• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Neuroendocrine mechanism of precocious puberty caused by fetal stress in utero

Research Project

Project/Area Number 20K16123
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 48020:Physiology-related
Research InstitutionIwate Medical University (2021-2022)
Nippon Medical School (2020)

Principal Investigator

Minabe Shiori  岩手医科大学, いわて東北メディカル・メガバンク機構, 特命助教 (40781571)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords思春期早発症 / 神経内分泌学 / 性成熟 / 胎児プログラミング / 視床下部 / Kisspeptin / ゴナドトロピン / GnRH
Outline of Research at the Start

思春期早発症は第二次性徴が早期に現れる疾患である。本症の問題点として、本人の心理的・社会的な問題を引き起こすことや、骨年齢の促進による最終的な低身長などがあげられるが、発症機序の詳細は不明である。これまでに申請者は、制限給餌した母ラットから生まれてきた胎児期ストレスモデルの雌の仔ラットにおいて、性成熟の早期化を認めている。この予備実験を踏まえ、「人生初期のストレス環境はエピゲノム変化による発症素因を形成し、思春期早発症の原因となる」と仮説を立てた。本研究の目的は、胎児期ストレスによる思春期早発症の神経内分泌メカニズムを解明し、エピゲノム解析による思春期早発症の責任因子の同定することである。

Outline of Final Research Achievements

This study aims to examine the neuroendocrine mechanisms of precocious puberty induced by fetal stress to experimentally prove the DOHaD hypothesis, which states that the growth environment during development influences health and disease onset in later life. In this study, female rats born to mothers whose food intake was restricted to 50% of that of the control group were used as a model of fetal nutritional stress (UN group) to analyze their reproductive function. The results showed that nutritional deficiency during the fetal period induces fetal programming in the hypothalamus of female rats and changes in KNDy gene expression at different life stages, resulting in altered reproductive function.

Academic Significance and Societal Importance of the Research Achievements

思春期早発症は第二次性徴が早期に現れる疾患である。本症の問題点として、本人の心理的・社会的な問題を引き起こすことや、骨年齢の促進による最終的な低身長などがあげられるが、発症機序の詳細は不明である。本研究により、思春期早発症が視床下部の生殖中枢の胎児プログラミングが関与することが示されたことで、これまで発症機序が謎であった思春期早発症の神経内分泌メカニズムの一端を解明でき、学術的な意義は極めて高い。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (15 results)

All 2023 2022 2021 2020

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Long-term effects of prenatal undernutrition on female rat hypothalamic KNDy neurons2023

    • Author(s)
      Minabe Shiori、Iwata Kinuyo、Watanabe Youki、Ishii Hirotaka、Ozawa Hitoshi
    • Journal Title

      Endocrine Connections

      Volume: 12 Issue: 1

    • DOI

      10.1530/ec-22-0307

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deterioration of mitochondrial biogenesis and degradation in the endometrium is a cause of subfertility in cows2023

    • Author(s)
      Matsuyama Shuichi、Nakamura Sho、Minabe Shiori、Sakatani Miki、Takenouchi Naoki、Sasaki Takuya、Inoue Yuki、Iwata Hisataka、Kimura Koji
    • Journal Title

      Molecular Reproduction and Development

      Volume: 90 Issue: 3 Pages: 141-152

    • DOI

      10.1002/mrd.23670

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of short-term epigenetic age fluctuation2022

    • Author(s)
      Komaki Shohei、Ohmomo Hideki、Hachiya Tsuyoshi、Sutoh Yoichi、Ono Kanako、Furukawa Ryohei、Umekage So、Otsuka-Yamasaki Yayoi、Minabe Shiori、Takashima Akira、Tanno Kozo、Sasaki Makoto、Shimizu Atsushi
    • Journal Title

      Clinical Epigenetics

      Volume: 14 Issue: 1 Pages: 76-76

    • DOI

      10.1186/s13148-022-01293-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <i>Kiss1</i>-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats2022

    • Author(s)
      Chen Jing、Minabe Shiori、Munetomo Arisa、Magata Fumie、Sato Marimo、Nakamura Sho、Hirabayashi Masumi、Ishihara Yasuhiro、Yamazaki Takeshi、Uenoyama Yoshihisa、Tsukamura Hiroko、Matsuda Fuko
    • Journal Title

      Endocrine Journal

      Volume: 69 Issue: 7 Pages: 797-807

    • DOI

      10.1507/endocrj.EJ21-0620

    • NAID

      130008157963

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological Analysis of the Hindbrain Glucose Sensor-Hypothalamic Neural Pathway Activated by Hindbrain Glucoprivation2021

    • Author(s)
      Sato Marimo、Minabe Shiori、Sakono Takahiro、Magata Fumie、Nakamura Sho、Watanabe Youki、Inoue Naoko、Uenoyama Yoshihisa、Tsukamura Hiroko、Matsuda Fuko
    • Journal Title

      Endocrinology

      Volume: 162 Issue: 9 Pages: 1-18

    • DOI

      10.1210/endocr/bqab125

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis2021

    • Author(s)
      Wang Tse-En、Minabe Shiori、Matsuda Fuko、Li Sheng-Hsiang、Tsukamura Hiroko、Maeda Kei-Ichiro、Smith Lee、O’Hara Laura、Gadella Bart M、Tsai Pei-Shiue
    • Journal Title

      Reproduction

      Volume: 161 Issue: 5 Pages: 593-602

    • DOI

      10.1530/rep-20-0629

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gene-expression profile and postpartum transition of bovine endometrial side population cells†2021

    • Author(s)
      Tatebayashi Ryoki、Nakamura Sho、Minabe Shiori、Furusawa Tadashi、Abe Ryoya、Kajisa Miki、Morita Yasuhiro、Ohkura Satoshi、Kimura Koji、Matsuyama Shuichi
    • Journal Title

      Biology of Reproduction

      Volume: 104 Issue: 4 Pages: 850-860

    • DOI

      10.1093/biolre/ioab004

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of diet-induced obesty Kiss1/Tac3/Pdyn gene expression in the arcuate nucleus and luteinizing hormone secretion in sex hormone-primed male and female rats.2021

    • Author(s)
      10.10.16/j.peptides.2021.170546
    • Journal Title

      Peptides

      Volume: in press Pages: 170546-170546

    • DOI

      10.1016/j.peptides.2021.170546

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice2020

    • Author(s)
      Shiori Minabe, Sho Nakamura, Eri Fukushima, Marimo Sato, Kana Ikegami, Teppei Goto, Makoto Sanbo, Masumi Hirabayashi, Junko Tomikawa, Takuya Imamura, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Kei-Ichiro Maeda, Fuko Matsuda
    • Journal Title

      Journal of Reproduction and Development

      Volume: Epub Issue: 4 Pages: 369-375

    • DOI

      10.1262/jrd.2019-164

    • NAID

      130007888724

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 発達期環境ストレスによる生殖機能不全をもたらす神経内分泌メカニズム2022

    • Author(s)
      美辺詩織、岩田衣世、渡辺雄貴、石井寛高、井上直子、上野山賀久、束村博子、小澤一史
    • Organizer
      日本内分泌学会第 40 回内分泌代謝学サマーセミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 発達期エストロゲン曝露による生殖機能不全をもたらす神経内分泌メカニズム2022

    • Author(s)
      美辺詩織、井上直子、上野山賀久、小澤一史、束村博子
    • Organizer
      第94回日本内分泌学会学術総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 発達期環境ストレスと神経内分泌メカニズム2022

    • Author(s)
      美辺詩織、井上直子、上野山賀久、小澤一史、束村博子
    • Organizer
      第22回日本内分泌学会関東甲信越支部学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Effects of Diet-Induced Obesity on Hypothalamic Kisspeptin-Neurokinin B-Dynorphin (KNDy) Neurons and Luteinizing Hormone Secretion in Sex Hormone-Primed Male and Female Rats2021

    • Author(s)
      Minabe, S., Iwata, K. and Ozawa, H.
    • Organizer
      ENDO2021
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neonatal exposure to estrogen causes irreversible infertility via specific suppressive action on hypothalamic Kiss1 neurons in male and female rodents2021

    • Author(s)
      美辺詩織、井上直子、上野山賀久、小澤一史、束村博子
    • Organizer
      第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会 合同大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Book] 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用2022

    • Author(s)
      執筆者:81名、技術情報協会
    • Total Pages
      530
    • Publisher
      技術情報協会
    • ISBN
      9784861048777
    • Related Report
      2021 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi