Evolution of cerebro-cerebellar system investigated using resting-state functional connectivity in macaque and human
| Project/Area Number |
20K15945
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 46030:Function of nervous system-related
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
アウティオ ヨーナス 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (40755485)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Project Status |
Granted (Fiscal Year 2022)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Evolution / Cerebellum / Human / Macaque / fMRI / cerebellum / macaque / Cerebro-cerebellar / Resting-state / System neuroscience / Functional / MRI |
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| Outline of Research at the Start |
Cerebellum contain the large majority of the neurons in the brain (80% in humans) and contributes to a wide range of brain functions. However, little is known about the evolution of cerebro-cerebellar system due to the technical challenge imposed by the multi-synaptic circuitry. To corroborate the evolution of primate cerebro-cerebellar communication, here, I investigate the cerebro-cerebellar functional connectivity by capitalizing on our recent advances in the resting-state functional magnetic resonance imaging in awake behaving macaque monkeys and compare the findings with those in humans.
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| Outline of Annual Research Achievements |
In summary, our results study shows that cognition plays a major role in human cerebellum (> 40%) whereas in macaque only a small fraction is associated with cognitive functions (< 15%). Interestingly, in macaques we find cerebro-cerebral functional connectivity associated with early auditory processing which is absent in humans. Based on topological arrangement, this macaque cerebro-cerebral auditory circuit appears to have evolved into a human language network. Relevant to the grant, two first authorship publications have been completed (2x NeuroImage) and further three first authorship manuscripts are under preparation.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Data acquisition has been successfully completed and the initial data analyses proceeded according to the plan. However, the project was delayed by two major and unfortunate set backs: 1) the data acquisition was delayed due to covid-19 and 2) initial macaque and human data analyses were lost due to the failure of data server system summer 2022. Both of the factors were independent from the principal investigator (me). Notwithstanding, data is currently being re-analyzed and figures for the publication re-generated.
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| Strategy for Future Research Activity |
All raw data has been recovered that was lost in the server failure (see above). The data analysis pipeline is almost re-established for the macaque monkey. This will be followed by manual artifact de-noising of each subject and generation of robust group-level functional connectivity maps. Then, newly acquired high-resolution structural MR images will be used for generation of cerebellum surface map in macaques. Finally, the functional cerebellum surface maps will be directly compared with those achieved in humans.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing2020
Author(s)
Autio JA, Glasser MF, Ose T, Donahue CJ, Bastiani M, Ohno M, Kawabata Y, Urushibata Y, Murata K, Nishigori K, Yamaguchi M, Hori Y, Yoshida A, Go Y, Coalson TS, Jbabdi S, Sotiropoulos SN, Kennedy H, Smith S, Van Essen DC, Hayashi T.
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Journal Title
NeuroImage
Volume: 215
Pages: 116800-116800
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Laminar Myeloarchitectonic Mapping using T1- and T2-weighted MRI in Macaque Monkeys2022
Author(s)
Autio, J.A., Ose, T., Uematsu, A., Ikeda, T., Ohno, M., Matsumoto, Y., Kennedy, H., Van Essen, D.C Glasser, M.F., Hayashi, T
Organizer
International Society for Magnetic Resonance and Medicine
Related Report
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[Presentation] Surface-based analysis of owl monkey brain with high-resolution MRI2022
Author(s)
Ikeda, T., Kawasaki, A., Takeda, C., Ose, T., Autio, J.A., Takada, M., Glasser, M.F., Van Essen, D.C., Hayashi,
Organizer
5th Japanese Meeting for Human Brain Imaging
Related Report
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