, Yunosuke Yuchi, Haruka Kanno, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
    • Organizer
      The American College of Veterinary Internal Medicine Forum On Demand
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tricuspid Annular Plane Systolic Excursion Normalized by Right Ventricular Size in Dogs with Pulmonary Hypertension2020

    • Author(s)
      Yunosuke Yuchi, Ryohei Suzuki, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
    • Organizer
      The American College of Veterinary Internal Medicine Forum On Demand
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 拘束型心筋症罹患猫におけるスペックルトラッキング法による 層別および多方向の心筋機能評価2020

    • Author(s)
      菅野 はるか, 鈴木 亮平, 湯地 勇之輔, 手嶋 隆洋, 松本 浩毅, 小山 秀一
    • Organizer
      日本臨床獣医学フォーラム 第22回年次大会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2023-01-30  

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