• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of the Effect of Myokine on Immunotherapeutic Efficacy and Safety in Patients with Non-Small Cell Lung Cancer

Research Project

Project/Area Number 20K16432
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 50020:Tumor diagnostics and therapeutics-related
Research InstitutionNational Hospital Organization, Kyushu Cancer Center

Principal Investigator

Takamori Shinkichi  独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 呼吸器腫瘍科医師 (20839542)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsマイオカイン / サルコペニア / 骨格筋 / 肺癌 / 免疫チェックポイント阻害薬 / バイオマーカー / 非小細胞肺癌 / 免疫治療 / 免疫チェックポイント阻害剤
Outline of Research at the Start

進行非小細胞肺癌の薬物治療として免疫チェックポイント阻害剤が開発され、治療成績の向上に寄与している。免疫チェックポイント阻害剤の効果予測因子として、患者の栄養状態が注目されている。中でも骨格筋量は、栄養状態の指標として広く使用されている。担癌患者において、治療前のサルコペニアが予後と関係するという主旨の報告は多い。しかしながら、その生物学的背景について検討・議論された報告は極めて少ない。近年、骨格筋由来のサイトカイン(マイオカイン)が注目されている。我々は本研究の目的を、免疫チェックポイント阻害剤による治療を受ける進行非小細胞肺癌患者における、マイオカインの生物学的影響を解明する事とした。

Outline of Final Research Achievements

Skeletal muscle area was measured on pretreatment CT images. Blood myokines were measured comprehensively for 15 types using Filgen's MILLIPLEX Human Myokine Panel. When 123 blood samples were submitted to Filgen, 10 of the 15 myokines were found to be almost below detection sensitivity. Among the 5 myokines that were measurable, SPARC (secreted protein acidic and rich in cysteine) correlated with skeletal muscle mass and tended to be higher in patients who responded to immunotherapy. These results were presented at the 63rd Annual Meeting of the Japanese Lung Cancer Association, Scientific Committee Symposium Session, and are currently being discussed.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果、マイオカインのSPARC (secreted protein acidic and rich in cysteine)が免疫治療効果と関係することが明らかとなった。この結果から、骨格筋量減少(サルコペニア)を有する患者に対する解決策に繋がることが期待される。今後、サルコペニアの肺癌患者にマイオカインのSPARC を補充する新規薬剤開発に繋がる可能性がある。サルコペニアの肺癌患者に対する様々な介入試験を行う際の重要なrationaleとなると考えられ、肺癌免疫療法や肺癌悪液質の領域におけるBreakthroughに繋がる可能性がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (49 results)

All 2022 2021 2020

All Journal Article (37 results) (of which Int'l Joint Research: 21 results,  Peer Reviewed: 37 results,  Open Access: 16 results) Presentation (12 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Journal Article] The clinical impact of concomitant medication?use on the outcome of postoperative recurrent non-small-cell lung cancer in patients receiving immune checkpoint inhibitors2022

    • Author(s)
      Takada Kazuki、Shimokawa Mototsugu、Takamori Shinkichi、Shimamatsu Shinichiro、Hirai Fumihiko、Ono Yuki、Tagawa Tetsuzo、Okamoto Tatsuro、Hamatake Motoharu、Okamoto Isamu、Mori Masaki
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 2 Pages: 0263247-0263247

    • DOI

      10.1371/journal.pone.0263247

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comments on ‘The Impact of Beta Blockers on Survival Outcomes in Patients With Non-small-cell Lung Cancer Treated With Immune Checkpoint Inhibitors’2022

    • Author(s)
      Takada Kazuki、Takamori Shinkichi、Miura Naoko、Shikada Yasunori、Shimokawa Mototsugu
    • Journal Title

      Clinical Lung Cancer

      Volume: 23 Issue: 3 Pages: e174-e175

    • DOI

      10.1016/j.cllc.2021.08.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comments on “Lobe-specific Lymph Node Dissection in Clinical Stage IA Solid-dominant Non-small-cell Lung Cancer: A Propensity Score Matching Study”2022

    • Author(s)
      Takamori Shinkichi、Takada Kazuki、Shimokawa Mototsugu、Okamoto Tatsuro
    • Journal Title

      Clinical Lung Cancer

      Volume: 23 Issue: 2 Pages: e135-e136

    • DOI

      10.1016/j.cllc.2021.06.014

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prospective observational study of nutritional/immunologic indices as predictive biomarkers for the response to anti-PD-1 drugs in non-small cell lung cancer (ICI-PREDICT study)2021

    • Author(s)
      Takamori Shinkichi、Ohba Taro、Shimokawa Mototsugu、Matsubara Taichi、Haratake Naoki、Miura Naoko、Toyozawa Ryo、Yamaguchi Masafumi、Seto Takashi、Takenoyama Mitsuhiro
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 10 Pages: 0258616-0258616

    • DOI

      10.1371/journal.pone.0258616

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Correspondence Regarding “Tolerability of Coronavirus Disease 2019 Vaccines BNT162b2 and mRNA-1273 in Patients With Thymic Epithelial Tumors”2021

    • Author(s)
      Takada Kazuki、Takamori Shinkichi、Miura Naoko、Shikada Yasunori、Shimokawa Mototsugu
    • Journal Title

      JTO Clinical and Research Reports

      Volume: 2 Issue: 11 Pages: 100238-100238

    • DOI

      10.1016/j.jtocrr.2021.100238

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful treatment of locally advanced lung cancer using late concurrent chemoradiation therapy administered after immune checkpoint inhibitor plus platinum chemotherapy2021

    • Author(s)
      Matsubara Taichi、Takamori Shinkichi、Fujishita Takatoshi、Toyozawa Ryo、Ito Kensaku、Yamaguchi Masafumi、Seto Takashi、Okamoto Tatsuro
    • Journal Title

      Thoracic Cancer

      Volume: 12 Issue: 23 Pages: 3286-3289

    • DOI

      10.1111/1759-7714.14200

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic impact of chronological age on efficacy of immune checkpoint inhibitors in non‐small‐cell lung cancer: Real‐world data from 86?173 patients2021

    • Author(s)
      Takamori Shinkichi、Shimokawa Mototsugu、Komiya Takefumi
    • Journal Title

      Thoracic Cancer

      Volume: 12 Issue: 21 Pages: 2943-2948

    • DOI

      10.1111/1759-7714.14178

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic Impact of Single and Multiple Descriptors in Pathologically Staged T3N0M0 NSCLC2021

    • Author(s)
      Komiya Takefumi、Powell Emily、Takamori Shinkichi
    • Journal Title

      JTO Clinical and Research Reports

      Volume: 2 Issue: 3 Pages: 100111-100111

    • DOI

      10.1016/j.jtocrr.2020.100111

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Re: COVID-19 in patients with neuroendocrine neoplasms: Preliminary results of a worldwide survey (The INTENSIVE study)2021

    • Author(s)
      Takada Kazuki、Takamori Shinkichi、Miura Naoko、Shikada Yasunori、Shimokawa Mototsugu
    • Journal Title

      European Journal of Cancer

      Volume: 157 Pages: 529-530

    • DOI

      10.1016/j.ejca.2021.07.046

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeted Therapy for RET Fusion Lung Cancer: Breakthrough and Unresolved Issue2021

    • Author(s)
      Takamori Shinkichi、Matsubara Taichi、Haratake Naoki、Toyokawa Gouji、Fujishita Takatoshi、Toyozawa Ryo、Ito Kensaku、Yamaguchi Masafumi、Taguchi Kenichi、Okamoto Tatsuro、Seto Takashi
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 704084-704084

    • DOI

      10.3389/fonc.2021.704084

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sarcoid‐like reaction of the extrathoracic lymph node in a patient with lung adenocarcinoma treated with pembrolizumab2021

    • Author(s)
      Takamori Shinkichi、Furubayashi Nobuki、Taguchi Kenichi、Matsubara Taichi、Fujishita Takatoshi、Ito Kensaku、Yamaguchi Masafumi、Toyozawa Ryo、Seto Takashi、Negishi Takahito、Nakamura Motonobu、Okamoto Tatsuro
    • Journal Title

      Thoracic Cancer

      Volume: 12 Issue: 14 Pages: 2122-2125

    • DOI

      10.1111/1759-7714.14011

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti?PD-1 Monotherapy for Advanced NSCLC Patients with Older Age or Those with Poor Performance Status2021

    • Author(s)
      Matsubara Taichi、Seto Takashi、Takamori Shinkichi、Fujishita Takatoshi、Toyozawa Ryo、Ito Kensaku、Yamaguchi Masafumi、Okamoto Tatsuro
    • Journal Title

      OncoTargets and Therapy

      Volume: Volume 14 Pages: 1961-1968

    • DOI

      10.2147/ott.s301500

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dramatic intracranial response to tepotinib in a patient with lung adenocarcinoma harboring <scp> <i>MET</i> </scp> exon 14 skipping mutation2021

    • Author(s)
      Takamori Shinkichi、Matsubara Taichi、Fujishita Takatoshi、Ito Kensaku、Toyozawa Ryo、Seto Takashi、Yamaguchi Masafumi、Okamoto Tatsuro
    • Journal Title

      Thoracic Cancer

      Volume: 12 Issue: 6 Pages: 978-980

    • DOI

      10.1111/1759-7714.13871

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Survival benefit from immunocheckpoint inhibitors in stage IV non‐small cell lung cancer patients with brain metastases: A National Cancer Database propensity‐matched analysis2021

    • Author(s)
      Takamori Shinkichi、Komiya Takefumi、Powell Emily
    • Journal Title

      Cancer Medicine

      Volume: 10 Issue: 3 Pages: 923-932

    • DOI

      10.1002/cam4.3675

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reasons to Consider the COVID-19 Vaccination Status of Patients With Cancer When Analyzing Their COVID-19 Outcomes2021

    • Author(s)
      Takada Kazuki、Takamori Shinkichi、Miura Naoko、Shikada Yasunori、Shimokawa Mototsugu
    • Journal Title

      Journal of Clinical Oncology

      Volume: 39 Issue: 35 Pages: 3996-3996

    • DOI

      10.1200/jco.21.01561

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Re: Predictive ability of a drug-based score in patients with advanced non-small-cell lung cancer receiving first-line immunotherapy2021

    • Author(s)
      Takada Kazuki、Takamori Shinkichi、Miura Naoko、Shikada Yasunori、Shimokawa Mototsugu
    • Journal Title

      European Journal of Cancer

      Volume: 155 Pages: 313-314

    • DOI

      10.1016/j.ejca.2021.06.057

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mutual checking system for assessing trainee skills of thoracic surgery2021

    • Author(s)
      Miura Naoko、Matsubara Taichi、Takamori Shinkichi、Akamine Takaki、Haratake Naoki、Shikada Yasunori、Yamaguchi Masafumi、Okamoto Tatsuro、Takenoyama Mitsuhiro
    • Journal Title

      Asian Cardiovascular and Thoracic Annals

      Volume: 29 Issue: 8 Pages: 792-797

    • DOI

      10.1177/02184923211025439

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prognostic impact of primary cancer adjoining emphysematous bullae in non-small cell lung cancer patients treated with immune checkpoint inhibitors2021

    • Author(s)
      Takamori Shinkichi、Takada Kazuki、Shimokawa Mototsugu、Jinnnouchi Mikako、Matsubara Taichi、Haratake Naoki、Miura Naoko、Toyozawa Ryo、Yamaguchi Masafumi、Takenoyama Mitsuhiro、Yoneshima Yasuto、Tanaka Kentaro、Okamoto Isamu、Tagawa Tetsuzo、Mori Masaki
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 70 Issue: 6 Pages: 1745-1753

    • DOI

      10.1007/s00262-020-02783-6

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical course and prognosis of patients with lung cancer who develop anticancer therapy-related pneumonitis2021

    • Author(s)
      Matsubara Taichi、Yamaguchi Masafumi、Jinnouchi Mikako、Takamori Shinkichi、Fujishita Takatoshi、Toyozawa Ryo、Ito Kensaku、Shimokawa Mototsugu、Seto Takashi、Okamoto Tatsuro
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 147 Issue: 6 Pages: 1857-1864

    • DOI

      10.1007/s00432-020-03478-2

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical utility of pretreatment Glasgow prognostic score in non-small-cell lung cancer patients treated with immune checkpoint inhibitors2021

    • Author(s)
      Takamori Shinkichi、Takada Kazuki、Shimokawa Mototsugu、Matsubara Taichi、Fujishita Takatoshi、Ito Kensaku、Toyozawa Ryo、Yamaguchi Masafumi、Okamoto Tatsuro、Yoneshima Yasuto、Tanaka Kentaro、Okamoto Isamu、Tagawa Tetsuzo、Mori Masaki
    • Journal Title

      Lung Cancer

      Volume: 152 Pages: 27-33

    • DOI

      10.1016/j.lungcan.2020.11.026

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of thoracic radiation in extensive stage small cell lung cancer: a NCDB analysis2021

    • Author(s)
      Komiya Takefumi、Powell Emily、Takamori Shinkichi
    • Journal Title

      Medical Oncology

      Volume: 38 Issue: 4

    • DOI

      10.1007/s12032-021-01489-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical impact of probiotics on the efficacy of anti‐PD‐1 monotherapy in patients with nonsmall cell lung cancer: A multicenter retrospective survival analysis study with inverse probability of treatment weighting2021

    • Author(s)
      Takada Kazuki、Shimokawa Mototsugu、Takamori Shinkichi、Shimamatsu Shinichiro、Hirai Fumihiko、Tagawa Tetsuzo、Okamoto Tatsuro、Hamatake Motoharu、Tsuchiya‐Kawano Yuko、Otsubo Kohei、Inoue Koji、Yoneshima Yasuto、Tanaka Kentaro、Okamoto Isamu、Nakanishi Yoichi、Mori Masaki
    • Journal Title

      International Journal of Cancer

      Volume: - Issue: 2 Pages: 473-482

    • DOI

      10.1002/ijc.33557

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of preoperative inflammatory markers in non-small cell lung cancer patients: A multicenter retrospective study2020

    • Author(s)
      Takada Kazuki、Takamori Shinkichi、Matsubara Taichi、Haratake Naoki、Akamine Takaki、Kinoshita Fumihiko、Ono Yuki、Wakasu Sho、Tanaka Kensuke、Oku Yuka、Oba Taro、Osoegawa Atsushi、Tagawa Tetsuzo、Takenoyama Mitsuhiro、Shimokawa Mototsugu、Oda Yoshinao、Mori Masaki
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 11 Pages: e0241580-e0241580

    • DOI

      10.1371/journal.pone.0241580

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of the Best Prognostic Marker Among Immunonutritional Parameters Using Serum C-Reactive Protein and Albumin in Non-Small Cell Lung Cancer2020

    • Author(s)
      Matsubara Taichi、Takamori Shinkichi、Haratake Naoki、Fujishita Takatoshi、Toyozawa Ryo、Ito Kensaku、Shimokawa Mototsugu、Yamaguchi Masafumi、Seto Takashi、Okamoto Tatsuro
    • Journal Title

      Annals of Surgical Oncology

      Volume: 28 Issue: 6 Pages: 3046-3054

    • DOI

      10.1245/s10434-020-09230-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cohesion between pulmonary artery and bronchus after immune checkpoint inhibitor therapy in a lung cancer patient2020

    • Author(s)
      Takamori Shinkichi、Takenoyama Mitsuhiro、Matsubara Taichi、Fujishita Takatoshi、Ito Kensaku、Yamaguchi Masafumi、Toyozawa Ryo、Seto Takashi、Okamoto Tatsuro
    • Journal Title

      Thoracic Cancer

      Volume: 11 Issue: 12 Pages: 3605-3608

    • DOI

      10.1111/1759-7714.13697

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic Impact of Smoking Period in Patients with Surgically Resected Non-small Cell Lung Cancer2020

    • Author(s)
      Takamori Shinkichi、Shimokawa Mototsugu、Matsubara Taichi、Haratake Naoki、Toyozawa Ryo、Miura Naoko、Yamaguchi Masafumi、Seto Takashi、Tagawa Tetsuzo、Okamoto Tatsuro、Takenoyama Mitsuhiro、Maehara Yoshihiko、Mori Masaki
    • Journal Title

      Annals of Surgical Oncology

      Volume: 28 Issue: 2 Pages: 685-694

    • DOI

      10.1245/s10434-020-08851-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] ASO Author Reflections: Which of Smoking Duration or Smoking Intensity Contributes to Poor Prognosis After Resection of Non-small Cell Lung Cancer?2020

    • Author(s)
      Takamori Shinkichi、Okamoto Tatsuro、Mori Masaki
    • Journal Title

      Annals of Surgical Oncology

      Volume: 27 Issue: S3 Pages: 834-835

    • DOI

      10.1245/s10434-020-08852-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histological conversion from adenocarcinoma to small cell carcinoma of the lung after treatment with an immune checkpoint inhibitor: a case report2020

    • Author(s)
      Miura Naoko、Matsubara Taichi、Takamori Shinkichi、Haratake Naoki、Toyozawa Ryo、Yamaguchi Masafumi、Seto Takashi、Taguchi Kenichi、Takenoyama Mitsuhiro
    • Journal Title

      Oxford Medical Case Reports

      Volume: 2020 Issue: 4-5

    • DOI

      10.1093/omcr/omaa026

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brain cavernous hemangioma mimicking radiation‐induced necrosis in a patient with non‐small cell lung cancer2020

    • Author(s)
      Takamori Shinkichi、Seto Takashi、Jinnouchi Mikako、Matsubara Taichi、Haratake Naoki、Miura Naoko、Toyozawa Ryo、Yamaguchi Masafumi、Takenoyama Mitsuhiro
    • Journal Title

      Thoracic Cancer

      Volume: 11 Issue: 7 Pages: 2056-2058

    • DOI

      10.1111/1759-7714.13494

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of immune-inflammation-nutritional parameters on the prognosis of non-small cell lung cancer patients treated with atezolizumab2020

    • Author(s)
      Matsubara Taichi、Takamori Shinkichi、Haratake Naoki、Toyozawa Ryo、Miura Naoko、Shimokawa Mototsugu、Yamaguchi Masafumi、Seto Takashi、Takenoyama Mitsuhiro
    • Journal Title

      Journal of Thoracic Disease

      Volume: 12 Issue: 4 Pages: 1520-1528

    • DOI

      10.21037/jtd.2020.02.27

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum markers associated with treatment response and survival in non-small cell lung cancer patients treated with anti-PD-1 therapy2020

    • Author(s)
      Takada Kazuki、Takamori Shinkichi、Yoneshima Yasuto、Tanaka Kentaro、Okamoto Isamu、Shimokawa Mototsugu、Oba Taro、Osoegawa Atsushi、Tagawa Tetsuzo、Takenoyama Mitsuhiro、Oda Yoshinao、Nakanishi Yoichi、Mori Masaki
    • Journal Title

      Lung Cancer

      Volume: 145 Pages: 18-26

    • DOI

      10.1016/j.lungcan.2020.04.034

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predictive and prognostic impact of primary tumor‐bearing lobe in nonsmall cell lung cancer patients treated with anti‐PD ‐1 therapy2020

    • Author(s)
      Takamori Shinkichi、Takada Kazuki、Shimokawa Mototsugu、Matsubara Taichi、Haratake Naoki、Miura Naoko、Toyozawa Ryo、Yamaguchi Masafumi、Takenoyama Mitsuhiro、Yoneshima Yasuto、Tanaka Kentaro、Okamoto Isamu、Tagawa Tetsuzo、Mori Masaki
    • Journal Title

      International Journal of Cancer

      Volume: 147 Issue: 8 Pages: 2327-2334

    • DOI

      10.1002/ijc.33030

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgically Resected Second Primary Lung Adenocarcinoma After Pembrolizumab Administration2020

    • Author(s)
      Takamori Shinkichi、Matsubara Taichi、Haratake Naoki、Miura Naoko、Yamaguchi Masafumi、Toyozawa Ryo、Seto Takashi、Taguchi Kenichi、Takenoyama Mitsuhiro
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 110 Issue: 5 Pages: e377-e379

    • DOI

      10.1016/j.athoracsur.2020.03.059

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of skeletal muscle area in patients with non-small cell lung cancer treated with anti-PD-1 inhibitors2020

    • Author(s)
      Takada Kazuki、Yoneshima Yasuto、Tanaka Kentaro、Okamoto Isamu、Shimokawa Mototsugu、Wakasu Sho、Takamori Shinkichi、Toyokawa Gouji、Oba Taro、Osoegawa Atsushi、Tagawa Tetsuzo、Oda Yoshinao、Nakanishi Yoichi、Mori Masaki
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 146 Issue: 5 Pages: 1217-1225

    • DOI

      10.1007/s00432-020-03146-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] <p>Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with <em>ROS1</em>-Positive Lung Adenocarcinoma</p>2020

    • Author(s)
      Takamori Shinkichi、Seto Takashi、Jinnouchi Mikako、Oba Taro、Yamaguchi Masafumi、Takenoyama Mitsuhiro
    • Journal Title

      Therapeutics and Clinical Risk Management

      Volume: Volume 16 Pages: 17-20

    • DOI

      10.2147/tcrm.s229860

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute Generalized Exanthematous Pustulosis Caused by the Combination of Pembrolizumab Plus Chemotherapy in a Patient With Squamous-Cell Carcinoma2020

    • Author(s)
      Matsubara Taichi、Uchi Hiroshi、Haratake Naoki、Takamori Shinkichi、Toyozawa Ryo、Miura Naoko、Yamaguchi Masafumi、Seto Takashi、Takenoyama Mitsuhiro
    • Journal Title

      Clinical Lung Cancer

      Volume: 21 Issue: 2 Pages: e54-e56

    • DOI

      10.1016/j.cllc.2019.11.009

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic Impact of Postoperative Skeletal Muscle Decrease in Non-Small Cell Lung Cancer2020

    • Author(s)
      Takamori Shinkichi、Tagawa Tetsuzo、Toyokawa Gouji、Shimokawa Mototsugu、Kinoshita Fumihiko、Kozuma Yuka、Matsubara Taichi、Haratake Naoki、Akamine Takaki、Hirai Fumihiko、Honda Hiroshi、Maehara Yoshihiko
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 109 Issue: 3 Pages: 914-920

    • DOI

      10.1016/j.athoracsur.2019.09.035

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 切除可能肺がん患者におけるサルコペニアの診断、治療介入と手術成績の話題提供:外科医の立場から2022

    • Author(s)
      高森 信吉、渡部 健二、橋之口 朝仁、松堂 響人、長野 太智 河野 幹寛、三浦 奈央子、竹中 朋祐、吉住 朋晴
    • Organizer
      第63回 日本肺癌学会学術集会 学術委員会シンポジウムセッション
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Survival benefit from immunocheckpoint inhibitors in stage IV non-small cell lung cancer patients 75 years old of age2021

    • Author(s)
      Shinkichi Takamori, Takefumi Komiya, Emily Powell
    • Organizer
      IASLC World Conference on Lung Cancer 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Albumin-bilirubin grade as a significant prognostic factor in patients with non-small cell lung cancer treated with anti-PD-1-based therapy: A multicenter retrospective study2021

    • Author(s)
      Shinkichi Takamori, Kazuki Takada, Mototsugu Shimokawa, Gouji Toyokawa, Shinichiro Shimamatsu, Fumihiko Hirai, Tetsuzo Tagawa,5 Tatsuro Okamoto, Motoharu Hamatake, Yuko Tsuchiya-Kawano, Kohei Otsubo, Koji Inoue, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Yoichi Nakanishi, Masaki Mori
    • Organizer
      American Society of Clinical Oncology 2021
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 根治照射不能な進行非小細胞肺癌患者における免疫チェックポイント阻害剤の効果予測因子としての栄養免疫学的指標の臨床的意義2021

    • Author(s)
      高森 信吉、竹之山 光広、松原 太一、藤下 卓才、豊澤 亮、伊藤 謙作、山口 正史、岡本 龍郎
    • Organizer
      第18回日本免疫治療学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 臨床病期I期の非小細胞肺癌において原発肺葉部位が術後予後に与える影響2021

    • Author(s)
      高森 信吉、松原 太一、藤下 卓才、伊藤 謙作、山口 正史、岡本 龍郎
    • Organizer
      第38回 日本呼吸器外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 悪性胸膜中皮腫患者における新規予後因子derived NLRの有用性について2021

    • Author(s)
      高森 信吉、松原 太一、藤下 卓才、伊藤 謙作、山口 正史、田川 哲三、岡本 龍郎、森 正樹
    • Organizer
      第121回 日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Survival Benefit From Immunocheckpoint Inhibitors in Stage IV Non-Small Cell Lung Cancer Patients With Brain Metastases2020

    • Author(s)
      Shinkichi Takamori, Takefumi Komiya, Emily Powell
    • Organizer
      World Conference on Lung Cancer 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] PREDICTIVE AND PROGNOSTIC SIGNIFICANCE OF TUMOR LOCATION IN NON-SMALL CELL LUNG CANCER PATIENTS TREATED WITH ANTI-PD-1 THERAPY2020

    • Author(s)
      Shinkichi Takamori, Kazuki Takada, Mototsugu Shimokawa, Taichi Matsubara, Naoki Haratake, Naoko Miura, Ryo Toyozawa, Masafumi Yamaguchi, Mitsuhiro Takenoyama, Isamu Okamoto, Tetsuzo Tagawa, Masaki Mori
    • Organizer
      CHEST Annual Meeting 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Significant impact of preoperative smoking period on postoperative prognosis in patients with surgically resected non-small cell lung cancer2020

    • Author(s)
      Shinkichi Takamori, Mototsugu Shimokawa, Taichi Matsubara, Takatoshi Fujishita, Kensaku Ito, Masafumi Yamaguchi, Ryo Toyozawa, Takashi Seto, Tatsuro Okamoto
    • Organizer
      European Society for Medical Oncology Cancer Congress 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Predictive impact of primary tumor-bearing lobe in non-small cell lung cancer patients treated with anti-PD-1 therapy2020

    • Author(s)
      Shinkichi Takamori, Kazuki Takada, Mototsugu Shimokawa, Taichi Matsubara, Takatoshi Fujishita, Ryo Toyozawa, Kensaku Ito, Masafumi Yamaguchi, Tatsuro Okamoto, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Tetsuzo Tagawa, Masaki Mori
    • Organizer
      第61回 日本肺癌学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 完全切除可能な非小細胞肺癌患者における喫煙年数と1日あたりの喫煙本数の予後予測因子としての臨床的意義 -単施設・後方視的な1,134例の解析-2020

    • Author(s)
      高森 信吉、下川 元継、松原 太一、原武 直紀、豊澤 亮、三浦 奈央子、山口 正史、竹之山 光広
    • Organizer
      第120回 日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 高森 信吉、松原 太一、原武 直紀、三浦 奈央子、山口 正史、竹之山 光広2020

    • Author(s)
      完全切除可能な非小細胞肺癌患者における術後合併症の予後予測因子としての臨床的意義
    • Organizer
      第37回 日本呼吸器外科学会定期学術集会
    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi