| Project/Area Number |
20K15758
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 43040:Biophysics-related
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| Research Institution | Osaka University |
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Principal Investigator |
Bekker Gerardu 大阪大学, 蛋白質研究所, 特任助教(常勤) (80813758)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Granted (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | Molecular Dynamics / Protein stability |
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| Outline of Research at the Start |
Local protein dynamics are crucial for understanding, modulating and improving the mechanism, function and stability of proteins, yet no integrated source for such data is currently available. This work aims to estimate the local dynamics of proteins and by extension their local stability, either in isolation or complexed with other proteins, DNA, RNA or small compounds as stored in the PDB, via Molecular Dynamics simulations and store it into a public database.
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