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Precision Diagnosis for pediatric brain tumor

Research Project

Project/Area Number 20K16791
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKyushu University

Principal Investigator

Kikuchi Kazufumi  九州大学, 医学研究院, 助教 (20529838)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsMRI / 小児脳腫瘍 / 拡散強調画像 / Arterial Spin Labeling / Stretched DWI / CEST / Amide Proton Transfer / arterial spin labeling / amide proton transfer / heterogeneity index / マルチパラメトリック解析 / 動脈血スピンラベル画像 / 化学交換飽和移動画像 / 動脈スピンラベリング法 / 化学交換飽和移動 / stretched-DWI / IVIM / 機会学習 / テキスチャー解析 / 精密診断 / Radiogenomics / 分子イメージング
Outline of Research at the Start

脳腫瘍はまれな疾患であるが、小児固形腫瘍においては最多であり、術前画像診断は治療法の選択・決定や予後予測において極めて重要である。本研究の目的は、以下の3つである。
1. 造影剤を用いない非侵襲的なMRI画像撮像法の比較・分析
2. Radiomics手法を用いた画像特徴量の抽出・分析
3. AIを用いた診断法の最適化 (Multiparametric) による精密な診断法の確立
本研究では、非造影による非侵襲的な撮像法で得られた画像から、Radiomics法による特徴量の抽出により、形態的診断を超えて「目には見えない」遺伝子異常を画像から診断する方法の確立を目指す。

Outline of Final Research Achievements

The aim of this study was to identify factors that contribute to the preoperative assessment of brain tumor grading in pediatric patients using multiparametric MR analysis. By achieving accurate imaging diagnostics, it is expected to avoid biopsies or determine the optimal biopsy sites and assist in the prioritization and selection of MR sequences. It was found that α value, which indicates tumor homogeneity, and CBF, which indicates tumor blood flow, are the most useful factors for distinguishing between benign and malignant tumors. Prioritizing these parameters in imaging is critical, especially in pediatric patients who require sedation. The results of this study are expected to lead to accurate diagnosis of brain tumors, avoid the use of contrast agents and their associated injections and allergic reactions, minimize sedation-related side effects, and reduce medical costs.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、小児脳腫瘍の術前診断において、MRIのmultiparametric解析が悪性度評価に有効であることを明らかにした点にある。特に、腫瘍内部の均一性を示すα値と腫瘍血流量を示すCBFが良悪性の鑑別に寄与することを示したことは、臨床現場における診断精度の向上が期待される。これにより、生検の回避や部位の適正化が行われ、患者の負担を軽減できる可能性がある。
社会的意義は、MRIシークエンスの選択と優先順位の最適化により、鎮静や造影剤使用のリスクを低減し、医療費の抑制が期待される。また、正確な診断によって治療計画が適切に立てられ、治療効果の向上や予後の改善に繋がることが期待される。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (19 results)

All 2024 2023 2022 2021 2020

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 8 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Book (2 results)

  • [Journal Article] Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted2024

    • Author(s)
      Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Momosaka Daichi、Kikuchi Yoshitomo、Kuga Daisuke、Yuhei Sangatsuda、Fujioka Yutaka、Narutomi Fumiya、Obara Makoto、Yoshimoto Koji、Ishigami Kousei
    • Journal Title

      Neuroradiology

      Volume: 66 Issue: 3 Pages: 333-341

    • DOI

      10.1007/s00234-024-03288-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function2024

    • Author(s)
      Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Isoda Takuro、Nishimura Ataru、Arimura Koichi、Nakamizo Akira、Yoshimoto Koji、Ishigami Kousei
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 5468-5468

    • DOI

      10.1038/s41598-024-56210-2

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Grading of gliomas using 3D CEST imaging with compressed sensing and sensitivity encoding2023

    • Author(s)
      Tatsuhiro Wada, Osamu Togao, Chiaki Tokunaga, Masahiro Oga, Kazufumi Kikuchi, Koji Yamashita, Hidetaka Yamamoto, Masami Yoneyama, Koji Kobayashi, Toyoyuki Kato, Kousei Ishigami, Hidetake Yabuuchi
    • Journal Title

      European Journal of Radiology

      Volume: 158 Pages: 110654-110654

    • DOI

      10.1016/j.ejrad.2022.110654

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative relaxometry using synthetic MRI could be better than T2-FLAIR mismatch sign for differentiation of IDH-mutant gliomas: a pilot study2022

    • Author(s)
      Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Momosaka Daichi、Kikuchi Yoshitomo、Kuga Daisuke、Hata Nobuhiro、Mizoguchi Masahiro、Yamamoto Hidetaka、Iwaki Toru、Hiwatashi Akio、Ishigami Kousei
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1-8

    • DOI

      10.1038/s41598-022-13036-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional chemical exchange saturation transfer imaging using compressed SENSE for full z-spectrum acquisition.2022

    • Author(s)
      Tatsuhiro Wada, Chiaki Tokunaga, Osamu Togao, Akio Hiwatashi, Kazufumi Kikuchi, Masami Yoneyama, Koji Kobayashi, Toyoyuki Kato, Koji Yoshimoto, Kousei Ishigami, Hidetake Yabuuchi
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 92 Pages: 58-66

    • DOI

      10.1016/j.mri.2022.05.014

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A deep learning-based approach for the diagnosis of adrenal adenoma: a new trial using CT2022

    • Author(s)
      Kusunoki Masaoki、Nakayama Tomohiro、Nishie Akihiro、Yamashita Yasuo、Kikuchi Kazufumi、Eto Masatoshi、Oda Yoshinao、Ishigami Kousei
    • Journal Title

      The British Journal of Radiology

      Volume: 95 Issue: 1135

    • DOI

      10.1259/bjr.20211066

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects2022

    • Author(s)
      Hasuzawa Suguru、Tomiyama Hirofumi、Murayama Keitaro、Ohno Aikana、Kang Mingi、Mizobe Taro、Kato Kenta、Matsuo Akira、Kikuchi Kazufumi、Togao Osamu、Nakao Tomohiro
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13

    • DOI

      10.3389/fpsyt.2022.836965

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A deep convolutional neural network-based automatic detection of brain metastases with and without blood vessel suppression2022

    • Author(s)
      Kikuchi Yoshitomo、Togao Osamu、Kikuchi Kazufumi、Momosaka Daichi、Obara Makoto、Van Cauteren Marc、Fischer Alexander、Ishigami Kousei、Hiwatashi Akio
    • Journal Title

      European Radiology

      Volume: 32 Issue: 5 Pages: 2998-3005

    • DOI

      10.1007/s00330-021-08427-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gamma distribution model of diffusion MRI for evaluating the isocitrate dehydrogenase mutation status of glioblastomas2022

    • Author(s)
      Takase Hanae、Togao Osamu、Kikuchi Kazufumi、Hata Nobuhiro、Hatae Ryusuke、Chikui Toru、Tokumori Kenji、Kami Yukiko、Kuga Daisuke、Sangatsuda Yuhei、Mizoguchi Masahiro、Hiwatashi Akio、Ishigami Kousei
    • Journal Title

      The British Journal of Radiology

      Volume: 95 Issue: 1133

    • DOI

      10.1259/bjr.20210392

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vessel-Selective 4D-MRA Using Superselective Pseudocontinuous Arterial Spin-Labeling with Keyhole and View-Sharing for Visualizing Intracranial Dural AVFs2022

    • Author(s)
      Togao O.、Obara M.、Kikuchi K.、Helle M.、Arimura K.、Nishimura A.、Wada T.、Murazaki H.、Van Cauteren M.、Hiwatashi A.、Ishigami K.
    • Journal Title

      American Journal of Neuroradiology

      Volume: 43 Issue: 3 Pages: 368-375

    • DOI

      10.3174/ajnr.a7426

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of cerebral perfusion in moyamoya disease with dynamic pseudo-continuous arterial spin labeling using a variable repetition time scheme with optimized background suppression2022

    • Author(s)
      Togao Osamu、Obara Makoto、Yamashita Koji、Kikuchi Kazufumi、Arimura Koichi、Nishimura Ataru、Nakamizo Akira、Wada Tatsuhiro、Tokunaga Chiaki、Mikayama Ryoji、Yamashita Yasuo、Hamano Hiroshi、Van Cauteren Marc、Ishigami Kousei、Baba Shingo
    • Journal Title

      Neuroradiology

      Volume: 65 Issue: 3 Pages: 529-538

    • DOI

      10.1007/s00234-022-03095-5

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Papillary craniopharyngioma coexisting with an intratumoral abscess in a pediatric patient: A case report and review of the literature2021

    • Author(s)
      Takagi Katsuhiro、Kikuchi Kazufumi、Hiwatashi Akio、Togao Osamu、Sangatsuda Yuhei、Kuga Daisuke、Mizoguchi Masahiro、Yamamoto Hidetaka、Iwaki Toru、Ishigami Kousei
    • Journal Title

      Acta Radiologica Open

      Volume: 10 Issue: 7 Pages: 1-6

    • DOI

      10.1177/20584601211030661

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiation of high-grade from low-grade diffuse gliomas using diffusion-weighted imaging: a comparative study of mono-, bi-, and stretched-exponential diffusion models2020

    • Author(s)
      Kusunoki Masaoki、Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Momosaka Daichi、Kikuchi Yoshitomo、Kuga Daisuke、Hata Nobuhiro、Mizoguchi Masahiro、Iihara Koji、Suzuki Satoshi O.、Iwaki Toru、Akamine Yuta、Hiwatashi Akio
    • Journal Title

      Neuroradiology

      Volume: 62 Issue: 7 Pages: 815-823

    • DOI

      10.1007/s00234-020-02456-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic accuracy for the epileptogenic zone detection in focal epilepsy could be higher in FDG-PET/MRI than in FDG-PET/CT2020

    • Author(s)
      Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Momosaka Daichi、Nakayama Tomohiro、Kitamura Yoshiyuki、Kikuchi Yoshitomo、Baba Shingo、Sagiyama Koji、Ishimatsu Keisuke、Kamei Ryotaro、Mukae Nobutaka、Iihara Koji、Suzuki Satoshi O.、Iwaki Toru、Hiwatashi Akio
    • Journal Title

      European Radiology

      Volume: - Issue: 5 Pages: 2915-2922

    • DOI

      10.1007/s00330-020-07389-1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] VISIBLE: Improvement in Vessel Visibility and Application of Machine Learning to Detect Brain Metastases2023

    • Author(s)
      Kikuchi K, Togao O, Yamashita K, Obara M, Ishigami K
    • Organizer
      2023 ISMRM & ISMRT Annual Meeting & Exhibition
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 毛様細胞性星細胞腫とびまん性星細胞腫の比較: 非造影MRIによるヒストグラム解析2020

    • Author(s)
      菊地一史、栂尾 理、桃坂大地、菊池嘉朋、樋渡昭雄
    • Organizer
      第79回日本医学放射線学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Differentiation between Pilocytic Astrocytomas and Diffuse Astrocytomas using DWI, ASL, and CEST: A Histogram Analysis.2020

    • Author(s)
      Kikuchi K, Togao O, Momosaka D, Kikuchi Y, Hiwatashi A.
    • Organizer
      ASNR 58th Annual Meeting & NER Foundation Symposium 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Book] 症例で学ぶ中枢神経の画像診断2023

    • Author(s)
      安陪 等思 (監修), 平井 俊範 (編集), 吉浦 敬 (編集), 上谷 浩之 (編集, 著)
    • Total Pages
      400
    • Publisher
      金原出版
    • Related Report
      2023 Annual Research Report
  • [Book] 症例で学ぶ中枢神経の画像診断[Web動画付]2023

    • Author(s)
      安陪 等思、平井 俊範、吉浦 敬、上谷 浩之
    • Total Pages
      400
    • Publisher
      金原出版
    • ISBN
      9784307071307
    • Related Report
      2022 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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