| Project/Area Number |
20K15784
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 43060:System genome science-related
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| Research Institution | Waseda University (2021-2022)
National Institute of Advanced Industrial Science and Technology (2020) |
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Principal Investigator |
ZENG CHAO 早稲田大学, 理工学術院総合研究所(理工学研究所), 次席研究員(研究院講師) (80822460)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GCR / genetic compensation / 遺伝子補償応答 / RNA-chromatin / RNA degradation / Genetic compensation / lncRNA / RNA decay / NMD |
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| Outline of Research at the Start |
Understanding the role of long noncoding RNA (lncRNA) in gene regulation expands our knowledge of life and disease. Here, we raise and try to uncover that lncRNA decay (death) may trigger to up-regulate the expression of other genes (birth). This study promises to reveal a novel mechanism of lncRNA.
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| Outline of Final Research Achievements |
Degraded transcript (referred to as deGene) may trigger the genetic compensation response (GCR), potentially leading to an increase in the transcriptional expression of sequence-similar adapting genes (adGene). In this study, we aimed to predict gene pairs involved in GCR in human cells using RNA-seq data. From the knockdown data of multiple RNA degradation factors, we identified hundreds of deGene-adGene pairs, with little overlap suggested between different datasets. These results provide new insights into the complex dynamics of gene expression regulation in human cells.
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| Academic Significance and Societal Importance of the Research Achievements |
この研究は、特に遺伝的補償応答（GCR）の役割に焦点を当て、ヒト細胞における遺伝子発現調節の複雑なダイナミクスについての理解を深める可能性があります。GCRに関与する数百の遺伝子ペアを特定することで、遺伝子調節を理解し、可能ならば治療目的で操作するための新たな途が開かれます。これは、遺伝性疾患や病気の治療に広範な影響を及ぼす可能性があり、社会の健康と福祉に寄与することになります。
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