| Project/Area Number |
20K16140
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 48040:Medical biochemistry-related
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| Research Institution | Tohoku University |
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Principal Investigator |
Trinh DucAnh 東北大学, 加齢医学研究所, 助教 (30837761)
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | INGs / Cellular stress / ING4 / Ing5 / Nucleolar stress / ING proteins / ING5 / ING cellular stress / ING5 response heat shock / ING5 RNA interaction / cellular stress / nucleolar stress / DNA damage |
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| Outline of Research at the Start |
The study aims to elucidate the mechanisms of cell in stress adaptation, in relevant to inhibitor of growth protein 4 (ING4). In this project, I will describe the role of ING4 and its modifications in regulation of key cellular responses to stress, including nucleolar stress and DNA damage.
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| Outline of Final Research Achievements |
We studied the nature of the cellular stress response by challenging cells to stress factors such as DNA damage, and nucleolar stress. We have found that growth protein inhibitors, including ING4 and ING5, translocated to granules at a very early stage of cellular stress. The instant translocation of ING4 in response to laser micro-irradiation-induced DNA damage showed a new role for the ING protein in the DNA damage response. The transformation to granules (cytoplasm and / or nucleus)-a characteristic found in proteins with high content of intrinsically disordered domains supported the idea that ING proteins protect cells from harmful effects under stress.
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| Academic Significance and Societal Importance of the Research Achievements |
We expanded the knowledge of the nature of cellular stress responses. We agued novel functions of ING protein as guardians of cells from stress conditions beyond their given role in regulation of cell growth. The proposed mechanisms were involved in ING intrinsically disordered domains.
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