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The development of a novel histopathological predictive method of sudden cardiac death in patients with tetralogy of Fallot

Research Project

Project/Area Number 20K17085
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53020:Cardiology-related
Research InstitutionKyushu University

Principal Investigator

Ishikita Ayako  九州大学, 大学病院, 学術研究員 (60829232)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords成人先天性心疾患 / ファロー四徴症 / 右室心筋傷害 / 突然死 / ファロー四徴症修復術後 / 肺動脈弁閉鎖不全症 / 右室心筋線維化 / 非侵襲的画像評価 / 非侵襲画像評価 / Fallot四徴症 / 肺動脈弁置換術 / 心筋傷害 / 心筋病理
Outline of Research at the Start

心臓外科手術の進歩により、複雑心奇形を含む先天性心疾患の多くが成人期まで生存できるようになってきた。しかし、多くの患者は完全な根治には至らず、術後も合併症・遺残症・続発症を伴うことが少なくない。ファロー四徴症の初回心臓外科手術後遠隔期の合併症に対する、適切な手術タイミングについて、心臓MRI・心内電位検査・心筋生検を用いて検証を行う。より適切な再手術のタイミングを提唱することで成人ファロー四徴症患者の長期生存率の改善に寄与したい。

Outline of Final Research Achievements

Right ventricular myocardium specimens by a transcatheter biopsy from adult patients with repaired tetralogy of Fallot were assessed pathologically. As a result, the right ventricular myocardium was moderately hypertrophied, and the right ventricle was moderate to highly fibrotic. In addition, fibrosis in the right ventricle correlated with an index called extracellular volume fraction measured by CT or MRI. Therefore, it was suggested that non-invasive image evaluation could provide the same information as invasive right ventricular myocardium evaluation.
Furthermore, this right ventricular myocardial injury was also confirmed in asymptomatic patients. Thus, preventing sudden death requires regular right ventricular myocardial damage assessment, including non-invasive imaging, and is considered an intervention indicator.

Academic Significance and Societal Importance of the Research Achievements

医学の進歩により以前は救命できなかったファロー四徴症患者の多くが若年成人まで生存できるようになった。しかし、無症状で社会的に自立している若年成人患者にも、突然死の危険性があり、解決が急務である。本研究により、無症候のうちから右室心筋傷害が進行していること、および非侵襲検査でも右室心筋傷害を評価できることが示された。外来での、定期的な右室心筋傷害評価の意義が明確となり、より適切なタイミングでの治療介入が予後改善に寄与できると期待される。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2021 2020

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (5 results)

  • [Journal Article] Usefulness of <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Infective Endocarditis in Patients With Adult Congenital Heart Disease2021

    • Author(s)
      Ishikita Ayako、Sakamoto Ichiro、Yamamura Kenichiro、Umemoto Shintaro、Nagata Hazumu、Kitamura Yoshiyuki、Yamasaki Yuzo、Sonoda Hiromichi、Tatewaki Hideki、Shiose Akira、Tsutsui Hiroyuki
    • Journal Title

      Circulation Journal

      Volume: 85 Issue: 9 Pages: 1505-1513

    • DOI

      10.1253/circj.CJ-20-1067

    • NAID

      130008077931

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-08-25
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preoperative Threshold for Normalizing Right Ventricular Volume After Transcatheter Closure of Adult Atrial Septal Defect2020

    • Author(s)
      Umemoto Shintaro、Sakamoto Ichiro、Abe Kohtaro、Ishikita Ayako、Yamasaki Yuzo、Hiasa Ken-ichi、Ide Tomomi、Tsutsui Hiroyuki
    • Journal Title

      Circulation Journal

      Volume: 84 Issue: 8 Pages: 1312-1319

    • DOI

      10.1253/circj.cj-20-0136

    • NAID

      130007879328

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Portosystemic venous shunt in the patients with Fontan circulation2020

    • Author(s)
      Nagata Hazumu、Sakamoto Ichiro、Fukuoka Shouji、Ishikita Ayako、Uike Kiyoshi、Nagatomo Yusaku、Hirata Yuichiro、Yamamura Kenichiro、Ohga Shouichi
    • Journal Title

      Heart and Vessels

      Volume: 36 Issue: 2 Pages: 285-290

    • DOI

      10.1007/s00380-020-01685-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elaborate evaluation of serial changes in electrocardiograms of atrial septal defects after transcatheter closure for a better understanding of the recovery process.2020

    • Author(s)
      Kang M, Sawatari H, Chishaki H, Shinbara R, Yamasaki K, Sato T, Fujita K, Sakamoto I, Hiasa K, Ishikita A, Umemoto S, Tsutsui H, Kamiya C, Niwa K, Chishaki A
    • Journal Title

      Heart and Vessels

      Volume: 35(11) Issue: 11 Pages: 1594-1604

    • DOI

      10.1007/s00380-020-01632-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Extracellular Volume Measured by Computed Tomography was Correlated with Right Ventricular Fibrosis in Patients with Adult Congenital Heart Disease2021

    • Author(s)
      Ayako Ishikita, Ichiro Sakamoto, Yuzo Yamasaki, Yuichi Yamada, Akiko Nishizaki, Shintaro Umemoto, Hazumu Nagata, Kenichiro Yamamura, Hiroyuki Tsutsui
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Leaflet Anomaly is Responsible for Tricuspid Regurgitation in Congenitally Corrected Transposition of the Great Arteries and Systemic Right Ventricle2021

    • Author(s)
      Ichiro Sakamoto, Ayako Ishikita, Akiko Nishizaki, Shintaro Umemoto, Hazumu Nagata, Kenichiro Yamamura, Hiromichi Sonoda, Akira Shiose, Hiroyuki Tsutsui
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Treat and Repairを行った 重症肺高血圧症合併の心室中隔欠損症2021

    • Author(s)
      石北綾子, 坂本一郎, 細川和也, 阿部弘太郎, 梅本真太郎, 永田弾, 山村健一郎, 帯刀英樹, 塩瀬明, 筒井裕之
    • Organizer
      第6回日本肺高血圧・肺循環学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Catheter Ablation is an Effective Management Strategy for Tachyarrhythmias in Patients with Adult Congenital Heart Disease2020

    • Author(s)
      Ayako Ishikita, Ichiro Sakamoto, Shintaro Umemoto, Yasushi Mukai, Kazuo Sakamoto, Susumu Takase, Shunsuke Kawai, Kazuhiro Nagaoka, Kohtaro Abe, Hazumu Nagata, Kenichiro Yamamura, Akiko Chishaki, Hiroyuki Tsutsui
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 18F-FDG PET/CT could Increase the Diagnostic Accuracy of Infective Endocarditisin Patients with Adult Congenital Heart Disease2020

    • Author(s)
      1Ayako Ishikita, 1Ichiro Sakamoto, 1Shintaro Umemoto, Kohtaro Abe, Hazumu Nagata, Kenichiro Yamamura, Hideki Tatewaki, Akira Shiose, Hiroyuki Tsutsui
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2023-01-30  

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