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Exploring the biological response dynamics after proton beam irradiation through time-lapse observation: a study towards the development of optimal fractionation methods

Research Project

Project/Area Number 20K16830
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionNagoya City University

Principal Investigator

Nakajima Koichiro  名古屋市立大学, 医薬学総合研究院(医学), 研究員 (50866176)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords陽子線治療 / FLASH照射 / ショウジョウバエ / タイムラプスイメージング / 線量分割 / 生物学的効果
Outline of Research at the Start

陽子線照射後の生体内細胞応答から組織損傷(もしくは組織回復)に至るまでのプロセスは、X線照射後のそれとは異なる時間経過により実行されている可能性がある。本研究では、培養細胞とショウジョウバエのモデルを用いて、照射後の動態をタイムラプスイメージングにより観察し、そこに分子生物学的解析を加えることでいくつかの評価項目における線種毎の経時的変化を整理し、線種間の違いを比較していく。最終的には陽子線治療独自の最適な線量分割法に対する示唆を与える基礎生物学的データを発信していきたい。

Outline of Final Research Achievements

In the initial plan of this study, experiments on cultured cells and Drosophila were intended to be conducted concurrently. However, priority was given to ultra-high dose rate proton irradiation (FLASH irradiation) experiments on Drosophila. Experiments comparing normal dose rate irradiation and FLASH irradiation were conducted using wild-type Drosophila third instar larvae and virgin female adults. Post-irradiation gene expression analysis revealed differential gene expression levels due to varying dose rates in specific genes. In contrast, in the irradiation experiments on virgin female adults, no significant differences were observed in the pupation and eclosion rates of the first generation offspring (F1), nor in their activity levels per unit time post-eclosion.

Academic Significance and Societal Importance of the Research Achievements

陽子線治療は低侵襲ながん治療の選択肢として重要な役割を果たしている。「超高線量率照射=FLASH照射」は、未だ生物学的機序において不明な点が多いが、臨床応用されれば、さらなる低侵襲化を可能とする画期的な照射法として期待されている。本研究の成果は、FLASH照射の生物学的基礎研究の普及に向けた実験モデルの構築に寄与するものであり、ショウジョウバエにおいても線量率の違いにより反応に差が出る可能性が示唆されたことは、今後に期待の持てる結果であった。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 2021

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] Outcomes of proton therapy for non-small cell lung cancer in patients with interstitial pneumonia2022

    • Author(s)
      Shingo Hashimoto, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Kento Nomura, Kensuke Hayashi, Toshiyuki Toshito, Eiko Yamamori, Kenji Akita, Jun-etsu Mizoe, Hiroyuki Ogino, Yuta Shibamoto
    • Journal Title

      Radiation Oncology

      Volume: 17 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s13014-022-02027-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spot Scanning Proton Therapy for Sinonasal Malignant Tumors.2021

    • Author(s)
      Koichiro Nakajima, Hiromitsu Iwata, Yukiko Hattori, Kento Nomura, Shingo Hashimoto, Toshiyuki Toshito, Kensuke Hayashi, Yo Kuroda, Hideo Fukano, Hiroyuki Ogino, Yuta Shibamoto
    • Journal Title

      International journal of particle therapy

      Volume: 8 Issue: 1 Pages: 189-199

    • DOI

      10.14338/ijpt-d-20-00043.1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological effects of passive scattering and spot scanning proton beams at the distal end of the spread-out Bragg peak in single cells and multicell spheroids2021

    • Author(s)
      Nomura Kento、Iwata Hiromitsu、Toshito Toshiyuki、Omachi Chihiro、Nagayoshi Junpei、Nakajima Koichiro、Ogino Hiroyuki、Shibamoto Yuta
    • Journal Title

      International Journal of Radiation Biology

      Volume: 97 Issue: 5 Pages: 695-703

    • DOI

      10.1080/09553002.2021.1889704

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concurrent Chemo-Proton Therapy Using Adaptive Planning for Unresectable Stage 3 Non-Small Cell Lung Cancer: A Phase 2 Study.2021

    • Author(s)
      Hiromitsu Iwata, Kenji Akita, Yusuke Yamaba, Eiji Kunii, Osamu Takakuwa, Misuzu Yoshihara, Yukiko Hattori, Koichiro Nakajima, Kensuke Hayashi, Toshiyuki Toshito, Hiroyuki Ogino, Yuta Shibamoto
    • Journal Title

      International journal of radiation oncology, biology, physics

      Volume: 109 Issue: 5 Pages: 1359-1367

    • DOI

      10.1016/j.ijrobp.2020.11.035

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy.2021

    • Author(s)
      Yukiko Hattori, Hiromitsu Iwata, Koichiro Nakajima, Kento Nomura, Kensuke Hayashi, Toshiyuki Toshito, Shingo Hashimoto, Yukihiro Umemoto, Jun-Etsu Mizoe, Hiroyuki Ogino, Yuta Shibamoto
    • Journal Title

      Journal of radiation research

      Volume: 62 Issue: 3 Pages: 517-524

    • DOI

      10.1093/jrr/rrab002

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Phase II Study of Image-guided Proton Therapy for Operable or Ablation-treatable Primary Hepatocellular Carcinoma2021

    • Author(s)
      Iwata Hiromitsu、Ogino Hiroyuki、Hattori Yukiko、Nakajima Koichiro、Nomura Kento、Hashimoto Shingo、Hayashi Kensuke、Toshito Toshiyuki、Sasaki Shigeru、Mizoe Jun-etsu、Shibamoto Yuta
    • Journal Title

      International Journal of Radiation Oncology*Biology*Physics

      Volume: 30 Issue: 1 Pages: 360-360

    • DOI

      10.1016/j.ijrobp.2021.03.049

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Patient-Reported Quality of Life Outcomes after Moderately Hypofractionated and Normofractionated Proton Therapy for Localized Prostate Cancer2021

    • Author(s)
      Koichiro Nakajima, Hiromitsu Iwata, Yukiko Hattori, Kento Nomura, Kensuke Hayashi, Toshiyuki Toshito, Yukihiro Umemoto, Shingo Hashimoto, Hiroyuki Ogino, Yuta Shibamoto
    • Journal Title

      Cancers

      Volume: 14 Issue: 3 Pages: 517-517

    • DOI

      10.3390/cancers14030517

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] ショウジョウバエを用いた陽子線FLASH照射に関する実験モデルの検討2023

    • Author(s)
      中嶌晃一朗、江上涼、冨田淳、粂和彦、岩田宏満、歳藤利行、大町千尋、梅澤真澄、山田雅史、荻野浩幸
    • Organizer
      第23回菅原・大西記念癌治療増感シンポジウム
    • Related Report
      2022 Research-status Report
  • [Presentation] Ⅲ期肺がんに対する陽子線治療 -臨床から基礎へ-2021

    • Author(s)
      中嶌 晃一朗、岩田 宏満、野村 研人、秋田 憲志、荻野 浩幸、芝本 雄太
    • Organizer
      第49回放射線による制癌シンポジウム
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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