Quantitative Evaluation of Cardiac Sarcoidosis Activity Using PET-MRI

• Project/Area Number: 20K16726
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kobe University
• Principal Investigator: Yoshiaki Watanabe 神戸大学, 医学研究科, 医学研究員 (80769612)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2022: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
• Keywords: MRI / PETMRI / 心臓サルコイドーシス / PET-MRI / 心臓MRI

Outline of Research at the Start

心臓に発症したサルコイドーシス症は予後が悪く、早期発見と最適な治療が必要となる。しかし実臨床では、心サ症は多彩な病態を示すること、侵襲的な心筋生検を用いても診断には難渋することにより、治療介入が遅れるケースがしばしば経験される。本研究では心臓サルコイドーシスの早期発見および治療介入評価を行うためのPETMRIによる非侵襲的な画像評価法の検討に加え、その知見を応用しPET-MRIをハブとして、心サ症の心臓MRIによる新しい画像評価法および定量化を可能にすることを目的としている。

Outline of Final Research Achievements

The correlation between ECV and prognosis was investigated using TAVI cases, for which a sufficient number of cases were available for quantitative evaluation of myocardium. This study demonstrates that ECV measurements on CT can quantify myocardial characteristics and predict prognosis without the use of MRI. This study was published in J Am Heart Assoc. 2021
Sep21;10(18):e020655. doi:10.1161/JAHA.120.020655. published in Epub 2021 Sep 6. The usefulness of MRI for visualization of the ablation site, which has been studied since last year, was also examined. This study was published in J Cardiovasc Electrophysiol.

Academic Significance and Societal Importance of the Research Achievements

実際にPETMRIで心臓サルコイドーシスを診断するまでは至らなかったが、心臓をPETMRIで撮像する際に必要な同期や収集方法の検討は行えたと考える。ネガティブデータになってしまったので論文の形にはできなかったが、心電図呼吸同時の同期は収集時間を縮めてしまうだけで有効でないというのは今後のPETMRIで心臓の評価を行うにあたり重要な知見と考える。また、定量化という意味ではCTでの定量化も検討できた。このCTでの定量化も今後心臓評価の重要な手法になりうると考える
これらの方法をもとに今後心臓サルコイドーシスのみならず、様々な疾患に対してPETMRIで評価を行う下地が整ったと考える。

Research Products

• [Journal Article] Diversity and determinants of the sigmoid septum and its impact on morphology of the outflow tract as revealed using cardiac computed tomography (2022)
  • Author(s): Tsuda Daisuke、Mori Shumpei、Izawa Yu、Toh Hiroyuki、Suzuki Masataka、Takahashi Yu、Toba Takayoshi、Fujiwara Sei、Tanaka Hidekazu、Watanabe Yoshiaki、Kono Atsushi K.、Hirata Ken‐ichi
  • Journal Title: Echocardiography Volume: 39 Issue: 2 Pages: 248-259
  • DOI: 10.1111/echo.15298
  • Peer Reviewed
• [Journal Article] The impact of the atrial wall thickness in normal/mild late‐gadolinium enhancement areas on atrial fibrillation rotors in persistent atrial fibrillation patients (2022)
  • Author(s): Nakamura Toshihiro、Kiuchi Kunihiko、Fukuzawa Koji、Takami Mitsuru、Watanabe Yoshiaki、Izawa Yu、Takemoto Makoto、Sakai Jun、Yatomi Atsusuke、Sonoda Yusuke、Takahara Hiroyuki、Nakasone Kazutaka、Yamamoto Kyoko、Suzuki Yuya、Tani Ken‐ichi、Negi Noriyuki、Kono Atsushi、Ashihara Takashi、Hirata Ken‐ichi
  • Journal Title: Journal of Arrhythmia Volume: 38 Issue: 2 Pages: 221-231
  • DOI: 10.1002/joa3.12676
  • Peer Reviewed / Open Access
• [Journal Article] Normative Aortic Valvar Measurements in Adults Using Cardiac Computed Tomography ― A Potential Guide to Further Sophisticate Aortic Valve-Sparing Surgery ― (2021)
  • Author(s): Izawa Yu、Mori Shumpei、Tretter Justin T.、Quintessenza James A.、Toh Hiroyuki、Toba Takayoshi、Watanabe Yoshiaki、Kono Atsushi K.、Okada Kenji、Hirata Ken-ichi
  • Journal Title: Circulation Journal Volume: 85 Issue: 7 Pages: 1059-1067
  • DOI: 10.1253/circj.CJ-20-0938
  • NAID: 130008056921
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-06-25
  • Peer Reviewed
• [Journal Article] The impact of computed tomography-derived aortic atheroma volume on prognosis after transcatheter aortic valve replacement (2021)
  • Author(s): Fujita Hiroshi、Toba Takayoshi、Miwa Keisuke、Suzuki Masataka、Takahashi Yu、Toh Hiroyuki、Izawa Yu、Kawamori Hiroyuki、Otake Hiromasa、Fujiwara Sei、Watanabe Yoshiaki、Kono Atsushi、Hirata Ken-ichi
  • Journal Title: International Journal of Cardiology Volume: 344 Pages: 60-65
  • DOI: 10.1016/j.ijcard.2021.09.053
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Myocardial Extracellular Volume Fraction Assessment Using Dual‐Energy Computed Tomography in Patients Treated With Aortic Valve Replacement for Severe Aortic Stenosis (2021)
  • Author(s): Suzuki Masataka、Toba Takayoshi、Izawa Yu、Fujita Hiroshi、Miwa Keisuke、Takahashi Yu、Toh Hiroyuki、Kawamori Hiroyuki、Otake Hiromasa、Tanaka Hidekazu、Fujiwara Sei、Watanabe Yoshiaki、Kono Atsushi K.、Okada Kenji、Hirata Ken‐ichi
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 18 Pages: 221-231
  • DOI: 10.1161/jaha.120.020655
  • NAID: 120007159912
  • Peer Reviewed
• [Journal Article] Visualization of intensive atrial inflammation and fibrosis after cryoballoon ablation: PET/MRI and LGE‐MRI analysis (2020)
  • Author(s): Kiuchi Kunihiko、Fukuzawa Koji、Nogami Munenobu、Watanabe Yoshiaki、Takami Mitsuru、Izawa Yu、Negi Noriyuki、Kyotani Katsusuke、Mori Shumpei、Hirata Ken‐Ichi
  • Journal Title: Journal of Arrhythmia Volume: 37 Issue: 1 Pages: 52-59
  • DOI: 10.1002/joa3.12454
  • NAID: 120006975811
  • Peer Reviewed / Open Access
• [Presentation] Cardiac, respiratory and dual-gated PET reconstruction for PET/MRI: Image quality assessment of the pulmonary vein after atrial fibrillation ablation (2020)
  • Author(s): Watanabe Yoshiaki
  • Organizer: European Congress of Radiology
  • Int'l Joint Research