Establishment a new 5-FU therapy in pancreatic cancer through the combination of tumor-specific DPD expression inhibitory compounds

• Project/Area Number: 20K16225
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49030:Experimental pathology-related
• Research Institution: Nagoya City University
• Principal Investigator: Hiroyuki Kato 名古屋市立大学, 医薬学総合研究院(医学), 講師 (80791293)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膵癌 / 5-FU / DPYD / ルテオリン / Luteolin / 遺伝子改変マウス / 膵管癌 / STAT3 / Luteoiln / KPCマウス / DPD

Outline of Research at the Start

私たちは、フラボノイドの一種であるLuteolinが膵癌化学予防物質として有効であることを証明し、そのメカニズムとしてDPDという膵癌の標準治療で用いられる5-FUの代謝分解酵素の発現抑制が重要であることを解明しました。この事から、『5-FUとLuteolinの併用療法は、Luteolin単独投与による膵癌増殖抑制効果に加え、膵癌腫瘍内のDPD発現抑制による5-FUの治療増強効果が期待できる』と考え、膵癌動物モデルや培養細胞を用いて新規膵癌治療補助療法へ直結する研究を行います。

Outline of Final Research Achievements

It was found that Luteolin, a type of flavonoid, has a suppressive effect on pancreatic cancer development and inhibits the expression of DPYD, a 5-FU degradation enzyme. Therefore, this study examined the pancreatic cancer suppression effect of combined administration of Luteolin and 5-FU. Using KPPC mice models and xenograft models of human pancreatic cancer cell lines with DPYD overexpressed, it was revealed that combined administration showed a significant tumor suppression effect. Additionally, it was found that DPYD contributes to proliferation, invasion, and angiogenesis, and that metallopeptidase activity including MMP9 and MEP1A contributes to invasion. Results of examining substances with flavonoids other than Luteolin or with modified side chains showed that Luteolin has the highest inhibitory effect on DPYD. This study suggests the potential for pancreatic cancer suppression through combined administration of Luteolin and 5-FU.

Academic Significance and Societal Importance of the Research Achievements

ルテオリンはサプリメントとしても販売されている安全性の高い物質である。現在までにフラボノイドなどの生理活性物質は単独での薬効はそれほど高くないため、化学予防物質などでの研究がなされてきた。本研究は5-FUという膵癌の標準治療と組み合わせることによって、5-FUの治療特異的に治療効果を上昇する事が期待でき、予後の悪い膵癌への治療応用性が期待できる有用な物質である可能性がある。安全性も担保された臨床応用可能な物質であり、その社会的意義や還元性は高いと考えられる。

Research Products

• [Journal Article] Concomitant Pancreatic Ductal Adenocarcinoma and Type 1 Autoimmune Pancreatitis: A Potential Issue in the Diagnosis of Carcinoma by Endoscopic Ultrasound-guided Fine-needle Biopsy (2023)
  • Author(s): Kachi Kenta、Naitoh Itaru、Yoshida Michihiro、et al.
  • Journal Title: Internal Medicine Volume: 62 Issue: 4 Pages: 545-551
  • DOI: 10.2169/internalmedicine.0075-22
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2023-02-15
  • Peer Reviewed / Open Access
• [Journal Article] Low TINAGL1 expression is a marker for poor prognosis in breast cancer (2022)
  • Author(s): Akiko Kato, Naoto Kondo, Yumi Wanifuchi-Endo, Takashi Fujita, Tomoko Asano, Tomoka Hisada, Yasuaki Uemoto, Mitsuo Terada, Hiroyuki Kato, Masayuki Komura, Katsuhiro Okuda, Satoru Takahashi, Tatsuya Toyama
  • Journal Title: Journal of Cancer Research and Clinical Oncology Volume: epub Issue: 8 Pages: 4771-4782
  • DOI: 10.1007/s00432-022-04394-3
  • Peer Reviewed
• [Journal Article] Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer (2022)
  • Author(s): Hisada T, Kondo N, Wanifuchi-Endo Y, Osaga S, Fujita T, Asano T, Uemoto Y, Nishikawa S, Katagiri Y, Terada M, Kato A, Sugiura H, Okuda K, Kato H, Komura M, Morita S, Takahashi S, Toyama T.
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 16515-16515
  • DOI: 10.1038/s41598-022-20225-4
  • Peer Reviewed / Open Access
• [Journal Article] Use of Endoscopic Scraper and Cell Block Technique as a Replacement for Conventional Brush for Diagnosing Malignant Biliary Strictures (2022)
  • Author(s): Kato A, Kato H, Naitoh I, Hayashi K, Yoshida M, Hori Y, Kachi K, Asano G, Sahashi H, Toyohara T, Kuno K, Kito Y, Takahashi S, Kataoka H.
  • Journal Title: Cancers Volume: 14 Issue: 17 Pages: 4147-4147
  • DOI: 10.3390/cancers14174147
  • Peer Reviewed / Open Access
• [Journal Article] Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature (2022)
  • Author(s): Cholopek M, Lasota J, Thompson LDR, Szczepaniak M, Kuzniacka A, Hincza K, Kubicka K, Kaczorowski M, Newford M, Liu Y, Agaimy A, Biernat W, Durzynska M, Dziuba I, Hartmann A, Inaguma S, Izycka-Swieszewska E, Kato H, Kopczynski J, Michal M, Michal M, Peksa R, Prochorec-Sobieszek M, Starzynska A, Takahashi S, et al.
  • Journal Title: Modern Pathology Volume: 35 Issue: 11 Pages: 1609-1617
  • DOI: 10.1038/s41379-022-01122-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer (2022)
  • Author(s): Kato A, Naitoh I, Naiki-Ito A, Hayashi K, Okumura F, Fujita Y, Sano H, Nishi Y, Miyabe K, Inoue T, Hirano A, Takada H, Yoshida M, Hori Y, Natsume M, Kato H, Takahashi S, Kataoka H.
  • Journal Title: Pancreas Volume: 51 Issue: 4 Pages: 372-379
  • DOI: 10.1097/mpa.0000000000002032
  • Peer Reviewed / Open Access
• [Journal Article] Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer (2022)
  • Author(s): Yasuaki Uemoto, Eriko Katsuta, Naoto Kondo, Yumi Wanifuchi-Endo, Takashi Fujita, Tomoko Asano, Tomoka Hisada, Mitsuo Terada, Akiko Kato, Katsuhiro Okuda, Hiroshi Sugiura, Masayuki Komura, Hiroyuki Kato, Satoshi Osaga, Satoru Takahashi, Tatsuya Toyama
  • Journal Title: American Journal of Cancer Research Volume: 12 Pages: 1593-1605
  • Peer Reviewed
• [Journal Article] Discovering novel mechanisms of taxane resistance in human breast cancer by whole-exome sequencing (2022)
  • Author(s): Yumi Wanifuchi-Endo, Naoto Kondo, Yu Dong, Takashi Fujita, Tomoko Asano, Tomoka Hisada, Yasuaki Uemoto, Sayaka Nishikawa, Yusuke Katagiri, Akiko Kato, Mitsuo Terada, Hiroshi Sugiura, Katsuhiro Okuda, Hiroyuki Kato, Satoru Takahashi, Tatsuya Toyama
  • Journal Title: Oncology letters Volume: 23 Issue: 2 Pages: 60-60
  • DOI: 10.3892/ol.2021.13178
  • Peer Reviewed / Open Access
• [Journal Article] The Risk Analyses of Lymph Node Metastasis and Recurrence for Submucosal Invasive Colorectal Cancer: Novel Criteria to Skip Completion Surgery (2022)
  • Author(s): Ozeki T, Shimura T, Ozeki T, Ebi M, Iwasaki H, Kato H, Inaguma S, Okuda Y, Katano T, Nishie H, Takahashi S, Kataoka H
  • Journal Title: Cancers Volume: 14 Issue: 3 Pages: 822-822
  • DOI: 10.3390/cancers14030822
  • Peer Reviewed / Open Access
• [Journal Article] Relevance of gene mutations and methylation to the growth of pancreatic intraductal papillary mucinous neoplasms based on pyrosequencing. (2022)
  • Author(s): Asano, G., Miyabe, K., Kato, H., Yoshida, M., Sawada, T., Okamoto, Y., Sahashi, H., Atsuta, N., Kachi, K., Kato, A., Jinno, N., Natsume, M., Hori, Y., Naitoh, I., Hayashi, K., Matsuo, Y., Takahashi, S., Suzuki, H., Kataoka, H.
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 419-419
  • DOI: 10.1038/s41598-021-04335-z
  • Peer Reviewed / Open Access
• [Journal Article] Lactoferrin Prevents Hepatic Injury and Fibrosis via the Inhibition of NF-κB Signaling in a Rat Non-Alcoholic Steatohepatitis Model (2021)
  • Author(s): Aoyama Yoshinaga、Naiki-Ito Aya、Xiaochen Kuang、Komura Masayuki、Kato Hiroyuki、Nagayasu Yuko、Inaguma Shingo、Tsuda Hiroyuki、Tomita Mamoru、Matsuo Yoichi、Takiguchi Shuji、Takahashi Satoru
  • Journal Title: Nutrients Volume: 14 Issue: 1 Pages: 42-42
  • DOI: 10.3390/nu14010042
  • Peer Reviewed / Open Access
• [Journal Article] Anti-Allergic Drug Suppressed Pancreatic Carcinogenesis via Down-Regulation of Cellular Proliferation (2021)
  • Author(s): Kachi Kenta、Kato Hiroyuki、Naiki-Ito Aya、Komura Masayuki、Nagano-Matsuo Aya、Naitoh Itaru、Hayashi Kazuki、Kataoka Hiromi、Inaguma Shingo、Takahashi Satoru
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 14 Pages: 7444-7444
  • DOI: 10.3390/ijms22147444
  • Peer Reviewed / Open Access
• [Journal Article] Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review (2021)
  • Author(s): Isobe Teruki、Naiki Taku、Naiki‐Ito Aya、Kawai Tatsuya、Etani Toshiki、Nagai Takashi、Nozaki Satoshi、Kobayakawa Yuki、Iwatsuki Shoichiro、Matsuyama Nayuka、Kato Hiroyuki、Kawai Noriyasu、Yasui Takahiro
  • Journal Title: IJU Case Reports Volume: 4 Issue: 3 Pages: 188-191
  • DOI: 10.1002/iju5.12279
  • Peer Reviewed / Open Access
• [Journal Article] Nuclear grade and comedo necrosis of ductal carcinoma in situ as histopathological eligible criteria for the Japan Clinical Oncology Group 1505 trial: an interobserver agreement study (2021)
  • Author(s): Tsuda H、Yoshida M、Akiyama F、Ohi Y、Kinowaki K、Kumaki N、Kondo Y、Saito A、Sasaki E、Nishimura R、Fujii S、Homma K、Horii R、Murata Y、Itami M、Kajita S、Kato H、Kurosumi M、Sakatani T、Shimizu S、Taniguchi K、Tamiya S、Nakamura H、Kanbayashi C、Shien T、Iwata H
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 51 Issue: 3 Pages: 434-443
  • DOI: 10.1093/jjco/hyaa235
  • Peer Reviewed
• [Journal Article] Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin (2021)
  • Author(s): Suzuki S, Cohen SM, Arnold LL, Pennington KL, Gi M, Kato H, Naiki T, Naiki-Ito A, Wanibuchi H, Takahashi S.
  • Journal Title: Toxicology Letters Volume: 336 Pages: 32-38
  • DOI: 10.1016/j.toxlet.2020.11.005
  • NAID: 120007181781
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Low RAI2 expression is a marker of poor prognosis in breast cancer (2021)
  • Author(s): Nishikawa S, Uemoto Y, Kim TS, Hisada T, Kondo N, Wanifuchi-Endo Y, Fujita T, Asano T, Katagiri Y, Terada M, Kato A, Dong Y, Sugiura H, Okuda K, Kato H, Osaga S, Takahashi S, Toyama T.
  • Journal Title: Breast Cancer Research and Treatment Volume: 187 Issue: 1 Pages: 81-93
  • DOI: 10.1007/s10549-021-06176-w
  • Peer Reviewed / Open Access
• [Journal Article] PBK expression predicts favorable survival in colorectal cancer patients (2021)
  • Author(s): Nagano-Matsuo A, Inoue S, Koshino A, Ota A, Nakao K, Komura M, Kato H, Naiki-Ito A, Watanabe K, Nagayasu Y, Hosokawa Y, Takiguchi S, Kasugai K, Kasai K, Inaguma S, Takahashi S
  • Journal Title: Virchows Archiv Volume: - Issue: 2 Pages: 277-284
  • DOI: 10.1007/s00428-021-03062-0
  • Peer Reviewed / Open Access
• [Journal Article] DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer (2021)
  • Author(s): Kato H, Naiki-Ito A, Suzuki S, Inaguma S, Komura M, Nakao K, Naiki T, Kachi K, Kato A, Matsuo Y, Takahashi S.
  • Journal Title: Carcinogenesis Volume: - Issue: 7 Pages: 940-950
  • DOI: 10.1093/carcin/bgab017
  • Peer Reviewed / Open Access
• [Journal Article] Novel case of androgen receptor‐positive cancer of unknown primary without serum prostate‐specific antigen elevation that became progression free in the long term after primary combined androgen blockade (2020)
  • Author(s): Matsuyama Nayuka、Naiki Taku、Naiki‐Ito Aya、Chaya Ryosuke、Kawai Tatsuya、Etani Toshiki、Nagai Takashi、Kato Hiroyuki、Kubota Yasue、Yasui Takahiro
  • Journal Title: IJU Case Reports Volume: 4 Issue: 1 Pages: 59-63
  • DOI: 10.1002/iju5.12241
  • Peer Reviewed / Open Access
• [Journal Article] Hexane insoluble fraction from purple rice extract retards carcinogenesis and castration-resistant cancer growth of prostate through suppression of androgen receptor mediated cell proliferation and metabolism. (2020)
  • Author(s): 5.Yeewa, R., Naiki-Ito, A., Naiki, T., Kato, H., Suzuki, S., Chewonarin, T., Takahashi, S.
  • Journal Title: Nutrients Volume: 12 Issue: 2 Pages: 558-558
  • DOI: 10.3390/nu12020558
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sentinel lymph node biopsy may be unnecessary for ductal carcinoma in situ of the breast that is small and diagnosed by preoperative biopsy (2020)
  • Author(s): Uemoto Y, Kondo N, Wanifuchi-Endo Y, Asano T, Hisada T, Nishikawa S, Katagiri Y, Terada M, Kato A, Okuda K, Sugiura H, Kato H, Takahashi S, Toyama T.
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 50 Issue: 12 Pages: 1364-1369
  • DOI: 10.1093/jjco/hyaa151
  • Peer Reviewed
• [Journal Article] Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats (2020)
  • Author(s): Suzuki S, Gi M, Toyoda T, Kato H, Naiki-Ito A, Kakehashi A, Ogawa K, Takahashi S, Wanibuchi H.
  • Journal Title: Journal of Toxicologic Pathology Volume: 33 Issue: 4 Pages: 279-285
  • DOI: 10.1293/tox.2020-0038
  • NAID: 130007931389
  • ISSN: 0914-9198, 1881-915X
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo (2020)
  • Author(s): Suzuki Shugo、Cohen Samuel M.、Arnold Lora L.、Pennington Karen L.、Kato Hiroyuki、Naiki Taku、Naiki-Ito Aya、Yamashita Yoriko、Takahashi Satoru
  • Journal Title: Toxicology Volume: 429 Pages: 152325-152325
  • DOI: 10.1016/j.tox.2019.152325
  • Peer Reviewed / Open Access
• [Journal Article] Selective lysine-specific demethylase 1 inhibitor, NCL1, could cause testicular toxicity via the regulation of apoptosis (2020)
  • Author(s): Nozaki S, Naiki T, Naiki-Ito A, Iwatsuki S, Takeda T, Etani T, Nagai T, Iida K, Kato H, Suzuki T, Takahashi S, Umemoto Y, Yasui T.
  • Journal Title: Andrology Volume: 8 Issue: 6 Pages: 1895-1906
  • DOI: 10.1111/andr.12846
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rare case of carcinoma in situ originated in right retrocaval ureter successfully managed with laparoscopic procedure (2020)
  • Author(s): Noda Yusuke、Naiki Taku、Naiki‐Ito Aya、Kato Hiroyuki、Etani Toshiki、Shimizu Nobuhiko、Nagai Takashi、Iwatsuki Shoichiro、Hamamoto Shuzo、Yasui Takahiro
  • Journal Title: IJU Case Reports Volume: 3 Issue: 4 Pages: 128-131
  • DOI: 10.1002/iju5.12163
  • Peer Reviewed
• [Journal Article] Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum (2020)
  • Author(s): Nakanishi, H. Sawada, T. Kaizaki, Y. Ota, R. Suzuki, H. Yamamoto, E. Aoki, H. Eizuka, M. Hasatani, K. Takahashi, N. Inagaki, S. Ebi, M. Kato, H. Kubota, E. Kataoka, H. Takahashi, S. Tokino, T. Minamoto, T. Sugai, T. Sasaki, Y.
  • Journal Title: PLoS One Volume: 15 Issue: 2 Pages: e0229262-e0229262
  • DOI: 10.1371/journal.pone.0229262
  • Peer Reviewed / Open Access
• [Journal Article] A novel model of non-alcoholic steatohepatitis with fibrosis and carcinogenesis in connexin 32 dominant-negative transgenic rats (2020)
  • Author(s): Naiki-Ito A, Kato H, Naiki T, Yeewa R, Aoyama Y, Nagayasu Y, Suzuki S, Inaguma S, Takahashi S.
  • Journal Title: Archives of Toxicology Volume: 94 Issue: 12 Pages: 4085-4097
  • DOI: 10.1007/s00204-020-02873-5
  • Peer Reviewed / Open Access
• [Journal Article] Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo (2020)
  • Author(s): Mapoung S, Suzuki S, Fuji S, Naiki-Ito A, Kato H, Yodkeeree S, Sakorn N, Ovatlarnporn C, Takahashi S, Limtrakul Dejkriengkraikul P.
  • Journal Title: Molecules Volume: 25 Issue: 12 Pages: 2737-2737
  • DOI: 10.3390/molecules25122737
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epithelial cyst arising in an intrapancreatic accessory spleen: a case report of robotic surgery and review of minimally invasive treatment (2020)
  • Author(s): Kato Tomokatsu、Matsuo Yoichi、Ueda Goro、Aoyama Yoshinaga、Omi Kan、Hayashi Yuichi、Imafuji Hiroyuki、Saito Kenta、Tsuboi Ken、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Kato Hiroyuki、Yoshida Michihiro、Naitoh Itaru、Hayashi Kazuki、Takahashi Satoru、Takiguchi Shuji
  • Journal Title: BMC Surgery Volume: 20 Issue: 1 Pages: 263-263
  • DOI: 10.1186/s12893-020-00927-0
  • Peer Reviewed / Open Access
• [Journal Article] The standard form of CD44 as a marker for invasion of encapsulated papillary carcinoma of the breast (2020)
  • Author(s): Kato H, Naiki-Ito A, Yamada T, Suzuki S, Yamashita Y, Inaguma S, Kondo N, Wanifuchi-Endo Y, Toyama T, Takahashi S.
  • Journal Title: Pathology International Volume: 70 Issue: 11 Pages: 835-843
  • DOI: 10.1111/pin.13001
  • Peer Reviewed
• [Journal Article] Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway (2020)
  • Author(s): Iida Keitaro、Naiki Taku、Naiki‐Ito Aya、Suzuki Shugo、Kato Hiroyuki、Nozaki Satoshi、Nagai Takashi、Etani Toshiki、Nagayasu Yuko、Ando Ryosuke、Kawai Noriyasu、Yasui Takahiro、Takahashi Satoru
  • Journal Title: Cancer Science Volume: 111 Issue: 4 Pages: 1165-1179
  • DOI: 10.1111/cas.14334
  • Peer Reviewed / Open Access
• [Presentation] 全身性ヘモクロマトーシスを伴う有口赤血球症の１剖検例 (2022)
  • Author(s): 加藤 寛之、小村 理行、内木 綾、稲熊 真悟、高橋 智
  • Organizer: 第111回日本病理学会総会
• [Presentation] DPYD and STAT3 pathway are inhibited by luteolin and show interdependent expression in pancreatic cancer (2022)
  • Author(s): Hiroyuki Kato, Naiki-Aya Ito, Komura Masayuki, Shingo Inaguma, Satoru Takahashi
  • Organizer: The 7th JCA-AACR Special Joint Conference
  • Int'l Joint Research
• [Presentation] The role of dipyrimidine dehydrogenase in pancreatic cancer (2022)
  • Author(s): Hiroyuki Kato, Aya Naiki-Ito, Shingo Inaguma, Komura Masayuki, Satoru Takahashi
  • Organizer: The 81th Annual Meeting of Japanese Cancer Association
• [Presentation] 膵癌におけるLuteolinのDPYD抑制効果の意義と5-FU併用投与による効果の検討 (2022)
  • Author(s): 加藤 寛之、内木 綾、小村 理行、高橋 智
  • Organizer: 第39回日本同区性病理学会及び学術総会
• [Presentation] 膵癌におけるDPYD発現の寄与と発現抑制機序の検討 (2022)
  • Author(s): 加藤寛之、内木綾、小村理行、高橋智
  • Organizer: 第38回日本毒性病理学会総会及び学術集会
• [Presentation] エラグ酸の膵発癌抑制効果の検討 (2021)
  • Author(s): 加藤寛之、内木綾、小村理行、高橋智
  • Organizer: 第110回日本病理学会総会
• [Presentation] STAT3-DPYD経路を介したLuteolinの膵癌化学予防効果の検討 (2021)
  • Author(s): 加藤寛之、内木綾
  • Organizer: 第27回日本食品化学学会学術大会
• [Presentation] DPYD regulation in pancreatic cancer cell (2021)
  • Author(s): Hiroyuki Kato, Aya Naiki-Ito, Shingo Inaguma, Komura Masayuki, Satoru Takahashi
  • Organizer: The 80th Annual Meeting of the Japanese Cancer Association
• [Presentation] 加藤 寛之、内木 綾、小村 理行、高橋 智 (2021)
  • Author(s): エラグ酸の膵発癌抑制効果と膵癌におけるレジスチンの効果の検討
  • Organizer: 第37回日本毒性病理学会総会及び学術集会
• [Presentation] LuteolinはSTAT3経路とDPD発現を低下させ膵発癌を抑制する (2020)
  • Author(s): 加藤 寛之, 内木 綾, 鈴木 周五, 山下 依子, 稲熊 真悟, 高橋 智
  • Organizer: 第109回日本病理学会総会
• [Presentation] Ellagic acid prevents pancreatic carcinogenesis in hamster model (2020)
  • Author(s): Hiroyuki Kato, Aya Naiki-Ito, Masayuki Komura, Shingo Inaguma, Satoru Takahashi
  • Organizer: The 79th Annual Meeting of the Japanese Cancer Association