Precision Diagnosis for pediatric brain tumor

• Project/Area Number: 20K16791
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyushu University
• Principal Investigator: 菊地 一史 九州大学, 医学研究院, 助教 (20529838)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 小児脳腫瘍 / MRI / 拡散強調画像 / arterial spin labeling / amide proton transfer / heterogeneity index / マルチパラメトリック解析 / 動脈血スピンラベル画像 / 化学交換飽和移動画像 / 動脈スピンラベリング法 / 化学交換飽和移動 / stretched-DWI / IVIM / 機会学習 / テキスチャー解析 / 精密診断 / Radiogenomics / 分子イメージング

Outline of Research at the Start

脳腫瘍はまれな疾患であるが、小児固形腫瘍においては最多であり、術前画像診断は治療法の選択・決定や予後予測において極めて重要である。本研究の目的は、以下の３つである。
1. 造影剤を用いない非侵襲的なMRI画像撮像法の比較・分析
2. Radiomics手法を用いた画像特徴量の抽出・分析
3. AIを用いた診断法の最適化 (Multiparametric) による精密な診断法の確立
本研究では、非造影による非侵襲的な撮像法で得られた画像から、Radiomics法による特徴量の抽出により、形態的診断を超えて「目には見えない」遺伝子異常を画像から診断する方法の確立を目指す。

Outline of Annual Research Achievements

小児の脳腫瘍の画像的診断は、経験豊富な神経放射線科医にとっても困難であるため、multiparametric MRIを用いて、小児悪性度の術前評価を行い、各種パラメータを比較し、最良の悪性度予測因子を見つけることを研究目的とした。本研究には、19名の小児患者 (男児11名、女児8名；中央値年齢4歳、範囲1-17歳) が参加し、拡散強調画像、arterial spin labelingによる灌流画像、amide protein transfer (APT) によるタンパク、アミド強調画像、腫瘍内不均一性関連パラメータを含むmultiparametric MRIを評価した。各腫瘍のT2延長領域の最大断面に関心領域を置いて、前述の8つのパラメータを測定・分析した。高悪性度・低悪性度の腫瘍の2群についてヒストグラム解析を使用して、各パラメータのパーセンタイル、平均値、歪度、尖度をマン・ホイットニーU検定で、比較した。また、Receiver Operating Characteristic分析を用いて各パラメータの診断能を評価した。その結果、拡散パラメータは、高悪性度腫瘍で低値を示し、灌流パラメータは、高悪性度腫瘍で高値を示した。腫瘍不均一性パラメータは、高悪性度腫瘍で低値を示し、歪度と尖度のαが最も優れた診断能を示した (AUC：1.00)。これらの結果から、腫瘍不均一性パラメータ αは小児脳内腫瘍の悪性度評価に有用なツールであると示唆され、術前のMRIの撮像シーケンスの優先順位決定や悪性度評価に役立つと期待された。

Research Products

• [Journal Article] Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted (2024)
  • Author(s): Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Momosaka Daichi、Kikuchi Yoshitomo、Kuga Daisuke、Yuhei Sangatsuda、Fujioka Yutaka、Narutomi Fumiya、Obara Makoto、Yoshimoto Koji、Ishigami Kousei
  • Journal Title: Neuroradiology Volume: 66 Issue: 3 Pages: 333-341
  • DOI: 10.1007/s00234-024-03288-0
  • Peer Reviewed / Open Access
• [Journal Article] Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function (2024)
  • Author(s): Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Isoda Takuro、Nishimura Ataru、Arimura Koichi、Nakamizo Akira、Yoshimoto Koji、Ishigami Kousei
  • Journal Title: Scientific Reports Volume: 14 Issue: 1 Pages: 5468-5468
  • DOI: 10.1038/s41598-024-56210-2
  • Peer Reviewed / Open Access
• [Journal Article] Grading of gliomas using 3D CEST imaging with compressed sensing and sensitivity encoding (2023)
  • Author(s): Tatsuhiro Wada, Osamu Togao, Chiaki Tokunaga, Masahiro Oga, Kazufumi Kikuchi, Koji Yamashita, Hidetaka Yamamoto, Masami Yoneyama, Koji Kobayashi, Toyoyuki Kato, Kousei Ishigami, Hidetake Yabuuchi
  • Journal Title: European Journal of Radiology Volume: 158 Pages: 110654-110654
  • DOI: 10.1016/j.ejrad.2022.110654
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative relaxometry using synthetic MRI could be better than T2-FLAIR mismatch sign for differentiation of IDH-mutant gliomas: a pilot study (2022)
  • Author(s): Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Momosaka Daichi、Kikuchi Yoshitomo、Kuga Daisuke、Hata Nobuhiro、Mizoguchi Masahiro、Yamamoto Hidetaka、Iwaki Toru、Hiwatashi Akio、Ishigami Kousei
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 1-8
  • DOI: 10.1038/s41598-022-13036-0
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional chemical exchange saturation transfer imaging using compressed SENSE for full z-spectrum acquisition. (2022)
  • Author(s): Tatsuhiro Wada, Chiaki Tokunaga, Osamu Togao, Akio Hiwatashi, Kazufumi Kikuchi, Masami Yoneyama， Koji Kobayashi, Toyoyuki Kato, Koji Yoshimoto, Kousei Ishigami, Hidetake Yabuuchi
  • Journal Title: Magnetic Resonance Imaging Volume: 92 Pages: 58-66
  • DOI: 10.1016/j.mri.2022.05.014
  • Peer Reviewed / Open Access
• [Journal Article] A deep learning-based approach for the diagnosis of adrenal adenoma: a new trial using CT (2022)
  • Author(s): Kusunoki Masaoki、Nakayama Tomohiro、Nishie Akihiro、Yamashita Yasuo、Kikuchi Kazufumi、Eto Masatoshi、Oda Yoshinao、Ishigami Kousei
  • Journal Title: The British Journal of Radiology Volume: 95 Issue: 1135
  • DOI: 10.1259/bjr.20211066
  • Peer Reviewed
• [Journal Article] Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects (2022)
  • Author(s): Hasuzawa Suguru、Tomiyama Hirofumi、Murayama Keitaro、Ohno Aikana、Kang Mingi、Mizobe Taro、Kato Kenta、Matsuo Akira、Kikuchi Kazufumi、Togao Osamu、Nakao Tomohiro
  • Journal Title: Frontiers in Psychiatry Volume: 13
  • DOI: 10.3389/fpsyt.2022.836965
  • Peer Reviewed
• [Journal Article] A deep convolutional neural network-based automatic detection of brain metastases with and without blood vessel suppression (2022)
  • Author(s): Kikuchi Yoshitomo、Togao Osamu、Kikuchi Kazufumi、Momosaka Daichi、Obara Makoto、Van Cauteren Marc、Fischer Alexander、Ishigami Kousei、Hiwatashi Akio
  • Journal Title: European Radiology Volume: 32 Issue: 5 Pages: 2998-3005
  • DOI: 10.1007/s00330-021-08427-2
  • Peer Reviewed
• [Journal Article] Gamma distribution model of diffusion MRI for evaluating the isocitrate dehydrogenase mutation status of glioblastomas (2022)
  • Author(s): Takase Hanae、Togao Osamu、Kikuchi Kazufumi、Hata Nobuhiro、Hatae Ryusuke、Chikui Toru、Tokumori Kenji、Kami Yukiko、Kuga Daisuke、Sangatsuda Yuhei、Mizoguchi Masahiro、Hiwatashi Akio、Ishigami Kousei
  • Journal Title: The British Journal of Radiology Volume: 95 Issue: 1133
  • DOI: 10.1259/bjr.20210392
  • Peer Reviewed
• [Journal Article] Vessel-Selective 4D-MRA Using Superselective Pseudocontinuous Arterial Spin-Labeling with Keyhole and View-Sharing for Visualizing Intracranial Dural AVFs (2022)
  • Author(s): Togao O.、Obara M.、Kikuchi K.、Helle M.、Arimura K.、Nishimura A.、Wada T.、Murazaki H.、Van Cauteren M.、Hiwatashi A.、Ishigami K.
  • Journal Title: American Journal of Neuroradiology Volume: 43 Issue: 3 Pages: 368-375
  • DOI: 10.3174/ajnr.a7426
  • Peer Reviewed
• [Journal Article] Assessment of cerebral perfusion in moyamoya disease with dynamic pseudo-continuous arterial spin labeling using a variable repetition time scheme with optimized background suppression (2022)
  • Author(s): Togao Osamu、Obara Makoto、Yamashita Koji、Kikuchi Kazufumi、Arimura Koichi、Nishimura Ataru、Nakamizo Akira、Wada Tatsuhiro、Tokunaga Chiaki、Mikayama Ryoji、Yamashita Yasuo、Hamano Hiroshi、Van Cauteren Marc、Ishigami Kousei、Baba Shingo
  • Journal Title: Neuroradiology Volume: 65 Issue: 3 Pages: 529-538
  • DOI: 10.1007/s00234-022-03095-5
  • Peer Reviewed
• [Journal Article] Papillary craniopharyngioma coexisting with an intratumoral abscess in a pediatric patient: A case report and review of the literature (2021)
  • Author(s): Takagi Katsuhiro、Kikuchi Kazufumi、Hiwatashi Akio、Togao Osamu、Sangatsuda Yuhei、Kuga Daisuke、Mizoguchi Masahiro、Yamamoto Hidetaka、Iwaki Toru、Ishigami Kousei
  • Journal Title: Acta Radiologica Open Volume: 10 Issue: 7 Pages: 1-6
  • DOI: 10.1177/20584601211030661
  • Peer Reviewed / Open Access
• [Journal Article] Differentiation of high-grade from low-grade diffuse gliomas using diffusion-weighted imaging: a comparative study of mono-, bi-, and stretched-exponential diffusion models (2020)
  • Author(s): Kusunoki Masaoki、Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Momosaka Daichi、Kikuchi Yoshitomo、Kuga Daisuke、Hata Nobuhiro、Mizoguchi Masahiro、Iihara Koji、Suzuki Satoshi O.、Iwaki Toru、Akamine Yuta、Hiwatashi Akio
  • Journal Title: Neuroradiology Volume: 62 Issue: 7 Pages: 815-823
  • DOI: 10.1007/s00234-020-02456-2
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic accuracy for the epileptogenic zone detection in focal epilepsy could be higher in FDG-PET/MRI than in FDG-PET/CT (2020)
  • Author(s): Kikuchi Kazufumi、Togao Osamu、Yamashita Koji、Momosaka Daichi、Nakayama Tomohiro、Kitamura Yoshiyuki、Kikuchi Yoshitomo、Baba Shingo、Sagiyama Koji、Ishimatsu Keisuke、Kamei Ryotaro、Mukae Nobutaka、Iihara Koji、Suzuki Satoshi O.、Iwaki Toru、Hiwatashi Akio
  • Journal Title: European Radiology Volume: - Issue: 5 Pages: 2915-2922
  • DOI: 10.1007/s00330-020-07389-1
  • Peer Reviewed / Open Access
• [Presentation] VISIBLE: Improvement in Vessel Visibility and Application of Machine Learning to Detect Brain Metastases (2023)
  • Author(s): Kikuchi K, Togao O, Yamashita K, Obara M, Ishigami K
  • Organizer: 2023 ISMRM & ISMRT Annual Meeting & Exhibition
  • Int'l Joint Research
• [Presentation] 毛様細胞性星細胞腫とびまん性星細胞腫の比較: 非造影MRIによるヒストグラム解析 (2020)
  • Author(s): 菊地一史、栂尾 理、桃坂大地、菊池嘉朋、樋渡昭雄
  • Organizer: 第79回日本医学放射線学会総会
• [Presentation] Differentiation between Pilocytic Astrocytomas and Diffuse Astrocytomas using DWI, ASL, and CEST: A Histogram Analysis. (2020)
  • Author(s): Kikuchi K, Togao O, Momosaka D, Kikuchi Y, Hiwatashi A.
  • Organizer: ASNR 58th Annual Meeting & NER Foundation Symposium 2020
  • Int'l Joint Research
• [Book] 症例で学ぶ中枢神経の画像診断 (2023)
  • Author(s): 安陪 等思 (監修), 平井 俊範 (編集), 吉浦 敬 (編集), 上谷 浩之 (編集, 著)
  • Total Pages: 400
  • Publisher: 金原出版
• [Book] 症例で学ぶ中枢神経の画像診断［Web動画付］ (2023)
  • Author(s): 安陪 等思、平井 俊範、吉浦 敬、上谷 浩之
  • Total Pages: 400
  • Publisher: 金原出版
  • ISBN: 9784307071307